DK0414274T3 - Fremgangsmåde til fremstilling af 1-aminomethyl-1-cyclohexaneddikesyre - Google Patents
Fremgangsmåde til fremstilling af 1-aminomethyl-1-cyclohexaneddikesyreInfo
- Publication number
- DK0414274T3 DK0414274T3 DK90116292.5T DK90116292T DK0414274T3 DK 0414274 T3 DK0414274 T3 DK 0414274T3 DK 90116292 T DK90116292 T DK 90116292T DK 0414274 T3 DK0414274 T3 DK 0414274T3
- Authority
- DK
- Denmark
- Prior art keywords
- aminomethyl
- preparing
- acetic acid
- cyclohexane acetic
- reaction
- Prior art date
Links
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 238000006845 Michael addition reaction Methods 0.000 abstract 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 abstract 1
- 150000008041 alkali metal carbonates Chemical class 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 229960002870 gabapentin Drugs 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/12—Formation of amino and carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3928182A DE3928182A1 (de) | 1989-08-25 | 1989-08-25 | Verfahren zur herstellung von gabapentin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0414274T3 true DK0414274T3 (da) | 1993-08-09 |
Family
ID=6387900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90116292.5T DK0414274T3 (da) | 1989-08-25 | 1990-08-24 | Fremgangsmåde til fremstilling af 1-aminomethyl-1-cyclohexaneddikesyre |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5091567A (sv) |
| EP (1) | EP0414274B1 (sv) |
| JP (1) | JP2846084B2 (sv) |
| AT (1) | ATE90936T1 (sv) |
| DE (2) | DE3928182A1 (sv) |
| DK (1) | DK0414274T3 (sv) |
| ES (1) | ES2058707T3 (sv) |
| FI (1) | FI103040B (sv) |
| HU (1) | HU207284B (sv) |
| IL (1) | IL95479A (sv) |
| MY (1) | MY107055A (sv) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69518578T2 (de) * | 1994-05-18 | 2001-04-26 | Sharp Kk | Kartenartige Kamera mit Bildverarbeitungsfunktion |
| PT888286E (pt) * | 1996-03-14 | 2002-04-29 | Warner Lambert Co | Novos amino acidos ciclicos substituidos como agentes farmaceuticos |
| US6372792B1 (en) | 1996-04-26 | 2002-04-16 | Guy Chouinard | Method for treating anxiety, anxiety disorders and insomnia |
| PL192180B1 (pl) | 1997-09-18 | 2006-09-29 | Warner Lambert Co | Sposób wytwarzania analogów gabapentyny o wzorze I,II,III,IV |
| AU9318398A (en) | 1997-10-07 | 1999-04-27 | Warner-Lambert Company | Process for preparing a cyclic amino acid anticonvulsant compound |
| HU225502B1 (en) * | 1998-12-29 | 2007-01-29 | Richter Gedeon Vegyeszet | Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates |
| US6333352B1 (en) * | 2000-04-05 | 2001-12-25 | Mimicking Man Manually, Inc. | Method of treating benign positional vertigo |
| PT1289364E (pt) | 2000-06-16 | 2004-04-30 | Teva Pharma | Gabapentina estavel contendo mais do que 20 ppm de iao cloreto |
| KR100667721B1 (ko) * | 2000-06-16 | 2007-01-15 | 테바 파마슈티컬 인더스트리즈 리미티드 | 제어 범위 내의 ｐｈ를 갖는 안정한 가바펜틴 |
| CN1471507A (zh) * | 2000-11-02 | 2004-01-28 | ������ҩ��ҵ����˾ | 用于制备加巴喷丁中间体的改进方法 |
| ITMI20011132A1 (it) | 2001-05-29 | 2002-11-29 | Procos Spa | Procedimento per la preparazione dell'acido 1-amminometil-1-cicloesanacetico |
| US20030119908A1 (en) * | 2001-12-21 | 2003-06-26 | Zambon Group S.P.A. | Stable gabapentin compositions |
| ITMI20012750A1 (it) | 2001-12-21 | 2003-06-21 | Procos Spa | Processo per la produzione dell'acido 1-(amminometil)-cicloesil-acetico in forma pura |
| DE10203122A1 (de) | 2002-01-25 | 2003-07-31 | Gruenenthal Gmbh | Verfahren zur Herstellung von substituierten Acrylsäureestern bzw. deren Einsatz zur Herstellung von substituierten gamma-Aminosäuren |
| US20040034248A1 (en) * | 2002-04-16 | 2004-02-19 | Taro Pharmaceutical Industries, Ltd. | Process for preparing gabapentin |
| ITMI20022071A1 (it) * | 2002-10-01 | 2004-04-02 | Erregierre Spa | Processo di sintesi dell'acido 1-(aminometil)cicloesanacetico cloridato. |
| US7632953B2 (en) * | 2002-11-20 | 2009-12-15 | Hikal Limited | Process for the preparation of gabalactam |
| EP1615875A2 (en) * | 2003-04-21 | 2006-01-18 | Matrix Laboratories Limited | Process for the preparation of gabapentin form-ii |
| US20050148792A1 (en) * | 2004-01-02 | 2005-07-07 | Damodaragounder Gopal | Process for the preparation of gabapentin |
| US20050187295A1 (en) * | 2004-02-19 | 2005-08-25 | Surendra Kalyan | Processes for the preparation of gabapentin |
| ITMI20040579A1 (it) * | 2004-03-25 | 2004-06-25 | Zambon Spa | Processo di preparazione di gabapentina |
| ITMI20041271A1 (it) * | 2004-06-24 | 2004-09-24 | Zambon Spa | Processo di preparazione di gabapentina |
| GB0416228D0 (en) | 2004-07-20 | 2004-08-25 | Sandoz Ind Products S A | Process for the preparation of gabapentin |
| EP1853551A1 (en) * | 2005-02-28 | 2007-11-14 | S.A. Medichem | Process and methods for the preparation of gabapentin and its intermediates |
| US7442834B2 (en) * | 2006-06-12 | 2008-10-28 | Zhejiang Chiral Medicine Chemicals Co., Ltd. | Process suitable for industrial scale production of gabapentin |
| CN100404504C (zh) * | 2006-06-12 | 2008-07-23 | 浙江手心医药化学品有限公司 | 3，3-亚戊基丁内酰胺的制备方法 |
| CA2660769C (en) * | 2006-06-30 | 2013-12-03 | Zach System S.P.A. | Process for preparing gabapentin |
| US8431739B2 (en) | 2010-06-14 | 2013-04-30 | Divi's Laboratories, Ltd. | Process for the preparation of gabapentin |
| ITMI20131757A1 (it) | 2013-10-22 | 2015-04-23 | Zach System Spa | Processo di preparazione di gabapentina |
| WO2015144825A1 (en) | 2014-03-27 | 2015-10-01 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Oral liquid pharmaceutical solution of gabapentin |
| EP3169666B1 (en) | 2014-07-15 | 2018-06-06 | Grünenthal GmbH | Substituted azaspiro(4.5)decane derivatives |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| CN104151180A (zh) * | 2014-08-28 | 2014-11-19 | 太仓运通生物化工有限公司 | 一种加巴喷丁盐酸盐的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2825739A (en) * | 1952-10-06 | 1958-03-04 | British Celanese | Production of amino acids and their derivatives |
| GB825562A (en) * | 1955-07-18 | 1959-12-16 | Upjohn Co | Substituted spiro-pyrrolidines |
| US2812334A (en) * | 1956-02-10 | 1957-11-05 | Upjohn Co | Organic compounds |
| US3253039A (en) * | 1962-02-05 | 1966-05-24 | Engelhard Ind Inc | Catalytic hydrogenation of organic nitrocompounds |
| US3417090A (en) * | 1965-09-15 | 1968-12-17 | Bayer Ag | Reduction of nitro compounds to amines |
| US3624127A (en) * | 1966-10-11 | 1971-11-30 | Sterling Drug Inc | Basic esters of cyclohexylideneacetic acids and intermediates |
| US3594419A (en) * | 1968-04-15 | 1971-07-20 | Gulf Research Development Co | Process for converting nitroparaffins to amines |
| US3595875A (en) * | 1968-12-09 | 1971-07-27 | Texaco Inc | Preparation of 2-pyrrolidinone |
| US3766271A (en) * | 1971-03-04 | 1973-10-16 | Texaco Inc | Homogeneous catalysts useful in the reduction of nitroparaffins to amines |
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| DE2626467C2 (de) * | 1976-06-12 | 1984-11-22 | Gödecke AG, 1000 Berlin | 1-(N-Isopropylaminomethyl)-cyclohexanessigsäure, Verfahren zu deren Herstellung und diese Verbindung enthaltende Arzneimittel |
| FR2431494A1 (fr) * | 1978-07-17 | 1980-02-15 | Logeais Labor Jacques | Nouveaux derives du benzofuranne, leur procede de preparation et leur application en therapeutique |
| JPS5865255A (ja) * | 1981-10-13 | 1983-04-18 | Tanabe Seiyaku Co Ltd | γ−アミノ酪酸カルシウム塩の製法 |
| US4894476A (en) * | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
-
1989
- 1989-08-25 DE DE3928182A patent/DE3928182A1/de not_active Withdrawn
-
1990
- 1990-08-21 MY MYPI90001396A patent/MY107055A/en unknown
- 1990-08-21 US US07/570,487 patent/US5091567A/en not_active Expired - Lifetime
- 1990-08-23 IL IL9547990A patent/IL95479A/en active IP Right Grant
- 1990-08-24 EP EP90116292A patent/EP0414274B1/de not_active Expired - Lifetime
- 1990-08-24 ES ES90116292T patent/ES2058707T3/es not_active Expired - Lifetime
- 1990-08-24 AT AT90116292T patent/ATE90936T1/de not_active IP Right Cessation
- 1990-08-24 FI FI904203A patent/FI103040B/sv active IP Right Grant
- 1990-08-24 DE DE9090116292T patent/DE59001851D1/de not_active Expired - Lifetime
- 1990-08-24 DK DK90116292.5T patent/DK0414274T3/da active
- 1990-08-24 HU HU905332A patent/HU207284B/hu unknown
- 1990-08-24 JP JP2221421A patent/JP2846084B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI103040B1 (sv) | 1999-04-15 |
| ES2058707T3 (es) | 1994-11-01 |
| JPH03118355A (ja) | 1991-05-20 |
| ATE90936T1 (de) | 1993-07-15 |
| EP0414274B1 (de) | 1993-06-23 |
| MY107055A (en) | 1995-09-30 |
| US5091567A (en) | 1992-02-25 |
| HUT54623A (en) | 1991-03-28 |
| EP0414274A2 (de) | 1991-02-27 |
| EP0414274A3 (en) | 1991-05-15 |
| DE3928182A1 (de) | 1991-02-28 |
| FI904203A0 (fi) | 1990-08-24 |
| HU207284B (en) | 1993-03-29 |
| IL95479A (en) | 1996-09-12 |
| IL95479A0 (en) | 1991-06-30 |
| FI103040B (sv) | 1999-04-15 |
| JP2846084B2 (ja) | 1999-01-13 |
| HU905332D0 (en) | 1991-02-28 |
| DE59001851D1 (de) | 1993-07-29 |
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