DE932147C - Process for obtaining highly effective adrenal extracts - Google Patents

Process for obtaining highly effective adrenal extracts

Info

Publication number
DE932147C
DE932147C DEB22746A DEB0022746A DE932147C DE 932147 C DE932147 C DE 932147C DE B22746 A DEB22746 A DE B22746A DE B0022746 A DEB0022746 A DE B0022746A DE 932147 C DE932147 C DE 932147C
Authority
DE
Germany
Prior art keywords
highly effective
obtaining highly
adrenal
extracts
adrenal extracts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEB22746A
Other languages
German (de)
Inventor
Hansjuergen Dipl-Ch Staudinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DEB22746A priority Critical patent/DE932147C/en
Application granted granted Critical
Publication of DE932147C publication Critical patent/DE932147C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/064—Saccharomycetales, e.g. baker's yeast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medical Informatics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)

Description

Verfahren zur Gewinnung hochwirksamer Nebennieren-Extrakte Im Patent 879 902 ist ein Verfahren zur Steigerung der Wirksamkeit von nach üblichen Methoden hergestellten Nebennieren-Extrakten beschrieben, welches darauf beruht, daß man den Organbrei vor der Extraktion mit solchen physiologischen Stoffen behandelt, die in den natürlichen Stoffwechsel der Nebennierenrinde eingreifen, selbst aber keine corticoide Wirkung aufweisen.Process for obtaining highly effective adrenal extracts In the patent 879 902 is a method for increasing the effectiveness of by conventional methods produced adrenal extracts described, which is based on the fact that one treats the organ pulp with such physiological substances before extraction, which intervene in the natural metabolism of the adrenal cortex, but themselves have no corticoid effect.

Es wurde nun gefunden, daß man eine Aktivitätssteigerung von (nach an sich üblichen Methoden gewonnenen) Nebennieren-Extrakten auch erreichen kann, wenn man die in dem Hauptpatent vorgeschlagenen Stoffe teilweise durch Hefe ersetzt, welche - wie Versuche ergeben haben - weitgehend imstande ist, die bei der biosynthetischen Bildung von corticoiden Hormonen erforderlichen Substrate und Fermente zu liefern. Weitere Wirksamkeitssteigerungen an den verfahrensgemäß herzustellenden Konzentraten lassen sich dadurch erzielen, daß man gemäß dem Verfahren der Patentschrift 94 053 den zu »bebrütenden« Organextrakten zusätzlich Oxydasen hinzufügt; als Lieferanten solcher Oxydasen sind dort verschiedene Pflanzensäfte, wie Gurken- und Kürbissaft, genannt. Das vorliegende Verfahren erbringt wegen der leichten Zugänglichkeit der Hefe einen erheblichen technischen Fortschritt.It has now been found that an increase in activity from (to adrenal gland extracts obtained using customary methods, if the substances proposed in the main patent are partially replaced by yeast, which - as experiments have shown - is largely capable of the biosynthetic one Formation of corticoid hormones to supply substrates and ferments required. Further increases in the effectiveness of the concentrates to be produced in accordance with the process can be achieved by following the process of patent specification 94 053 adds oxidases to the organ extracts to be "incubated"; as a supplier such oxidases are various vegetable juices, such as cucumber and pumpkin juice, called. The present method provides because of the ease of access the yeast a considerable technical advance.

Beispiele i. Wird Organ-Hefe-Brei mit 5 g Ascorbinsäure versetzt und bebrütet, so zeigt das nach Aufarbeitung gewonnene Konzentrat einen auf etwa das Doppelte gesteigerten Hormongehalt.Examples i. If organ yeast pulp is mixed with 5 g of ascorbic acid and incubated, the concentrate obtained after work-up shows one to about that Twice the increased hormone content.

2. Das gleiche Gemisch wie im Beispiel i, dem aber noch ioo ccm Gurkensaft zugesetzt sind, ergibt nach Bebrütung und Aufarbeitung gegenüber dem dort gewonnenen Konzentrat eine weitere Wirkungssteigerung auf etwa das Fünffache.2. The same mixture as in example i, but with 100 cc of cucumber juice are added, results after incubation and work-up compared to that obtained there Concentrate a further increase in effectiveness by about five times.

Claims (2)

PATENTANSPRÜCHE: i. Verfahren zur Gewinnung hochwirksamer Nebennieren-Extrakte nach Patent 879 9o2, dahin abgeändert, daß man die Organzubereitungen zusätzlicherweise mit Hefe behandelt. PATENT CLAIMS: i. Process for obtaining highly effective adrenal extracts according to patent 879 902, modified so that the organ preparations are additionally treated with yeast. 2. Verfahren gemäß Anspruch i, dadurch gekennzeichnet, daß man die Organzubereitungen zusätzlich mit Oxydasen, z. B. oxydasenhaltigen Pflanzensäften, versetzt. Angezogene Druckschriften: Deutsche Patentschriften Nr. 820 788, 471 793.2. The method according to claim i, characterized in that the organ preparations are additionally treated with oxidases, for. B. oxidase-containing plant juices, added. Cited publications: German Patent Specifications No. 820 788, 471 793.
DEB22746A 1952-11-04 1952-11-04 Process for obtaining highly effective adrenal extracts Expired DE932147C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEB22746A DE932147C (en) 1952-11-04 1952-11-04 Process for obtaining highly effective adrenal extracts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB22746A DE932147C (en) 1952-11-04 1952-11-04 Process for obtaining highly effective adrenal extracts

Publications (1)

Publication Number Publication Date
DE932147C true DE932147C (en) 1955-08-25

Family

ID=6960992

Family Applications (1)

Application Number Title Priority Date Filing Date
DEB22746A Expired DE932147C (en) 1952-11-04 1952-11-04 Process for obtaining highly effective adrenal extracts

Country Status (1)

Country Link
DE (1) DE932147C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012010698A1 (en) 2010-07-23 2012-01-26 Somfy Sas Device for controlling the state of a mobile panel of a device for closing a building

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE471793C (en) * 1927-11-01 1929-05-31 Alfons Krzykawski Dr Process for obtaining preparations from animal organs with the aid of yeast fermentation
DE820788C (en) * 1949-05-20 1952-01-10 Waldhof Zellstoff Fab Process for the production of a yeast liver preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE471793C (en) * 1927-11-01 1929-05-31 Alfons Krzykawski Dr Process for obtaining preparations from animal organs with the aid of yeast fermentation
DE820788C (en) * 1949-05-20 1952-01-10 Waldhof Zellstoff Fab Process for the production of a yeast liver preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012010698A1 (en) 2010-07-23 2012-01-26 Somfy Sas Device for controlling the state of a mobile panel of a device for closing a building

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