DK0538300T3 - O-Glycosyleret IFN-alfa - Google Patents
O-Glycosyleret IFN-alfaInfo
- Publication number
- DK0538300T3 DK0538300T3 DK91912306.7T DK91912306T DK0538300T3 DK 0538300 T3 DK0538300 T3 DK 0538300T3 DK 91912306 T DK91912306 T DK 91912306T DK 0538300 T3 DK0538300 T3 DK 0538300T3
- Authority
- DK
- Denmark
- Prior art keywords
- alpha
- glycosylated ifn
- glycosylated
- ifn
- objects
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19904021917 DE4021917A1 (de) | 1990-07-10 | 1990-07-10 | Glykosyliertes ifnalpha |
DE19904035877 DE4035877A1 (de) | 1990-11-12 | 1990-11-12 | O-glycosyliertes ifn-alfa2 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0538300T3 true DK0538300T3 (da) | 1994-10-10 |
Family
ID=25894855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91912306.7T DK0538300T3 (da) | 1990-07-10 | 1991-07-06 | O-Glycosyleret IFN-alfa |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0538300B1 (hu) |
JP (1) | JPH06502987A (hu) |
KR (1) | KR930701601A (hu) |
AT (1) | ATE104348T1 (hu) |
AU (1) | AU650893B2 (hu) |
CA (1) | CA2084514A1 (hu) |
CZ (1) | CZ386392A3 (hu) |
DE (1) | DE59101397D1 (hu) |
DK (1) | DK0538300T3 (hu) |
ES (1) | ES2063515T3 (hu) |
FI (1) | FI930058A (hu) |
HU (1) | HUT65846A (hu) |
NO (1) | NO930059L (hu) |
PL (1) | PL297610A1 (hu) |
SK (1) | SK386392A3 (hu) |
WO (1) | WO1992001055A1 (hu) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ245771A (en) * | 1992-02-07 | 1994-08-26 | New England Medical Center Inc | Mammalian gastrin/cholecystokinin b (cck-b) receptor and antagonists |
US5541071A (en) * | 1992-02-07 | 1996-07-30 | New England Medical Center Hospitals, Inc. | Assay for identifying antagonists of gastrin and CCK-B receptors |
EP0626448A3 (de) * | 1993-05-26 | 1998-01-14 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Verfahren zur Herstellung und Reinigung von alpha-Interferon |
EP0788556A1 (en) | 1994-10-28 | 1997-08-13 | Innogenetics N.V. | New polynucleic acid sequences for use in the detection and differentiation of prokaryotic organisms |
WO1998006863A1 (en) * | 1996-08-14 | 1998-02-19 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | A vector for polynucleotide vaccines |
GB9904695D0 (en) * | 1999-03-01 | 1999-04-21 | Imp Cancer Res Tech | Peptide |
WO2001077137A1 (en) | 2000-04-12 | 2001-10-18 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
DK2279755T3 (da) * | 2001-10-10 | 2014-05-26 | Ratiopharm Gmbh | Remodellering og glycokonjugering af fibroblastvækstfaktor (FGF) |
JP5424521B2 (ja) | 2001-12-21 | 2014-02-26 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | アルブミン融合タンパク質 |
KR20060003862A (ko) | 2003-03-14 | 2006-01-11 | 네오스 테크놀로지스, 인크. | 수용성분기폴리머 및 그 접합체 |
SG155777A1 (en) | 2003-04-09 | 2009-10-29 | Neose Technologies Inc | Glycopegylation methods and proteins/peptides produced by the methods |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
CN101072789B (zh) | 2004-01-08 | 2013-05-15 | 生物种属学股份公司 | 肽的o-连接的糖基化 |
WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
EP1799249A2 (en) | 2004-09-10 | 2007-06-27 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
PL2586456T3 (pl) | 2004-10-29 | 2016-07-29 | Ratiopharm Gmbh | Remodeling i glikopegilacja czynnika wzrostu fibroblastów (FGF) |
ES2449195T3 (es) | 2005-01-10 | 2014-03-18 | Ratiopharm Gmbh | Factor estimulante de colonias de granulocitos glicopegilado |
WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
EP2975135A1 (en) | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glycopegylated factor IX |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
AR078117A1 (es) | 2006-06-20 | 2011-10-19 | Protech Pharma S A | Una muteina recombinante del interferon alfa humano glicosilado, un gen que codifica para dicha muteina, un metodo de produccion de dicho gen, un metodo para obtener una celula eucariota productora de dicha muteina, un metodo para producir dicha muteina, un procedimiento para purificar dicha muteina |
CN101516388B (zh) | 2006-07-21 | 2012-10-31 | 诺和诺德公司 | 通过o-联糖基化序列的肽的糖基化 |
WO2008057683A2 (en) | 2006-10-03 | 2008-05-15 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
AU2008237411B2 (en) | 2007-04-03 | 2013-10-03 | Ratiopharm Gmbh | Methods of treatment using glycopegylated G-CSF |
WO2008154639A2 (en) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Improved process for the production of nucleotide sugars |
US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
CN103497246B (zh) | 2008-02-27 | 2016-08-10 | 诺沃—诺迪斯克有限公司 | 缀合的因子viii分子 |
WO2014102101A1 (en) | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Novel intron sequences |
WO2014102103A2 (en) | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Heterologous intron within a signal peptide |
RU2610173C1 (ru) * | 2016-03-30 | 2017-02-08 | Илья Александрович Марков | Рекомбинантная плазмида pFM-IFN-17, обеспечивающая экспрессию интерферона альфа-2b человека, рекомбинантная плазмида pFM-АР, обеспечивающая экспрессию фермента метионинаминопептидазы E. coli, биплазмидный штамм Escherichia coli FM-IFN-АР (pFM-IFN-17, pFM-АР) - продуцент (Met-) рекомбинантного интерферона альфа-2b человека |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN150740B (hu) * | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
JPS58501543A (ja) * | 1981-08-14 | 1983-09-16 | エイ/エス アルフレツド ベンツオン | ヒトインタ−フエロン蛋白とヒトインタ−フエロン蛋白に対する抗体に関する改良 |
DE3306060A1 (de) * | 1983-02-22 | 1984-08-23 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung |
FR2560212B1 (fr) * | 1984-02-24 | 1989-12-29 | Unicet | Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps |
-
1991
- 1991-07-06 HU HU9300036A patent/HUT65846A/hu unknown
- 1991-07-06 DE DE59101397T patent/DE59101397D1/de not_active Expired - Fee Related
- 1991-07-06 EP EP91912306A patent/EP0538300B1/de not_active Expired - Lifetime
- 1991-07-06 PL PL29761091A patent/PL297610A1/xx unknown
- 1991-07-06 WO PCT/EP1991/001266 patent/WO1992001055A1/de not_active Application Discontinuation
- 1991-07-06 CA CA002084514A patent/CA2084514A1/en not_active Abandoned
- 1991-07-06 ES ES91912306T patent/ES2063515T3/es not_active Expired - Lifetime
- 1991-07-06 AT AT91912306T patent/ATE104348T1/de not_active IP Right Cessation
- 1991-07-06 JP JP3511638A patent/JPH06502987A/ja active Pending
- 1991-07-06 DK DK91912306.7T patent/DK0538300T3/da active
- 1991-07-06 SK SK3863-92A patent/SK386392A3/sk unknown
- 1991-07-06 AU AU82082/91A patent/AU650893B2/en not_active Ceased
- 1991-07-06 KR KR1019930700049A patent/KR930701601A/ko not_active Application Discontinuation
-
1992
- 1992-12-23 CZ CS923863A patent/CZ386392A3/cs unknown
-
1993
- 1993-01-08 FI FI930058A patent/FI930058A/fi not_active Application Discontinuation
- 1993-01-08 NO NO93930059A patent/NO930059L/no unknown
Also Published As
Publication number | Publication date |
---|---|
WO1992001055A1 (de) | 1992-01-23 |
FI930058A0 (fi) | 1993-01-08 |
EP0538300B1 (de) | 1994-04-13 |
NO930059D0 (no) | 1993-01-08 |
KR930701601A (ko) | 1993-06-12 |
DE59101397D1 (de) | 1994-05-19 |
EP0538300A1 (de) | 1993-04-28 |
FI930058A (fi) | 1993-01-08 |
PL297610A1 (hu) | 1992-07-13 |
AU8208291A (en) | 1992-02-04 |
JPH06502987A (ja) | 1994-04-07 |
HU9300036D0 (en) | 1993-04-28 |
CA2084514A1 (en) | 1992-01-11 |
HUT65846A (en) | 1994-07-28 |
CZ386392A3 (en) | 1993-08-11 |
ES2063515T3 (es) | 1995-01-01 |
NO930059L (no) | 1993-01-08 |
AU650893B2 (en) | 1994-07-07 |
ATE104348T1 (de) | 1994-04-15 |
SK386392A3 (en) | 1994-08-10 |
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