DE69904442T2 - Cyclohexandiol-derivate - Google Patents

Cyclohexandiol-derivate

Info

Publication number
DE69904442T2
DE69904442T2 DE69904442T DE69904442T DE69904442T2 DE 69904442 T2 DE69904442 T2 DE 69904442T2 DE 69904442 T DE69904442 T DE 69904442T DE 69904442 T DE69904442 T DE 69904442T DE 69904442 T2 DE69904442 T2 DE 69904442T2
Authority
DE
Germany
Prior art keywords
cyclohexanediol derivatives
cyclohexanediol
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69904442T
Other languages
English (en)
Other versions
DE69904442D1 (en
Inventor
Pierre Barbier
Franz Bauer
Peter Mohr
Marc Muller
Wolfgang Pirson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Basilea Pharmaceutica AG
Original Assignee
Basilea Pharmaceutica AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG
Publication of DE69904442D1 publication Critical patent/DE69904442D1/de
Application granted granted Critical
Publication of DE69904442T2 publication Critical patent/DE69904442T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/02Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/19Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/20Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/26Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C47/263Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups acyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/20Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/26Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C47/273Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09Geometrical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
DE69904442T 1998-02-26 1999-02-20 Cyclohexandiol-derivate Expired - Lifetime DE69904442T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98103346 1998-02-26
PCT/EP1999/001118 WO1999043646A1 (en) 1998-02-26 1999-02-20 Cyclohexanediole derivatives

Publications (2)

Publication Number Publication Date
DE69904442D1 DE69904442D1 (en) 2003-01-23
DE69904442T2 true DE69904442T2 (de) 2003-09-25

Family

ID=8231480

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69904442T Expired - Lifetime DE69904442T2 (de) 1998-02-26 1999-02-20 Cyclohexandiol-derivate

Country Status (21)

Country Link
US (1) US6184422B1 (de)
EP (1) EP1056716B1 (de)
JP (1) JP3507435B2 (de)
KR (1) KR20010041313A (de)
CN (1) CN1133621C (de)
AR (1) AR018120A1 (de)
AT (1) ATE229503T1 (de)
AU (1) AU751241B2 (de)
BR (1) BR9908315A (de)
CA (1) CA2320180C (de)
CO (1) CO4980898A1 (de)
DE (1) DE69904442T2 (de)
DK (1) DK1056716T3 (de)
ES (1) ES2188134T3 (de)
MA (1) MA26609A1 (de)
MY (1) MY133520A (de)
PE (1) PE20000267A1 (de)
PT (1) PT1056716E (de)
TR (1) TR200002477T2 (de)
WO (1) WO1999043646A1 (de)
ZA (1) ZA991550B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01009893A (es) * 1999-04-01 2003-07-28 Esperion Therapeutics Inc Compuestos con eter, composiciones y usos de estos.
EP1094060B1 (de) * 1999-10-18 2004-04-28 Basilea Pharmaceutica AG Verfahren zur Herstellung von Retiferolderivaten
US6310262B1 (en) 1999-10-18 2001-10-30 Basilea Pharmaceutica Ag Process for preparing retiferol derivatives
MXPA03004074A (es) * 2000-11-22 2003-09-04 Hoffmann La Roche Derivados de retiferol y su uso en el tratamiento de enfermedades o trastornos de la piel asociadas con fotoda°o.
AU2002360015A1 (en) * 2001-12-26 2003-07-15 Chugai Seiyaku Kabushiki Kaisha 2-substituted vitamin d derivatives
US6723755B2 (en) 2002-06-12 2004-04-20 Piotr Chomczynski Method of treating rosacea
US7812057B2 (en) * 2004-08-25 2010-10-12 Molecular Research Center, Inc. Cosmetic compositions
WO2007028000A2 (en) * 2005-08-30 2007-03-08 Wisconsin Alumni Research Foundation Des-c,d analogs of 1alpha,25-dihydroxy-19-norvitamin d3
GB0712653D0 (en) 2007-06-28 2007-08-08 Syngenta Ltd Novel herbicides
AU2009206449B2 (en) * 2008-01-22 2014-04-24 Wisconsin Alumni Research Foundation 13,13-Dimethyl-des-C,D analogs of 1alpha, 25-dihydroxy-19-nor-vitamin D3 compounds and topical composition dosage forms and methods of treating skin conditions
EA026334B1 (ru) * 2009-01-27 2017-03-31 БЕРГ ЭлЭлСи Применение соединения витамина d для предотвращения или снижения развития химиотерапевтически индуцированной нейтропении
CA2770683C (en) 2009-08-14 2018-09-04 Berg Biosystems, Llc Vitamin d3 and analogs thereof for treating alopecia
CN112156097A (zh) 2013-05-29 2021-01-01 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发
CN114044788A (zh) * 2021-08-12 2022-02-15 甘肃皓天医药科技有限责任公司 一种氟骨化醇cd环的制备方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU699200B2 (en) 1993-07-09 1998-11-26 Roger Bouillon Novel structural analogues of vitamin D
PL174912B1 (pl) 1994-01-24 1998-10-30 Inst Farmaceutyczny Nowe związki farmakologicznie czynne z grupy witamin D i sposób ich otrzymywania
US5461116A (en) 1994-11-10 1995-10-24 Shell Oil Company Core functionalized star block copolymers
CA2288629A1 (en) * 1997-05-23 1998-11-26 F. Hoffmann-La Roche Ag Cyclohexanediol derivatives

Also Published As

Publication number Publication date
DK1056716T3 (da) 2003-04-07
AU751241B2 (en) 2002-08-08
TR200002477T2 (tr) 2001-03-21
CA2320180C (en) 2005-06-07
JP3507435B2 (ja) 2004-03-15
MY133520A (en) 2007-11-30
MA26609A1 (fr) 2004-12-20
DE69904442D1 (en) 2003-01-23
ZA991550B (en) 1999-08-26
KR20010041313A (ko) 2001-05-15
JP2002504537A (ja) 2002-02-12
US6184422B1 (en) 2001-02-06
CN1133621C (zh) 2004-01-07
PT1056716E (pt) 2003-04-30
CN1291974A (zh) 2001-04-18
CA2320180A1 (en) 1999-09-02
PE20000267A1 (es) 2000-04-10
ES2188134T3 (es) 2003-06-16
EP1056716A1 (de) 2000-12-06
CO4980898A1 (es) 2000-11-27
AR018120A1 (es) 2001-10-31
AU2624699A (en) 1999-09-15
EP1056716B1 (de) 2002-12-11
BR9908315A (pt) 2000-11-07
WO1999043646A1 (en) 1999-09-02
ATE229503T1 (de) 2002-12-15

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