BR112013023740A2 - métodos e materiais para prolongamento da armazenagem útil de preparações de glóbulo vermelho e preparações de plaqueta - Google Patents

métodos e materiais para prolongamento da armazenagem útil de preparações de glóbulo vermelho e preparações de plaqueta

Info

Publication number
BR112013023740A2
BR112013023740A2 BR112013023740A BR112013023740A BR112013023740A2 BR 112013023740 A2 BR112013023740 A2 BR 112013023740A2 BR 112013023740 A BR112013023740 A BR 112013023740A BR 112013023740 A BR112013023740 A BR 112013023740A BR 112013023740 A2 BR112013023740 A2 BR 112013023740A2
Authority
BR
Brazil
Prior art keywords
materials
red blood
blood cell
methods
preparations
Prior art date
Application number
BR112013023740A
Other languages
English (en)
Inventor
Daniel Grant Ericson
Michael J Joyner
Original Assignee
Dynasil Biomedical Corp
Mayo Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dynasil Biomedical Corp, Mayo Foundation filed Critical Dynasil Biomedical Corp
Publication of BR112013023740A2 publication Critical patent/BR112013023740A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Mechanical Engineering (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

patente de invenção: métodos e materiais para prolongamento da armazenagem útil de preparações de glóbulo vermelho e preparações de plaqueta este documento fornece métodos e materiais para realce das capacidades de armazenagem de preparações de glóbulo branco. por exemplo, métodos e materiais para uso de co^ 2^ para armazenar glóbulos vermelhos de uma maneira que (a) redução do nível de consumo de glicose ou 2,3-dpg ou redução do nível de produção de 2,3-dpg por uma preparação de glóbulo vermelho, (b) redução o nível de formação de lactato por uma preparação de glóbulo vermelho, e/ou (c) redução do nível de ph de uma preparação de glóbulo vermelho sejam reduzidos. tais métodos e materiais podem tais métodos e materiais podem resultar no prolongamento do tempo de vida útil dos glóbulos vermelhos da preparação de glóbulo vermelho. este documento também fornece métodos e materiais envolvidos no prolongamento de armazenagem de preparações de plaqueta. por exemplo, métodos e materiais para armazenar plaquetas de uma maneira que a redução de metabolismo de plaqueta, que a preservação da função de plaqueta, e/ou que a redução do risco de contaminação bacteriana sejam fornecidas.
BR112013023740A 2011-03-16 2012-03-16 métodos e materiais para prolongamento da armazenagem útil de preparações de glóbulo vermelho e preparações de plaqueta BR112013023740A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161453455P 2011-03-16 2011-03-16
US201161562331P 2011-11-21 2011-11-21
PCT/US2012/029510 WO2012125955A2 (en) 2011-03-16 2012-03-16 Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations

Publications (1)

Publication Number Publication Date
BR112013023740A2 true BR112013023740A2 (pt) 2016-08-02

Family

ID=46831377

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013023740A BR112013023740A2 (pt) 2011-03-16 2012-03-16 métodos e materiais para prolongamento da armazenagem útil de preparações de glóbulo vermelho e preparações de plaqueta

Country Status (9)

Country Link
US (1) US9315775B2 (pt)
EP (1) EP2685815A4 (pt)
JP (1) JP2014510731A (pt)
KR (1) KR20140033015A (pt)
CN (1) CN103702557A (pt)
AU (1) AU2012228972A1 (pt)
BR (1) BR112013023740A2 (pt)
CA (1) CA2830420A1 (pt)
WO (1) WO2012125955A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012125955A2 (en) 2011-03-16 2012-09-20 Mayo Foundation For Medical Education And Research Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations
MX2019010395A (es) 2017-03-03 2020-02-05 Rich Tech Holding Company Llc Dispositivo para conservar hemoderivados y cultivos celulares en un medio de gas bajo presión.
CN114288484B (zh) * 2021-12-10 2023-01-03 中国人民解放军军事科学院军事医学研究院 低氧过滤血袋系统、血袋系统以及血液处理方法
CN114600872A (zh) * 2022-04-13 2022-06-10 西安北光医学生物技术有限公司 一种细胞、组织或器官的抗损伤保存的方法及保存系统

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3729947A (en) 1970-12-04 1973-05-01 Alza Corp Process for storing blood platelets
US4280497A (en) 1979-10-09 1981-07-28 Cutter Laboratories, Inc. Container for platelet storage
US4496361A (en) 1981-08-05 1985-01-29 E. I. Du Pont De Nemours And Company Platelet storage container
US4455299A (en) * 1981-11-20 1984-06-19 Baxter Travenol Laboratories, Inc. Storage of blood platelets
US4588401A (en) 1982-06-29 1986-05-13 E. I. Du Pont De Nemours And Company Platelet storage container
WO1984001292A1 (en) * 1982-09-27 1984-04-12 Baxter Travenol Lab Method and container for storing platelets
AU565267B2 (en) 1982-12-27 1987-09-10 Pall Corporation Container for blood and blood components
US4670013A (en) 1982-12-27 1987-06-02 Miles Laboratories, Inc. Container for blood and blood components
US4828976A (en) 1983-12-29 1989-05-09 Thomas Jefferson University Glucose free media for storing blood platelets
US4992363A (en) 1983-11-09 1991-02-12 Thomas Jefferson University Method for preparing glucose free media for storing blood platelets
CA1244774A (en) 1983-11-09 1988-11-15 Thomas Jefferson University Medium for storing blood platelets
US4695460A (en) 1986-03-19 1987-09-22 American Red Cross Synthetic, plasma-free, transfusible platelet storage medium
US5248506A (en) 1986-03-19 1993-09-28 American National Red Cross Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets
EP0330151A3 (en) 1988-02-23 1991-07-03 Nissho Corporation Bag for the storage of blood platelets
US4994367A (en) 1988-10-07 1991-02-19 East Carolina University Extended shelf life platelet preparations and process for preparing the same
US4967763A (en) 1989-03-13 1990-11-06 Becton, Dickinson And Company Platelet stable blood collection assembly
CA2067134C (en) 1989-10-06 2001-02-13 Harold T. Meryman Procedure for storing red cells with prolonged maintenance of cellular concentrations of atp and 2,3 dpg
IL95912A (en) 1989-10-06 1998-08-16 American Nat Red Cross A method for extending the shelf life of blood cells
US5147776A (en) 1990-02-26 1992-09-15 University Of Iowa Research Foundation Use of 2,5-anhydromannitol for control of pH during blood storage
CA2071835A1 (en) 1990-11-07 1992-05-08 Gerald A. Grode Blood platelet storage medium
US5569579A (en) 1991-04-01 1996-10-29 Thomas Jefferson University Synthetic-based platelet storage media
US5262180A (en) 1991-04-15 1993-11-16 University Of North Carolina At Chapel Hill Method for treating acute alkali exposure with carbon dioxide
DK0525292T3 (da) 1991-05-24 1995-01-02 Technica Entwicklung Fremgangsmåde og arrangement til behandling af hår, hovedbund og/eller kropshud
US5639382A (en) 1991-12-23 1997-06-17 Baxter International Inc. Systems and methods for deriving recommended storage parameters for collected blood components
SE9201413L (sv) 1992-04-30 1993-10-31 Stiftelsen Foer Medicinsk Tekn Beredning och sätt för aferesframställning av trombocytkoncentrat med väsentligt förlängd hållbarhet
US5378601A (en) 1992-07-24 1995-01-03 Montefiore Medical Center Method of preserving platelets with apyrase and an antioxidant
US5358844A (en) 1993-02-18 1994-10-25 Brigham And Women's Hospital, Inc. Preservation of blood platelets
US5476764A (en) 1994-09-16 1995-12-19 The Regents Of The University Of California Method using CO for extending the useful shelf-life of refrigerated red blood cells
US5622867A (en) 1994-10-19 1997-04-22 Lifecell Corporation Prolonged preservation of blood platelets
US6221669B1 (en) 1994-10-19 2001-04-24 Lifecell Corporation Prolonged preservation of blood platelets
DE69523568T2 (de) * 1994-11-22 2002-06-06 Baxter Int Lagerbehälter für blutteilchen
US5624794A (en) 1995-06-05 1997-04-29 The Regents Of The University Of California Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas
US5674190A (en) 1995-08-28 1997-10-07 Organetics, Ltd. Extracorporeal whole body hyperthermia using alpha-stat regulation of blood pH and pCO2
ES2163574T3 (es) 1995-12-04 2002-02-01 Jms Co Ltd Recipiente para uso medico.
JP4270285B2 (ja) * 1995-12-04 2009-05-27 株式会社ジェイ・エム・エス 血液成分収納容器と該血液成分収納容器を連結した血液成分収納具
US6162396A (en) 1997-04-26 2000-12-19 The Regents Of The University Of California Blood storage device and method for oxygen removal
US5789151A (en) 1997-05-15 1998-08-04 The Regents Of The University Of California Prolonged cold storage of red blood cells by oxygen removal and additive usage
US6087087A (en) 1997-07-03 2000-07-11 Takashi Yonetani Treatment of hemoglobin with nitric oxide
US6315767B1 (en) 1998-08-19 2001-11-13 Gambro, Inc. Cell storage maintenance and monitoring system
US6413713B1 (en) 1998-10-30 2002-07-02 Hyperbaric Systems Method for preserving blood platelets
AU6427699A (en) 1999-03-11 2000-09-28 Human BioSystems. Compositions and methods for preserving platelets
WO2000054825A1 (en) 1999-03-15 2000-09-21 Implant Innovations, Inc. Platelet collection system
US6468732B1 (en) 2000-04-04 2002-10-22 Bayer Corporation Method and long-term stable bicarbonate-containing diluent composition, and storage means therefor, for reducing or reversing aeration induced cell shrinkage and storage induced cell swelling of a whole blood sample
AUPQ906300A0 (en) 2000-07-28 2000-08-24 Monash University Method of preserving cells and uses thereof
CA2431332A1 (en) 2000-11-06 2002-05-10 Denisa D. Wagner Compositions and methods for prolonging survival of chilled platelets
US6730267B2 (en) 2001-02-09 2004-05-04 Cardiovention, Inc. Integrated blood handling system having active gas removal system and methods of use
US20050019743A1 (en) 2001-05-03 2005-01-27 Center For Blood Research, Inc. Compounds and methods for improving platelet recovery and function
JP4521183B2 (ja) 2001-06-21 2010-08-11 ベス・イスラエル・ディーコニス・メディカル・センター・インコーポレーテッド 組織および臓器移植の転帰を改善しかつアポトーシスを抑制する一酸化炭素
US20030153074A1 (en) 2001-11-16 2003-08-14 Bitensky Mark W. Method for extending the useful shelf-life of refrigerated red blood cells by nutrient supplementation
US20030124504A1 (en) 2001-11-16 2003-07-03 Bitensky Mark W. Additive solution for blood preservation
US7838699B2 (en) 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
IL149611A (en) * 2002-05-13 2011-07-31 Safetin Ltd Method for extended storage of viable and pathogen-safe blood and blood components using carbon monoxide
AU2003279236B8 (en) 2002-06-21 2009-02-19 Beth Israel Deaconess Medical Center, Inc. Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
US20040081580A1 (en) 2002-09-10 2004-04-29 Doug Hole Use of nitric oxide and a device in the therapeutic management of pathogens in mammals
US7531133B2 (en) 2002-09-10 2009-05-12 Pulmonox Technologies Corporation Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma
EP1562422A4 (en) 2002-11-08 2012-04-25 Brigham & Womens Hospital COMPOSITIONS AND METHODS FOR EXTENDING THE SURVIVAL OF BLOODPLATES
WO2004105837A2 (en) 2003-05-22 2004-12-09 Center For Blood Research, Inc. Compounds and methods for improving platelet recovery and function
WO2005001059A2 (en) 2003-06-23 2005-01-06 Novasterilis Inc. Inactivating organisms using carbon dioxide at or near its supercritical pressure and temperature conditions
US20070003432A1 (en) 2004-06-17 2007-01-04 Christensen Timothy W Sterilization methods and apparatus which employ additive-containing supercritical carbon dioxide sterilant
US20050170019A1 (en) 2003-10-22 2005-08-04 Fred Hutchinson Cancer Research Center Methods, compositions and devices for inducing stasis in cells
US8052667B2 (en) 2004-09-07 2011-11-08 Velico Medical, Inc. Apparatus for prolonging survival of platelets
US20120225044A9 (en) 2004-09-07 2012-09-06 Zymequest, Inc. Compositions and methods for prolonging survival of platelets
JP5123663B2 (ja) 2004-10-15 2013-01-23 ベリコ メディカル インコーポレイティッド 血小板の生存延長のための組成物および方法
WO2006076401A2 (en) 2005-01-12 2006-07-20 Biovec, Llc Composition for preserving platelets and method of using the same
US8129104B2 (en) 2005-01-12 2012-03-06 Biovec Transfusion, Llc Platelet preservation composition comprising a short to ultra-short acting antiplatelet agent and anticoagulant with hemoglobin
US8142992B2 (en) 2005-01-12 2012-03-27 Biovec Transfusion, Llc Platelet preservation package comprising a short to ultra-short acting antiplatelet agent and anticoagulant with an oxygen carrier
WO2007008618A2 (en) 2005-07-13 2007-01-18 University Of South Carolina Sterilization using high-pressure carbon dioxide
WO2008017123A1 (en) 2006-08-11 2008-02-14 The Walter And Eliza Hall Institute Of Medical Research Methods for modulating apoptosis in platelets
WO2008017121A1 (en) 2006-08-11 2008-02-14 The Walter And Eliza Hall Institute Of Medical Research Methods for modulating apoptosis in platelets
EP1902740A1 (en) * 2006-09-19 2008-03-26 Maco Pharma S.A. Blood bag system and process for the inactivation of pathogens in platelet concentrates by use of the blood bag system
DE102007038121A1 (de) 2007-07-31 2009-02-05 Novalung Gmbh Konditionierung von Blut eines Patienten durch Gase
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
US8158339B2 (en) 2008-07-07 2012-04-17 Rich Products Corporation Method of preserving a platelet concentrate under elevated xenon concentration and pressure with refrigeration
US8178318B2 (en) 2008-08-06 2012-05-15 Praxair Technology, Inc. Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield
WO2010088364A2 (en) 2009-01-30 2010-08-05 L'air Liquide Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Process for preserving biological materials for extended periods of time
EP2459247A4 (en) 2009-07-31 2013-08-28 Univ Pittsburgh DEOXYGENATION OF BIOLOGICAL FLUIDS
AU2010306920A1 (en) 2009-10-12 2012-05-31 New Health Sciences, Inc. Oxygen depletion devices and methods for removing oxygen from red blood cells
WO2011046841A1 (en) 2009-10-12 2011-04-21 New Health Sciences, Inc. Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
EP2608816B1 (en) 2010-08-25 2023-07-05 Hemanext Inc. Method for enhancing red blood cell quality and survival during storage
PT3539381T (pt) 2010-11-05 2023-09-26 Hemanext Inc Irradiação de glóbulos vermelhos e armazenamento anaeróbico
WO2012109107A1 (en) 2011-02-07 2012-08-16 Rich Products Corporation Method for preserving cells and cell cultures
US20130143196A1 (en) 2011-03-16 2013-06-06 Dynasil Biomedical Corporation Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations
WO2012125955A2 (en) 2011-03-16 2012-09-20 Mayo Foundation For Medical Education And Research Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations

Also Published As

Publication number Publication date
US9315775B2 (en) 2016-04-19
EP2685815A4 (en) 2014-09-17
CN103702557A (zh) 2014-04-02
AU2012228972A1 (en) 2013-10-24
JP2014510731A (ja) 2014-05-01
US20140295402A1 (en) 2014-10-02
WO2012125955A3 (en) 2012-12-27
WO2012125955A2 (en) 2012-09-20
EP2685815A2 (en) 2014-01-22
KR20140033015A (ko) 2014-03-17
CA2830420A1 (en) 2012-09-20

Similar Documents

Publication Publication Date Title
Yancey et al. Co-evolution of proteins and solutions: protein adaptation versus cytoprotective micromolecules and their roles in marine organisms
Pati et al. Protective effects of fresh frozen plasma on vascular endothelial permeability, coagulation, and resuscitation after hemorrhagic shock are time dependent and diminish between days 0 and 5 after thaw
Cain et al. Absence of sclerostin adversely affects B‐cell survival
BR112013023740A2 (pt) métodos e materiais para prolongamento da armazenagem útil de preparações de glóbulo vermelho e preparações de plaqueta
Patel et al. Extracellular ubiquitin increases in packed red blood cell units during storage
GB201117304D0 (en) Use
Bissoyi et al. Recent advances and future direction in lyophilisation and desiccation of mesenchymal stem cells
Gazmuri et al. Sodium-hydrogen exchanger isoform-1 inhibition: A promising pharmacological intervention for resuscitation from cardiac arrest
EA201591246A1 (ru) Раствор для сохранения сосудистых трубок
BR112015028054A2 (pt) método para obter uma suspensão estabilizada de glóbulos vermelhos e suspensão estabilizada
AR087980A1 (es) Actividad de dnasa endogena para reducir el contenido de adn
CY1111008T1 (el) Προϊον με ζωντανους προβιοτικους μικροοργανισμους
BR112017004017A2 (pt) sistema de fermentação para processos de moagem seca
Bian et al. Lowering of elevated tissue PCO2 in a hemorrhagic shock rat model after reinfusion of a novel nanobiotechnological polyhemoglobin-superoxide dismutase-catalase-carbonic anhydrase that is an oxygen and a carbon dioxide carrier with enhanced antioxidant properties
Wu et al. Nrf2 is crucial to graft survival in a rodent model of heart transplantation
de Souza et al. Effect of milk renewal on human periodontal ligament fibroblast viability in vitro
CN104107436A (zh) 一种用于保存犬全血的保存液及其应用
aRCE DoMÍNGUEZ et al. Diet of Phyllobates aurotaenia and Oophaga histrionica (Anura: Dendrobatidae), municipality of Alto Baudó, Chocó, Colombia
Nnodim et al. Altered membrane potential and electrolyte in sickle cell anemia
Li et al. Polymerized placenta hemoglobin improves cardiac functional recovery and reduces infarction size of isolated rat heart
WO2005013689A3 (en) Preservation of blood cells
CL2009001888A1 (es) Formula nutricional que tiene un ph en el estado liquido de 4,8 a 5,2, que comprende 1 a 1,2% de acido lactico y entre 0,9 a 1,4% de una sal de acido lactico, seleccionada de lactato de sodio, de potasio o de calcio.
Rautanen et al. Response to Schöneweck et al.: Common genomic variation in the FER gene: useful to stratify patients with sepsis due to pneumonia?
Tai et al. Natural Killer Cell Transfer Assay
Medvedev et al. Itravascular activity of trombocytes in arterial hypertension patients with dislipidemia on a background fluvastatine

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.