DE69942329D1 - Hlpc gerät zur fraktionierung und vorbereitung einer probe für nmr spektrometrie und verfahren zur änderung der mobilen phase - Google Patents

Hlpc gerät zur fraktionierung und vorbereitung einer probe für nmr spektrometrie und verfahren zur änderung der mobilen phase

Info

Publication number
DE69942329D1
DE69942329D1 DE69942329T DE69942329T DE69942329D1 DE 69942329 D1 DE69942329 D1 DE 69942329D1 DE 69942329 T DE69942329 T DE 69942329T DE 69942329 T DE69942329 T DE 69942329T DE 69942329 D1 DE69942329 D1 DE 69942329D1
Authority
DE
Germany
Prior art keywords
fractionizing
hlpc
modifying
preparing
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69942329T
Other languages
English (en)
Inventor
Yumi Yokoyama
Naoya Kishi
Masayuki Tanaka
Naoki Asakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Application granted granted Critical
Publication of DE69942329D1 publication Critical patent/DE69942329D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8411—Intermediate storage of effluent, including condensation on surface
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8429—Preparation of the fraction to be distributed adding modificating material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4808—Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
DE69942329T 1998-05-26 1999-05-26 Hlpc gerät zur fraktionierung und vorbereitung einer probe für nmr spektrometrie und verfahren zur änderung der mobilen phase Expired - Lifetime DE69942329D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14445298 1998-05-26
PCT/JP1999/002783 WO1999061905A1 (fr) 1998-05-26 1999-05-26 Appareil hplc permettant de fractionner et de preparer des echantillons pour la spectrometrie rmn et procede de modification de la phase mobile

Publications (1)

Publication Number Publication Date
DE69942329D1 true DE69942329D1 (de) 2010-06-17

Family

ID=15362581

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69942329T Expired - Lifetime DE69942329D1 (de) 1998-05-26 1999-05-26 Hlpc gerät zur fraktionierung und vorbereitung einer probe für nmr spektrometrie und verfahren zur änderung der mobilen phase

Country Status (5)

Country Link
US (1) US6498040B1 (de)
EP (1) EP1001263B1 (de)
JP (1) JP3720058B2 (de)
DE (1) DE69942329D1 (de)
WO (1) WO1999061905A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6668623B2 (en) * 2000-03-03 2003-12-30 Mitsubishi Materials Corporation Method and apparatus for analyzing organic macromolecular component and application thereof
DE60001177T2 (de) 2000-10-25 2003-10-23 Bruker Biospin Gmbh LC-NMR System, enthaltend eine Vorrichtung zum Einfangen von mindestens einer Komponente eines Chromatographieflusses
US6402946B1 (en) 2000-10-26 2002-06-11 Bruker Analytik Gmbh Device for feeding a chromatography flow
WO2003076930A1 (en) * 2002-03-14 2003-09-18 Warner-Lambert Company Llc Method for characterizing metabolites using hydrogen/deuterium exchange
JP3816883B2 (ja) * 2003-03-06 2006-08-30 株式会社日立ハイテクノロジーズ 液体クロマトグラフ質量分析装置
US20070023639A1 (en) * 2003-09-05 2007-02-01 Kazuko Yamashita Liquid chromatographic apparatus
JP2006125856A (ja) 2004-10-26 2006-05-18 Sumitomo Chemical Co Ltd 液体クロマトグラフィー装置
US8567441B2 (en) * 2007-09-28 2013-10-29 Shimadzu Corporation Sample introduction device
GB2465956B (en) * 2007-10-02 2012-05-09 Shimadzu Corp Preparative separation/ purification system
US8932468B2 (en) * 2010-01-12 2015-01-13 The United States Of America As Represented By The Secretary Of The Army Separation of enzymatically synthesized polyepicatechin via high performance liquid chromatography
CN106716105B (zh) * 2014-08-19 2020-09-11 基础科学公司 用于质谱分析法的利用注射器输送的超净自动进样器
WO2016098169A1 (ja) * 2014-12-15 2016-06-23 株式会社島津製作所 液体クロマトグラフ
US10241013B2 (en) * 2015-12-08 2019-03-26 Elemental Scientific, Inc. Inline dilution and autocalibration for ICP-MS speciation analysis
EP4081795A1 (de) 2019-12-23 2022-11-02 Waters Technologies Corporation Probendosierung und injektion für flüssigchromatografie

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5842935Y2 (ja) * 1979-04-20 1983-09-28 日本電子株式会社 Ｎｍｒ装置の試料装置
DE4104075C1 (de) * 1991-02-11 1992-03-19 Bruker Analytische Messtechnik Gmbh, 7512 Rheinstetten, De
JPH06256227A (ja) 1993-03-04 1994-09-13 Japan Energy Corp 光学活性な化合物の光学分割法及び光学純度測定方法

Also Published As

Publication number Publication date
EP1001263A4 (de) 2000-08-23
EP1001263B1 (de) 2010-05-05
JP3720058B2 (ja) 2005-11-24
EP1001263A1 (de) 2000-05-17
US6498040B1 (en) 2002-12-24
WO1999061905A1 (fr) 1999-12-02

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Legal Events

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