DK0527821T3 - Oxidationsresistente thrombomodulinanaloger - Google Patents
Oxidationsresistente thrombomodulinanalogerInfo
- Publication number
- DK0527821T3 DK0527821T3 DK91908593.6T DK91908593T DK0527821T3 DK 0527821 T3 DK0527821 T3 DK 0527821T3 DK 91908593 T DK91908593 T DK 91908593T DK 0527821 T3 DK0527821 T3 DK 0527821T3
- Authority
- DK
- Denmark
- Prior art keywords
- analogs
- oxidation
- thrombomodulin
- thrombomodulin analogues
- resistant thrombomodulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Semiconductor Memories (AREA)
- Semiconductor Integrated Circuits (AREA)
- External Artificial Organs (AREA)
- Paints Or Removers (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/506,325 US5256770A (en) | 1990-04-09 | 1990-04-09 | Oxidation resistant thrombomodulin analogs |
PCT/US1991/002442 WO1991015514A1 (en) | 1990-04-09 | 1991-04-09 | Oxidation resistant thrombomodulin analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0527821T3 true DK0527821T3 (da) | 1997-12-15 |
Family
ID=24014143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91908593.6T DK0527821T3 (da) | 1990-04-09 | 1991-04-09 | Oxidationsresistente thrombomodulinanaloger |
Country Status (11)
Country | Link |
---|---|
US (1) | US5256770A (da) |
EP (1) | EP0527821B1 (da) |
JP (1) | JP3051995B2 (da) |
AT (1) | ATE153346T1 (da) |
AU (1) | AU650880B2 (da) |
CA (1) | CA2077691C (da) |
DE (1) | DE69126205T2 (da) |
DK (1) | DK0527821T3 (da) |
ES (1) | ES2103810T3 (da) |
GR (1) | GR3024099T3 (da) |
WO (1) | WO1991015514A1 (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0458903A4 (en) * | 1989-02-17 | 1992-06-17 | Codon | Soluble analogs of thrombomodulin |
US6063763A (en) * | 1989-04-28 | 2000-05-16 | Schering Aktiengesellschaft | Protease-resistant thrombomodulin analogs |
EP0489180A4 (en) * | 1990-06-27 | 1993-03-31 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant polypeptides |
ES2170747T3 (es) * | 1990-08-15 | 2002-08-16 | Paion Gmbh | Analogos superiores de trombomodulina para uso farmaceutico. |
DE69232084T2 (de) * | 1991-07-01 | 2002-05-02 | Berlex Lab | Neuartige methoden der mutagenese und reagentien dafür |
PT641215E (pt) * | 1992-02-05 | 2004-09-30 | Paion Gmbh | Analogos de trombomodulina resistentes a proteases |
DE4323754C1 (de) * | 1993-07-15 | 1994-12-01 | Gruenenthal Gmbh | Bifunktionelle Urokinasevarianten mit verbesserten fibrinolytischen Eigenschaften und thrombinhemmender Wirkung |
US5585095A (en) * | 1993-09-14 | 1996-12-17 | Regents Of The University Of Minnesota | Method to enhance thrombomodulin APC generation using cationic proteins |
DE4440892A1 (de) * | 1994-11-17 | 1996-05-23 | Gruenenthal Gmbh | Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften |
ATE361667T1 (de) * | 1999-03-23 | 2007-06-15 | Hibernation Therapeutics Ltd | Stoppen, schützen und konservieren von organen |
US6632791B1 (en) | 2000-06-21 | 2003-10-14 | Schering Aktiengesellschaft | Thrombomodulin analogs for pharmaceutical use |
US20020111296A1 (en) * | 2000-08-31 | 2002-08-15 | Festoff Barry W. | Thrombomodulin analogs for use in recovery of spinal cord injury |
US6706068B2 (en) | 2002-04-23 | 2004-03-16 | Bret A. Ferree | Artificial disc replacements with natural kinematics |
US7579000B2 (en) | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
MXPA04010795A (es) * | 2002-05-01 | 2005-03-07 | Schering Ag | Nuevos anticuerpos dirigidos al factor tisular como anticoagulantes. |
AUPS312602A0 (en) * | 2002-06-21 | 2002-07-18 | James Cook University | Organ arrest, protection, preservation and recovery |
WO2004056181A1 (en) * | 2002-12-23 | 2004-07-08 | Global Cardiac Solutions Pty Ltd | Organ preconditioning, arrest, protection, preservation and recovery (2) |
US7833978B2 (en) | 2004-02-20 | 2010-11-16 | Emory University | Thrombomodulin derivatives and conjugates |
WO2006005362A1 (en) * | 2004-07-13 | 2006-01-19 | Paion Deutschland Gmbh | Production of mammalian proteins in plant cells |
AU2005313971B2 (en) * | 2004-12-08 | 2011-10-13 | Immunomedics, Inc. | Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer |
CA2609262A1 (en) | 2005-06-03 | 2006-12-07 | Mochida Pharmaceutical Co., Ltd. | Anti-cd14 antibody fusion protein |
EP2079301B1 (en) | 2006-05-29 | 2017-03-15 | Hibernation Therapeutics, a KF LLC | Improved tissue maintenance |
EP2139316B1 (en) * | 2006-07-25 | 2015-03-18 | Hibernation Therapeutics, a KF LLC | Trauma therapy |
US8541236B2 (en) * | 2006-12-08 | 2013-09-24 | University Of Washington | Mutant apolipoprotein A-1 polypeptide with increased resistance to oxidation and reactive carbonyls |
US20100119554A1 (en) * | 2007-03-02 | 2010-05-13 | Hibernation Therapeutics Limited | Transplants |
AU2008280836A1 (en) * | 2007-07-25 | 2009-01-29 | Hibernation Therapeutics, A Kf Llc | Improved organ protection, preservation and recovery |
EP2120049A1 (de) | 2008-05-14 | 2009-11-18 | PAION Deutschland GmbH | Lösliches Thrombomodulin als Biomarker bei Therapien mit Gerinnungshemmern |
US8241861B1 (en) | 2008-07-08 | 2012-08-14 | Insilicos, Llc | Methods and compositions for diagnosis or prognosis of cardiovascular disease |
CN102481344A (zh) | 2009-06-12 | 2012-05-30 | 帕昂德国有限公司 | 具有纤溶亢进的凝血病的治疗 |
CA2802072A1 (en) | 2010-06-14 | 2011-12-22 | Paion Deutschland Gmbh | Treatment of coagulopathy with hyperfibrinolysis |
KR20130099027A (ko) * | 2010-08-05 | 2013-09-05 | 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 | 혈전용해 및 응고억제 특성을 갖는 단백질 융합 구조물 |
WO2014020183A1 (de) | 2012-08-03 | 2014-02-06 | Ici Immunochemical Intelligence Gmbh | In-vitro-assay zur diagnose von störungen der hämostase |
CN105705151A (zh) | 2013-07-17 | 2016-06-22 | 低温药理Kf有限公司 | 一种用于治疗出血、休克和脑损伤的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4752585A (en) * | 1985-12-17 | 1988-06-21 | Cetus Corporation | Oxidation-resistant muteins |
DE3856335T2 (de) * | 1987-01-08 | 2000-01-27 | Asahi Chemical Ind | Peptid zur beschleunigung der wirkung des proteins-c mit thrombin |
US4835260A (en) * | 1987-03-20 | 1989-05-30 | Genetics Institute, Inc. | Erythropoietin composition |
US4912207A (en) * | 1987-05-06 | 1990-03-27 | Washington University | DNA clone of human thrombomodulin and portions thereof |
DE3824595A1 (de) * | 1988-07-19 | 1990-01-25 | Buechler B Set Ag | Palette |
-
1990
- 1990-04-09 US US07/506,325 patent/US5256770A/en not_active Expired - Lifetime
-
1991
- 1991-04-09 ES ES91908593T patent/ES2103810T3/es not_active Expired - Lifetime
- 1991-04-09 JP JP3508342A patent/JP3051995B2/ja not_active Expired - Fee Related
- 1991-04-09 WO PCT/US1991/002442 patent/WO1991015514A1/en active IP Right Grant
- 1991-04-09 EP EP91908593A patent/EP0527821B1/en not_active Expired - Lifetime
- 1991-04-09 AU AU77784/91A patent/AU650880B2/en not_active Ceased
- 1991-04-09 DK DK91908593.6T patent/DK0527821T3/da active
- 1991-04-09 CA CA002077691A patent/CA2077691C/en not_active Expired - Lifetime
- 1991-04-09 DE DE69126205T patent/DE69126205T2/de not_active Expired - Fee Related
- 1991-04-09 AT AT91908593T patent/ATE153346T1/de not_active IP Right Cessation
-
1997
- 1997-07-15 GR GR970401750T patent/GR3024099T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0527821B1 (en) | 1997-05-21 |
DE69126205D1 (en) | 1997-06-26 |
WO1991015514A1 (en) | 1991-10-17 |
AU7778491A (en) | 1991-10-30 |
JP3051995B2 (ja) | 2000-06-12 |
EP0527821A1 (en) | 1993-02-24 |
CA2077691A1 (en) | 1991-10-10 |
EP0527821A4 (en) | 1993-05-05 |
US5256770A (en) | 1993-10-26 |
AU650880B2 (en) | 1994-07-07 |
JPH05508150A (ja) | 1993-11-18 |
ATE153346T1 (de) | 1997-06-15 |
GR3024099T3 (en) | 1997-10-31 |
ES2103810T3 (es) | 1997-10-01 |
DE69126205T2 (de) | 1998-08-20 |
CA2077691C (en) | 2001-11-20 |
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