DK0411907T3 - Apparat til scanning og detektering af samlet indre reflektans under anvendelse af spredt lys - Google Patents

Apparat til scanning og detektering af samlet indre reflektans under anvendelse af spredt lys

Info

Publication number
DK0411907T3
DK0411907T3 DK90308424.2T DK90308424T DK0411907T3 DK 0411907 T3 DK0411907 T3 DK 0411907T3 DK 90308424 T DK90308424 T DK 90308424T DK 0411907 T3 DK0411907 T3 DK 0411907T3
Authority
DK
Denmark
Prior art keywords
scanning
total internal
scattered light
internal reflectance
interface
Prior art date
Application number
DK90308424.2T
Other languages
English (en)
Inventor
Ernest G Schutt
David L Greenwood
Karin Utberg
Original Assignee
Ortho Diagnostic Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Diagnostic Systems Inc filed Critical Ortho Diagnostic Systems Inc
Application granted granted Critical
Publication of DK0411907T3 publication Critical patent/DK0411907T3/da

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55Specular reflectivity
    • G01N21/552Attenuated total reflection
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553Metal or metal coated
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/0205Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0216Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using light concentrators or collectors or condensers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/0205Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0243Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows having a through-hole enabling the optical element to fulfil an additional optical function, e.g. a mirror or grating having a throughhole for a light collecting or light injecting optical fiber
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02Details
    • G01J3/0297Constructional arrangements for removing other types of optical noise or for performing calibration
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21Polarisation-affecting properties
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
DK90308424.2T 1989-08-01 1990-07-31 Apparat til scanning og detektering af samlet indre reflektans under anvendelse af spredt lys DK0411907T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/388,193 US4979821A (en) 1988-01-27 1989-08-01 Cuvette for receiving liquid sample

Publications (1)

Publication Number Publication Date
DK0411907T3 true DK0411907T3 (da) 1998-01-12

Family

ID=23533078

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90308424.2T DK0411907T3 (da) 1989-08-01 1990-07-31 Apparat til scanning og detektering af samlet indre reflektans under anvendelse af spredt lys

Country Status (9)

Country Link
US (1) US4979821A (da)
EP (1) EP0411907B1 (da)
JP (1) JPH03115956A (da)
AT (1) ATE154437T1 (da)
CA (1) CA2022292A1 (da)
DE (1) DE69030902T2 (da)
DK (1) DK0411907T3 (da)
ES (1) ES2102362T3 (da)
GR (3) GR1002311B (da)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337173C (en) * 1989-04-28 1995-10-03 Westaim Biomedical Corp. Thin film diagnostic device
DE69110032T2 (de) * 1991-06-08 1995-12-21 Hewlett Packard Gmbh Verfahren und Gerät zur Feststellung und/oder Konzentrationsbestimmung von Biomolekülen.
FR2679661B1 (fr) * 1991-07-26 1994-10-14 Sfri Appareil d'analyse automatique d'echantillons.
EP0601205B1 (en) * 1992-06-26 1999-03-10 Daikin Industries, Ltd. Optical measurement instrument
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
NZ299724A (en) * 1995-11-15 1997-03-24 Nihon Mediphysics Co Ltd Analysis of liquid using diminished intensity of a reflected beam, use in analysing trace samples and apparatus therefor
US5657118A (en) * 1996-01-23 1997-08-12 Lee; John T. S. Device and method for detection/measurement of light
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
DE19628002C1 (de) * 1996-07-11 1997-12-18 Inst Chemo Biosensorik Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests
JP4209471B2 (ja) 1997-02-20 2009-01-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プラズモン共鳴粒子、方法、および装置
US6344272B1 (en) * 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US6852252B2 (en) 1997-03-12 2005-02-08 William Marsh Rice University Use of metalnanoshells to impede the photo-oxidation of conjugated polymer
GB2326229A (en) * 1997-06-13 1998-12-16 Robert Jeffrey Geddes Carr Detecting and analysing submicron particles
US6097025A (en) * 1997-10-31 2000-08-01 Ljl Biosystems, Inc. Light detection device having an optical-path switching mechanism
US6258326B1 (en) 1997-09-20 2001-07-10 Ljl Biosystems, Inc. Sample holders with reference fiducials
US6071748A (en) 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6469311B1 (en) 1997-07-16 2002-10-22 Molecular Devices Corporation Detection device for light transmitted from a sensed volume
US6294327B1 (en) 1997-09-08 2001-09-25 Affymetrix, Inc. Apparatus and method for detecting samples labeled with material having strong light scattering properties, using reflection mode light and diffuse scattering
US6326605B1 (en) 1998-02-20 2001-12-04 Ljl Biosystems, Inc. Broad range light detection system
US6992761B2 (en) 1997-09-20 2006-01-31 Molecular Devices Corporation Broad range light detection system
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
WO2000050877A1 (en) 1999-02-23 2000-08-31 Ljl Biosystems, Inc. Frequency-domain light detection device
US6982431B2 (en) 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6576476B1 (en) 1998-09-02 2003-06-10 Ljl Biosystems, Inc. Chemiluminescence detection method and device
US6271970B1 (en) * 1997-12-13 2001-08-07 Lightchip, Inc. Wavelength division multiplexing/demultiplexing devices using dual homogeneous refractive index lenses
US6699724B1 (en) 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
DE19815932C2 (de) * 1998-04-09 2000-06-21 Glukomeditech Ag Verfahren zur Miniaturisierung eines Polarimeters zur Analyse niedrig konzentrierter Komponenten im flüssigen Meßgut auf optischer Basis sowie Vorrichtung zu seiner Durchführung
EP1071942A1 (en) 1998-04-17 2001-01-31 LJL Biosystems, Inc. Sample-holding devices and systems
US6139831A (en) * 1998-05-28 2000-10-31 The Rockfeller University Apparatus and method for immobilizing molecules onto a substrate
AU4999099A (en) * 1998-07-15 2000-02-07 Ljl Biosystems, Inc. Evanescent field illumination devices and methods
AU5223899A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
AU5667599A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for time-resolved spectroscopic measurements
DE59813265D1 (de) * 1998-08-17 2006-01-12 Hoffmann La Roche Verfahren zur Ueberwachung von Pipettiervorgängen
PT1079226E (pt) 1999-08-24 2004-07-30 Stiftung Fur Diagnostische For Dispositivo destinado a realizacao de testes de imunizacao
WO2001069207A1 (fr) * 2000-03-16 2001-09-20 Fuji Photo Film Co., Ltd. Procede et instrument de mesure utilisant l'attenuation de la reflexion totale
JP2001330560A (ja) * 2000-03-16 2001-11-30 Fuji Photo Film Co Ltd 全反射減衰を利用した測定方法および装置
JP2002048707A (ja) * 2000-05-22 2002-02-15 Fuji Photo Film Co Ltd 全反射減衰を利用した測定方法および装置
AU2001275475A1 (en) * 2000-06-12 2001-12-24 Genicon Sciences Corporation Assay for genetic polymorphisms using scattered light detectable labels
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US20020132360A1 (en) 2000-11-17 2002-09-19 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
WO2002061858A2 (en) 2000-11-17 2002-08-08 Thermogenic Imaging, Inc. Apparatus and methods for infrared calorimetric measurements
US20050148063A1 (en) * 2003-12-24 2005-07-07 Cracauer Raymond F. Disposable reaction vessel with integrated optical elements
SE528470C2 (sv) * 2004-02-03 2006-11-21 Mircona Ab Vibrationsdämpad verktygshållare med viskoelastiskt dämpningsmaterial
JP4095968B2 (ja) * 2004-02-06 2008-06-04 株式会社日立ハイテクノロジーズ 液体分注装置、それを用いた自動分析装置、及び液面検出装置
SE528247C2 (sv) * 2004-05-07 2006-10-03 Mircona Ab Vibrationsdämpad verktygshållare
US7651869B2 (en) * 2006-03-14 2010-01-26 Research International, Inc. Optical assay apparatus and methods
WO2008139356A1 (en) * 2007-05-09 2008-11-20 Koninklijke Philips Electronics N. V. A cartridge for sample investigations
JP5283364B2 (ja) * 2007-10-22 2013-09-04 富士フイルム株式会社 センシング装置
JP5424610B2 (ja) * 2007-11-07 2014-02-26 株式会社東芝 光導波路型センサチップ、光導波路型センサチップの製造方法、物質の測定方法、物質測定用キットおよび光導波路型センサ
US20090124024A1 (en) 2007-11-07 2009-05-14 Shingo Kasai Optical-waveguide sensor chip, method of manufacturing the same, method of measuring substance, substance-measuring kit and optical-waveguide sensor
JP2009133717A (ja) * 2007-11-30 2009-06-18 Konica Minolta Holdings Inc 分析素子チップ、及びこれを用いた分析装置
JP2010127624A (ja) * 2008-11-25 2010-06-10 Fujifilm Corp 全反射照明型センサチップ
JP5987573B2 (ja) * 2012-09-12 2016-09-07 セイコーエプソン株式会社 光学モジュール、電子機器、及び駆動方法
CN103713124B (zh) * 2013-12-27 2015-12-09 中国科学院苏州生物医学工程技术研究所 一种用于检测液体中微量蛋白的试剂盒及其操作方法
US10416358B2 (en) 2015-10-20 2019-09-17 Tintometer, Gmbh Device for removing energy from a beam and a method(s) of use thereof
US11435277B2 (en) 2015-10-20 2022-09-06 Tintometer, Gmbh Device for removing energy from a beam and a method(s) of use thereof
US10197558B1 (en) 2016-09-16 2019-02-05 Cbrn International, Ltd Environmental sampling and assay device
JP6838612B2 (ja) 2017-02-15 2021-03-03 コニカミノルタ株式会社 検査チップ及び検査システム

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3604927A (en) * 1966-11-16 1971-09-14 Block Engineering Total reflection fluorescence spectroscopy
US3715585A (en) * 1971-06-07 1973-02-06 N Harrick Fluorescence spectrophotometry using multiple reflections to enhance sample absorption and fluorescence collection
US3893754A (en) * 1973-06-21 1975-07-08 Xerox Corp Combination paraboloid-ellipsoid mirror system
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US4181441A (en) * 1977-12-07 1980-01-01 G. D. Searle & Co. Internal reflectance spectrometer
NL7807532A (nl) * 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4591266A (en) * 1981-08-10 1986-05-27 Laser Precision Corporation Parabolic focusing apparatus for optical spectroscopy
DE3135196A1 (de) * 1981-09-05 1983-03-17 Merck Patent Gmbh, 6100 Darmstadt Verfahren, mittel und vorrichtung zur bestimmung biologischer komponenten
JPS5999304A (ja) * 1982-11-30 1984-06-08 Asahi Optical Co Ltd 顕微鏡系のレーザ光による比較測長装置
JPS6041001A (ja) * 1983-08-16 1985-03-04 Agency Of Ind Science & Technol 集光装置
DE3343868A1 (de) * 1983-12-03 1985-06-13 Zeiss Carl Fa Objektiv mit kegelschnittflaechen fuer die mikrozonenabbildung
US5017009A (en) * 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
US4844593A (en) * 1988-05-16 1989-07-04 Hewlett-Packard Company Optical feedback isolator

Also Published As

Publication number Publication date
EP0411907A3 (en) 1991-07-24
CA2022292A1 (en) 1991-02-02
GR920100164A (el) 1994-03-31
DE69030902T2 (de) 1997-11-06
GR900100571A (en) 1991-12-30
GR1002310B (el) 1996-06-30
US4979821A (en) 1990-12-25
GR920100165A (el) 1994-03-31
GR1000982B (el) 1993-03-31
EP0411907B1 (en) 1997-06-11
ES2102362T3 (es) 1997-08-01
JPH03115956A (ja) 1991-05-16
GR1002311B (el) 1996-06-30
DE69030902D1 (de) 1997-07-17
EP0411907A2 (en) 1991-02-06
ATE154437T1 (de) 1997-06-15

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