DE69910993D1 - Azatrizyclische verbindungen - Google Patents

Azatrizyclische verbindungen

Info

Publication number
DE69910993D1
DE69910993D1 DE69910993T DE69910993T DE69910993D1 DE 69910993 D1 DE69910993 D1 DE 69910993D1 DE 69910993 T DE69910993 T DE 69910993T DE 69910993 T DE69910993 T DE 69910993T DE 69910993 D1 DE69910993 D1 DE 69910993D1
Authority
DE
Germany
Prior art keywords
hydrogen
substituent
sigma
azatrizyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69910993T
Other languages
English (en)
Other versions
DE69910993T2 (de
Inventor
Anthony Crooks
Madhukar Deo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Catalyst Biosciences Inc
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of DE69910993D1 publication Critical patent/DE69910993D1/de
Application granted granted Critical
Publication of DE69910993T2 publication Critical patent/DE69910993T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69910993T 1998-04-02 1999-02-26 Azatrizyclische verbindungen Expired - Fee Related DE69910993T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/054,179 US5986100A (en) 1998-04-02 1998-04-02 Pharmaceutical compositions and methods for use
US54179 1998-04-02
PCT/US1999/004324 WO1999051601A1 (en) 1998-04-02 1999-02-26 Azatricyclic compounds

Publications (2)

Publication Number Publication Date
DE69910993D1 true DE69910993D1 (de) 2003-10-09
DE69910993T2 DE69910993T2 (de) 2004-07-22

Family

ID=21989278

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69910993T Expired - Fee Related DE69910993T2 (de) 1998-04-02 1999-02-26 Azatrizyclische verbindungen

Country Status (14)

Country Link
US (2) US5986100A (de)
EP (1) EP1066287B1 (de)
JP (1) JP2002510689A (de)
KR (1) KR100613050B1 (de)
AT (1) ATE248839T1 (de)
AU (1) AU2794899A (de)
BR (1) BR9907191A (de)
CA (1) CA2317570A1 (de)
DE (1) DE69910993T2 (de)
DK (1) DK1066287T3 (de)
ES (1) ES2205778T3 (de)
MX (1) MXPA00009624A (de)
PT (1) PT1066287E (de)
WO (1) WO1999051601A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ID27544A (id) * 1998-08-18 2001-04-12 Ucb Sa Agonis dan antagonis muskarinat
EP1463481A4 (de) * 2001-12-14 2008-06-25 Targacept Inc Verfahren und zusammensetzungen zur behandlung von erkrankungen des zentralen nervensystems
US20030162770A1 (en) 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US7897766B2 (en) * 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
AU2012203831B2 (en) * 2006-11-06 2013-12-19 Abbvie Bahamas Ltd Azaadamantane derivatives and their uses as nicotinic acetylcholine receptors ligands
ATE538122T1 (de) * 2007-03-23 2012-01-15 Abbott Lab Acetamid- und carboxamid-derivate von azaadamantan sowie verfahren zu ihrer verwendung
MX2009010176A (es) 2007-03-23 2009-10-12 Abbott Lab Derivados de aza-adamantano 4-substituidos y metodos de uso de los mismos.
EP2619205B1 (de) 2010-09-23 2017-05-17 AbbVie Bahamas Ltd. Monohydrat eines azaadamantanderivates
TWI773657B (zh) 2015-12-18 2022-08-11 美商亞德利克斯公司 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2022886A1 (en) * 1989-08-08 1991-02-09 Raymond Baker Substituted pyridines, their preparation, formulations and use in dementia
US5110933A (en) * 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
EP0492903A1 (de) * 1990-12-21 1992-07-01 MERCK SHARP & DOHME LTD. Substituierte Pyrazine, Pyrimidine und Pyridazine zur Anwendung in der Behandlung von Glaukoma
WO1995003306A1 (en) * 1993-07-22 1995-02-02 E.I. Du Pont De Nemours And Company Arthropodicidal azacyclic heterocycles
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
US5583140A (en) * 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
WO1996036637A1 (en) * 1995-05-17 1996-11-21 R.J. Reynolds Tobacco Company Pharmaceutical compositions for prevention and treatment of central nervous system disorders
US5684159A (en) * 1995-05-30 1997-11-04 Rhone-Poulenc Rorer S.A. L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds

Also Published As

Publication number Publication date
ATE248839T1 (de) 2003-09-15
US5986100A (en) 1999-11-16
KR100613050B1 (ko) 2006-08-25
US6211372B1 (en) 2001-04-03
DK1066287T3 (da) 2004-01-19
ES2205778T3 (es) 2004-05-01
MXPA00009624A (es) 2005-06-20
EP1066287A1 (de) 2001-01-10
JP2002510689A (ja) 2002-04-09
DE69910993T2 (de) 2004-07-22
AU2794899A (en) 1999-10-25
PT1066287E (pt) 2004-01-30
BR9907191A (pt) 2000-12-26
CA2317570A1 (en) 1999-10-14
WO1999051601A1 (en) 1999-10-14
EP1066287B1 (de) 2003-09-03
KR20010052172A (ko) 2001-06-25

Similar Documents

Publication Publication Date Title
HK1072770A1 (en) Bicyclic compound
TW328535B (en) Functional photoinitiators and their manufacture
AU2003222450A1 (en) Stabilized ascorbic acid derivatives
BG103415A (en) Heteroaryl succinamides and their application as inhibitors of metalloproteinase
CA2418770A1 (en) Acylacetonitrile compound, process for preparation thereof, and miticide containing the same
DE69910993D1 (de) Azatrizyclische verbindungen
GEP20043172B (en) Combination Chemotherapy
GB0021421D0 (en) Compounds
EP1090922A3 (de) Organophosphor-Zusamensetzung, Verfahren zur Herstellung einer Organophosphor-Verbindung, Polyester-Zusamensetzung und Verfahren zur Herstellung davon
ATE240331T1 (de) Azatricyclo(3.3.1.1)decanderivate und diese enthaltende phrmazeutische zubereitungen
EP0945764A3 (de) Fotoresistzusammensetzung
SG104327A1 (en) Electron withdrawing group-containing metal compound
MY133299A (en) Skin moisturizing composition comprising a choline salt
WO1999009965A3 (en) Anti-inflammatory agent
WO2002062736A1 (fr) Diphenol et procede de production de ce diphenol
WO2002083616A1 (fr) DERIVE D'ACIDE GRAS φomega;-ARYLE α-SUBSTITUE
WO2003078390A8 (en) Phenolic compound and recording material containing the same
GB0317920D0 (en) Solid-phase synthesis
ATE260285T1 (de) Geschützte phenylalkylsilane
CA2191947A1 (en) Pirydyl Imidazole Derivatives and Processes for the Preparation Thereof
BG107048A (en) Method for the preparation of citalopram
IL152632A0 (en) Trimethyldecenyl compounds
EP0516860A4 (en) Chromone derivative and aldose reductase inhibitor containing the same as active ingredient
MXPA03002081A (es) Accesorios quirales de 4-ciclohexil-1, 3, 2-oxazaborolidina.
EP1826214B8 (de) Zusammensetzung enthaltend Ferrocen-Derivate und Treibstoff diese enthaltend

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee