DE69937576D1 - Bioabbaubare niedermolekulare triblock-polyester-polyethylenglykol-copolymere mit umgekehrter thermischer gelierung - Google Patents

Bioabbaubare niedermolekulare triblock-polyester-polyethylenglykol-copolymere mit umgekehrter thermischer gelierung

Info

Publication number
DE69937576D1
DE69937576D1 DE69937576T DE69937576T DE69937576D1 DE 69937576 D1 DE69937576 D1 DE 69937576D1 DE 69937576 T DE69937576 T DE 69937576T DE 69937576 T DE69937576 T DE 69937576T DE 69937576 D1 DE69937576 D1 DE 69937576D1
Authority
DE
Germany
Prior art keywords
bioabcanable
geling
molecular
low
polyethylene glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69937576T
Other languages
English (en)
Other versions
DE69937576T2 (de
Inventor
Ramesh C Rathi
Gaylen M Zentner
Byeongmoon Jeong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Inc
Original Assignee
Protherics Salt Lake City Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/396,589 external-priority patent/US6201072B1/en
Application filed by Protherics Salt Lake City Inc filed Critical Protherics Salt Lake City Inc
Application granted granted Critical
Publication of DE69937576D1 publication Critical patent/DE69937576D1/de
Publication of DE69937576T2 publication Critical patent/DE69937576T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
DE69937576T 1998-10-01 1999-09-30 Bioabbaubare niedermolekulare triblock-polyester-polyethylenglykol-copolymere mit umgekehrter thermischer gelierung Expired - Lifetime DE69937576T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/164,865 US6117949A (en) 1998-10-01 1998-10-01 Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US164865 1998-10-01
US09/396,589 US6201072B1 (en) 1997-10-03 1999-09-15 Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US396589 1999-09-15
PCT/US1999/022755 WO2000018821A1 (en) 1998-10-01 1999-09-30 Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties

Publications (2)

Publication Number Publication Date
DE69937576D1 true DE69937576D1 (de) 2007-12-27
DE69937576T2 DE69937576T2 (de) 2008-09-18

Family

ID=22596415

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69937576T Expired - Lifetime DE69937576T2 (de) 1998-10-01 1999-09-30 Bioabbaubare niedermolekulare triblock-polyester-polyethylenglykol-copolymere mit umgekehrter thermischer gelierung

Country Status (5)

Country Link
US (1) US6117949A (de)
AR (1) AR022105A1 (de)
DE (1) DE69937576T2 (de)
PT (1) PT1141079E (de)
ZA (1) ZA200102453B (de)

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