ES2153671T3 - Peptidos neuroactivos. - Google Patents
Peptidos neuroactivos.Info
- Publication number
- ES2153671T3 ES2153671T3 ES97927691T ES97927691T ES2153671T3 ES 2153671 T3 ES2153671 T3 ES 2153671T3 ES 97927691 T ES97927691 T ES 97927691T ES 97927691 T ES97927691 T ES 97927691T ES 2153671 T3 ES2153671 T3 ES 2153671T3
- Authority
- ES
- Spain
- Prior art keywords
- neuroactive peptides
- specific identification
- neuroactive
- peptides
- nmda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE DESCRIBEN COMPOSICIONES Y PROCEDIMIENTOS PARA LA IDENTIFICACION ESPECIFICA DE RECEPTORES DE NMDA, ASI COMO PARA LA IDENTIFICACION ESPECIFICA Y MANIPULACION DE LA ACTIVIDAD BIOLOGICA CO - AGONISTA DE LA GLICINA DEL NMDA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/649,272 US5763393A (en) | 1996-05-17 | 1996-05-17 | Neuroactive peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2153671T3 true ES2153671T3 (es) | 2001-03-01 |
Family
ID=24604116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97927691T Expired - Lifetime ES2153671T3 (es) | 1996-05-17 | 1997-05-16 | Peptidos neuroactivos. |
Country Status (12)
Country | Link |
---|---|
US (2) | US5763393A (es) |
EP (2) | EP1077217A3 (es) |
JP (1) | JP2000501746A (es) |
AT (1) | ATE197307T1 (es) |
AU (1) | AU3209097A (es) |
CA (1) | CA2255659C (es) |
DE (1) | DE69703449T2 (es) |
DK (1) | DK0914331T3 (es) |
ES (1) | ES2153671T3 (es) |
GR (1) | GR3035227T3 (es) |
PT (1) | PT914331E (es) |
WO (1) | WO1997043306A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1296999A2 (en) * | 2000-06-22 | 2003-04-02 | NYXIS NeuroTherapies, Inc. | Neuroactive peptides for treatment of hypoxia and related conditions |
WO2003010540A1 (en) * | 2001-07-25 | 2003-02-06 | Nyxis Neurotherapies, Inc. | Method of identifying nmda-related agent |
CN102186883B (zh) | 2008-09-18 | 2016-08-03 | 西北大学 | Nmda受体调节剂和其用途 |
PL2985032T3 (pl) | 2009-10-05 | 2019-07-31 | Northwestern University | Glyx do stosowania do leczenia choroby alzheimera, choroby parkinsona lub choroby huntingtona |
US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
CN102933226A (zh) | 2010-02-11 | 2013-02-13 | 西北大学 | 二级结构稳定化的nmda受体调节剂及其用途 |
KR101692275B1 (ko) * | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | 2차 구조 안정화된 nmda 수용체 조절제 및 그의 용도 |
KR20140043078A (ko) | 2011-04-27 | 2014-04-08 | 노오쓰웨스턴 유니버시티 | 알츠하이머병, 헌팅톤병, 자폐증 또는 기타 장애의 치료 방법 |
US8798716B1 (en) | 2011-11-03 | 2014-08-05 | Solstice Corporation | Fiducial markers and related methods |
US8974365B2 (en) | 2012-11-25 | 2015-03-10 | Steven Richard Devore Best | Treatment of thalamocortical dysrhythmia |
EP3228313B1 (en) | 2013-01-22 | 2019-09-11 | Vistagen Therapeutics, Inc. | Dosage forms and therapeutic uses of l-4-chlorokynurenine |
CN105408336B (zh) | 2013-01-29 | 2018-06-26 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
EP2951186B1 (en) | 2013-01-29 | 2018-07-25 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
AU2014212501A1 (en) | 2013-01-29 | 2015-07-30 | Aptinyx, Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
CA2898861C (en) | 2013-01-29 | 2021-07-20 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
SG11201505934XA (en) | 2013-01-29 | 2015-09-29 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
GB201319437D0 (en) * | 2013-11-04 | 2013-12-18 | Nanomerics Ltd | Delivery of drugs |
JP6702883B2 (ja) | 2014-04-25 | 2020-06-03 | ノーレックス インコーポレイテッド | 向神経活性ペプチドの安定な組成物 |
EP3171941B1 (en) * | 2014-07-24 | 2021-03-24 | Naurex Inc. | N-methyl-d-aspartate receptor modulators and methods of making and using same |
US20170296616A1 (en) | 2014-08-14 | 2017-10-19 | Naurex, Inc. | Methods of treating depression using nmda modulators |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA3024606C (en) | 2016-05-19 | 2019-09-03 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2018026763A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA3031539C (en) | 2016-08-01 | 2023-11-28 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
EP3490990B1 (en) | 2016-08-01 | 2023-12-06 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam nmda modulators and methods of using same |
PE20190503A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos |
BR112019001926A2 (pt) | 2016-08-01 | 2019-08-06 | Aptinyx Inc | moduladores do receptor nmda espiro-lactama e bis-espiro-lactama e usos destes |
WO2019094676A1 (en) | 2017-11-10 | 2019-05-16 | Naurex Inc. | Methods of administration of nmda receptor agonists |
CA3084437A1 (en) | 2017-12-05 | 2019-06-13 | Naurex Inc. | Nmda receptor modulators (rapastinel) combination for use in combined treatment (sleep and cns disorder) |
PE20210455A1 (es) | 2018-01-31 | 2021-03-08 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5854217A (en) * | 1992-09-28 | 1998-12-29 | Bearsden Bio, Inc. | Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function |
US5428069A (en) * | 1993-01-11 | 1995-06-27 | The United States Of America As Represented By The Department Of Health & Human Services | Treating cognition with, aminocyclopropanecarboxylic derivatives |
JPH07101999A (ja) * | 1993-10-06 | 1995-04-18 | Hagiwara Yoshihide | 抗癌ヒトモノクローナル抗体に対する抗イデイオタイプ抗体のアミノ酸配列およびそれをコードするdna塩基配列 |
-
1996
- 1996-05-17 US US08/649,272 patent/US5763393A/en not_active Expired - Lifetime
-
1997
- 1997-05-16 PT PT97927691T patent/PT914331E/pt unknown
- 1997-05-16 CA CA002255659A patent/CA2255659C/en not_active Expired - Lifetime
- 1997-05-16 AT AT97927691T patent/ATE197307T1/de not_active IP Right Cessation
- 1997-05-16 AU AU32090/97A patent/AU3209097A/en not_active Abandoned
- 1997-05-16 EP EP00118013A patent/EP1077217A3/en not_active Withdrawn
- 1997-05-16 EP EP97927691A patent/EP0914331B1/en not_active Expired - Lifetime
- 1997-05-16 WO PCT/US1997/008667 patent/WO1997043306A1/en active IP Right Grant
- 1997-05-16 DE DE69703449T patent/DE69703449T2/de not_active Expired - Fee Related
- 1997-05-16 DK DK97927691T patent/DK0914331T3/da active
- 1997-05-16 JP JP9541206A patent/JP2000501746A/ja not_active Ceased
- 1997-05-16 ES ES97927691T patent/ES2153671T3/es not_active Expired - Lifetime
-
1998
- 1998-06-08 US US09/105,799 patent/US6107271A/en not_active Expired - Fee Related
-
2001
- 2001-01-11 GR GR20010400043T patent/GR3035227T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69703449D1 (de) | 2000-12-07 |
CA2255659A1 (en) | 1997-11-20 |
EP0914331B1 (en) | 2000-11-02 |
DE69703449T2 (de) | 2001-06-07 |
DK0914331T3 (da) | 2001-02-12 |
JP2000501746A (ja) | 2000-02-15 |
CA2255659C (en) | 2005-03-15 |
EP1077217A3 (en) | 2004-01-02 |
US5763393A (en) | 1998-06-09 |
WO1997043306A1 (en) | 1997-11-20 |
US6107271A (en) | 2000-08-22 |
PT914331E (pt) | 2001-04-30 |
EP1077217A2 (en) | 2001-02-21 |
EP0914331A1 (en) | 1999-05-12 |
GR3035227T3 (en) | 2001-04-30 |
AU3209097A (en) | 1997-12-05 |
ATE197307T1 (de) | 2000-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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