DE69918322D1 - Verwendung von optisch reinem (r)-tofizopam zur behandlung und pravention von angststörungen - Google Patents
Verwendung von optisch reinem (r)-tofizopam zur behandlung und pravention von angststörungenInfo
- Publication number
- DE69918322D1 DE69918322D1 DE69918322T DE69918322T DE69918322D1 DE 69918322 D1 DE69918322 D1 DE 69918322D1 DE 69918322 T DE69918322 T DE 69918322T DE 69918322 T DE69918322 T DE 69918322T DE 69918322 D1 DE69918322 D1 DE 69918322D1
- Authority
- DE
- Germany
- Prior art keywords
- prevention
- treatment
- tofizopam
- anxiety disorders
- optically pure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10580398P | 1998-10-27 | 1998-10-27 | |
| US105803P | 1998-10-27 | ||
| PCT/US1999/025040 WO2000024400A1 (en) | 1998-10-27 | 1999-10-27 | Use of optically pure (r)-tofisopam for treating and preventing anxiety disorders and composition thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69918322D1 true DE69918322D1 (de) | 2004-07-29 |
| DE69918322T2 DE69918322T2 (de) | 2005-09-15 |
Family
ID=22307874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69918322T Expired - Fee Related DE69918322T2 (de) | 1998-10-27 | 1999-10-27 | Verwendung von optisch reinem (r)-tofizopam zur behandlung und pravention von angststörungen |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1124556B1 (de) |
| JP (2) | JP2003522112A (de) |
| AT (1) | ATE269705T1 (de) |
| AU (1) | AU1451900A (de) |
| BR (1) | BR9914899A (de) |
| CA (1) | CA2348281A1 (de) |
| DE (1) | DE69918322T2 (de) |
| DK (1) | DK1124556T3 (de) |
| ES (1) | ES2224751T3 (de) |
| GB (1) | GB2367748A (de) |
| HK (2) | HK1040908B (de) |
| IL (2) | IL142803A0 (de) |
| NZ (1) | NZ511744A (de) |
| PT (1) | PT1124556E (de) |
| WO (1) | WO2000024400A1 (de) |
| ZA (1) | ZA200103376B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6649607B2 (en) | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures |
| EP1499309A4 (de) * | 2002-04-24 | 2008-05-28 | Cypress Bioscience Inc | Prävention und behandlung von funktionellen somatischen erkrankungen, einschliesslich stressbedingten erkrankungen |
| US6864251B2 (en) * | 2002-12-03 | 2005-03-08 | Vela Pharmaceuticals, Inc. | Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines |
| US6638928B1 (en) * | 2002-12-03 | 2003-10-28 | Vela Pharmaceuticals, Inc. | Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines |
| US7022700B2 (en) | 2002-12-03 | 2006-04-04 | Vela Pharmaceuticals, Inc. | Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines |
| EP1567161A4 (de) | 2002-12-03 | 2008-09-03 | Vela Acquisition Corp | Pharmazeutische zusammensetzung aus 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepinund ihre verwendung |
| CA2510275A1 (en) * | 2002-12-03 | 2004-08-19 | Vela Pharmaceuticals, Inc. | Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof |
| WO2004103154A2 (en) * | 2003-05-16 | 2004-12-02 | Vela Pharmaceuticals, Inc. | Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine |
| JP2007513171A (ja) * | 2003-12-03 | 2007-05-24 | ヴェラ ファーマスーティカルズ インコーポレイテッド | ２，３−ベンゾジアゼピン低投与量による上皮の炎症性疾患の治療 |
| FR2870539B1 (fr) * | 2004-05-19 | 2006-08-04 | Greenpharma Sa Sa | Nouvelles methodes et medicaments |
| US7541355B2 (en) | 2005-05-23 | 2009-06-02 | Vela Acquisition Corporation | Conversion process for 2,3-benzodiazepine enantiomers |
| CN102836162A (zh) * | 2012-04-10 | 2012-12-26 | 珠海亿邦制药股份有限公司 | 一种以托非索泮为活性成分的口服固体制剂及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK118660B (da) * | 1966-12-09 | 1970-09-21 | Egyt Gyogyszervegyeszeti Gyar | Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid. |
| ZA712798B (en) * | 1970-11-06 | 1972-02-23 | Egyt Gyogyszervegyeszeti Gyar | New,pharmaceutically active 2,3-diazabicyclo(5.4.0)undecapentaene derivative and process for preparing same |
| HU178516B (en) * | 1978-05-05 | 1982-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing enanthiomeres of 1-bracket-3,4-dimethoxy-phenyl-bracket closed-5-ethyl-7,8-dimethoxy-4-methyl-5h-2,3-benzodiazepine and pharmacologically acceptable soles of the /-/-enanthiomere |
| HU209530B (en) * | 1988-08-31 | 1994-07-28 | Magnezitipari Muevek Rt | Process for manufacturing of cromit-like, fire resistant materials |
-
1999
- 1999-10-27 JP JP2000578009A patent/JP2003522112A/ja active Pending
- 1999-10-27 WO PCT/US1999/025040 patent/WO2000024400A1/en active IP Right Grant
- 1999-10-27 GB GB0111739A patent/GB2367748A/en not_active Withdrawn
- 1999-10-27 AT AT99970920T patent/ATE269705T1/de not_active IP Right Cessation
- 1999-10-27 PT PT99970920T patent/PT1124556E/pt unknown
- 1999-10-27 IL IL14280399A patent/IL142803A0/xx active IP Right Grant
- 1999-10-27 BR BR9914899-4A patent/BR9914899A/pt not_active Application Discontinuation
- 1999-10-27 NZ NZ511744A patent/NZ511744A/en unknown
- 1999-10-27 DK DK99970920T patent/DK1124556T3/da active
- 1999-10-27 AU AU14519/00A patent/AU1451900A/en not_active Abandoned
- 1999-10-27 CA CA002348281A patent/CA2348281A1/en not_active Abandoned
- 1999-10-27 DE DE69918322T patent/DE69918322T2/de not_active Expired - Fee Related
- 1999-10-27 EP EP99970920A patent/EP1124556B1/de not_active Expired - Lifetime
- 1999-10-27 ES ES99970920T patent/ES2224751T3/es not_active Expired - Lifetime
-
2001
- 2001-04-25 ZA ZA200103376A patent/ZA200103376B/en unknown
- 2001-04-25 IL IL142803A patent/IL142803A/en not_active IP Right Cessation
-
2002
- 2002-02-07 HK HK02100988.2A patent/HK1040908B/zh not_active IP Right Cessation
- 2002-09-17 HK HK02106802.3A patent/HK1046500A1/zh unknown
-
2007
- 2007-05-23 JP JP2007136619A patent/JP2007211028A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2224751T3 (es) | 2005-03-01 |
| EP1124556B1 (de) | 2004-06-23 |
| JP2003522112A (ja) | 2003-07-22 |
| WO2000024400A1 (en) | 2000-05-04 |
| DE69918322T2 (de) | 2005-09-15 |
| BR9914899A (pt) | 2001-07-17 |
| PT1124556E (pt) | 2004-10-29 |
| HK1046500A1 (zh) | 2003-01-17 |
| DK1124556T3 (da) | 2004-10-11 |
| AU1451900A (en) | 2000-05-15 |
| HK1040908A1 (en) | 2002-06-28 |
| GB0111739D0 (en) | 2001-07-04 |
| IL142803A (en) | 2006-10-05 |
| HK1040908B (zh) | 2005-04-22 |
| CA2348281A1 (en) | 2000-05-04 |
| EP1124556A1 (de) | 2001-08-22 |
| IL142803A0 (en) | 2002-03-10 |
| NZ511744A (en) | 2004-04-30 |
| GB2367748A (en) | 2002-04-17 |
| GB2367748A8 (en) | 2002-12-19 |
| ZA200103376B (en) | 2003-09-09 |
| ATE269705T1 (de) | 2004-07-15 |
| JP2007211028A (ja) | 2007-08-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: VELA PHARMACEUTICALS, INC., EWING, N.J., US |
|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |