DK0540956T3 - Fremgangsmåde til fremstilling af substituerede maleinimider - Google Patents
Fremgangsmåde til fremstilling af substituerede maleinimiderInfo
- Publication number
- DK0540956T3 DK0540956T3 DK92118164.0T DK92118164T DK0540956T3 DK 0540956 T3 DK0540956 T3 DK 0540956T3 DK 92118164 T DK92118164 T DK 92118164T DK 0540956 T3 DK0540956 T3 DK 0540956T3
- Authority
- DK
- Denmark
- Prior art keywords
- formula
- chem
- alkyl
- aryl
- above significance
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919123396A GB9123396D0 (en) | 1991-11-04 | 1991-11-04 | A process for the manufacture of substituted maleimides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0540956T3 true DK0540956T3 (da) | 1998-04-14 |
Family
ID=10704041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92118164.0T DK0540956T3 (da) | 1991-11-04 | 1992-10-23 | Fremgangsmåde til fremstilling af substituerede maleinimider |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5399712A (zh) |
| EP (1) | EP0540956B1 (zh) |
| JP (1) | JP2799271B2 (zh) |
| CN (1) | CN1041308C (zh) |
| AT (1) | ATE157664T1 (zh) |
| AU (1) | AU658017B2 (zh) |
| CA (1) | CA2081805C (zh) |
| DE (1) | DE69221988T2 (zh) |
| DK (1) | DK0540956T3 (zh) |
| ES (1) | ES2107487T3 (zh) |
| GB (1) | GB9123396D0 (zh) |
| GR (1) | GR3025396T3 (zh) |
| NZ (1) | NZ244952A (zh) |
| ZA (1) | ZA928340B (zh) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374727A (en) * | 1992-06-19 | 1994-12-20 | Hoffmann-La Roche Inc. | Asymmetric hydrogenation of dihydro-pyrido [1,2-a]indoles |
| US5721230A (en) * | 1993-05-10 | 1998-02-24 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| US5843935A (en) * | 1993-12-07 | 1998-12-01 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| IL111851A (en) * | 1993-12-07 | 1998-09-24 | Lilly Co Eli | Improved synthesis of bisindolylsimilides and process for its preparation |
| US5723456A (en) * | 1993-12-07 | 1998-03-03 | Eli Lilly & Company | Therapeutic treatment for cardiovascular diseases |
| AU687909B2 (en) * | 1993-12-07 | 1998-03-05 | Eli Lilly And Company | Protein kinase C inhibitors |
| EP0817627B1 (en) * | 1993-12-23 | 2005-03-09 | Eli Lilly And Company | Protein kinase c inhibitors |
| US5491242A (en) * | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5481003A (en) * | 1994-06-22 | 1996-01-02 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| US5919946A (en) * | 1996-03-20 | 1999-07-06 | Eli Lilly And Company | Synthesis of indolylmaleimides |
| CA2263862A1 (en) * | 1996-08-23 | 1998-02-26 | Margaret Mary Faul | Synthesis of bisindolylmalimides |
| SE9603283D0 (sv) * | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
| TW472045B (en) | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
| US5859261A (en) * | 1997-03-20 | 1999-01-12 | Eli Lilly And Company | Synthesis of indolylmaleimides |
| US6133452A (en) * | 1997-08-22 | 2000-10-17 | Eli Lilly And Company | Synthesis of bisindolylmalimides |
| AR017200A1 (es) | 1997-12-23 | 2001-08-22 | Astrazeneca Ab | Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos |
| SE9800835D0 (sv) | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
| CA2338866A1 (en) * | 1998-07-30 | 2000-02-10 | Japan Tobacco Inc. | Disubstituted maleimide compound and pharmaceutical use thereof |
| US6492406B1 (en) | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
| US6284783B1 (en) | 1999-06-09 | 2001-09-04 | The Uab Research Foundation | Use of bisindolylmaleimide compounds to induce Fas-mediated apoptosis |
| US6346625B1 (en) | 1999-06-23 | 2002-02-12 | Astrazeneca Ab | Protein kinase inhibitors |
| EP1224932A4 (en) * | 1999-08-20 | 2002-10-16 | Sagami Chem Res | DRUGS INHIBITING CELL DEATH |
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| CA2308994A1 (en) * | 2000-05-19 | 2001-11-19 | Aegera Therapeutics Inc. | Neuroprotective compounds |
| CZ2003555A3 (en) | 2000-07-27 | 2004-03-17 | F. Hoffmann-La Roche Ag | 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta |
| US6645970B2 (en) | 2000-11-07 | 2003-11-11 | Novartis Ag | Indolylmaleimide derivatives |
| ATE318596T1 (de) * | 2001-03-29 | 2006-03-15 | Topotarget As | Succinimid- und maleimidderivate und ihre verwendung als katalytische inhibitoren der topoisomerase ii |
| DK1397130T3 (da) | 2001-06-20 | 2007-11-12 | Wyeth Corp | Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1) |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
| CA2393720C (en) | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
| AU2003296324A1 (en) | 2002-12-10 | 2004-06-30 | Wyeth | Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| CN1723197A (zh) | 2002-12-10 | 2006-01-18 | 惠氏公司 | 作为纤溶酶原激活物抑制剂－1(pai－1)的抑制剂的取代3－烷基和3－芳基烷基1h－吲哚－1－基乙酸衍生物 |
| AU2003296323A1 (en) | 2002-12-10 | 2004-06-30 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| DE60306548T2 (de) | 2002-12-10 | 2007-06-21 | Wyeth | Substituierte 3-carbonyl-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor(pai-1) inhibitoren |
| GB0303319D0 (en) | 2003-02-13 | 2003-03-19 | Novartis Ag | Organic compounds |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7534894B2 (en) | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| WO2006023864A1 (en) | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as pai-1 inhibitors |
| JP2008510816A (ja) | 2004-08-23 | 2008-04-10 | ワイス | チアゾロ−ナフチル酸 |
| MX2007002178A (es) | 2004-08-23 | 2007-04-02 | Wyeth Corp | Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares. |
| EP1819697B1 (en) | 2004-12-08 | 2012-08-01 | Johannes Gutenberg-Universität Mainz | 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors |
| EP1904482B1 (en) | 2005-07-11 | 2011-01-19 | Novartis AG | Indolylmaleimide derivatives |
| AU2006279496A1 (en) | 2005-08-17 | 2007-02-22 | Wyeth | Substituted indoles and use thereof |
| KR101061764B1 (ko) * | 2008-02-29 | 2011-09-05 | (주)에스에이치제약 | 신경보호효과를 가지는 피루베이트 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물 |
| EP2343291A1 (en) | 2009-12-18 | 2011-07-13 | Johannes Gutenberg-Universität Mainz | 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| EP2474541A1 (en) | 2010-12-23 | 2012-07-11 | Johannes- Gutenberg-Universität Mainz | Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
| CN103491775A (zh) * | 2011-04-21 | 2014-01-01 | 巴斯夫欧洲公司 | 3,4-二取代的吡咯-2,5-二酮及其作为杀真菌剂的用途 |
| EP3169337A1 (en) | 2014-07-17 | 2017-05-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| EP3187495A1 (en) | 2015-12-30 | 2017-07-05 | Johannes Gutenberg-Universität Mainz | 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4332822A (en) * | 1980-02-05 | 1982-06-01 | John Wyeth & Brother Limited | Guanidine derivatives |
| DE3631414A1 (de) * | 1986-09-16 | 1988-03-24 | Basf Ag | Verfahren zur herstellung von (alpha)-pyrrolidonen, deren verwendung und neue (alpha)-pyrrolidone |
| DE3707719A1 (de) * | 1987-03-11 | 1988-09-22 | Degussa | Verfahren zur herstellung von (r)-4-amino-3-hydroxybutansaeure (gabob) |
| NZ227850A (en) * | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
| MC2096A1 (fr) * | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
| IL94274A0 (en) * | 1989-05-05 | 1991-03-10 | Goedecke Ag | Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same |
| CA2046801C (en) * | 1990-08-07 | 2002-02-26 | Peter D. Davis | Substituted pyrroles |
-
1991
- 1991-11-04 GB GB919123396A patent/GB9123396D0/en active Pending
-
1992
- 1992-10-23 EP EP92118164A patent/EP0540956B1/en not_active Expired - Lifetime
- 1992-10-23 ES ES92118164T patent/ES2107487T3/es not_active Expired - Lifetime
- 1992-10-23 AT AT92118164T patent/ATE157664T1/de not_active IP Right Cessation
- 1992-10-23 DE DE69221988T patent/DE69221988T2/de not_active Expired - Fee Related
- 1992-10-23 DK DK92118164.0T patent/DK0540956T3/da active
- 1992-10-28 ZA ZA928340A patent/ZA928340B/xx unknown
- 1992-10-29 AU AU27419/92A patent/AU658017B2/en not_active Ceased
- 1992-10-30 CA CA002081805A patent/CA2081805C/en not_active Expired - Fee Related
- 1992-10-30 NZ NZ244952A patent/NZ244952A/en not_active IP Right Cessation
- 1992-11-02 JP JP4317907A patent/JP2799271B2/ja not_active Expired - Fee Related
- 1992-11-03 CN CN92112704A patent/CN1041308C/zh not_active Expired - Fee Related
- 1992-11-04 US US07/971,370 patent/US5399712A/en not_active Expired - Fee Related
-
1997
- 1997-11-17 GR GR970403040T patent/GR3025396T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9123396D0 (en) | 1991-12-18 |
| CN1041308C (zh) | 1998-12-23 |
| DE69221988D1 (de) | 1997-10-09 |
| DE69221988T2 (de) | 1998-02-05 |
| NZ244952A (en) | 1995-10-26 |
| CN1072409A (zh) | 1993-05-26 |
| US5399712A (en) | 1995-03-21 |
| AU2741992A (en) | 1993-05-06 |
| GR3025396T3 (en) | 1998-02-27 |
| JPH05221977A (ja) | 1993-08-31 |
| JP2799271B2 (ja) | 1998-09-17 |
| ATE157664T1 (de) | 1997-09-15 |
| CA2081805C (en) | 1999-12-14 |
| AU658017B2 (en) | 1995-03-30 |
| ES2107487T3 (es) | 1997-12-01 |
| CA2081805A1 (en) | 1993-05-05 |
| EP0540956B1 (en) | 1997-09-03 |
| ZA928340B (en) | 1993-05-04 |
| EP0540956A1 (en) | 1993-05-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0540956T3 (da) | Fremgangsmåde til fremstilling af substituerede maleinimider | |
| PT655996E (pt) | Benzilaminas substituidas contendo heterociclicos nao aromaticos contendo azoto | |
| FI924397A0 (fi) | Substituerade pyrimidiner. | |
| MX9307810A (es) | Heterociclicos no aromaticos sustituidos con aminometileno. | |
| ES480704A1 (es) | Procedimiento para la obtencion de amidas de acido carboxi- lico. | |
| ATE103812T1 (de) | Zusammensetzung zur behandlung von ischaemischen stoerungen in organen. | |
| DE68916174D1 (de) | Mevalonolactone vom Thienopyridin-Typ. | |
| DE69201596D1 (de) | 7-Oxabicycloheptyl-substituierte, heterocyclische Amid-Prostaglandin-Analoge, verwendbar bei der Behandlung von vasospastischen und thrombotischen Krankheiten. | |
| DK164498C (da) | 3,5-dicarboxylsyreestere af 2,6-bis-(fluoralkyl)-tetrahydropyraner og -piperidiner med herbicid aktivitet | |
| DE69527854D1 (de) | Derivate substituierter amidinonaphthylester | |
| DE60013515D1 (de) | 4-Arylpiperidinderivate zur Behandlung von Pruritus | |
| ATE283269T1 (de) | 5-(heteroaryl)alkyl)-3-oxo-pyrido(1,2- a)benzimidazol-4-carboxamid (pbi) derivate zur behandlung von störungen des zentralen nervensystems | |
| HK1047081A1 (en) | Novel carboxylic acid derivatives and process for producing the same. | |
| ATE209651T1 (de) | Pyridoncarbonsäure-derivate und zwischenverbindungen für deren herstellung | |
| ATE89818T1 (de) | Dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
| NO924701L (no) | Amid-bundete pyridyl-benzosyrederivater for behandling avleukotrien-relaterte sykdommer |