DE871951C - Process for the preparation of rich aqueous solutions of dihalodioxybenzilen - Google Patents

Process for the preparation of rich aqueous solutions of dihalodioxybenzilen

Info

Publication number
DE871951C
DE871951C DEF3319D DEF0003319D DE871951C DE 871951 C DE871951 C DE 871951C DE F3319 D DEF3319 D DE F3319D DE F0003319 D DEF0003319 D DE F0003319D DE 871951 C DE871951 C DE 871951C
Authority
DE
Germany
Prior art keywords
aqueous solutions
dihalodioxybenzilen
preparation
rich aqueous
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEF3319D
Other languages
German (de)
Inventor
Richard Dr Kuhn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DEF3319D priority Critical patent/DE871951C/en
Application granted granted Critical
Publication of DE871951C publication Critical patent/DE871951C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

Verfahren zur Herstellung von gehaitreichen wäßrigen Lösungen von Dihalogendioxybenzilen Einer parenteralen Anwendung von Dihalogendioxybenzilen steht ihre sehr geringe Löslichkeit in Wasser entgegen. So ist beispielsweise das 2, 2'-Dioxy-5, 5'-dibrombenzil zu weniger als O,OOI°/o in Wasser löslich. Process for the preparation of rich aqueous solutions of Dihalodioxybencilene Parenteral use of dihalodioxybenzilene is available opposed to their very low solubility in water. For example, the 2, 2'-dioxy-5, 5'-dibromobenzil is less than 0.010 ° / o soluble in water.

Es wurde gefunden, daß man gehaltreiche wäßrige Lösungen von Dihalogendioxybenzilen erhalten kann, wenn man Borsäure bzw. borsaure Salze als Lösungsvermittler verwendet. Die so erhaltenen Lösungen sind für Injektionszwecke brauchbar. Die Wirksamkeit der Dihalogendioxybenzilen gegenüber Mikroorganismen wird durch den Borzusatz nicht beeinträchtigt. It has been found that rich aqueous solutions of dihalodioxybenzilene can be obtained can be obtained if boric acid or boric acid salts are used as solubilizers. The solutions thus obtained can be used for injection purposes. The effectiveness the dihalodioxybenzilene against microorganisms is not due to the addition of boron impaired.

Beispiel I 5 g 5, 5'-Dibrom-2, 2'-dioxybenzil ergeben mit 3,I g Borsäure und 2 g Natriumhydroxyd in 50 ccm Wasser eine klare, fast farblose Lösung vom PH 9,8. Example I 5 g of 5,5'-dibromo-2, 2'-dioxybenzil give 3.1 g of boric acid and 2 g of sodium hydroxide in 50 cc of water, a clear, almost colorless solution of the pH 9.8.

Beim Erhitzen wird die Farbe intensiv gelb, beim Erkalten geht sie wieder zurück.When heated, the color becomes intense yellow, when cooled it goes back again.

Beispiel 2 50 ccm der nach Beispiel 1 erhaltenen Lösung werden mit 50 ccm Wasser verdünnt und mit 2,5 g Kaliummonophosphat versetzt. Die Lösung bleibt klar, der pH-Wert beträgt 7,8. Example 2 50 ccm of the solution obtained according to Example 1 are mixed with Diluted 50 ccm of water and mixed with 2.5 g of potassium monophosphate. The solution remains clear, the pH is 7.8.

Beispiel 3 5 g 5, 5'-Dtbrom-2 2'-dioxybenzil und 6 g Na2B4O7 . 10 H2O werden in 3 1 Wasser gelöst, mit rund I00 ccm m/I5-KH2PO4 auf pn 7,5 gebracht und mit Wasser auf 5 1 aufgefüllt. Example 3 5 g of 5,5'-dtbromo-2 2'-dioxybenzil and 6 g of Na2B4O7. 10 H2O are dissolved in 3 liters of water, brought to pn 7.5 with around 100 ccm m / I5-KH2PO4 and made up to 5 liters with water.

In entsprechender Weise läßt sich auch das 5,5'-Dijod-2,2'-dioxybenzil in Lösung bringen. The 5,5'-diiodo-2,2'-dioxybenzil can also be used in a corresponding manner bring into solution.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung gehaltreicher wäß riger Lösungen von Dihalogendioxybenzilen, dadurch gekennzeichnet, daß man Borsäure bzw. borsaure Salze als Lösungsvermittler verwendet. PATENT CLAIM: Process for the production of high-content aqueous Solutions of dihalodioxybenzilen, characterized in that boric acid or boric acid salts used as solubilizers.
DEF3319D 1943-12-16 1943-12-16 Process for the preparation of rich aqueous solutions of dihalodioxybenzilen Expired DE871951C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEF3319D DE871951C (en) 1943-12-16 1943-12-16 Process for the preparation of rich aqueous solutions of dihalodioxybenzilen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF3319D DE871951C (en) 1943-12-16 1943-12-16 Process for the preparation of rich aqueous solutions of dihalodioxybenzilen

Publications (1)

Publication Number Publication Date
DE871951C true DE871951C (en) 1953-03-26

Family

ID=7083766

Family Applications (1)

Application Number Title Priority Date Filing Date
DEF3319D Expired DE871951C (en) 1943-12-16 1943-12-16 Process for the preparation of rich aqueous solutions of dihalodioxybenzilen

Country Status (1)

Country Link
DE (1) DE871951C (en)

Similar Documents

Publication Publication Date Title
GB496252A (en) Improvements relating to photographic treating solutions
JPS53112299A (en) Production of alumina sol
DE871951C (en) Process for the preparation of rich aqueous solutions of dihalodioxybenzilen
JPS5692116A (en) Settling agent for red mud
DE625446C (en) Process for the production of nitrogen-containing polyvinyl derivatives
DE876309C (en) Process for the production of color-stable aqueous azulene solutions
DE362646C (en) Process for the preparation of o-oxyazo dyes
DE900380C (en) Process for the production of aqueous solutions of p-aminobenzenesulfonamide or of Abkoemmlingen the same
DE929092C (en) Process for the production of polyamide solutions
DE458803C (en) Manufacture of dye inks
DE832754C (en) Process for the production of aqueous solutions of poorly soluble xanthine compounds
DE745099C (en) Process for the manufacture of products from formaldehyde, other aldehydes and ammonium salts
DE701527C (en) Process for the preparation of solutions of poorly soluble aryl arsine oxides in water
DE870844C (en) Process for the preparation of soluble salts of p-aminobenzenesulfonylthiourea
AT156812B (en) Process for the production of easily soluble formaldehyde preparations.
DE432420C (en) Process for the preparation of N-methylsulphurous acid salts of secondary amines
DE897555C (en) Process for the preparation of 3-ketocarboxylic acids
DE637441C (en) Process for the preparation of anhydrous ethyl alcohol
DE887412C (en) Process for the preparation of condensation products which are easily emulsifiable in water
CH236158A (en) Process for the preparation of aqueous, highly viscous colloidal solutions of water-insoluble alkali metaphosphates.
DE651794C (en) Wetting agent for mercerising liquors
AT152825B (en) Process for the preparation of basic substituted aminoazo compounds.
DE618374C (en) Process for the production of water-soluble silver salts of glycerol phosphoric acids
AT272266B (en) Process for the preparation of a low-silica sodium fluoride
DE868493C (en) Process for the production of aqueous solutions of p-aminobenzene sulfonamide or of decoctions of the same