DK0527821T3 - Oxidationsresistente thrombomodulinanaloger - Google Patents

Oxidationsresistente thrombomodulinanaloger

Info

Publication number
DK0527821T3
DK0527821T3 DK91908593.6T DK91908593T DK0527821T3 DK 0527821 T3 DK0527821 T3 DK 0527821T3 DK 91908593 T DK91908593 T DK 91908593T DK 0527821 T3 DK0527821 T3 DK 0527821T3
Authority
DK
Denmark
Prior art keywords
analogs
oxidation
thrombomodulin
thrombomodulin analogues
resistant thrombomodulin
Prior art date
Application number
DK91908593.6T
Other languages
English (en)
Inventor
Michael John Morser
Charles B Glaser
David Richard Light
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0527821T3 publication Critical patent/DK0527821T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Semiconductor Memories (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Paints Or Removers (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK91908593.6T 1990-04-09 1991-04-09 Oxidationsresistente thrombomodulinanaloger DK0527821T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/506,325 US5256770A (en) 1990-04-09 1990-04-09 Oxidation resistant thrombomodulin analogs
PCT/US1991/002442 WO1991015514A1 (en) 1990-04-09 1991-04-09 Oxidation resistant thrombomodulin analogs

Publications (1)

Publication Number Publication Date
DK0527821T3 true DK0527821T3 (da) 1997-12-15

Family

ID=24014143

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91908593.6T DK0527821T3 (da) 1990-04-09 1991-04-09 Oxidationsresistente thrombomodulinanaloger

Country Status (11)

Country Link
US (1) US5256770A (da)
EP (1) EP0527821B1 (da)
JP (1) JP3051995B2 (da)
AT (1) ATE153346T1 (da)
AU (1) AU650880B2 (da)
CA (1) CA2077691C (da)
DE (1) DE69126205T2 (da)
DK (1) DK0527821T3 (da)
ES (1) ES2103810T3 (da)
GR (1) GR3024099T3 (da)
WO (1) WO1991015514A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR920701459A (ko) * 1989-02-17 1992-08-11 코돈 트롬보모듈린의 가용성 유사체
US6063763A (en) * 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
EP0489180A4 (en) * 1990-06-27 1993-03-31 Mochida Pharmaceutical Co., Ltd. Anticoagulant polypeptides
ATE211390T1 (de) * 1990-08-15 2002-01-15 Paion Gmbh Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung
DE69232084T2 (de) * 1991-07-01 2002-05-02 Berlex Lab Neuartige methoden der mutagenese und reagentien dafür
ATE264913T1 (de) * 1992-02-05 2004-05-15 Paion Gmbh Protease-resistente analoge des thrombomodulin
DE4323754C1 (de) * 1993-07-15 1994-12-01 Gruenenthal Gmbh Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung
US5585095A (en) * 1993-09-14 1996-12-17 Regents Of The University Of Minnesota Method to enhance thrombomodulin APC generation using cationic proteins
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
CA2364687C (en) * 1999-03-23 2014-11-18 James Cook University Organ arrest, protection and preservation
US6632791B1 (en) 2000-06-21 2003-10-14 Schering Aktiengesellschaft Thrombomodulin analogs for pharmaceutical use
US20020111296A1 (en) * 2000-08-31 2002-08-15 Festoff Barry W. Thrombomodulin analogs for use in recovery of spinal cord injury
US6706068B2 (en) 2002-04-23 2004-03-16 Bret A. Ferree Artificial disc replacements with natural kinematics
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
UA81114C2 (en) * 2002-05-01 2007-12-10 Schering Ag Novel antibodies to tissue factor as anticoagulants
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
WO2004056180A1 (en) * 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery (1)
US7833978B2 (en) 2004-02-20 2010-11-16 Emory University Thrombomodulin derivatives and conjugates
WO2006005362A1 (en) * 2004-07-13 2006-01-19 Paion Deutschland Gmbh Production of mammalian proteins in plant cells
US8420783B2 (en) * 2004-12-08 2013-04-16 Immunomedics, Inc. Method and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases
JP4067557B2 (ja) 2005-06-03 2008-03-26 持田製薬株式会社 抗ｃｄ１４抗体融合蛋白質
CA2688028A1 (en) * 2006-05-29 2007-12-06 Hibernation Therapeutics Limited Improved tissue maintenance
CN103495173B (zh) * 2006-07-25 2016-11-23 低温药理Kf有限公司 创伤治疗
US8541236B2 (en) * 2006-12-08 2013-09-24 University Of Washington Mutant apolipoprotein A-1 polypeptide with increased resistance to oxidation and reactive carbonyls
US20100119554A1 (en) * 2007-03-02 2010-05-13 Hibernation Therapeutics Limited Transplants
US20100256083A1 (en) * 2007-07-25 2010-10-07 Hibernation Therapeutics Limited Organ protection, preservation and recovery
EP2120049A1 (de) 2008-05-14 2009-11-18 PAION Deutschland GmbH Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern
US8241861B1 (en) 2008-07-08 2012-08-14 Insilicos, Llc Methods and compositions for diagnosis or prognosis of cardiovascular disease
US20120270789A1 (en) 2009-06-12 2012-10-25 Paion Deutschland Gmbh Treatment of coagulopathy with hyperfibrinolysis
CN103037893A (zh) 2010-06-14 2013-04-10 帕昂德国有限公司 具有纤溶亢进的凝血病的治疗
EP2600891B1 (en) * 2010-08-05 2018-01-17 Council of Scientific & Industrial Research Protein fusion constructs possessing thrombolytic and anticoagulant properties
WO2014020183A1 (de) 2012-08-03 2014-02-06 Ici Immunochemical Intelligence Gmbh In-vitro-assay zur diagnose von störungen der hämostase
US20160166598A1 (en) 2013-07-17 2016-06-16 Hibernation Therapeutics, A Kf Llc A method for treating infection, sepsis and injury

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4752585A (en) * 1985-12-17 1988-06-21 Cetus Corporation Oxidation-resistant muteins
DE3856335T2 (de) * 1987-01-08 2000-01-27 Asahi Chemical Ind Peptid zur beschleunigung der wirkung des proteins-c mit thrombin
US4835260A (en) * 1987-03-20 1989-05-30 Genetics Institute, Inc. Erythropoietin composition
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
DE3824595A1 (de) * 1988-07-19 1990-01-25 Buechler B Set Ag Palette

Also Published As

Publication number Publication date
DE69126205D1 (en) 1997-06-26
EP0527821A4 (en) 1993-05-05
ATE153346T1 (de) 1997-06-15
JPH05508150A (ja) 1993-11-18
CA2077691A1 (en) 1991-10-10
US5256770A (en) 1993-10-26
DE69126205T2 (de) 1998-08-20
CA2077691C (en) 2001-11-20
EP0527821A1 (en) 1993-02-24
EP0527821B1 (en) 1997-05-21
AU650880B2 (en) 1994-07-07
WO1991015514A1 (en) 1991-10-17
AU7778491A (en) 1991-10-30
JP3051995B2 (ja) 2000-06-12
ES2103810T3 (es) 1997-10-01
GR3024099T3 (en) 1997-10-31

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