ES2102362T3 - Aparato de reflectancia interna total que usa la difusion de la luz. - Google Patents
Aparato de reflectancia interna total que usa la difusion de la luz.Info
- Publication number
- ES2102362T3 ES2102362T3 ES90308424T ES90308424T ES2102362T3 ES 2102362 T3 ES2102362 T3 ES 2102362T3 ES 90308424 T ES90308424 T ES 90308424T ES 90308424 T ES90308424 T ES 90308424T ES 2102362 T3 ES2102362 T3 ES 2102362T3
- Authority
- ES
- Spain
- Prior art keywords
- light
- total internal
- internal reflectance
- interface
- detection
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000009792 diffusion process Methods 0.000 title 1
- 238000001514 detection method Methods 0.000 abstract 2
- 238000003018 immunoassay Methods 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
- G01N33/553—Metal or metal coated
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/0216—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using light concentrators or collectors or condensers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
- G01J3/0243—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows having a through-hole enabling the optical element to fulfil an additional optical function, e.g. a mirror or grating having a throughhole for a light collecting or light injecting optical fiber
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
- G01J3/0297—Constructional arrangements for removing other types of optical noise or for performing calibration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/21—Polarisation-affecting properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Radar Systems And Details Thereof (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
Abstract
SE PROPORCIONA UN SISTEMA NUEVO DE INMUNOENSAYO PARA LA DETECCION DE LIGANDOS O MODELOS DE UNION DE LIGANDOS EN SOLUCION EN UN FORMATO HETEROGENEO. LA INVENCION SE APOYA EN LA DETECCION DE LUZ POSTERIOR EXTENDIDA DESDE UNA ONDA EVANESCENTE PERTURBADA POR LA PRESENCIA DE UNA ETIQUETA DE ORO COLOIDAL LLEVADA AL INTERFAZ MEDIANTE UNA REACCION INMUNOLOGICA. LA ONDA EVANESCENTE EXISTENTE EN EL INTERFAZ ES, A SU VEZ, EL RESULTADO DE UNA ONDA DE LUZ INCIDENTE TOTAL E INTERNAMENTE REFLEJADA. LA COLOCACION DEL DETECTOR EN EL ANGULO POSTERIOR, POR ENCIMA DEL ANGULO CRITICO, ASEGURA UNA PROPORCION SUPERIOR DE SEÑAL A RUIDO. SE PROPORCIONAN APARATO Y METODOS PARA EXPLORAR, DETECTAR Y MANEJAR LUZ, INCLUYENDO UN SISTEMA DE INMUNOENSAYO DE REFLECTANCIA TOTAL INTERNA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/388,193 US4979821A (en) | 1988-01-27 | 1989-08-01 | Cuvette for receiving liquid sample |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2102362T3 true ES2102362T3 (es) | 1997-08-01 |
Family
ID=23533078
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90308424T Expired - Lifetime ES2102362T3 (es) | 1989-08-01 | 1990-07-31 | Aparato de reflectancia interna total que usa la difusion de la luz. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4979821A (es) |
EP (1) | EP0411907B1 (es) |
JP (1) | JPH03115956A (es) |
AT (1) | ATE154437T1 (es) |
CA (1) | CA2022292A1 (es) |
DE (1) | DE69030902T2 (es) |
DK (1) | DK0411907T3 (es) |
ES (1) | ES2102362T3 (es) |
GR (3) | GR1002311B (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1337173C (en) * | 1989-04-28 | 1995-10-03 | Westaim Biomedical Corp. | Thin film diagnostic device |
DE69110032T2 (de) * | 1991-06-08 | 1995-12-21 | Hewlett Packard Gmbh | Verfahren und Gerät zur Feststellung und/oder Konzentrationsbestimmung von Biomolekülen. |
FR2679661B1 (fr) * | 1991-07-26 | 1994-10-14 | Sfri | Appareil d'analyse automatique d'echantillons. |
CA2116568A1 (en) * | 1992-06-26 | 1994-01-06 | Kaori Tosa | Optical measurement instrument |
US5599668A (en) * | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
AU7066996A (en) * | 1995-11-15 | 1997-05-22 | Arkray, Inc. | Liquid detection method and device therefor |
US5657118A (en) * | 1996-01-23 | 1997-08-12 | Lee; John T. S. | Device and method for detection/measurement of light |
US6586193B2 (en) * | 1996-04-25 | 2003-07-01 | Genicon Sciences Corporation | Analyte assay using particulate labels |
DE19628002C1 (de) * | 1996-07-11 | 1997-12-18 | Inst Chemo Biosensorik | Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests |
DE69836734D1 (de) | 1997-02-20 | 2007-02-08 | Univ California | Plasmon-schwingteilchen, methode und vorrichtung |
US6852252B2 (en) | 1997-03-12 | 2005-02-08 | William Marsh Rice University | Use of metalnanoshells to impede the photo-oxidation of conjugated polymer |
US6344272B1 (en) | 1997-03-12 | 2002-02-05 | Wm. Marsh Rice University | Metal nanoshells |
GB2326229A (en) * | 1997-06-13 | 1998-12-16 | Robert Jeffrey Geddes Carr | Detecting and analysing submicron particles |
US6258326B1 (en) | 1997-09-20 | 2001-07-10 | Ljl Biosystems, Inc. | Sample holders with reference fiducials |
US6071748A (en) | 1997-07-16 | 2000-06-06 | Ljl Biosystems, Inc. | Light detection device |
US6469311B1 (en) | 1997-07-16 | 2002-10-22 | Molecular Devices Corporation | Detection device for light transmitted from a sensed volume |
US6097025A (en) * | 1997-10-31 | 2000-08-01 | Ljl Biosystems, Inc. | Light detection device having an optical-path switching mechanism |
US6294327B1 (en) * | 1997-09-08 | 2001-09-25 | Affymetrix, Inc. | Apparatus and method for detecting samples labeled with material having strong light scattering properties, using reflection mode light and diffuse scattering |
WO2000006990A2 (en) | 1998-07-27 | 2000-02-10 | Ljl Biosystems, Inc. | Apparatus and methods for time-resolved spectroscopic measurements |
WO2000004364A2 (en) * | 1998-07-15 | 2000-01-27 | Ljl Biosystems, Inc. | Evanescent field illumination devices and methods |
US6825921B1 (en) | 1999-11-10 | 2004-11-30 | Molecular Devices Corporation | Multi-mode light detection system |
US6297018B1 (en) | 1998-04-17 | 2001-10-02 | Ljl Biosystems, Inc. | Methods and apparatus for detecting nucleic acid polymorphisms |
WO2000050877A1 (en) | 1999-02-23 | 2000-08-31 | Ljl Biosystems, Inc. | Frequency-domain light detection device |
US6576476B1 (en) | 1998-09-02 | 2003-06-10 | Ljl Biosystems, Inc. | Chemiluminescence detection method and device |
US6326605B1 (en) | 1998-02-20 | 2001-12-04 | Ljl Biosystems, Inc. | Broad range light detection system |
US6992761B2 (en) | 1997-09-20 | 2006-01-31 | Molecular Devices Corporation | Broad range light detection system |
US6982431B2 (en) | 1998-08-31 | 2006-01-03 | Molecular Devices Corporation | Sample analysis systems |
US6271970B1 (en) * | 1997-12-13 | 2001-08-07 | Lightchip, Inc. | Wavelength division multiplexing/demultiplexing devices using dual homogeneous refractive index lenses |
US6428811B1 (en) | 1998-03-11 | 2002-08-06 | Wm. Marsh Rice University | Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery |
US6699724B1 (en) | 1998-03-11 | 2004-03-02 | Wm. Marsh Rice University | Metal nanoshells for biosensing applications |
DE19815932C2 (de) * | 1998-04-09 | 2000-06-21 | Glukomeditech Ag | Verfahren zur Miniaturisierung eines Polarimeters zur Analyse niedrig konzentrierter Komponenten im flüssigen Meßgut auf optischer Basis sowie Vorrichtung zu seiner Durchführung |
EP1071942A1 (en) | 1998-04-17 | 2001-01-31 | LJL Biosystems, Inc. | Sample-holding devices and systems |
US6139831A (en) * | 1998-05-28 | 2000-10-31 | The Rockfeller University | Apparatus and method for immobilizing molecules onto a substrate |
AU5223899A (en) | 1998-07-27 | 2000-02-21 | Ljl Biosystems, Inc. | Apparatus and methods for spectroscopic measurements |
ES2253797T3 (es) * | 1998-08-17 | 2006-06-01 | F. Hoffmann-La Roche Ag | Dispositivo para el control de los procesos de pipeteado. |
DK1079226T3 (da) * | 1999-08-24 | 2004-05-10 | Leuze Electronic Gmbh & Co Kg | Anordning til gennemförelse af immunoassays |
EP1947446A3 (en) * | 2000-03-16 | 2008-10-29 | FUJIFILM Corporation | Measuring method and apparatus using attenuation in total reflection |
JP2001330560A (ja) * | 2000-03-16 | 2001-11-30 | Fuji Photo Film Co Ltd | 全反射減衰を利用した測定方法および装置 |
JP2002048707A (ja) * | 2000-05-22 | 2002-02-15 | Fuji Photo Film Co Ltd | 全反射減衰を利用した測定方法および装置 |
WO2001096604A2 (en) * | 2000-06-12 | 2001-12-20 | Genicon Sciences Corporation | Assay for genetic polymorphisms using scattered light detectable labels |
US7126688B2 (en) * | 2000-07-11 | 2006-10-24 | Maven Technologies, Llc | Microarray scanning |
US6821787B2 (en) | 2000-11-17 | 2004-11-23 | Thermogenic Imaging, Inc. | Apparatus and methods for infrared calorimetric measurements |
US20020132360A1 (en) | 2000-11-17 | 2002-09-19 | Flir Systems Boston, Inc. | Apparatus and methods for infrared calorimetric measurements |
US20050148063A1 (en) * | 2003-12-24 | 2005-07-07 | Cracauer Raymond F. | Disposable reaction vessel with integrated optical elements |
SE528470C2 (sv) * | 2004-02-03 | 2006-11-21 | Mircona Ab | Vibrationsdämpad verktygshållare med viskoelastiskt dämpningsmaterial |
JP4095968B2 (ja) * | 2004-02-06 | 2008-06-04 | 株式会社日立ハイテクノロジーズ | 液体分注装置、それを用いた自動分析装置、及び液面検出装置 |
SE528247C2 (sv) * | 2004-05-07 | 2006-10-03 | Mircona Ab | Vibrationsdämpad verktygshållare |
US7651869B2 (en) * | 2006-03-14 | 2010-01-26 | Research International, Inc. | Optical assay apparatus and methods |
WO2008139356A1 (en) * | 2007-05-09 | 2008-11-20 | Koninklijke Philips Electronics N. V. | A cartridge for sample investigations |
JP5283364B2 (ja) * | 2007-10-22 | 2013-09-04 | 富士フイルム株式会社 | センシング装置 |
US20090124024A1 (en) * | 2007-11-07 | 2009-05-14 | Shingo Kasai | Optical-waveguide sensor chip, method of manufacturing the same, method of measuring substance, substance-measuring kit and optical-waveguide sensor |
JP5424610B2 (ja) * | 2007-11-07 | 2014-02-26 | 株式会社東芝 | 光導波路型センサチップ、光導波路型センサチップの製造方法、物質の測定方法、物質測定用キットおよび光導波路型センサ |
JP2009133717A (ja) * | 2007-11-30 | 2009-06-18 | Konica Minolta Holdings Inc | 分析素子チップ、及びこれを用いた分析装置 |
JP2010127624A (ja) * | 2008-11-25 | 2010-06-10 | Fujifilm Corp | 全反射照明型センサチップ |
JP5987573B2 (ja) * | 2012-09-12 | 2016-09-07 | セイコーエプソン株式会社 | 光学モジュール、電子機器、及び駆動方法 |
CN103713124B (zh) * | 2013-12-27 | 2015-12-09 | 中国科学院苏州生物医学工程技术研究所 | 一种用于检测液体中微量蛋白的试剂盒及其操作方法 |
SI3365657T1 (sl) | 2015-10-20 | 2023-08-31 | Tintometer Gmbh | Naprava za odstranjevanje energije iz žarka in metoda/-e za njeno uporabo |
US11435277B2 (en) | 2015-10-20 | 2022-09-06 | Tintometer, Gmbh | Device for removing energy from a beam and a method(s) of use thereof |
US10197558B1 (en) | 2016-09-16 | 2019-02-05 | Cbrn International, Ltd | Environmental sampling and assay device |
WO2018150944A1 (ja) | 2017-02-15 | 2018-08-23 | コニカミノルタ株式会社 | 検査チップ及び検査システム |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3604927A (en) * | 1966-11-16 | 1971-09-14 | Block Engineering | Total reflection fluorescence spectroscopy |
US3715585A (en) * | 1971-06-07 | 1973-02-06 | N Harrick | Fluorescence spectrophotometry using multiple reflections to enhance sample absorption and fluorescence collection |
US3893754A (en) * | 1973-06-21 | 1975-07-08 | Xerox Corp | Combination paraboloid-ellipsoid mirror system |
US3939350A (en) * | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US4181441A (en) * | 1977-12-07 | 1980-01-01 | G. D. Searle & Co. | Internal reflectance spectrometer |
NL7807532A (nl) * | 1978-07-13 | 1980-01-15 | Akzo Nv | Metaal-immunotest. |
US4591266A (en) * | 1981-08-10 | 1986-05-27 | Laser Precision Corporation | Parabolic focusing apparatus for optical spectroscopy |
DE3135196A1 (de) * | 1981-09-05 | 1983-03-17 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren, mittel und vorrichtung zur bestimmung biologischer komponenten |
JPS5999304A (ja) * | 1982-11-30 | 1984-06-08 | Asahi Optical Co Ltd | 顕微鏡系のレーザ光による比較測長装置 |
JPS6041001A (ja) * | 1983-08-16 | 1985-03-04 | Agency Of Ind Science & Technol | 集光装置 |
DE3343868A1 (de) * | 1983-12-03 | 1985-06-13 | Zeiss Carl Fa | Objektiv mit kegelschnittflaechen fuer die mikrozonenabbildung |
US5017009A (en) * | 1986-06-26 | 1991-05-21 | Ortho Diagnostic Systems, Inc. | Scattered total internal reflectance immunoassay system |
US4844593A (en) * | 1988-05-16 | 1989-07-04 | Hewlett-Packard Company | Optical feedback isolator |
-
1989
- 1989-08-01 US US07/388,193 patent/US4979821A/en not_active Expired - Lifetime
-
1990
- 1990-07-25 GR GR920100165A patent/GR1002311B/el not_active IP Right Cessation
- 1990-07-25 GR GR920100164A patent/GR1002310B/el not_active IP Right Cessation
- 1990-07-25 GR GR900100571A patent/GR1000982B/el not_active IP Right Cessation
- 1990-07-30 CA CA002022292A patent/CA2022292A1/en not_active Abandoned
- 1990-07-31 DE DE69030902T patent/DE69030902T2/de not_active Expired - Lifetime
- 1990-07-31 JP JP2201566A patent/JPH03115956A/ja active Pending
- 1990-07-31 EP EP90308424A patent/EP0411907B1/en not_active Expired - Lifetime
- 1990-07-31 ES ES90308424T patent/ES2102362T3/es not_active Expired - Lifetime
- 1990-07-31 DK DK90308424.2T patent/DK0411907T3/da active
- 1990-07-31 AT AT90308424T patent/ATE154437T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE154437T1 (de) | 1997-06-15 |
EP0411907A2 (en) | 1991-02-06 |
DK0411907T3 (da) | 1998-01-12 |
DE69030902D1 (de) | 1997-07-17 |
GR920100164A (el) | 1994-03-31 |
EP0411907B1 (en) | 1997-06-11 |
CA2022292A1 (en) | 1991-02-02 |
DE69030902T2 (de) | 1997-11-06 |
US4979821A (en) | 1990-12-25 |
GR1002310B (el) | 1996-06-30 |
JPH03115956A (ja) | 1991-05-16 |
GR1000982B (el) | 1993-03-31 |
GR920100165A (el) | 1994-03-31 |
GR900100571A (en) | 1991-12-30 |
EP0411907A3 (en) | 1991-07-24 |
GR1002311B (el) | 1996-06-30 |
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