DE69907247D1 - Verfahren und vorrichtung zum konservieren von biologischen materialien - Google Patents
Verfahren und vorrichtung zum konservieren von biologischen materialienInfo
- Publication number
- DE69907247D1 DE69907247D1 DE69907247T DE69907247T DE69907247D1 DE 69907247 D1 DE69907247 D1 DE 69907247D1 DE 69907247 T DE69907247 T DE 69907247T DE 69907247 T DE69907247 T DE 69907247T DE 69907247 D1 DE69907247 D1 DE 69907247D1
- Authority
- DE
- Germany
- Prior art keywords
- medium
- platelets
- biological materials
- plasma
- preserving biological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
- B01J3/04—Pressure vessels, e.g. autoclaves
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/0231—Chemically defined matrices, e.g. alginate gels, for immobilising, holding or storing cells, tissue or organs for preservation purposes; Chemically altering or fixing cells, tissue or organs, e.g. by cross-linking, for preservation purposes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
- A01N1/0257—Stationary or portable vessels generating cryogenic temperatures
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0278—Physical preservation processes
- A01N1/0289—Pressure processes, i.e. using a designated change in pressure over time
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J3/00—Processes of utilising sub-atmospheric or super-atmospheric pressure to effect chemical or physical change of matter; Apparatus therefor
- B01J3/03—Pressure vessels, or vacuum vessels, having closure members or seals specially adapted therefor
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Mechanical Engineering (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Dispersion Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US183581 | 1998-10-30 | ||
US09/183,581 US6413713B1 (en) | 1998-10-30 | 1998-10-30 | Method for preserving blood platelets |
PCT/US1999/023748 WO2000025580A1 (en) | 1998-10-30 | 1999-10-12 | Method and apparatus for preserving biological materials |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69907247D1 true DE69907247D1 (de) | 2003-05-28 |
DE69907247T2 DE69907247T2 (de) | 2004-02-26 |
Family
ID=22673424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69907247T Expired - Fee Related DE69907247T2 (de) | 1998-10-30 | 1999-10-12 | Verfahren und vorrichtung zum konservieren von biologischen materialien |
Country Status (8)
Country | Link |
---|---|
US (3) | US6413713B1 (de) |
EP (1) | EP1124413B1 (de) |
JP (1) | JP2002528469A (de) |
AT (1) | ATE237926T1 (de) |
AU (1) | AU1203100A (de) |
CA (1) | CA2348539A1 (de) |
DE (1) | DE69907247T2 (de) |
WO (1) | WO2000025580A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996014740A1 (en) * | 1992-03-02 | 1996-05-23 | Cerus Corporation | Synthetic media for blood components |
US20070048726A1 (en) * | 2000-01-14 | 2007-03-01 | Biolife Solutions, Inc. | Methods and Compositions for the Control of Molecular-Based Cell Death During Preservation of Cells, Tissues or Organs in a Gel-Like State |
US7604807B2 (en) * | 2000-12-01 | 2009-10-20 | Auburn University | Use of pullulan to isolate and preserve biological material |
US7022514B2 (en) | 2000-12-01 | 2006-04-04 | Auburn University | Use of Acacia Gum to isolate and preserve biological material |
WO2003000052A1 (en) * | 2001-06-26 | 2003-01-03 | Human Biosystems | Preservation of blood platelets at cold temperatures |
JP4511777B2 (ja) * | 2002-06-20 | 2010-07-28 | 株式会社ジェイ・エム・エス | 細胞保存容器 |
AU2004214932B2 (en) * | 2003-02-24 | 2009-12-03 | Marine Polymer Technologies, Inc. | Cell-polymer fiber compositions and use thereof |
US8828226B2 (en) | 2003-03-01 | 2014-09-09 | The Trustees Of Boston University | System for assessing the efficacy of stored red blood cells using microvascular networks |
CA2522941A1 (en) * | 2003-04-23 | 2004-11-04 | Human Biosystems | Improved methods and solutions for storing donor organs |
US20050010231A1 (en) * | 2003-06-20 | 2005-01-13 | Myers Thomas H. | Method and apparatus for strengthening the biomechanical properties of implants |
US8052667B2 (en) * | 2004-09-07 | 2011-11-08 | Velico Medical, Inc. | Apparatus for prolonging survival of platelets |
US7964338B2 (en) * | 2005-01-12 | 2011-06-21 | Biovec Transfusion, Llc | Platelet preservation composition containing eptifibatide, a reversible factor IIa inhibitor and a hemoglobin oxygen carrier |
JP5552231B2 (ja) * | 2005-10-14 | 2014-07-16 | ベリコ メディカル インコーポレイティッド | 血小板の生存延長のための組成物および方法 |
US8431334B2 (en) * | 2006-01-12 | 2013-04-30 | Biovec Transfusion, Llc | Method for removing antiplatelet agent and anticoagulant from a platelet composition by diafiltration |
US7964339B2 (en) * | 2007-02-09 | 2011-06-21 | Canadian Blood Services | Cold storage of modified platelets |
US8067151B2 (en) * | 2007-02-09 | 2011-11-29 | Canadian Blood Services | Cold storage of pegylated platelets at about or below 0° C. |
DE102007047040A1 (de) * | 2007-10-01 | 2009-04-16 | Fresenius Kabi Deutschland Gmbh | Transparentes Kältegel |
US8835104B2 (en) | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
WO2010005959A1 (en) * | 2008-07-07 | 2010-01-14 | Rich Products Corporation | Method for treatment and storage of platelets |
JP2010022269A (ja) * | 2008-07-18 | 2010-02-04 | Soka Univ | 細胞の保存方法及びその装置 |
DE602008005349D1 (de) * | 2008-12-29 | 2011-04-14 | Fiat Ricerche | Brennstoffeinspritzsystem mit hoher Betriebswiederholbarkeit und -stabilität für einen Verbrennungsmotor |
NZ622456A (en) | 2009-10-12 | 2015-09-25 | New Health Sciences Inc | Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities |
US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
JP2013507447A (ja) | 2009-10-12 | 2013-03-04 | ニュー ヘルス サイエンシーズ、インク. | 酸素減損装置及び赤血球から酸素を除去する方法 |
EP4091645A1 (de) | 2010-08-25 | 2022-11-23 | Hemanext Inc. | Verfahren zur erhöhung der qualität von erythrozyten und zur verlängerung ihrer lebensdauer während der lagerung |
ES2957338T3 (es) | 2010-11-05 | 2024-01-17 | Hemanext Inc | Irradiación de glóbulos rojos y almacenamiento anaeróbico |
US11178866B2 (en) | 2011-03-15 | 2021-11-23 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
US9867368B2 (en) * | 2011-03-15 | 2018-01-16 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
US8828710B2 (en) | 2011-03-15 | 2014-09-09 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
US9253976B2 (en) | 2011-03-15 | 2016-02-09 | Paragonix Technologies, Inc. | Methods and devices for preserving tissues |
BR112013023740A2 (pt) | 2011-03-16 | 2016-08-02 | Dynasil Biomedical Corp | métodos e materiais para prolongamento da armazenagem útil de preparações de glóbulo vermelho e preparações de plaqueta |
US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
WO2012139017A1 (en) | 2011-04-07 | 2012-10-11 | Fenwal, Inc. | Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates |
JP2014518283A (ja) | 2011-07-05 | 2014-07-28 | ニュー・ヘルス・サイエンシーズ・インコーポレイテッド | 赤血球の長期保存システムおよび使用方法 |
ES2923571T3 (es) | 2011-08-10 | 2022-09-28 | Hemanext Inc | Dispositivo integrado de filtrado de leucocitos, oxígeno y/o CO2 y separación de plasma |
DK2760991T3 (en) * | 2011-09-26 | 2018-01-22 | Rich Tech Holding Company Llc | Method of preserving living tissue |
EP2674033A1 (de) * | 2012-06-11 | 2013-12-18 | Deutsches Institut für Lebensmitteltechnik e.V. | Prozess zur Herstellung einer Zusammensetzung mit aktivem Follistatin |
EP2887800A4 (de) * | 2012-08-22 | 2016-07-27 | Haemonetics Corp | Blutvorratsbehälter mit einer wässrigen zusammensetzung zur lagerung von roten blutkörperchen |
US9686978B2 (en) * | 2012-12-19 | 2017-06-27 | Rich Technologies Holding Company, Llc | Platelet concentrate preservation method |
WO2014120886A1 (en) * | 2013-01-30 | 2014-08-07 | Velico Medical, Inc. | Platelet additive solution having a self-assembling hydrogel-forming peptide |
EP3967143A1 (de) | 2013-02-28 | 2022-03-16 | Hemanext Inc. | Gasanreicherungsvorrichtung zur blutbehandlung und zugehöriges verfahren |
IL299978B1 (en) | 2015-03-10 | 2024-04-01 | Hemanext Inc | Single-use oxygen reduction kits, devices and methods for their use |
KR20240067253A (ko) | 2015-04-23 | 2024-05-16 | 헤마넥스트 인코포레이티드 | 혐기성 혈액 저장 용기 |
MX2017014812A (es) | 2015-05-18 | 2018-05-11 | New Health Sciences Inc | Metodos para el almacenamiento de sangre completa y composiciones de esta. |
CN109195632A (zh) | 2016-05-27 | 2019-01-11 | 新健康科学股份有限公司 | 厌氧血液储存和病原体失活方法 |
IL263695B2 (en) | 2016-06-23 | 2023-03-01 | Hemanext Inc | Methods for treating side effects in patient populations that need transfusions |
MX2019013785A (es) | 2017-05-19 | 2020-01-13 | New Health Sciences Inc | Metodos y tratamiento de trauma. |
WO2018226993A1 (en) | 2017-06-07 | 2018-12-13 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
EP3880214A1 (de) | 2018-11-16 | 2021-09-22 | Hemanext Inc. | Verfahren zur verwaltung von nebenwirkungen in patienten mit entzündung |
US11632951B2 (en) | 2020-01-31 | 2023-04-25 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
USD1031028S1 (en) | 2022-09-08 | 2024-06-11 | Paragonix Technologies, Inc. | Tissue suspension adaptor |
WO2024064723A1 (en) | 2022-09-20 | 2024-03-28 | Hemanext Inc. | Oxygen reduced blood for use in the treatment of traumatic brain injury accompanied by hemorrhagic shock |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE395432C (de) | 1921-01-15 | 1924-06-12 | Basf Ag | Verfahren zum Abschliessen und OEffnen von Leitungen und Apparaten, z.B. Autoklaven |
US2662520A (en) | 1951-02-06 | 1953-12-15 | Little Inc A | Preservation and storage of biological materials |
US2786014A (en) | 1952-09-10 | 1957-03-19 | James L Tullis | Platelet preservation |
US3579999A (en) | 1968-08-08 | 1971-05-25 | Redeco | Method and apparatus for the preservation of biological substances |
US3729947A (en) * | 1970-12-04 | 1973-05-01 | Alza Corp | Process for storing blood platelets |
US3753357A (en) | 1970-12-14 | 1973-08-21 | Ovitron Res Corp | Method and apparatus for the preservation of cells and tissues |
US3931155A (en) * | 1973-04-25 | 1976-01-06 | Richardson-Merrell Inc. | Process for preparing 2-azacycloalkylmethyl ketones |
US4059967A (en) * | 1976-02-19 | 1977-11-29 | The Community Blood Council Of Greater New York, Inc. | Process for freezing blood platelets |
GB1527655A (en) | 1977-04-05 | 1978-10-04 | Boc Ltd | Preservation method |
DE2929278A1 (de) | 1979-07-19 | 1981-01-29 | Forschungsgesellschaft Fuer Bi | Verfahren zum eingefrieren von zellsuspensionen |
US4473552A (en) | 1981-03-16 | 1984-09-25 | Jost Leonora I | Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells |
SU1124974A1 (ru) | 1982-09-27 | 1984-11-23 | Институт Биофизики Со Ан Ссср | Способ хранени крови |
CA1216518A (en) * | 1982-11-01 | 1987-01-13 | Gail A. Rock | Plasma-free medium for platelet storage |
US4559298A (en) * | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
US4828976A (en) | 1983-12-29 | 1989-05-09 | Thomas Jefferson University | Glucose free media for storing blood platelets |
US4639373A (en) * | 1984-11-29 | 1987-01-27 | New England Medical Center Hospitals, Inc. | Stabilization of granulocytes |
US4688387A (en) | 1985-11-12 | 1987-08-25 | Vital Force, Inc. | Method for preservation and storage of viable biological materials at cryogenic temperatures |
US5248506A (en) * | 1986-03-19 | 1993-09-28 | American National Red Cross | Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets |
US4695460A (en) | 1986-03-19 | 1987-09-22 | American Red Cross | Synthetic, plasma-free, transfusible platelet storage medium |
FR2600671B1 (fr) | 1986-06-27 | 1991-01-25 | Merieux Inst | Procede de conservation cryogenique de substances et matieres organiques, notamment de cellules |
US4764463A (en) * | 1986-10-30 | 1988-08-16 | The University Of Tennessee Research Corporation | Platelet cyropreservation |
US5213814A (en) | 1989-04-10 | 1993-05-25 | Cryopharm Corporation | Lyophilized and reconstituted blood platelet compositions |
DE3938907C2 (de) * | 1989-11-24 | 1999-11-04 | Dade Behring Marburg Gmbh | Mittel zum Lagern und Suspendieren von Zellen, insbesondere Erythrozyten |
JP3182145B2 (ja) | 1990-04-16 | 2001-07-03 | 日本赤十字社 | 血小板保存液 |
US5474891A (en) * | 1991-10-30 | 1995-12-12 | Thomas Jefferson University | Plasma-based platelet concentrate preparations with additive |
JPH07190821A (ja) * | 1993-12-24 | 1995-07-28 | Nippondenso Co Ltd | 流量計 |
US5622867A (en) * | 1994-10-19 | 1997-04-22 | Lifecell Corporation | Prolonged preservation of blood platelets |
US6221669B1 (en) | 1994-10-19 | 2001-04-24 | Lifecell Corporation | Prolonged preservation of blood platelets |
US5635344A (en) | 1994-12-07 | 1997-06-03 | Cedra Corp. | Shipping medium for organ-derived cells |
JP2930908B2 (ja) * | 1995-07-19 | 1999-08-09 | 川澄化学工業株式会社 | 血小板保存液 |
US5827741A (en) * | 1996-11-19 | 1998-10-27 | The Regents Of The University Of California | Cryopreservation of human adult and fetal pancreatic cells and human platelets |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
EP1161143B1 (de) | 1999-03-11 | 2004-05-26 | Human BioSystems | Zusammensetzungen und verfahren zum konservieren von blutplättchen |
-
1998
- 1998-10-30 US US09/183,581 patent/US6413713B1/en not_active Expired - Fee Related
-
1999
- 1999-03-11 US US09/267,891 patent/US6828090B2/en not_active Expired - Fee Related
- 1999-10-12 WO PCT/US1999/023748 patent/WO2000025580A1/en active IP Right Grant
- 1999-10-12 EP EP99971264A patent/EP1124413B1/de not_active Expired - Lifetime
- 1999-10-12 JP JP2000579049A patent/JP2002528469A/ja active Pending
- 1999-10-12 DE DE69907247T patent/DE69907247T2/de not_active Expired - Fee Related
- 1999-10-12 AT AT99971264T patent/ATE237926T1/de not_active IP Right Cessation
- 1999-10-12 CA CA002348539A patent/CA2348539A1/en not_active Abandoned
- 1999-10-12 AU AU12031/00A patent/AU1203100A/en not_active Abandoned
-
2004
- 2004-06-09 US US10/865,292 patent/US7202020B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2000025580A1 (en) | 2000-05-11 |
US7202020B2 (en) | 2007-04-10 |
AU1203100A (en) | 2000-05-22 |
US20040223957A1 (en) | 2004-11-11 |
US6413713B1 (en) | 2002-07-02 |
US6828090B2 (en) | 2004-12-07 |
ATE237926T1 (de) | 2003-05-15 |
CA2348539A1 (en) | 2000-05-11 |
DE69907247T2 (de) | 2004-02-26 |
US20020009705A1 (en) | 2002-01-24 |
JP2002528469A (ja) | 2002-09-03 |
EP1124413A1 (de) | 2001-08-22 |
EP1124413B1 (de) | 2003-04-23 |
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