DE69939170D1 - Matrixunterstützte laser desorption unter atmosphärendruck - Google Patents

Matrixunterstützte laser desorption unter atmosphärendruck

Info

Publication number
DE69939170D1
DE69939170D1 DE69939170T DE69939170T DE69939170D1 DE 69939170 D1 DE69939170 D1 DE 69939170D1 DE 69939170 T DE69939170 T DE 69939170T DE 69939170 T DE69939170 T DE 69939170T DE 69939170 D1 DE69939170 D1 DE 69939170D1
Authority
DE
Germany
Prior art keywords
atmospheric pressure
laser desorption
under atmospheric
desorption under
matrix supported
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939170T
Other languages
English (en)
Inventor
Victor V Laiko
Alma L Burlingame
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22224202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69939170(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of DE69939170D1 publication Critical patent/DE69939170D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

Landscapes

  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Inorganic Insulating Materials (AREA)
  • Glass Compositions (AREA)
DE69939170T 1998-06-04 1999-04-02 Matrixunterstützte laser desorption unter atmosphärendruck Expired - Lifetime DE69939170D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/090,764 US5965884A (en) 1998-06-04 1998-06-04 Atmospheric pressure matrix assisted laser desorption
PCT/US1999/007268 WO1999063576A1 (en) 1998-06-04 1999-04-02 Atmospheric pressure matrix assisted laser desorption

Publications (1)

Publication Number Publication Date
DE69939170D1 true DE69939170D1 (de) 2008-09-04

Family

ID=22224202

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69939170T Expired - Lifetime DE69939170D1 (de) 1998-06-04 1999-04-02 Matrixunterstützte laser desorption unter atmosphärendruck

Country Status (8)

Country Link
US (1) US5965884A (de)
EP (1) EP1084505B1 (de)
JP (1) JP2002517886A (de)
AT (1) ATE402483T1 (de)
AU (1) AU3465199A (de)
CA (1) CA2333031C (de)
DE (1) DE69939170D1 (de)
WO (1) WO1999063576A1 (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE39099E1 (en) * 1998-01-23 2006-05-23 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US6331702B1 (en) 1999-01-25 2001-12-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
GB9807915D0 (en) * 1998-04-14 1998-06-10 Shimadzu Res Lab Europe Ltd Apparatus for production and extraction of charged particles
US6849847B1 (en) 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
JP4564696B2 (ja) * 1999-06-11 2010-10-20 アプライド バイオシステムズ， エルエルシー 不安定な分子の分子量を決定するための方法および装置
US6911650B1 (en) * 1999-08-13 2005-06-28 Bruker Daltonics, Inc. Method and apparatus for multiple frequency multipole
GB9922837D0 (en) * 1999-09-27 1999-11-24 Ludwig Inst Cancer Res Modified ion source targets for use in liquid maldi ms
US6744041B2 (en) 2000-06-09 2004-06-01 Edward W Sheehan Apparatus and method for focusing ions and charged particles at atmospheric pressure
US7375319B1 (en) 2000-06-09 2008-05-20 Willoughby Ross C Laser desorption ion source
GB0021902D0 (en) * 2000-09-06 2000-10-25 Kratos Analytical Ltd Ion optics system for TOF mass spectrometer
GB0025956D0 (en) * 2000-10-24 2000-12-13 Powell David J Improved method of measuring vacuum pressure in sealed vials
US6806468B2 (en) * 2001-03-01 2004-10-19 Science & Engineering Services, Inc. Capillary ion delivery device and method for mass spectroscopy
US6627883B2 (en) * 2001-03-02 2003-09-30 Bruker Daltonics Inc. Apparatus and method for analyzing samples in a dual ion trap mass spectrometer
DE10112386B4 (de) 2001-03-15 2007-08-02 Bruker Daltonik Gmbh Flugzeitmassenspektrometer mit Multiplex-Betrieb
US6777671B2 (en) * 2001-04-10 2004-08-17 Science & Engineering Services, Inc. Time-of-flight/ion trap mass spectrometer, a method, and a computer program product to use the same
US6617577B2 (en) 2001-04-16 2003-09-09 The Rockefeller University Method and system for mass spectroscopy
EP1402561A4 (de) * 2001-05-25 2007-06-06 Analytica Of Branford Inc Maldi-ionenquelle für atmosphären- und unterdruck
US6747274B2 (en) 2001-07-31 2004-06-08 Agilent Technologies, Inc. High throughput mass spectrometer with laser desorption ionization ion source
US6683300B2 (en) 2001-09-17 2004-01-27 Science & Engineering Services, Inc. Method and apparatus for mass spectrometry analysis of common analyte solutions
WO2003052399A2 (en) * 2001-12-14 2003-06-26 Mds Inc., D.B.A. Mds Sciex Method of chemical of ionization at reduced pressures
US20030155504A1 (en) * 2002-02-15 2003-08-21 Motchkine Viatcheslav S. Radiative sample warming for an ion mobility spectrometer
US7132670B2 (en) * 2002-02-22 2006-11-07 Agilent Technologies, Inc. Apparatus and method for ion production enhancement
US7135689B2 (en) * 2002-02-22 2006-11-14 Agilent Technologies, Inc. Apparatus and method for ion production enhancement
US6825462B2 (en) * 2002-02-22 2004-11-30 Agilent Technologies, Inc. Apparatus and method for ion production enhancement
US7372043B2 (en) * 2002-02-22 2008-05-13 Agilent Technologies, Inc. Apparatus and method for ion production enhancement
US6858841B2 (en) 2002-02-22 2005-02-22 Agilent Technologies, Inc. Target support and method for ion production enhancement
EP1492613A4 (de) 2002-03-21 2009-12-16 Thermo Finnigan Llc Ionisierungsvorrichtung und -verfahren für massenspektrometersystem
US6707036B2 (en) * 2002-03-21 2004-03-16 Thermo Finnigan Llc Ionization apparatus and method for mass spectrometer system
WO2004030024A2 (en) * 2002-05-31 2004-04-08 University Of Florida Research Foundation, Inc. Methods and devices for laser desorption chemical ionization
US6818889B1 (en) 2002-06-01 2004-11-16 Edward W. Sheehan Laminated lens for focusing ions from atmospheric pressure
US6888132B1 (en) 2002-06-01 2005-05-03 Edward W Sheehan Remote reagent chemical ionization source
US7095019B1 (en) 2003-05-30 2006-08-22 Chem-Space Associates, Inc. Remote reagent chemical ionization source
US20050185175A1 (en) * 2002-07-16 2005-08-25 Canos Avelino C. Rotary support and apparatus used for the multiple spectroscopic characterisation of samples of solid materials
US6624409B1 (en) 2002-07-30 2003-09-23 Agilent Technologies, Inc. Matrix assisted laser desorption substrates for biological and reactive samples
US6825466B2 (en) * 2002-08-01 2004-11-30 Automated Biotechnology, Inc. Apparatus and method for automated sample analysis by atmospheric pressure matrix assisted laser desorption ionization mass spectrometry
DE10236344B4 (de) * 2002-08-08 2007-03-29 Bruker Daltonik Gmbh Ionisieren an Atmosphärendruck für massenspektrometrische Analysen
US6707039B1 (en) * 2002-09-19 2004-03-16 Agilent Technologies, Inc. AP-MALDI target illumination device and method for using an AP-MALDI target illumination device
US7833802B2 (en) * 2002-11-21 2010-11-16 Ada Technologies, Inc. Stroboscopic liberation and methods of use
US6895804B2 (en) * 2002-11-21 2005-05-24 Ada Technologies, Inc. Strobe desorption method for high boiling point materials
US6878933B1 (en) 2002-12-10 2005-04-12 University Of Florida Method for coupling laser desorption to ion trap mass spectrometers
US6822230B2 (en) 2002-12-23 2004-11-23 Agilent Technologies, Inc. Matrix-assisted laser desorption/ionization sample holders and methods of using the same
ATE450050T1 (de) * 2003-02-14 2009-12-15 Mds Sciex Atmosphärendruck-diskriminator für geladene teilchen für massenspektrometrie
US6791080B2 (en) * 2003-02-19 2004-09-14 Science & Engineering Services, Incorporated Method and apparatus for efficient transfer of ions into a mass spectrometer
US6956208B2 (en) * 2003-03-17 2005-10-18 Indiana University Research And Technology Corporation Method and apparatus for controlling position of a laser of a MALDI mass spectrometer
US20040183009A1 (en) * 2003-03-17 2004-09-23 Reilly James P. MALDI mass spectrometer having a laser steering assembly and method of operating the same
US6861647B2 (en) * 2003-03-17 2005-03-01 Indiana University Research And Technology Corporation Method and apparatus for mass spectrometric analysis of samples
US20040195503A1 (en) * 2003-04-04 2004-10-07 Taeman Kim Ion guide for mass spectrometers
US20040217277A1 (en) * 2003-04-30 2004-11-04 Goodley Paul C. Apparatus and method for surface activation and selective ion generation for MALDI mass spectrometry
EP1639622B1 (de) 2003-06-07 2016-11-16 WILLOUGHBY, Ross, C. Laserdesorptions-ionenquelle
US6943346B2 (en) * 2003-08-13 2005-09-13 Science & Engineering Services, Inc. Method and apparatus for mass spectrometry analysis of aerosol particles at atmospheric pressure
US20050079631A1 (en) * 2003-10-09 2005-04-14 Science & Engineering Services, Inc. Method and apparatus for ionization of a sample at atmospheric pressure using a laser
DE102004002729B4 (de) * 2004-01-20 2008-11-27 Bruker Daltonik Gmbh Ionisierung desorbierter Analytmoleküle bei Atmosphärendruck
US7122789B2 (en) * 2004-05-11 2006-10-17 Science & Engineering Services, Inc. Method and apparatus to increase ionization efficiency in an ion source
DE102004051785B4 (de) * 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Proteinprofile mit Luft-MALDI
US7081621B1 (en) 2004-11-15 2006-07-25 Ross Clark Willoughby Laminated lens for focusing ions from atmospheric pressure
JP4645197B2 (ja) * 2005-01-05 2011-03-09 株式会社島津製作所 質量分析方法
US7161146B2 (en) * 2005-01-24 2007-01-09 Science & Engineering Services, Inc. Method and apparatus for producing an ion beam from an ion guide
US8377711B2 (en) * 2005-04-04 2013-02-19 Ada Technologies, Inc. Stroboscopic liberation and methods of use
US20060232369A1 (en) * 2005-04-14 2006-10-19 Makrochem, Ltd. Permanent magnet structure with axial access for spectroscopy applications
US7535329B2 (en) * 2005-04-14 2009-05-19 Makrochem, Ltd. Permanent magnet structure with axial access for spectroscopy applications
US7138626B1 (en) 2005-05-05 2006-11-21 Eai Corporation Method and device for non-contact sampling and detection
US7435951B2 (en) * 2005-06-08 2008-10-14 Agilent Technologies, Inc. Ion source sample plate illumination system
US7568401B1 (en) 2005-06-20 2009-08-04 Science Applications International Corporation Sample tube holder
US7576322B2 (en) * 2005-11-08 2009-08-18 Science Applications International Corporation Non-contact detector system with plasma ion source
GB0526245D0 (en) * 2005-12-22 2006-02-01 Shimadzu Res Lab Europe Ltd A mass spectrometer using a dynamic pressure ion source
JP2007257851A (ja) * 2006-03-20 2007-10-04 Shimadzu Corp 質量分析装置
US20080083882A1 (en) * 2006-10-06 2008-04-10 Jian Bai Laser desorption assisted field ionization device and method
WO2008092118A2 (en) 2007-01-25 2008-07-31 Ada Technologies, Inc. Stroboscopic signal amplification and surface enhanced raman spectroscopy
DE102007017236B4 (de) * 2007-04-12 2011-03-31 Bruker Daltonik Gmbh Einführung von Ionen in ein Magnetfeld
US8123396B1 (en) 2007-05-16 2012-02-28 Science Applications International Corporation Method and means for precision mixing
US8901487B2 (en) 2007-07-20 2014-12-02 George Washington University Subcellular analysis by laser ablation electrospray ionization mass spectrometry
US8067730B2 (en) * 2007-07-20 2011-11-29 The George Washington University Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry
US7964843B2 (en) 2008-07-18 2011-06-21 The George Washington University Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
DE102007043456B4 (de) * 2007-07-31 2012-02-09 Bruker Daltonik Gmbh Matrixunterstützte Laserdesorption hoher Ionisierungsausbeute
GB2453407B (en) * 2007-07-31 2012-07-18 Bruker Daltonik Gmbh Matrix-assisted laser desorption with high ionization yield
JP5023886B2 (ja) * 2007-08-28 2012-09-12 株式会社島津製作所 大気圧ｍａｌｄｉ質量分析装置
US8008617B1 (en) 2007-12-28 2011-08-30 Science Applications International Corporation Ion transfer device
US7750291B2 (en) * 2008-02-25 2010-07-06 National Sun Yat-Sen University Mass spectrometric method and mass spectrometer for analyzing a vaporized sample
US7872228B1 (en) 2008-06-18 2011-01-18 Bruker Daltonics, Inc. Stacked well ion trap
US20100207038A1 (en) * 2009-02-13 2010-08-19 Loughborough University Apparatus and method for laser irradiation
US8071957B1 (en) 2009-03-10 2011-12-06 Science Applications International Corporation Soft chemical ionization source
US8399830B2 (en) 2011-05-25 2013-03-19 Bruker Daltonics, Inc. Means and method for field asymmetric ion mobility spectrometry combined with mass spectrometry
US8927940B2 (en) 2011-06-03 2015-01-06 Bruker Daltonics, Inc. Abridged multipole structure for the transport, selection and trapping of ions in a vacuum system
US8969798B2 (en) 2011-07-07 2015-03-03 Bruker Daltonics, Inc. Abridged ion trap-time of flight mass spectrometer
US9184040B2 (en) 2011-06-03 2015-11-10 Bruker Daltonics, Inc. Abridged multipole structure for the transport and selection of ions in a vacuum system
US8829426B2 (en) 2011-07-14 2014-09-09 The George Washington University Plume collimation for laser ablation electrospray ionization mass spectrometry
US8809769B2 (en) 2012-11-29 2014-08-19 Bruker Daltonics, Inc. Apparatus and method for cross-flow ion mobility spectrometry
SG10201808165YA (en) 2013-04-17 2018-10-30 Fluidigm Canada Inc Sample analysis for mass cytometry
JP6004093B2 (ja) * 2013-04-19 2016-10-05 株式会社島津製作所 質量分析装置
US10090144B2 (en) 2014-03-18 2018-10-02 Micromass Uk Limited Liquid extraction matrix assisted laser desorption ionisation ion source
JP6642702B2 (ja) * 2016-04-18 2020-02-12 株式会社島津製作所 質量分析装置
US20180076014A1 (en) * 2016-09-09 2018-03-15 Science And Engineering Services, Llc Sub-atmospheric pressure laser ionization source using an ion funnel
CA3090811A1 (en) * 2018-03-14 2019-09-19 Biomerieux, Inc. Methods for aligning a light source of an instrument, and related instruments
WO2021001887A1 (ja) 2019-07-01 2021-01-07 株式会社島津製作所 イオン化装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2236186B (en) * 1989-08-22 1994-01-05 Finnigan Mat Gmbh Process and device for laser desorption of analyte molecular ions, especially of biomolecules
DE19608963C2 (de) * 1995-03-28 2001-03-22 Bruker Daltonik Gmbh Verfahren zur Ionisierung schwerer Moleküle bei Atmosphärendruck
CA2227806C (en) * 1998-01-23 2006-07-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use

Also Published As

Publication number Publication date
ATE402483T1 (de) 2008-08-15
CA2333031A1 (en) 1999-12-09
US5965884A (en) 1999-10-12
EP1084505B1 (de) 2008-07-23
WO1999063576A1 (en) 1999-12-09
CA2333031C (en) 2008-02-19
EP1084505A4 (de) 2005-09-21
JP2002517886A (ja) 2002-06-18
EP1084505A1 (de) 2001-03-21
AU3465199A (en) 1999-12-20

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