DK0574487T3 - Anvendelse af 5-fluor-2'-deoxy-thiacytidin til behandling af hepatitis B - Google Patents

Anvendelse af 5-fluor-2'-deoxy-thiacytidin til behandling af hepatitis B

Info

Publication number
DK0574487T3
DK0574487T3 DK92906520T DK92906520T DK0574487T3 DK 0574487 T3 DK0574487 T3 DK 0574487T3 DK 92906520 T DK92906520 T DK 92906520T DK 92906520 T DK92906520 T DK 92906520T DK 0574487 T3 DK0574487 T3 DK 0574487T3
Authority
DK
Denmark
Prior art keywords
hepatitis
treatment
thiacytidine
deoxy
fluoro
Prior art date
Application number
DK92906520T
Other languages
Danish (da)
English (en)
Inventor
Dennis C Liotta
Raymond F Schinazi
Woo-Baeg Choi
George Robert Painter Iii
Phillip Allen Furman
Original Assignee
Univ Emory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919104741A external-priority patent/GB9104741D0/en
Priority claimed from GB919109505A external-priority patent/GB9109505D0/en
Application filed by Univ Emory filed Critical Univ Emory
Application granted granted Critical
Publication of DK0574487T3 publication Critical patent/DK0574487T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK92906520T 1991-03-06 1992-03-05 Anvendelse af 5-fluor-2'-deoxy-thiacytidin til behandling af hepatitis B DK0574487T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919104741A GB9104741D0 (en) 1991-03-06 1991-03-06 Therapeutic nucleosides
GB919109505A GB9109505D0 (en) 1991-05-02 1991-05-02 Therapeutic nucleosides
PCT/GB1992/000388 WO1992015308A1 (fr) 1991-03-06 1992-03-05 Utilisation de 5-fluoro-2'-desoxy-3'-thiacytidine pour le traitement de l'hepatite b

Publications (1)

Publication Number Publication Date
DK0574487T3 true DK0574487T3 (da) 2002-10-14

Family

ID=26298535

Family Applications (2)

Application Number Title Priority Date Filing Date
DK01202860T DK1142891T3 (da) 1991-03-06 1992-03-05 Salte og amider af (-)cis-5-fluor-2'-deoxy-thiacytidin der er egnede til behandling af hepatitis B
DK92906520T DK0574487T3 (da) 1991-03-06 1992-03-05 Anvendelse af 5-fluor-2'-deoxy-thiacytidin til behandling af hepatitis B

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK01202860T DK1142891T3 (da) 1991-03-06 1992-03-05 Salte og amider af (-)cis-5-fluor-2'-deoxy-thiacytidin der er egnede til behandling af hepatitis B

Country Status (21)

Country Link
EP (3) EP0574487B1 (fr)
JP (5) JP3479068B2 (fr)
KR (1) KR100270806B1 (fr)
AT (2) ATE361293T1 (fr)
AU (1) AU662130B2 (fr)
CA (1) CA2105486C (fr)
CZ (1) CZ282747B6 (fr)
DE (2) DE69233693T2 (fr)
DK (2) DK1142891T3 (fr)
ES (2) ES2286072T3 (fr)
HU (1) HUT64844A (fr)
IE (1) IE920701A1 (fr)
IL (1) IL101144A (fr)
MX (1) MX9203213A (fr)
NZ (1) NZ264621A (fr)
PT (1) PT100198B (fr)
RU (1) RU2116789C1 (fr)
SK (1) SK279542B6 (fr)
TW (1) TW201268B (fr)
UA (1) UA54364C2 (fr)
WO (1) WO1992015308A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT674634E (pt) * 1989-02-08 2003-09-30 Iaf Biochem Int Processos para preparar 1,3-oxatiolanos substituidos com propriedades antivirais
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5827727A (en) * 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US6642245B1 (en) 1990-02-01 2003-11-04 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5925643A (en) * 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
IL100965A (en) 1991-02-22 1999-12-31 Univ Emory 2 - Hydroxymethyl - 5 -) 5 - Fluorocytocin - 1 - Eyal (- 1, 3 - Oxathiolane, its resolution and pharmaceuticals containing it
IL101144A (en) * 1991-03-06 1996-09-12 Wellcome Found Pharmaceutical preparations containing 1 -) 2 -) hydroxymethyl (- 1, 3 - oxathiolan-5 - il (5) fluorescitosin and its derivatives for the treatment of their hepatitis B virus infections
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
GB9110874D0 (en) * 1991-05-20 1991-07-10 Iaf Biochem Int Medicaments
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
GB9226927D0 (en) * 1992-12-24 1993-02-17 Iaf Biochem Int Dideoxy nucleoside analogues
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
JPH09504785A (ja) * 1993-09-10 1997-05-13 エモリー、ユニバーシティー 抗ｂ型肝炎ウイルス活性を有するヌクレオシド
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
IL115156A (en) 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
EP0831852B1 (fr) 1995-06-07 2006-11-29 Emory University Nucleosides ayant une activite anti-virus de l'hepatite b
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
CN1196701C (zh) * 1997-03-19 2005-04-13 埃莫里大学 1,3－氧硒戊环核苷的合成及抗人类免疫缺陷病毒和抗乙肝病毒活性
SG132498A1 (en) 1998-08-10 2007-06-28 Idenix Pharmaceuticals Inc Beta-l-2æ-deoxy-nucleosides for the treatment of hepatitis b
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
EP1104415B1 (fr) 1998-08-12 2004-11-10 Gilead Sciences, Inc. Methode de production de nucleosides de 1,3-oxathiolane
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CN1315862C (zh) 2000-05-26 2007-05-16 艾登尼科斯（开曼）有限公司 处理黄病毒和瘟病毒的方法和组合物
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
CA2826505A1 (fr) * 2001-05-18 2002-11-28 Rakesh Kumar Nucleosides antiviraux
TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
AU2003278816A1 (en) 2002-09-13 2004-04-30 Idenix (Cayman) Limited ss-L-2'-DEOXYNUCLEOSIDES FOR THE TREATMENT OF RESISTANT HBV STRAINS AND COMBINATION THERAPIES
PL377342A1 (pl) 2002-11-15 2006-01-23 Idenix (Cayman) Limited Nukleozydy rozgałęzione w pozycji 2' oraz mutacja Flaviviridae
CN102076215A (zh) 2008-06-30 2011-05-25 托卡根公司 5-氟胞嘧啶制剂及其用途
WO2013004658A1 (fr) * 2011-07-01 2013-01-10 Transgene Sa Formulations de 5-fluorocytosine et leurs utilisations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0206497B1 (fr) * 1985-05-15 1994-07-20 The Wellcome Foundation Limited Nucléosides thérapeutiques et leur préparation
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
IL100965A (en) * 1991-02-22 1999-12-31 Univ Emory 2 - Hydroxymethyl - 5 -) 5 - Fluorocytocin - 1 - Eyal (- 1, 3 - Oxathiolane, its resolution and pharmaceuticals containing it
IL101144A (en) * 1991-03-06 1996-09-12 Wellcome Found Pharmaceutical preparations containing 1 -) 2 -) hydroxymethyl (- 1, 3 - oxathiolan-5 - il (5) fluorescitosin and its derivatives for the treatment of their hepatitis B virus infections

Also Published As

Publication number Publication date
RU2116789C1 (ru) 1998-08-10
JP4891435B2 (ja) 2012-03-07
SK95093A3 (en) 1994-04-06
JP2011102308A (ja) 2011-05-26
CZ282747B6 (cs) 1997-09-17
TW201268B (fr) 1993-03-01
DE69233693D1 (de) 2007-06-14
DE69232649D1 (de) 2002-07-25
EP0574487B1 (fr) 2002-06-19
CA2105486C (fr) 2003-10-28
EP1142891B1 (fr) 2007-05-02
JP2010013466A (ja) 2010-01-21
EP1808434A3 (fr) 2008-04-02
HU9302493D0 (en) 1993-11-29
IL101144A (en) 1996-09-12
IE920701A1 (en) 1992-09-09
SK279542B6 (sk) 1998-12-02
AU1367692A (en) 1992-10-06
EP1808434A2 (fr) 2007-07-18
ES2179040T3 (es) 2003-01-16
MX9203213A (es) 1992-07-01
DE69233693T2 (de) 2008-01-24
EP1142891A1 (fr) 2001-10-10
UA54364C2 (uk) 2003-03-17
DK1142891T3 (da) 2007-08-27
AU662130B2 (en) 1995-08-24
CZ183593A3 (en) 1994-04-13
JP3987335B2 (ja) 2007-10-10
DE69232649T2 (de) 2002-11-28
JPH06505725A (ja) 1994-06-30
PT100198A (pt) 1993-05-31
KR100270806B1 (ko) 2000-11-01
JP2002220388A (ja) 2002-08-09
EP0574487A1 (fr) 1993-12-22
HUT64844A (en) 1994-03-28
JP2007246536A (ja) 2007-09-27
CA2105486A1 (fr) 1992-09-07
PT100198B (pt) 2000-03-31
JP3479068B2 (ja) 2003-12-15
JP4399478B2 (ja) 2010-01-13
WO1992015308A1 (fr) 1992-09-17
IL101144A0 (en) 1992-11-15
ES2286072T3 (es) 2007-12-01
IE20040402A1 (en) 2007-10-17
NZ264621A (en) 1997-09-22
ATE219366T1 (de) 2002-07-15
ATE361293T1 (de) 2007-05-15

Similar Documents

Publication Publication Date Title
DK0574487T3 (da) Anvendelse af 5-fluor-2'-deoxy-thiacytidin til behandling af hepatitis B
MD1224B2 (en) Application of nucleoside analogues with 1,3-oxathiolan for treatment of hepatitis B
IL101836A0 (en) Pharmaceutical compositions containing 1,3-oxathiolane nucleoside derivatives
RU93043875A (ru) 1-(2-гидроксиметил)-1,3-оксатиолан-5-ил)-5-фторцитозин и способ лечения
ITMI931522A0 (it) Composizione farmaceutiche per il trattamento dell'infezione da virus dell'epatite b (hbv)
ATE131730T1 (de) Nukleosidanalogen enthaltende antiviren- zubereitungen
TW366347B (en) Antiviral pharmaceutical compositions comprising 1,3-oxathiolane nucleoside analogues
FI933684A (fi) Antiviral 2-hydroximetyl-5-(5-fluorcytosin-1-yl)-1,3-oxatiolan och dess resolution
DK224286A (da) 2',3'-dideoxy-nucleosider
MY109796A (en) 1,3-oxathiolane nucleoside analogues.
MY127808A (en) Use of dideoxy nucleoside analogues in the treatment of viral infections
DK1115420T3 (da) Behandling af hepatitis B med thymosin-alpha-1 og lamivudin
MY137298A (en) Therapeutic nucleosides
DK0388049T3 (da) Penciclovirderivater til behandling af hepatitis B infektioner
RU93058325A (ru) Применение производных 1,3-оксатиолана для получения лекарственных препаратов для лечения или профилактики вирусной инфекции гепатита в, применение производных 1,3 - оксатиолана для лечения инфекций гепатита в, способ лечения гепатита в
MY113560A (en) Use of 5-fluoro-2'-deoxy-3'-thiacytidine for the treatment of hepatitis b
SE9602262D0 (sv) New use of derivatives of cystine