DE69925870D1 - Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten - Google Patents
Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchproduktenInfo
- Publication number
- DE69925870D1 DE69925870D1 DE69925870T DE69925870T DE69925870D1 DE 69925870 D1 DE69925870 D1 DE 69925870D1 DE 69925870 T DE69925870 T DE 69925870T DE 69925870 T DE69925870 T DE 69925870T DE 69925870 D1 DE69925870 D1 DE 69925870D1
- Authority
- DE
- Germany
- Prior art keywords
- beta
- igf
- tgf
- fraction
- preparations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 title 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title 1
- 238000011109 contamination Methods 0.000 title 1
- 235000013365 dairy product Nutrition 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 abstract 4
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 2
- 239000008267 milk Substances 0.000 abstract 2
- 210000004080 milk Anatomy 0.000 abstract 2
- 235000013336 milk Nutrition 0.000 abstract 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 2
- 108010023244 Lactoperoxidase Proteins 0.000 abstract 1
- 102000045576 Lactoperoxidases Human genes 0.000 abstract 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 229940057428 lactoperoxidase Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Feed For Specific Animals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/NL1999/000621 WO2001025276A1 (en) | 1999-10-06 | 1999-10-06 | Process for obtaining growth factor preparations (tgf-beta and igf-1) from milk products having low mutual cross-contamination |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69925870D1 true DE69925870D1 (de) | 2005-07-21 |
| DE69925870T2 DE69925870T2 (de) | 2005-12-08 |
Family
ID=19866618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69925870T Expired - Lifetime DE69925870T2 (de) | 1999-10-06 | 1999-10-06 | Verfahren zur bereitstellung von wachstumsfaktozubereitungen (tgf-beta und igf-1) mit niedriger gegenseitiger verunreinigung aus milchprodukten |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1218410B1 (de) |
| AT (1) | ATE297948T1 (de) |
| AU (1) | AU782573B2 (de) |
| CA (1) | CA2387686A1 (de) |
| DE (1) | DE69925870T2 (de) |
| DK (1) | DK1218410T3 (de) |
| NZ (1) | NZ518217A (de) |
| WO (1) | WO2001025276A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2827290B1 (fr) * | 2001-07-13 | 2004-07-09 | Pierre Jouan Biotechnologies Sa | Procede d'obtention d'une fraction proteique enrichie en tgf-beta sous forme activee, fraction proteique et applications therapeutiques |
| DE60230763D1 (de) * | 2001-07-20 | 2009-02-26 | Campina Bv | Verfahren zur herstellung von preparationen aus milchprodukten, welche wachstumsfaktoren (tgf-beta und igf-1), lactoperoxidase und immunglobuline mit niedriger gegenseitiger verunreinigung enthalten |
| US7572474B2 (en) | 2005-06-01 | 2009-08-11 | Mead Johnson Nutrition Company | Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants |
| US8075934B2 (en) | 2008-10-24 | 2011-12-13 | Mead Johnson Nutrition Company | Nutritional composition with improved digestibility |
| FR2889068B1 (fr) * | 2005-07-29 | 2012-03-02 | Cie Laitiere Europeenne | Nouvelles fractions proteiques laitieres et leur utilisation pour la prevention ou le traitement des maladies inflammatoires chroniques |
| US8350006B2 (en) | 2008-10-24 | 2013-01-08 | Mead Johnson Nutrition Company | Methods for determining the bioactivity of TGF-β in a composition |
| US8367354B2 (en) | 2008-10-24 | 2013-02-05 | Mead Johnson Nutrition Company | Methods for determining the levels of TGF-β in a composition |
| US8986769B2 (en) | 2008-10-24 | 2015-03-24 | Mead Johnson Nutrition Company | Methods for preserving endogenous TGF-β |
| MX2020007545A (es) | 2018-01-16 | 2020-09-09 | Frieslandcampina Nederland Bv | Leche de formula infantil hipoalergenica y metodos para prepararla. |
| US11109604B2 (en) | 2019-05-09 | 2021-09-07 | Memtec LLC | Dairy processing systems and methods |
| WO2023079080A1 (en) | 2021-11-05 | 2023-05-11 | Frieslandcampina Nederland B.V. | Use of tgf in the prevention virus infection of the respiratory tract |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8806893D0 (en) * | 1988-03-23 | 1988-04-27 | Unilever Plc | Cosmetic composition |
| FR2663816B1 (fr) * | 1990-06-28 | 1993-08-06 | Clar | Procede de traitement du colostrum par chromatographie d'adsorption sur hydroxyapatite, fraction active de colostrum obtenue et milieu cellulaire contenant ladite fraction active. |
| NZ238890A (en) * | 1990-07-13 | 1994-08-26 | Gropep Pty Ltd | Cell growth stimulating factor composition extracted from milk products and its use in culturing cells |
| JPH05202098A (ja) * | 1992-01-29 | 1993-08-10 | Snow Brand Milk Prod Co Ltd | 乳質原料から生理活性物質の製造法 |
| JP3544213B2 (ja) * | 1993-03-31 | 2004-07-21 | 雪印乳業株式会社 | インスリン様増殖因子−１含有組成物の製造法 |
| NL1005677C2 (nl) * | 1997-03-27 | 1998-09-29 | Campina Melkunie Bv | Werkwijze voor het winnen van groeifactoren, of een samenstelling die één of meer groeifactoren bevat, uit melk of een derivaat daarvan. |
-
1999
- 1999-10-06 EP EP99949462A patent/EP1218410B1/de not_active Expired - Lifetime
- 1999-10-06 DK DK99949462T patent/DK1218410T3/da active
- 1999-10-06 WO PCT/NL1999/000621 patent/WO2001025276A1/en active IP Right Grant
- 1999-10-06 AU AU62329/99A patent/AU782573B2/en not_active Ceased
- 1999-10-06 DE DE69925870T patent/DE69925870T2/de not_active Expired - Lifetime
- 1999-10-06 AT AT99949462T patent/ATE297948T1/de not_active IP Right Cessation
- 1999-10-06 NZ NZ518217A patent/NZ518217A/en not_active IP Right Cessation
- 1999-10-06 CA CA002387686A patent/CA2387686A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1218410B1 (de) | 2005-06-15 |
| ATE297948T1 (de) | 2005-07-15 |
| CA2387686A1 (en) | 2001-04-12 |
| NZ518217A (en) | 2003-09-26 |
| WO2001025276A1 (en) | 2001-04-12 |
| AU6232999A (en) | 2001-05-10 |
| DK1218410T3 (da) | 2005-08-08 |
| AU782573B2 (en) | 2005-08-11 |
| DE69925870T2 (de) | 2005-12-08 |
| EP1218410A1 (de) | 2002-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |