DE888597C - Process for the production of pills and similar medicinal preparations - Google Patents
Process for the production of pills and similar medicinal preparationsInfo
- Publication number
- DE888597C DE888597C DEK4518D DEK0004518D DE888597C DE 888597 C DE888597 C DE 888597C DE K4518 D DEK4518 D DE K4518D DE K0004518 D DEK0004518 D DE K0004518D DE 888597 C DE888597 C DE 888597C
- Authority
- DE
- Germany
- Prior art keywords
- pills
- production
- parts
- medicinal preparations
- formamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
Description
Verfahren zur Herstellung von Pillen und ähnlichen Arzneizubereitungen Pillen und ähnliche Arzneizubereitungen, z. B.Process for the production of pills and similar medicinal preparations Pills and similar medicinal preparations, e.g. B.
Stuhlzäpfchen, Vaginakugeln, Bougies, müssen derart hergestellt werden, daß der Arzneistoff möglichst homogen einverleibt wird, damit eine gleichmäßige Dosierung und Verteilung am Ort der Wirkung eintritt. Die beste Gewähr hierfür bietet die Ausflösung der Medikamente in der Grundmasse.Fecal suppositories, vaginal balls, bougies must be made in such a way that that the medicinal substance is incorporated as homogeneously as possible, so that it is uniform Dosage and distribution occurs at the point of effect. The best guarantee for this offers the dissolution of the drugs in the matrix.
Letztere darf außerdem nicht austrocknen, sondern soll bei genügender Plastizität nach der Applikation schmelzen, leicht zerfallen oder sich lösen.In addition, the latter must not dry out, but should be sufficient if it is sufficient Melting plasticity after application, easily disintegrating or dissolving.
Es wurde nun gefunden, daß Formamid vorgenannte Wirkungen in hervorragendem Maß erfüllt: Sein Lösungsvermögen für Arzneistoffe ist groß, seine Hygroskopizität verhindert das Austrocknen, nnd seine Verarbeitung mit nahezu allen Stoffen, die lals feste Bestandteile von Pillen, Suppositiorien usw. in Betracht kommen, liefert plastischQ leicht formbare Massen. Es können Pflanzenpulver, Bolus alba, Kaolin, Trockenhefe usw., aber auch konsistente Fette und Wachse benutzt werden. Bei letzteren ist es vorteilhaft, kleine Mengen von Emulgatoren, z. B. Eucerin, Sterine, Sulfonate usw., einzuarbeiten. Bei Verwendung von Seifen ist darauf zu achten, daß Formamid alkaliempfindlich ist; nur neutrale Seifen, zweckmäßig unter Zusatz von freien Fettsäuren, sind geeignet. It has now been found that formamide has the aforementioned effects in excellent Measure fulfilled: Its dissolving power for medicinal substances is great, its hygroscopicity prevents drying out, and its processing with almost all substances that l can be used as solid components of pills, suppositories, etc. plastischQ easily malleable masses. Plant powder, bolus alba, kaolin, Dry yeast etc., but also consistent fats and waxes can be used. With the latter it is advantageous to use small amounts of emulsifiers, e.g. B. Eucerin, sterols, sulfonates etc. to incorporate. When using soaps, make sure that formamide is sensitive to alkali; only neutral soaps, expediently with the addition of free fatty acids, are suitable.
Sofern die verwandten festen Pillenbestandteile in Formamid löslich oder quellbar sind, wie z. B.Provided the related solid pill ingredients are soluble in formamide or are swellable, such as. B.
Stärke, kann man daraus zunächst eine Grundmasse herstellen und dann die anderen Bestandteile einarbeiten.Starch, you can first make a base from it and then incorporate the other components.
Beispiele 1. 5 Teile salzaures Chinin und 10 Teile Trockenhefe werden unter Zusatz von 50%igem Formamid bis zur geeigneten Konsistenz angestoßen und aus der Masse 100 Pillen geformt. Examples 1. 5 parts hydrochloric quinine and 10 parts dry yeast are used with the addition of 50% formamide to a suitable consistency and done molded of the mass 100 pills.
2. 0,1 Teil arsenige Säure und 15 Teile Trockenhefe werden mit einer Aufquellung von 8% Stärke in 50%igem Formamid angestoßen und daraus 100 Pillen bereitet. 2. 0.1 part of arsenic acid and 15 parts of dry yeast are mixed with a Swelling of 8% starch in 50% formamide and made 100 pills from it.
3. 3 Teile Aloe und 6 Teile Radix Liquiritiae werden mit vorgenannter Stärke-Formamid-Paste zu 100 Pillen verarbeitet. 3. 3 parts of Aloe and 6 parts of Radix Liquiritiae are used with the aforementioned Starch-formamide paste made into 100 pills.
4. 6 Teile Digitalisblätter, 6 Teile Radix Liquiritiae und 2 Teile Trockenhefe werden mit 90%igem Formamid angestoßen und 60 Pillen geformt. 4. 6 parts of digitalis sheets, 6 parts of Radix Liquiritiae and 2 parts Dry yeast are clipped with 90% formamide and formed into 60 pills.
5. 5 Teile Stearin werden mit der berechneten Menge konzentriertem Ammoniak verseift. Dann fügt man auf dem Wasserbad zunächst 0,5 Teile Stearin, dann 50 Teile 50%iges Formamid hinzu und gießt in Formen. 5. 5 parts of stearin are concentrated with the calculated amount Saponified ammonia. Then you add 0.5 parts of stearin to the water bath, then 50 parts of 50% formamide are added and poured into molds.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEK4518D DE888597C (en) | 1945-03-03 | 1945-03-03 | Process for the production of pills and similar medicinal preparations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEK4518D DE888597C (en) | 1945-03-03 | 1945-03-03 | Process for the production of pills and similar medicinal preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE888597C true DE888597C (en) | 1953-09-03 |
Family
ID=7210378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEK4518D Expired DE888597C (en) | 1945-03-03 | 1945-03-03 | Process for the production of pills and similar medicinal preparations |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE888597C (en) |
-
1945
- 1945-03-03 DE DEK4518D patent/DE888597C/en not_active Expired
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