DK0557877T3 - Opløselige salte af 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-l-yl)-pyrimidin-5-carboxylsyre-eN-methyl-N-(3-trifluormethyl-phenyl)-amide,fremgangsmådetil deres fremstilling, deres anvendelse som lægemidler og udgangsprodukter - Google Patents

Opløselige salte af 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-l-yl)-pyrimidin-5-carboxylsyre-eN-methyl-N-(3-trifluormethyl-phenyl)-amide,fremgangsmådetil deres fremstilling, deres anvendelse som lægemidler og udgangsprodukter

Info

Publication number
DK0557877T3
DK0557877T3 DK93102451.7T DK93102451T DK0557877T3 DK 0557877 T3 DK0557877 T3 DK 0557877T3 DK 93102451 T DK93102451 T DK 93102451T DK 0557877 T3 DK0557877 T3 DK 0557877T3
Authority
DK
Denmark
Prior art keywords
pyrimidine
trifluoromethyl
amide
dimethyl
phenyl
Prior art date
Application number
DK93102451.7T
Other languages
Danish (da)
English (en)
Inventor
Ernold Dr Dr Granzer
Klaus-Dieter Dr Kampe
Michael Dr Leineweber
Manfred Prof Dr Huettinger
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0557877T3 publication Critical patent/DK0557877T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK93102451.7T 1992-02-22 1993-02-17 Opløselige salte af 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-l-yl)-pyrimidin-5-carboxylsyre-eN-methyl-N-(3-trifluormethyl-phenyl)-amide,fremgangsmådetil deres fremstilling, deres anvendelse som lægemidler og udgangsprodukter DK0557877T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4205483 1992-02-22

Publications (1)

Publication Number Publication Date
DK0557877T3 true DK0557877T3 (da) 1998-04-27

Family

ID=6452363

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93102451.7T DK0557877T3 (da) 1992-02-22 1993-02-17 Opløselige salte af 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-l-yl)-pyrimidin-5-carboxylsyre-eN-methyl-N-(3-trifluormethyl-phenyl)-amide,fremgangsmådetil deres fremstilling, deres anvendelse som lægemidler og udgangsprodukter

Country Status (16)

Country Link
US (1) US5795899A (fi)
EP (1) EP0557877B1 (fi)
JP (1) JP3258744B2 (fi)
AT (1) ATE158581T1 (fi)
AU (2) AU658265B2 (fi)
CA (1) CA2089956A1 (fi)
DE (1) DE59307402D1 (fi)
DK (1) DK0557877T3 (fi)
ES (1) ES2109382T3 (fi)
FI (1) FI105097B (fi)
GR (1) GR3025235T3 (fi)
HU (1) HU210621B (fi)
IL (1) IL104792A (fi)
NO (1) NO300892B1 (fi)
NZ (2) NZ264767A (fi)
ZA (1) ZA931183B (fi)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE147384T1 (de) * 1992-02-22 1997-01-15 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
DE19625089A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19625088A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE60025243T2 (de) * 1999-10-12 2006-06-22 Takeda Pharmaceutical Co. Ltd. Pyrimidin-5-carboximidverbindungen, verfahren zur herstellung derselben und deren verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2853220A1 (de) * 1978-12-09 1980-07-03 Hoechst Ag Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung
DE3522940A1 (de) * 1985-06-27 1987-01-08 Hoechst Ag 4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carbonsaeure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln
ATE147384T1 (de) * 1992-02-22 1997-01-15 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Also Published As

Publication number Publication date
DE59307402D1 (de) 1997-10-30
IL104792A (en) 1997-09-30
JP3258744B2 (ja) 2002-02-18
CA2089956A1 (en) 1993-08-23
FI930718A (fi) 1993-08-23
FI105097B (fi) 2000-06-15
NZ264767A (en) 1995-10-26
ATE158581T1 (de) 1997-10-15
AU658265B2 (en) 1995-04-06
HU9300459D0 (en) 1993-05-28
ES2109382T3 (es) 1998-01-16
AU669463B2 (en) 1996-06-06
AU1136595A (en) 1995-04-13
ZA931183B (en) 1993-09-16
HU210621B (en) 1995-06-28
NZ245937A (en) 1994-12-22
EP0557877B1 (de) 1997-09-24
NO930595L (no) 1993-08-23
FI930718A0 (fi) 1993-02-18
NO300892B1 (no) 1997-08-11
EP0557877A1 (de) 1993-09-01
JPH06184137A (ja) 1994-07-05
HUT63410A (en) 1993-08-30
NO930595D0 (no) 1993-02-19
AU3376093A (en) 1993-08-26
GR3025235T3 (en) 1998-02-27
IL104792A0 (en) 1993-06-10
US5795899A (en) 1998-08-18

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