DE69940853D1 - Modulation der polypeptidexpression auf modifizierten filamentösen phagen - Google Patents
Modulation der polypeptidexpression auf modifizierten filamentösen phagenInfo
- Publication number
- DE69940853D1 DE69940853D1 DE69940853T DE69940853T DE69940853D1 DE 69940853 D1 DE69940853 D1 DE 69940853D1 DE 69940853 T DE69940853 T DE 69940853T DE 69940853 T DE69940853 T DE 69940853T DE 69940853 D1 DE69940853 D1 DE 69940853D1
- Authority
- DE
- Germany
- Prior art keywords
- phagen
- modulation
- polypeptide expression
- modified filamentous
- phage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/73—Expression systems using phage (lambda) regulatory sequences
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9632698P | 1998-08-12 | 1998-08-12 | |
US09/198,839 US6190908B1 (en) | 1998-08-12 | 1998-12-24 | Modulation of polypeptide display on modified filamentous phage |
PCT/US1999/018207 WO2000009715A1 (en) | 1998-08-12 | 1999-08-11 | Modulation of polypeptide display on modified filamentous phage |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69940853D1 true DE69940853D1 (de) | 2009-06-18 |
Family
ID=26791575
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69940853T Expired - Lifetime DE69940853D1 (de) | 1998-08-12 | 1999-08-11 | Modulation der polypeptidexpression auf modifizierten filamentösen phagen |
Country Status (8)
Country | Link |
---|---|
US (3) | US6190908B1 (de) |
EP (1) | EP1127142B1 (de) |
JP (1) | JP2002522084A (de) |
AT (1) | ATE430805T1 (de) |
AU (1) | AU766253B2 (de) |
CA (1) | CA2336541C (de) |
DE (1) | DE69940853D1 (de) |
WO (1) | WO2000009715A1 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6589730B1 (en) | 1997-08-29 | 2003-07-08 | Selective Genetics, Inc. | Methods for identifying protein-protein interactions by selective transduction |
US6054312A (en) * | 1997-08-29 | 2000-04-25 | Selective Genetics, Inc. | Receptor-mediated gene delivery using bacteriophage vectors |
US6723512B2 (en) | 1997-08-29 | 2004-04-20 | Selective Genetics Inc. | Methods using genetic package display for detecting and identifying protein-protein interactions that facilitate internalization and transgene expression and cells or tissues competent for the same and methods for evolving gene delivery vectors |
US20030148263A1 (en) * | 1997-08-29 | 2003-08-07 | Selective Genetics, Inc. | Methods and compositions using genetic package display |
IL135776A0 (en) * | 1997-10-24 | 2001-05-20 | Life Technologies Inc | Recombinational cloning using nucleic acids having recombination sites |
WO1999040434A1 (en) | 1998-02-04 | 1999-08-12 | Invitrogen Corporation | Microarrays and uses therefor |
JP4540846B2 (ja) * | 1998-04-30 | 2010-09-08 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | 所望の生物学的特性を与えるクローンを発現ライブラリーから同定する新規方法 |
US20020119579A1 (en) * | 1998-07-14 | 2002-08-29 | Peter Wagner | Arrays devices and methods of use thereof |
US6780582B1 (en) * | 1998-07-14 | 2004-08-24 | Zyomyx, Inc. | Arrays of protein-capture agents and methods of use thereof |
US6406921B1 (en) * | 1998-07-14 | 2002-06-18 | Zyomyx, Incorporated | Protein arrays for high-throughput screening |
US20030138973A1 (en) * | 1998-07-14 | 2003-07-24 | Peter Wagner | Microdevices for screening biomolecules |
US6576478B1 (en) * | 1998-07-14 | 2003-06-10 | Zyomyx, Inc. | Microdevices for high-throughput screening of biomolecules |
AU5122499A (en) | 1998-07-27 | 2000-02-21 | Genentech Inc. | Improved transformation efficiency in phage display through modification of a coat protein |
US6190908B1 (en) * | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
US7803765B2 (en) * | 1999-05-05 | 2010-09-28 | Phylogica Limited | Methods of constructing biodiverse gene fragment libraries and biological modulators isolated therefrom |
EP2230303B1 (de) * | 1999-05-05 | 2013-01-16 | Phylogica Limited | Isolierung von biologischen Modulatoren aus biodiversen Genfragmentbibliotheken |
US7270969B2 (en) * | 1999-05-05 | 2007-09-18 | Phylogica Limited | Methods of constructing and screening diverse expression libraries |
JP2004511753A (ja) * | 2000-05-04 | 2004-04-15 | イエール ユニバーシティー | タンパク質活性のスクリーニング用タンパク質チップ |
US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
WO2002046434A2 (en) * | 2000-12-08 | 2002-06-13 | Alexion Pharmaceuticals, Inc. | Plasmid vectors |
EP1493028A4 (de) * | 2001-07-06 | 2006-06-14 | Genentech Inc | Im phagen-display präsentierte liganden der pdz-domäne |
US7799552B2 (en) | 2001-07-20 | 2010-09-21 | California Institute Of Technology | Protein and nucleic acid expression systems |
AU2003229048A1 (en) * | 2002-05-14 | 2003-12-02 | Alexion Pharmaceuticals, Inc. | T7 bacteriophage display of fabs |
AU2003257109A1 (en) * | 2002-08-05 | 2004-02-23 | Invitrogen Corporation | Compositions and methods for molecular biology |
US20050233473A1 (en) * | 2002-08-16 | 2005-10-20 | Zyomyx, Inc. | Methods and reagents for surface functionalization |
AU2003302470A1 (en) * | 2002-11-26 | 2004-06-18 | Dyax Corporation | Methods and compositions for controlling valency of phage display |
EP1587907B1 (de) * | 2003-01-07 | 2011-03-02 | Dyax Corporation | Kunitz-domäne-bibliothek |
US20040248323A1 (en) * | 2003-06-09 | 2004-12-09 | Protometrix, Inc. | Methods for conducting assays for enzyme activity on protein microarrays |
KR20060069825A (ko) * | 2003-08-01 | 2006-06-22 | 제넨테크, 인크. | 제한된 다양성을 갖는 항체 cdr 폴리펩티드 서열 |
US20050106667A1 (en) * | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
US20050048506A1 (en) * | 2003-09-03 | 2005-03-03 | Fredrick Joseph P. | Methods for encoding non-biological information on microarrays |
US20050049796A1 (en) * | 2003-09-03 | 2005-03-03 | Webb Peter G. | Methods for encoding non-biological information on microarrays |
US7108979B2 (en) * | 2003-09-03 | 2006-09-19 | Agilent Technologies, Inc. | Methods to detect cross-contamination between samples contacted with a multi-array substrate |
ATE469984T1 (de) | 2003-12-01 | 2010-06-15 | Life Technologies Corp | Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon |
AU2005250369A1 (en) * | 2004-05-18 | 2005-12-15 | Genentech, Inc. | M13 virus major coat protein variants for C-terminal and BI-terminal display of a heterologous protein |
WO2005119244A1 (en) * | 2004-06-03 | 2005-12-15 | Phylogica Limited | Peptide modulators of cellular phenotype and bi-nucleic acid fragment library |
EP1898701A1 (de) * | 2005-06-28 | 2008-03-19 | The Scripps Research Institute | Abgabe von wirkstoffproteinen an das zentralnervensystem mit phagenvektoren |
EP2465870A1 (de) | 2005-11-07 | 2012-06-20 | Genentech, Inc. | Bindepolypeptide mit verschiedenartigen und übereinstimmenden hypervariablen VH/VL-Sequenzen |
US20070237764A1 (en) * | 2005-12-02 | 2007-10-11 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
CA2638912A1 (en) * | 2006-02-20 | 2007-08-30 | Phylogica Limited | Method of constructing and screening libraries of peptide structures |
CA2663545A1 (en) * | 2006-09-19 | 2008-03-27 | Phylogica Limited | Neuroprotective peptide inhibitors of ap-1 signaling and uses thereof |
US8822409B2 (en) * | 2007-06-20 | 2014-09-02 | Phylogica Limited | Compositions and uses thereof for the treatment of acute respiratory distress syndrome (ARDS) and clinical disorders associated with therewith |
US9249408B2 (en) * | 2007-11-02 | 2016-02-02 | The Scripps Research Institute | Directed evolution using proteins comprising unnatural amino acids |
AU2012245073B2 (en) | 2011-04-21 | 2016-02-11 | Garvan Institute Of Medical Research | Modified variable domain molecules and methods for producing and using them b |
EP3209697A4 (de) | 2014-10-23 | 2018-05-30 | La Trobe University | Fn14-bindende proteine und verwendungen davon |
JP6863897B2 (ja) | 2015-01-09 | 2021-04-21 | アダルタ・リミテッド | Cxcr4結合分子 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5427908A (en) * | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
IL99552A0 (en) * | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
US5698426A (en) * | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
DE69233750D1 (de) * | 1991-04-10 | 2009-01-02 | Scripps Research Inst | Bibliotheken heterodimerer Rezeptoren mittels Phagemiden |
US6190908B1 (en) * | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
-
1998
- 1998-12-24 US US09/198,839 patent/US6190908B1/en not_active Expired - Lifetime
-
1999
- 1999-08-11 EP EP99942093A patent/EP1127142B1/de not_active Expired - Lifetime
- 1999-08-11 JP JP2000565149A patent/JP2002522084A/ja active Pending
- 1999-08-11 AT AT99942093T patent/ATE430805T1/de not_active IP Right Cessation
- 1999-08-11 AU AU55543/99A patent/AU766253B2/en not_active Ceased
- 1999-08-11 WO PCT/US1999/018207 patent/WO2000009715A1/en active IP Right Grant
- 1999-08-11 CA CA002336541A patent/CA2336541C/en not_active Expired - Fee Related
- 1999-08-11 DE DE69940853T patent/DE69940853D1/de not_active Expired - Lifetime
-
2000
- 2000-05-01 US US09/562,834 patent/US6323004B1/en not_active Expired - Lifetime
-
2001
- 2001-11-27 US US09/995,396 patent/US6586236B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2000009715A9 (en) | 2000-06-02 |
US20020146827A1 (en) | 2002-10-10 |
US6586236B2 (en) | 2003-07-01 |
AU766253B2 (en) | 2003-10-09 |
WO2000009715A1 (en) | 2000-02-24 |
ATE430805T1 (de) | 2009-05-15 |
EP1127142B1 (de) | 2009-05-06 |
CA2336541A1 (en) | 2000-02-24 |
AU5554399A (en) | 2000-03-06 |
EP1127142A1 (de) | 2001-08-29 |
EP1127142A4 (de) | 2004-05-26 |
US6323004B1 (en) | 2001-11-27 |
US6190908B1 (en) | 2001-02-20 |
JP2002522084A (ja) | 2002-07-23 |
CA2336541C (en) | 2009-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |