DE69901838T2 - Nicht-invasive darstellung der retinalen funktionstüchtigkeit - Google Patents
Nicht-invasive darstellung der retinalen funktionstüchtigkeitInfo
- Publication number
- DE69901838T2 DE69901838T2 DE69901838T DE69901838T DE69901838T2 DE 69901838 T2 DE69901838 T2 DE 69901838T2 DE 69901838 T DE69901838 T DE 69901838T DE 69901838 T DE69901838 T DE 69901838T DE 69901838 T2 DE69901838 T2 DE 69901838T2
- Authority
- DE
- Germany
- Prior art keywords
- retina
- imaging
- retinal
- image
- illuminator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002207 retinal effect Effects 0.000 title claims abstract description 46
- 238000003384 imaging method Methods 0.000 claims abstract description 67
- 210000001525 retina Anatomy 0.000 claims abstract description 65
- 238000005286 illumination Methods 0.000 claims abstract description 43
- 230000004044 response Effects 0.000 claims abstract description 22
- 230000004243 retinal function Effects 0.000 claims abstract description 11
- 230000006870 function Effects 0.000 claims abstract description 6
- 230000001939 inductive effect Effects 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims description 19
- 239000000523 sample Substances 0.000 claims description 11
- 238000004458 analytical method Methods 0.000 claims description 10
- 230000004936 stimulating effect Effects 0.000 claims description 6
- 230000000694 effects Effects 0.000 claims description 5
- 238000012935 Averaging Methods 0.000 claims description 3
- 230000004913 activation Effects 0.000 claims description 3
- 239000007850 fluorescent dye Substances 0.000 claims description 3
- 238000002372 labelling Methods 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims 1
- 238000000149 argon plasma sintering Methods 0.000 description 8
- 230000003287 optical effect Effects 0.000 description 8
- 210000003050 axon Anatomy 0.000 description 7
- 230000000638 stimulation Effects 0.000 description 6
- 238000004061 bleaching Methods 0.000 description 5
- 230000005856 abnormality Effects 0.000 description 4
- 230000005284 excitation Effects 0.000 description 4
- 238000002310 reflectometry Methods 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 230000000004 hemodynamic effect Effects 0.000 description 3
- 238000010191 image analysis Methods 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 3
- 210000002569 neuron Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000002059 diagnostic imaging Methods 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 238000002073 fluorescence micrograph Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- 238000012634 optical imaging Methods 0.000 description 2
- 230000000284 resting effect Effects 0.000 description 2
- 230000004256 retinal image Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 238000003325 tomography Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010033546 Pallor Diseases 0.000 description 1
- 201000010183 Papilledema Diseases 0.000 description 1
- 208000017442 Retinal disease Diseases 0.000 description 1
- 206010038886 Retinal oedema Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 238000013534 fluorescein angiography Methods 0.000 description 1
- 238000001215 fluorescent labelling Methods 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000012216 imaging agent Substances 0.000 description 1
- MOFVSTNWEDAEEK-UHFFFAOYSA-M indocyanine green Chemical compound [Na+].[O-]S(=O)(=O)CCCCN1C2=CC=C3C=CC=CC3=C2C(C)(C)C1=CC=CC=CC=CC1=[N+](CCCCS([O-])(=O)=O)C2=CC=C(C=CC=C3)C3=C2C1(C)C MOFVSTNWEDAEEK-UHFFFAOYSA-M 0.000 description 1
- 229960004657 indocyanine green Drugs 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 210000004088 microvessel Anatomy 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000004283 retinal dysfunction Effects 0.000 description 1
- 201000011195 retinal edema Diseases 0.000 description 1
- 230000004232 retinal microvasculature Effects 0.000 description 1
- 210000001116 retinal neuron Anatomy 0.000 description 1
- 239000000790 retinal pigment Substances 0.000 description 1
- 230000004233 retinal vasculature Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/1241—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Eye Examination Apparatus (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Image Processing (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12561498A IL125614A (en) | 1998-07-31 | 1998-07-31 | System and method for non-invasive imaging of retinal function |
| PCT/IL1999/000418 WO2000006015A1 (en) | 1998-07-31 | 1999-07-29 | Non-invasive imaging of retinal function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69901838D1 DE69901838D1 (de) | 2002-07-18 |
| DE69901838T2 true DE69901838T2 (de) | 2003-01-30 |
Family
ID=11071807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69901838T Expired - Lifetime DE69901838T2 (de) | 1998-07-31 | 1999-07-29 | Nicht-invasive darstellung der retinalen funktionstüchtigkeit |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6478424B1 (enExample) |
| EP (1) | EP1100370B1 (enExample) |
| JP (1) | JP4409091B2 (enExample) |
| CN (1) | CN1261071C (enExample) |
| AT (1) | ATE218835T1 (enExample) |
| AU (1) | AU5063099A (enExample) |
| DE (1) | DE69901838T2 (enExample) |
| HK (1) | HK1041192B (enExample) |
| IL (1) | IL125614A (enExample) |
| WO (1) | WO2000006015A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070091265A1 (en) * | 2002-01-18 | 2007-04-26 | Kardon Randy H | System and method for optical imaging of human retinal function |
| US7118217B2 (en) * | 2002-01-18 | 2006-10-10 | University Of Iowa Research Foundation | Device and method for optical imaging of retinal function |
| WO2003083434A2 (en) | 2002-04-02 | 2003-10-09 | Yeda Research And Development Co. Ltd. | Characterization of moving objects in a stationary background |
| US6709109B1 (en) | 2002-04-16 | 2004-03-23 | University Of South Florida | Differential spectroscopic imaging of the human retina |
| US7222961B2 (en) * | 2002-08-05 | 2007-05-29 | Kestrel Corporation | Method for detecting a functional signal in retinal images |
| WO2004049899A2 (en) | 2002-12-02 | 2004-06-17 | Yeda Research And Development Co. Ltd. | Characterization of arteriosclerosis by optical imaging |
| JP2004267616A (ja) * | 2003-03-11 | 2004-09-30 | Canon Inc | 眼科機器 |
| DE10331013A1 (de) * | 2003-07-09 | 2005-03-03 | Carl Zeiss Meditec Ag | Vorrichtung und Verfahren für ein ophthalmologisches Gerät, vorzugsweise eine Funduskamera |
| EP2412304B1 (en) * | 2003-09-04 | 2016-08-03 | The UAB Research Foundation | Method and apparatus for the detection of impaired dark adaptation |
| DE10357734B4 (de) * | 2003-12-05 | 2009-10-01 | Imedos Gmbh | Universelles ophthalmologisches Untersuchungsgerät und ophthalmologisches Untersuchungsverfahren |
| US7706863B2 (en) | 2004-01-21 | 2010-04-27 | University Of Washington | Methods for assessing a physiological state of a mammalian retina |
| US7512436B2 (en) * | 2004-02-12 | 2009-03-31 | The Regents Of The University Of Michigan | Method of evaluating metabolism of the eye |
| JPWO2005084526A1 (ja) * | 2004-02-20 | 2007-11-29 | 独立行政法人理化学研究所 | 網膜機能の光学計測方法と装置 |
| DE102004008675B4 (de) * | 2004-02-20 | 2009-05-07 | Imedos Gmbh | Bildgebendes Verfahren zur Erfassung medizinisch relevanter Unterschiede von Strukturen und Eigenschaften eines Untersuchungsobjektes und dazu geeignete Vorrichtung |
| JP4458935B2 (ja) * | 2004-06-01 | 2010-04-28 | 株式会社ニデック | 視野計 |
| CN101123910B (zh) * | 2004-10-05 | 2011-05-11 | 匹兹堡大学高等教育联邦体系 | 用于检测视网膜病的方法和设备 |
| JP4612396B2 (ja) * | 2004-11-10 | 2011-01-12 | 株式会社ニデック | 網膜機能計測装置 |
| JP4646027B2 (ja) * | 2005-03-03 | 2011-03-09 | 株式会社ニデック | 網膜機能計測装置 |
| JP5079240B2 (ja) | 2006-02-06 | 2012-11-21 | 株式会社ニデック | 網膜機能計測装置 |
| US8129105B2 (en) | 2006-04-13 | 2012-03-06 | Ralph Zuckerman | Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy |
| JP2007319393A (ja) * | 2006-05-31 | 2007-12-13 | Nidek Co Ltd | 網膜機能計測装置 |
| GB0612096D0 (en) * | 2006-06-19 | 2006-07-26 | Greater Glasgow Nhs Board | Functional imaging of the retina |
| DE102006030382A1 (de) * | 2006-06-29 | 2008-01-03 | Carl Zeiss Meditec Ag | Verfahren und Vorrichtung zur optischen Detektion am Auge |
| US8155730B2 (en) | 2006-10-24 | 2012-04-10 | The Research Foundation Of State University Of New York | Composition, method, system, and kit for optical electrophysiology |
| CA2667504C (en) * | 2006-11-02 | 2014-09-16 | Heidelberg Engineering Gmbh | Method and apparatus for retinal diagnosis |
| US7648239B2 (en) * | 2007-05-01 | 2010-01-19 | Richard Spaide | Autofluorescence photography using a fundus camera |
| WO2008133693A1 (en) * | 2007-05-01 | 2008-11-06 | Richard Spaide | Autofluorescence photography using a fundus camera |
| JP2008295971A (ja) * | 2007-06-04 | 2008-12-11 | Nidek Co Ltd | 眼底カメラ |
| KR101643953B1 (ko) * | 2007-11-13 | 2016-07-29 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | 눈과 관련된 질환을 검출하기 위한 방법 및 장치 |
| US8403862B2 (en) | 2007-12-20 | 2013-03-26 | Yeda Research And Development Co. Ltd. | Time-based imaging |
| DK2268193T3 (en) * | 2008-03-27 | 2016-07-04 | Cognoptix Inc | Ocular imaging for the diagnosis of neurodegenerative diseases |
| JP2010172614A (ja) * | 2009-01-30 | 2010-08-12 | Topcon Corp | 機能イメージング眼科装置 |
| CN105147239A (zh) * | 2009-03-04 | 2015-12-16 | 完美Ip有限公司 | 用于表征角膜并制造眼用透镜的系统 |
| WO2011017550A2 (en) | 2009-08-05 | 2011-02-10 | The Johns Hopkins University | Programmable multispectral illumination system for surgery and visualization of light-sensitive tissues |
| EP2301424B1 (de) * | 2009-09-29 | 2015-07-08 | OD-OS GmbH | Ophthalmoskop mit einer Laservorrichtung |
| WO2011059405A1 (en) * | 2009-11-12 | 2011-05-19 | Agency For Science, Technology And Research | Method and device for monitoring retinopathy |
| US20120001932A1 (en) * | 2010-07-02 | 2012-01-05 | Burnett William R | Systems and methods for assisting visually-impaired users to view visual content |
| KR101905436B1 (ko) | 2010-08-16 | 2018-10-08 | 코그놉틱스, 인코포레이티드 | 아밀로이드 단백질을 검출하기 위한 시스템 및 방법 |
| JP5666206B2 (ja) * | 2010-08-31 | 2015-02-12 | 株式会社ニデック | 視機能検査装置 |
| JP5702991B2 (ja) | 2010-11-19 | 2015-04-15 | キヤノン株式会社 | 画像処理装置及び画像処理方法 |
| GB2500930A (en) | 2012-04-05 | 2013-10-09 | Stfc Science & Technology | A retinal densitometer |
| JP6255662B2 (ja) * | 2012-11-16 | 2018-01-10 | 株式会社ニデック | 眼底撮影装置 |
| WO2015095344A1 (en) * | 2013-12-17 | 2015-06-25 | University Of Chicago | Voltage sensitive composition and method of use thereof |
| CN105574861B (zh) * | 2015-12-14 | 2018-05-08 | 上海交通大学 | 无标记的血流成像方法及系统 |
| EP3332695B1 (en) * | 2016-12-09 | 2021-05-26 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Measurement device |
| CN108670192B (zh) * | 2018-04-21 | 2019-08-16 | 重庆贝奥新视野医疗设备有限公司 | 一种动态视觉刺激的多光谱眼底成像系统及方法 |
| CN110060311B (zh) * | 2018-09-09 | 2020-03-20 | 深圳硅基仿生科技有限公司 | 视网膜刺激器的图像处理装置 |
| BR112021005394A2 (pt) | 2018-09-21 | 2021-06-15 | MacuLogix, Inc. | dispositivo utilizável na cabeça para medição de adaptação ao escuro em pelo menos um olho de um indivíduo, dispositivo para administrar um teste de diagnóstico oftálmico a um indivíduo, sistema de teste oftálmico, dispositivo eletrônico para teste oftálmico, sistema, sistema para medir adaptação ao escuro, vedação de luz para uso em um dispositivo utilizável na cabeça configurado para medir a adaptação ao escuro de um indivíduo, dispositivo utilizável na cabeça para administrar um teste oftálmico a um indivíduo, dispositivo utilizável na cabeça para administrar um teste de diagnóstico oftálmico a um indivíduo |
| FI129056B (en) * | 2019-05-31 | 2021-06-15 | Aalto Univ Foundation Sr | METHOD AND APPARATUS FOR DETERMINING CHANGES IN THE RETENTAL AND / OR BRAIN TEMPERATURE |
| EP4445828A4 (en) * | 2021-12-07 | 2025-11-26 | Univ Korea Res & Bus Found | AUTOFLUORESCENCE IMAGING DEVICE AND ITS OPERATING METHOD, AUTOFLUORESCENCE IMAGE EVALUATION DEVICE AND ITS EVALUATION METHOD |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4569354A (en) * | 1982-03-22 | 1986-02-11 | Boston University | Method and apparatus for measuring natural retinal fluorescence |
| US5150292A (en) | 1989-10-27 | 1992-09-22 | Arch Development Corporation | Method and system for determination of instantaneous and average blood flow rates from digital angiograms |
| US5186173A (en) | 1990-08-14 | 1993-02-16 | Drexel University | Method for in vivo measurement of oxygen concentration levels |
| US5400791A (en) * | 1991-10-11 | 1995-03-28 | Candela Laser Corporation | Infrared fundus video angiography system |
| US5485229A (en) | 1994-05-24 | 1996-01-16 | Allergan, Inc. | Method and apparatus for determining electrical activity in the retinal nerve fiber layer using intrinsic birefringent properties of retinal ganglion cell axons |
-
1998
- 1998-07-31 IL IL12561498A patent/IL125614A/xx not_active IP Right Cessation
-
1999
- 1999-07-29 DE DE69901838T patent/DE69901838T2/de not_active Expired - Lifetime
- 1999-07-29 AU AU50630/99A patent/AU5063099A/en not_active Abandoned
- 1999-07-29 US US09/744,716 patent/US6478424B1/en not_active Expired - Lifetime
- 1999-07-29 WO PCT/IL1999/000418 patent/WO2000006015A1/en not_active Ceased
- 1999-07-29 CN CNB998105465A patent/CN1261071C/zh not_active Expired - Lifetime
- 1999-07-29 EP EP99935029A patent/EP1100370B1/en not_active Expired - Lifetime
- 1999-07-29 AT AT99935029T patent/ATE218835T1/de not_active IP Right Cessation
- 1999-07-29 JP JP2000561875A patent/JP4409091B2/ja not_active Expired - Fee Related
- 1999-07-29 HK HK02102621.1A patent/HK1041192B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU5063099A (en) | 2000-02-21 |
| ATE218835T1 (de) | 2002-06-15 |
| US6478424B1 (en) | 2002-11-12 |
| EP1100370A1 (en) | 2001-05-23 |
| WO2000006015A1 (en) | 2000-02-10 |
| HK1041192A1 (en) | 2002-07-05 |
| IL125614A (en) | 2003-01-12 |
| JP4409091B2 (ja) | 2010-02-03 |
| IL125614A0 (en) | 1999-03-12 |
| DE69901838D1 (de) | 2002-07-18 |
| CN1316887A (zh) | 2001-10-10 |
| JP2002521115A (ja) | 2002-07-16 |
| CN1261071C (zh) | 2006-06-28 |
| HK1041192B (zh) | 2006-12-15 |
| EP1100370B1 (en) | 2002-06-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69901838T2 (de) | Nicht-invasive darstellung der retinalen funktionstüchtigkeit | |
| EP1906811B1 (de) | Einrichtung und verfahren zur beobachtung, dokumentation und/oder diagnose des augenhintergrundes | |
| DE102007048362B9 (de) | System und Verfahren zum Untersuchen eines Objekts | |
| EP0805348B1 (de) | Anordnung zur Diagnose von malignem Gewebe durch Fluoreszenzbetrachtung | |
| US7118217B2 (en) | Device and method for optical imaging of retinal function | |
| DE60024836T2 (de) | Bilderzeugungsvorrichtung zur darstellung von konzentrationsverhältnissen | |
| EP1048263B1 (de) | Verfahren und Anordnung zur Bestimmung von Fluorophoren an Objekten, insbesondere am lebenden Augenhintergrund | |
| DE102004008675B4 (de) | Bildgebendes Verfahren zur Erfassung medizinisch relevanter Unterschiede von Strukturen und Eigenschaften eines Untersuchungsobjektes und dazu geeignete Vorrichtung | |
| DE69902906T2 (de) | Bilddarstellung und untersuchung der bewegung von einzelnen erythrozyten in blutgefässen | |
| DE4215946A1 (de) | Vorrichtung zum ueberwachen physiologischer daten zur erfassung einer drogenbeeintraechtigung | |
| US20070091265A1 (en) | System and method for optical imaging of human retinal function | |
| EP3884840A1 (de) | Medizinische bildgebungsvorrichtung zur ortsaufgelösten aufnahme multispektraler videodaten | |
| DE69433413T2 (de) | Optische darstellung des blutkreislaufs und von abnormalen gefässstrukturen in der aderhaut des auges | |
| DE19741982A1 (de) | Vorrichtung zur ortsaufgelösten, berührungslosen und funktionellen Visualisierung der dermalen Blutperfusion | |
| Grinvald et al. | High-resolution functional optical imaging: from the neocortex to the eye | |
| EP3773147A1 (de) | Verfahren und vorrichtung zur untersuchung der neurovaskulären kopplung am auge eines patienten | |
| DE102014005407A1 (de) | Vorrichtung zum Auffinden eines funktionstragenden Gewebeareals in einem Gewebebereich | |
| WO2009121633A2 (de) | Verfahren und vorrichtung zum aufnehmen von farbbildern und ldi-signalen von einem objekt | |
| DE10357734B4 (de) | Universelles ophthalmologisches Untersuchungsgerät und ophthalmologisches Untersuchungsverfahren | |
| DE4410690C1 (de) | Anordnung zur spektrometrischen Untersuchung und deren Verwendungen | |
| EP4248924A1 (de) | Verfahren zur ermittlung von bestrahlungsparametern sowie vorrichtung zur bestrahlung | |
| DE102004015682B4 (de) | Verfahren und Gerät zur Detektion eines in den Körper eines Lebewesens injizierten Farbstoff-Bolus | |
| DE69431890T2 (de) | Verfahren und Vorrichtung zum Unterscheiden einer ersten Lage von Blutgefä en von einer zweiten | |
| WO2024218219A1 (de) | Vorrichtung zur erfassung von fluoreszenzbildern | |
| DE102022119578A1 (de) | Optische baugruppe zur detektion der vom auge reflektierten laserstrahlung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: YEDA RESEARCH AND DEVELOPMENT CO. LTD., REHOVOT, I |