DE69941371D1 - Nichtkovalente biokonjugate für diagnose und therapie - Google Patents
Nichtkovalente biokonjugate für diagnose und therapieInfo
- Publication number
- DE69941371D1 DE69941371D1 DE69941371T DE69941371T DE69941371D1 DE 69941371 D1 DE69941371 D1 DE 69941371D1 DE 69941371 T DE69941371 T DE 69941371T DE 69941371 T DE69941371 T DE 69941371T DE 69941371 D1 DE69941371 D1 DE 69941371D1
- Authority
- DE
- Germany
- Prior art keywords
- hapten
- carrier
- bioconjugates
- molecule
- daltons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000003745 diagnosis Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 229920001202 Inulin Polymers 0.000 abstract 1
- 229920000805 Polyaspartic acid Polymers 0.000 abstract 1
- 108010020346 Polyglutamic Acid Proteins 0.000 abstract 1
- 102000007562 Serum Albumin Human genes 0.000 abstract 1
- 108010071390 Serum Albumin Proteins 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 abstract 1
- 229940029339 inulin Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 abstract 1
- 108010011110 polyarginine Proteins 0.000 abstract 1
- 108010064470 polyaspartate Proteins 0.000 abstract 1
- 229920002643 polyglutamic acid Polymers 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
- A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8065898P | 1998-04-03 | 1998-04-03 | |
PCT/US1999/007061 WO1999051284A2 (en) | 1998-04-03 | 1999-03-31 | Non-covalent bioconjugates useful for diagnosis and therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69941371D1 true DE69941371D1 (de) | 2009-10-15 |
Family
ID=22158792
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69941371T Expired - Lifetime DE69941371D1 (de) | 1998-04-03 | 1999-03-31 | Nichtkovalente biokonjugate für diagnose und therapie |
Country Status (9)
Country | Link |
---|---|
US (1) | US6423547B1 (de) |
EP (3) | EP2283872A3 (de) |
JP (1) | JP4560209B2 (de) |
AT (1) | ATE441434T1 (de) |
AU (1) | AU766290B2 (de) |
CA (1) | CA2326650A1 (de) |
DE (1) | DE69941371D1 (de) |
ES (1) | ES2331671T3 (de) |
WO (1) | WO1999051284A2 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6228344B1 (en) * | 1997-03-13 | 2001-05-08 | Mallinckrodt Inc. | Method of measuring physiological function |
ES2331671T3 (es) * | 1998-04-03 | 2010-01-12 | Mallinckrodt Inc. | Bioconjugados no covalentes utiles para diagnostico y terapia. |
US6844425B1 (en) | 1999-02-24 | 2005-01-18 | Mallinckrodt Inc. | Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy |
US6217848B1 (en) * | 1999-05-20 | 2001-04-17 | Mallinckrodt Inc. | Cyanine and indocyanine dye bioconjugates for biomedical applications |
CA2322344A1 (en) * | 1999-12-08 | 2001-06-08 | Mallinckrodt Inc. | Non-covalent bioconjugates useful for magnetic resonance imaging |
US6180085B1 (en) * | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Dyes |
US20080233050A1 (en) * | 2000-01-18 | 2008-09-25 | Mallinckrodt Inc. | Diagnostic and therapeutic optical agents |
US7790144B2 (en) * | 2000-01-18 | 2010-09-07 | Mallinckrodt Inc. | Receptor-avid exogenous optical contrast and therapeutic agents |
AU2001258095A1 (en) | 2000-05-08 | 2001-11-20 | The University Of British Columbia | Drug delivery systems for photodynamic therapy |
US6617136B2 (en) | 2001-04-24 | 2003-09-09 | 3M Innovative Properties Company | Biological sample processing methods and compositions that include surfactants |
EP1293248B1 (de) * | 2001-09-17 | 2008-04-09 | Central P BV | Neue dispergierbare kolloidale Calixarene-Systeme in Form von Nanoteilchen |
US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
DE10324710A1 (de) | 2003-05-30 | 2004-12-16 | Supramol Parenteral Colloids Gmbh | Stärkederivatkomplexe |
US20060207881A1 (en) * | 2005-02-01 | 2006-09-21 | Sigma-Aldrich Co. | Detection of polyamino acids using trimethincyanine dyes |
US20080154102A1 (en) * | 2006-07-03 | 2008-06-26 | Frangioni John V | Intraoperative imaging methods |
DE102007007738A1 (de) * | 2007-02-09 | 2008-08-14 | Südzucker AG Mannheim/Ochsenfurt | Farbmarkierte Oligo- oder Polysaccharide |
WO2010129258A2 (en) | 2009-04-27 | 2010-11-11 | Mallinckrodt Inc. | Tissue sealant compositions, vascular closure devices, and uses thereof |
US8343463B2 (en) * | 2009-07-31 | 2013-01-01 | Numira Biosciences Inc. | Optical imaging agent |
KR101117209B1 (ko) * | 2009-10-12 | 2012-03-19 | 경북대학교 산학협력단 | 벤조티아졸계 세미스쿠아릴리움 염료 및 이를 이용한 수은 금속 이온 검출방법 |
HUE041616T2 (hu) | 2010-01-28 | 2019-05-28 | National Univ Corporation Mie Univ | Indocianin vegyület, szintézisének eljárása, tisztítási eljárása, indocianin vegyületet alkalmazó diagnosztikai készítmény, és készülék in vivo kinetika mérésére és készülék keringés megjelenítésére a diagnosztikai készítmény alkalmazásával |
JP5817073B2 (ja) * | 2010-01-28 | 2015-11-18 | 国立大学法人三重大学 | 新規インドシアニン化合物を用いた診断用組成物及び分析方法 |
US9636426B2 (en) * | 2011-09-05 | 2017-05-02 | Hiroshi Maeda | Polymer-type fluorescent molecule probe |
CN104491863A (zh) * | 2014-11-20 | 2015-04-08 | 浙江大学 | 基于聚谷氨酸与四氯四碘荧光素键合物的抗肿瘤药物及其制备方法和应用 |
CN113307863B (zh) * | 2021-05-25 | 2022-12-16 | 华南农业大学 | 一种聚天冬氨酸及其盐类抗体的制备方法和应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2155935B (en) * | 1984-02-16 | 1988-10-12 | Antibioticos Sa | Novel e. coli hybrid plasmid vector conferring sucrose fermenting capacity |
US4806488A (en) * | 1985-09-06 | 1989-02-21 | Syntex (U.S.A.) Inc. | Ligand-receptor assays employing squarate dye compositions |
US5110794A (en) * | 1987-01-30 | 1992-05-05 | Abbott Laboratories | Method of immunization with partially cationized substances and said partially cationized substances |
DE3828360A1 (de) * | 1988-08-20 | 1990-02-22 | Stanowsky Alexander Dr | Farbstoff-markierter antitumor-antikoerper und verfahren zu seiner herstellung |
EP0529002B1 (de) * | 1990-05-15 | 2001-10-04 | Hyperion, Inc. | Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden |
DE4445065A1 (de) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
ES2331671T3 (es) * | 1998-04-03 | 2010-01-12 | Mallinckrodt Inc. | Bioconjugados no covalentes utiles para diagnostico y terapia. |
-
1999
- 1999-03-31 ES ES99915152T patent/ES2331671T3/es not_active Expired - Lifetime
- 1999-03-31 US US09/646,765 patent/US6423547B1/en not_active Expired - Lifetime
- 1999-03-31 EP EP10179855A patent/EP2283872A3/de not_active Withdrawn
- 1999-03-31 AU AU33738/99A patent/AU766290B2/en not_active Ceased
- 1999-03-31 EP EP99915152A patent/EP1189645B1/de not_active Expired - Lifetime
- 1999-03-31 AT AT99915152T patent/ATE441434T1/de not_active IP Right Cessation
- 1999-03-31 DE DE69941371T patent/DE69941371D1/de not_active Expired - Lifetime
- 1999-03-31 EP EP09075280A patent/EP2108378A3/de not_active Withdrawn
- 1999-03-31 JP JP2000542054A patent/JP4560209B2/ja not_active Expired - Lifetime
- 1999-03-31 WO PCT/US1999/007061 patent/WO1999051284A2/en active IP Right Grant
- 1999-03-31 CA CA002326650A patent/CA2326650A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1189645B1 (de) | 2009-09-02 |
EP1189645A2 (de) | 2002-03-27 |
EP2283872A2 (de) | 2011-02-16 |
EP1189645A4 (de) | 2004-10-13 |
AU766290B2 (en) | 2003-10-16 |
EP2283872A3 (de) | 2011-02-23 |
WO1999051284A3 (en) | 2002-01-17 |
JP2002531377A (ja) | 2002-09-24 |
ES2331671T3 (es) | 2010-01-12 |
JP4560209B2 (ja) | 2010-10-13 |
EP2108378A3 (de) | 2010-10-27 |
EP2108378A2 (de) | 2009-10-14 |
ATE441434T1 (de) | 2009-09-15 |
AU3373899A (en) | 1999-10-25 |
CA2326650A1 (en) | 1999-10-14 |
WO1999051284A2 (en) | 1999-10-14 |
US6423547B1 (en) | 2002-07-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |