DE69618614D1 - NUKLEINSÄUREMOLEKÜLE MIT DER FÄHIGKEIT ZUR UNTERSCHEIDUNG VON PrPc UND PrPSc-PRIONPROTEIN-ISOFORMEN UND VERFAHREN ZU DEREN HERSTELLUNG - Google Patents
NUKLEINSÄUREMOLEKÜLE MIT DER FÄHIGKEIT ZUR UNTERSCHEIDUNG VON PrPc UND PrPSc-PRIONPROTEIN-ISOFORMEN UND VERFAHREN ZU DEREN HERSTELLUNGInfo
- Publication number
- DE69618614D1 DE69618614D1 DE69618614T DE69618614T DE69618614D1 DE 69618614 D1 DE69618614 D1 DE 69618614D1 DE 69618614 T DE69618614 T DE 69618614T DE 69618614 T DE69618614 T DE 69618614T DE 69618614 D1 DE69618614 D1 DE 69618614D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- acid molecules
- prpsc
- prpc
- prionprotein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95116890 | 1995-10-26 | ||
PCT/EP1996/004671 WO1997015685A1 (en) | 1995-10-26 | 1996-10-25 | NUCLEIC ACID MOLECULES CAPABLE OF DISTINGUISHING THE ISOFORMS PrPc AND PrPSc OF PRION PROTEINS AND PROCESSES FOR THEIR PRODUCTION |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69618614D1 true DE69618614D1 (de) | 2002-02-21 |
DE69618614T2 DE69618614T2 (de) | 2002-09-12 |
Family
ID=8219750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69618614T Expired - Fee Related DE69618614T2 (de) | 1995-10-26 | 1996-10-25 | NUKLEINSÄUREMOLEKÜLE MIT DER FÄHIGKEIT ZUR UNTERSCHEIDUNG VON PrPc UND PrPSc-PRIONPROTEIN-ISOFORMEN UND VERFAHREN ZU DEREN HERSTELLUNG |
Country Status (8)
Country | Link |
---|---|
US (2) | US6426409B1 (de) |
EP (1) | EP0862653B1 (de) |
JP (1) | JPH11514874A (de) |
AT (1) | ATE212065T1 (de) |
DE (1) | DE69618614T2 (de) |
DK (1) | DK0862653T3 (de) |
ES (1) | ES2171231T3 (de) |
WO (1) | WO1997015685A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002034935A2 (en) * | 2000-10-27 | 2002-05-02 | Research Development Foundation | In vitro selection of signaling aptamers |
DE59805338D1 (de) | 1997-09-19 | 2002-10-02 | Evotec Ag | Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen |
DE19916417A1 (de) * | 1999-04-01 | 2000-10-19 | Schering Ag | Amyloidspezifisches Aptamer |
DE19925073C2 (de) * | 1999-06-01 | 2001-07-19 | Stefan Weiss | Nucleinsäuremoleküle mit spezifischer Erkennung von nativem PrP·S··c·, Herstellung und Verwendung |
FR2808278A1 (fr) * | 2000-04-28 | 2001-11-02 | Inst Nat Sante Rech Med | Proteines a prions et leurs utilisations |
GB0012054D0 (en) * | 2000-05-18 | 2000-07-12 | Isis Innovation | Ligands |
WO2002097049A2 (en) * | 2001-05-31 | 2002-12-05 | Q-Rna | Compositions and methods for binding agglomeration proteins |
US20050261486A1 (en) * | 2001-05-31 | 2005-11-24 | Q-Rna | Compositions and methods for binding agglomeration proteins |
US20040005543A1 (en) * | 2002-01-18 | 2004-01-08 | Abraham Grossman | Compositions and methods for binding agglomeration proteins |
US20040096880A1 (en) * | 2001-08-07 | 2004-05-20 | Kmiec Eric B. | Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation |
US20040086924A1 (en) * | 2001-10-26 | 2004-05-06 | Research Development Foundation | In vitro selection of signaling aptamers |
WO2003089594A2 (en) * | 2002-04-15 | 2003-10-30 | Q-Rna, Inc. | A device and methods for concentrating prion protein isoforms |
WO2004016644A2 (en) * | 2002-08-15 | 2004-02-26 | Q-Rna, Inc. | Compositions and methods used for identifying factors required for the agglomeration of proteins |
KR101360955B1 (ko) * | 2002-09-13 | 2014-02-10 | 레플리코르 인코포레이티드 | 비서열 상보적 항바이러스 올리고뉴클레오티드 |
US20050196382A1 (en) * | 2002-09-13 | 2005-09-08 | Replicor, Inc. | Antiviral oligonucleotides targeting viral families |
US7399603B2 (en) * | 2002-12-19 | 2008-07-15 | Ortho-Clinical Diagnostics, Inc. | Antibodies for discrimination of prions |
EP1445615A1 (de) * | 2003-02-10 | 2004-08-11 | Ortho-Clinical Diagnostics, Inc. | Methode zur unterscheidung zwischen infektiösen und nicht-infektiösen prionen |
EP1667695A4 (de) * | 2003-09-11 | 2007-01-31 | Replicor Inc | Oligonucleotide gegen prionen-erkrankungen |
US20070123480A1 (en) * | 2003-09-11 | 2007-05-31 | Replicor Inc. | Oligonucleotides targeting prion diseases |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4917998A (en) * | 1986-05-06 | 1990-04-17 | Epitope, Inc. | Method of detecting AIDS virus infection |
US5270163A (en) * | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
US5567588A (en) * | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
US5582981A (en) * | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
US5573905A (en) * | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
-
1996
- 1996-10-25 US US09/051,962 patent/US6426409B1/en not_active Expired - Fee Related
- 1996-10-25 AT AT96937257T patent/ATE212065T1/de not_active IP Right Cessation
- 1996-10-25 EP EP96937257A patent/EP0862653B1/de not_active Expired - Lifetime
- 1996-10-25 DE DE69618614T patent/DE69618614T2/de not_active Expired - Fee Related
- 1996-10-25 DK DK96937257T patent/DK0862653T3/da active
- 1996-10-25 JP JP9516298A patent/JPH11514874A/ja not_active Ceased
- 1996-10-25 ES ES96937257T patent/ES2171231T3/es not_active Expired - Lifetime
- 1996-10-25 WO PCT/EP1996/004671 patent/WO1997015685A1/en active IP Right Grant
-
2002
- 2002-07-03 US US10/187,783 patent/US20030119019A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DK0862653T3 (da) | 2002-03-11 |
EP0862653A1 (de) | 1998-09-09 |
US6426409B1 (en) | 2002-07-30 |
ES2171231T3 (es) | 2002-09-01 |
WO1997015685A1 (en) | 1997-05-01 |
US20030119019A1 (en) | 2003-06-26 |
JPH11514874A (ja) | 1999-12-21 |
DE69618614T2 (de) | 2002-09-12 |
EP0862653B1 (de) | 2002-01-16 |
ATE212065T1 (de) | 2002-02-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |