DE69938184D1 - Stabilisierte ölige zubereitung von tobicillin (beta-lactam-antibiotika) - Google Patents

Stabilisierte ölige zubereitung von tobicillin (beta-lactam-antibiotika)

Info

Publication number
DE69938184D1
DE69938184D1 DE69938184T DE69938184T DE69938184D1 DE 69938184 D1 DE69938184 D1 DE 69938184D1 DE 69938184 T DE69938184 T DE 69938184T DE 69938184 T DE69938184 T DE 69938184T DE 69938184 D1 DE69938184 D1 DE 69938184D1
Authority
DE
Germany
Prior art keywords
beta
tobicillin
lactam antibiotics
oily preparation
stabilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69938184T
Other languages
English (en)
Other versions
DE69938184T2 (de
Inventor
Hatsuo Shibatani
Tomoyasu Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Schering Plough Animal Health KK
Original Assignee
Takeda Schering Plough Animal Health KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Schering Plough Animal Health KK filed Critical Takeda Schering Plough Animal Health KK
Publication of DE69938184D1 publication Critical patent/DE69938184D1/de
Application granted granted Critical
Publication of DE69938184T2 publication Critical patent/DE69938184T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
DE69938184T 1998-08-04 1999-06-16 Stabilisierte ölige zubereitung von tobicillin (beta-lactam-antibiotika) Expired - Fee Related DE69938184T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22016198 1998-08-04
JP22016198 1998-08-04
PCT/JP1999/003233 WO2000007628A1 (fr) 1998-08-04 1999-06-16 Preparations stabilisees de beta-lactamine

Publications (2)

Publication Number Publication Date
DE69938184D1 true DE69938184D1 (de) 2008-04-03
DE69938184T2 DE69938184T2 (de) 2009-03-26

Family

ID=16746851

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69938184T Expired - Fee Related DE69938184T2 (de) 1998-08-04 1999-06-16 Stabilisierte ölige zubereitung von tobicillin (beta-lactam-antibiotika)

Country Status (14)

Country Link
US (1) US6514962B1 (de)
EP (1) EP1101497B1 (de)
JP (1) JP3531648B2 (de)
KR (1) KR100412231B1 (de)
CN (1) CN1149102C (de)
AT (1) ATE386546T1 (de)
CA (1) CA2339147C (de)
DE (1) DE69938184T2 (de)
DK (1) DK1101497T3 (de)
ES (1) ES2297925T3 (de)
HK (1) HK1041217A1 (de)
PT (1) PT1101497E (de)
TW (1) TW550081B (de)
WO (1) WO2000007628A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2387016C (en) 1999-10-08 2010-09-28 William H. Miller Acrylamide derivatives as fab i inhibitors
DK1560584T3 (da) * 2001-04-06 2009-05-18 Affinium Pharm Inc Fab I inhibitorer
JP4859460B2 (ja) * 2002-12-06 2012-01-25 アフィニウム ファーマシューティカルズ， インク． ヘテロ環化合物、その製造方法および治療におけるその使用
CA2519429C (en) * 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
DK1828167T3 (da) 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
EP2054422B1 (de) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamidderivate als fab-i-inhibitoren
EP2125802A4 (de) * 2007-02-16 2014-08-20 Debiopharm Int Sa Salze, prodrugs und polymorphe von fab-i-inhibitoren
IN2014KN02915A (de) 2012-06-19 2015-05-08 Debiopharm Int Sa
TN2018000293A1 (en) 2016-02-26 2020-01-16 Debiopharm Int Sa Medicament for treatment of diabetic foot infections
WO2019010447A1 (en) 2017-07-07 2019-01-10 Epicentrx, Inc. COMPOSITIONS FOR PARENTERAL ADMINISTRATION OF THERAPEUTIC AGENTS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59176209A (ja) * 1983-03-28 1984-10-05 Sankyo Co Ltd β−ラクタム環を有する化合物の直腸投与用組成物
SE8405611D0 (sv) * 1984-11-09 1984-11-09 Astra Laekemedel Ab Process for stabilization of bacampicillin hydrochloride
US4731362A (en) * 1985-08-05 1988-03-15 Shionogi & Co., Ltd. Alkylcarbamoyloxymethylcephem compounds
DK8603837A (de) * 1985-08-13 1987-02-14
US5063074A (en) * 1990-01-30 1991-11-05 Rich Products Corporation Low fat low cholesterol milk products
JP3233434B2 (ja) * 1992-04-01 2001-11-26 塩野義製薬株式会社 カルバペネム誘導体
FR2698560B1 (fr) * 1992-11-30 1995-02-03 Virbac Laboratoires Principes actifs pulvérulents stabilisés, compositions les contenant, leur procédé d'obtention et leurs applications.
US5602118A (en) * 1993-03-16 1997-02-11 American Cyanamid Company 2-thiosubstituted carbapenems
JPH06298769A (ja) * 1993-04-13 1994-10-25 Fujisawa Pharmaceut Co Ltd アンピシリンフェニルエステルおよびその塩

Also Published As

Publication number Publication date
WO2000007628A1 (fr) 2000-02-17
CN1149102C (zh) 2004-05-12
EP1101497A4 (de) 2002-03-06
CA2339147A1 (en) 2000-02-17
PT1101497E (pt) 2008-04-23
DK1101497T3 (da) 2008-03-31
US6514962B1 (en) 2003-02-04
JP3531648B2 (ja) 2004-05-31
EP1101497B1 (de) 2008-02-20
ES2297925T3 (es) 2008-05-01
TW550081B (en) 2003-09-01
EP1101497A1 (de) 2001-05-23
HK1041217A1 (zh) 2002-07-05
KR100412231B1 (ko) 2003-12-24
CA2339147C (en) 2009-04-21
CN1322140A (zh) 2001-11-14
KR20010071964A (ko) 2001-07-31
DE69938184T2 (de) 2009-03-26
ATE386546T1 (de) 2008-03-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee