DE69929699D1 - Nukleinsäure, die spezifisch an ein ras zielprotein binden kann - Google Patents

Nukleinsäure, die spezifisch an ein ras zielprotein binden kann

Info

Publication number
DE69929699D1
DE69929699D1 DE69929699T DE69929699T DE69929699D1 DE 69929699 D1 DE69929699 D1 DE 69929699D1 DE 69929699 T DE69929699 T DE 69929699T DE 69929699 T DE69929699 T DE 69929699T DE 69929699 D1 DE69929699 D1 DE 69929699D1
Authority
DE
Germany
Prior art keywords
nucleic acid
target protein
specifically bind
ras target
ras
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69929699T
Other languages
English (en)
Other versions
DE69929699T2 (de
Inventor
Shigeyuki Yokoyama
Ichiro Hirao
Kensaku Sakamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
Original Assignee
Japan Science and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science and Technology Corp filed Critical Japan Science and Technology Corp
Publication of DE69929699D1 publication Critical patent/DE69929699D1/de
Application granted granted Critical
Publication of DE69929699T2 publication Critical patent/DE69929699T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69929699T 1998-08-14 1999-08-13 Nukleinsäure, die spezifisch an ein ras zielprotein binden kann Expired - Lifetime DE69929699T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP24259698 1998-08-14
JP24259698 1998-08-14
JP33328498 1998-11-24
JP33328498 1998-11-24
PCT/JP1999/004399 WO2000009684A1 (fr) 1998-08-14 1999-08-13 Acide nucleique capable de se lier specifiquement a une proteine cible ras

Publications (2)

Publication Number Publication Date
DE69929699D1 true DE69929699D1 (de) 2006-04-13
DE69929699T2 DE69929699T2 (de) 2006-08-24

Family

ID=26535833

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69929699T Expired - Lifetime DE69929699T2 (de) 1998-08-14 1999-08-13 Nukleinsäure, die spezifisch an ein ras zielprotein binden kann

Country Status (5)

Country Link
US (1) US6995249B1 (de)
EP (1) EP1026243B1 (de)
JP (1) JP3655550B2 (de)
DE (1) DE69929699T2 (de)
WO (1) WO2000009684A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10020138A1 (de) * 2000-04-14 2001-10-31 Ulf R Rapp Nukleinsäure codierend für zumindest eine raf Teilsequenz mit einer MEKK1 Bindungsstelle
EP1330544A4 (de) 2000-09-26 2005-04-06 Univ Duke Rna-aptamere und verfahren zu deren identifizierung
US7300922B2 (en) 2001-05-25 2007-11-27 Duke University Modulators of pharmacological agents
KR101185050B1 (ko) 2004-04-22 2012-10-04 레가도 바이오사이언스, 인코포레이티드 응고 인자의 개선된 모듈레이터
PL212696B1 (pl) * 2008-02-14 2012-11-30 Inst Chemii Bioorg Pan Inhibitor rybonukleazy Dicer
DE102011000807B4 (de) 2011-02-17 2012-11-29 Kludi Gmbh & Co. Kg Spül- und Prüfeinheit für eine Sanitärarmatur
DE202011050690U1 (de) 2011-07-11 2012-01-13 Kludi Gmbh & Co. Kg Anschluss- und Spüleinheit für eine Unterputz-Sanitärarmatur
KR20220139425A (ko) 2012-07-13 2022-10-14 웨이브 라이프 사이언시스 리미티드 키랄 제어

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE920562A1 (en) 1991-02-21 1992-08-26 Gilead Sciences Aptamer specific for biomolecules and method of making
US5582995A (en) * 1993-06-11 1996-12-10 The General Hospital Corporation Methods of screening for compounds which inhibit the direct binding of Ras to Raf
US5597719A (en) * 1994-07-14 1997-01-28 Onyx Pharmaceuticals, Inc. Interaction of RAF-1 and 14-3-3 proteins
US6103692A (en) * 1996-03-12 2000-08-15 The General Hospital Corporation Inhibiting protein interactions
DE69907153T2 (de) * 1998-02-18 2004-01-29 Theryte Ltd Krebsbehandlung
US20030170751A1 (en) * 1999-05-11 2003-09-11 Sherman Lawrence S. Immunohistochemical assay for ras activity

Also Published As

Publication number Publication date
WO2000009684A1 (fr) 2000-02-24
JP3655550B2 (ja) 2005-06-02
EP1026243A1 (de) 2000-08-09
EP1026243B1 (de) 2006-02-01
EP1026243A4 (de) 2003-09-17
US6995249B1 (en) 2006-02-07
DE69929699T2 (de) 2006-08-24

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Legal Events

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8364 No opposition during term of opposition