DE69835308D1 - Prodrugs und Konjugate von Selenoenthaltenden Verbindungen und ihre Verwendung - Google Patents

Prodrugs und Konjugate von Selenoenthaltenden Verbindungen und ihre Verwendung

Info

Publication number
DE69835308D1
DE69835308D1 DE69835308T DE69835308T DE69835308D1 DE 69835308 D1 DE69835308 D1 DE 69835308D1 DE 69835308 T DE69835308 T DE 69835308T DE 69835308 T DE69835308 T DE 69835308T DE 69835308 D1 DE69835308 D1 DE 69835308D1
Authority
DE
Germany
Prior art keywords
prodrugs
conjugates
containing compounds
selenium containing
selenium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69835308T
Other languages
English (en)
Other versions
DE69835308T2 (de
Inventor
Jeanette C Roberts
Megan D Short
Pamela K Dominick
Pamela B Cassidy
Britta H Wilmore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Original Assignee
University of Utah Research Foundation UURF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation UURF filed Critical University of Utah Research Foundation UURF
Application granted granted Critical
Publication of DE69835308D1 publication Critical patent/DE69835308D1/de
Publication of DE69835308T2 publication Critical patent/DE69835308T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/02—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms not condensed with other rings
    • C07D293/04—Five-membered rings
    • C07D293/06—Selenazoles; Hydrogenated selenazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • C07H5/10—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium to sulfur

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69835308T 1997-08-07 1998-08-06 Prodrugs und Konjugate von Selenoenthaltenden Verbindungen und ihre Verwendung Expired - Lifetime DE69835308T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5501997P 1997-08-07 1997-08-07
US55019P 1997-08-07

Publications (2)

Publication Number Publication Date
DE69835308D1 true DE69835308D1 (de) 2006-08-31
DE69835308T2 DE69835308T2 (de) 2007-08-09

Family

ID=21995038

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69835308T Expired - Lifetime DE69835308T2 (de) 1997-08-07 1998-08-06 Prodrugs und Konjugate von Selenoenthaltenden Verbindungen und ihre Verwendung
DE69825288T Expired - Fee Related DE69825288D1 (de) 1997-08-07 1998-08-06 Prodrugs und konjugate von selenolenthaltenden verbindungen und ihre verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69825288T Expired - Fee Related DE69825288D1 (de) 1997-08-07 1998-08-06 Prodrugs und konjugate von selenolenthaltenden verbindungen und ihre verwendung

Country Status (6)

Country Link
US (1) US6340746B1 (de)
EP (1) EP1003760B1 (de)
AU (1) AU750916C (de)
CA (1) CA2299271C (de)
DE (2) DE69835308T2 (de)
WO (1) WO1999007719A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6841536B2 (en) * 1997-08-07 2005-01-11 University Of Utah Research Foundation Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof
US7425635B2 (en) * 1997-08-07 2008-09-16 University Of Utah Research Foundation Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
US6852353B2 (en) * 2000-08-24 2005-02-08 Novartis Ag Process for surface modifying substrates and modified substrates resulting therefrom
DE10112825A1 (de) * 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
RU2329274C2 (ru) * 2002-09-11 2008-07-20 Фрезениус Каби Дойчланд Гмбх Способ получения производных гидроксиалкилкрахмала
DE10242076A1 (de) * 2002-09-11 2004-03-25 Fresenius Kabi Deutschland Gmbh HAS-Allergen-Konjugate
ES2314238T3 (es) * 2002-10-08 2009-03-16 Fresenius Kabi Deutschland Gmbh Conjugados de oligosacaridos farmaceuticamente activos.
WO2005014655A2 (en) * 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
SG145746A1 (en) * 2003-08-08 2008-09-29 Fresenius Kabi De Gmbh Conjugates of hydroxyalkyl starch and g-csf
BRPI0412671A (pt) * 2003-08-08 2006-10-03 Fresenius Kabi De Gmbh conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima
TWI417303B (zh) * 2004-03-11 2013-12-01 Fresenius Kabi De Gmbh 經由還原胺化作用製得之羥烷基澱粉及蛋白質的接合物
KR20070110902A (ko) * 2005-03-11 2007-11-20 프레제니우스 카비 도이치란트 게엠베하 비활성 출발 물질로부터 생물활성 당단백질의 생산
EP1762250A1 (de) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen
SI1986612T1 (sl) 2006-02-07 2013-01-31 Shire Human Genetic Therapies, Inc. Stabilizirana spojina glukocerebrosidaze
US9084803B2 (en) * 2007-06-29 2015-07-21 Board Of Trustees Of Northern Illinois University Therapeutic uses of glutathione mimics
EP2070950A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Hydroxyalkylstärkederivate und deren Herstellungsverfahren
EP2070951A1 (de) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Verfahren zur Herstellung eines Hydroxyalkylstärkederivats mit zwei Linkern
CN102686237B (zh) 2009-07-28 2018-10-19 夏尔人类遗传性治疗公司 用于治疗戈谢病的组合物
US8815942B2 (en) 2010-10-20 2014-08-26 The Royal Institution For The Advancement Of Learning/Mcgill University Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease
CN103917899B (zh) 2011-10-12 2018-04-03 诺华股份有限公司 通过涂布制备uv吸收性眼用透镜的方法
CN104519905A (zh) 2012-03-02 2015-04-15 夏尔人类遗传性治疗公司 用于治疗iii型戈谢病的组合物和方法
MY172901A (en) 2012-12-17 2019-12-13 Alcon Inc Method for making improved uv-absorbing ophthalmic lenses
MX2019008847A (es) * 2017-01-25 2019-12-16 Adare Pharmaceuticals Inc Profarmacos de cisteamina.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5126896A (en) * 1974-08-22 1976-03-05 Funai Yaihin Kogyo Kk Ss inoshirushisuteinno seizoho
FR2313937A1 (fr) * 1975-06-09 1977-01-07 Anvar Medicament a base de 5' thioethers de l'adenosine
FR2354100A2 (fr) * 1976-06-08 1978-01-06 Anvar Medicament a base de 5' thioethers de l'adenosine
US4617189A (en) * 1983-04-14 1986-10-14 Stockel Richard F Use of selenium-containing compounds for negating the toxic effects of platinum compounds used in chemotherapy, and a novel selenium-containing platinum compound and use thereof as an anti-cancer medicine
NL8700240A (nl) * 1987-01-30 1988-08-16 Tno Werkwijze voor het bereiden van thiolverbindingen.
US5578470A (en) * 1987-01-30 1996-11-26 Nederlandse Organisatie Voor Toegepast Method for preparing thiol compounds with bacterial β-lyase
US4868114A (en) 1987-08-05 1989-09-19 Regents Of The University Of Minnesota Method for elevating glutathione levels
NL9000750A (nl) * 1989-08-23 1991-03-18 Rijksuniversiteit D-mannitol derivaten, werkwijze voor het bereiden van 3-deoxy-d-manno-2-octulonzuur en derivaten daarvan.
FR2693198B1 (fr) * 1992-07-03 1994-09-30 Univ Paris Curie Composés sélénies-glucidiques et leurs procédés de préparation.
DE4328871A1 (de) * 1993-08-27 1995-03-02 Beiersdorf Ag Mittel gegen empfindliche, hyperreaktive Hautzustände, atopische Dermatiden, Pruritus, Psoriasis Prurigo, Photodermatosen und Ichthyosis
US5667791A (en) * 1996-05-31 1997-09-16 Thione International, Inc. X-ray induced skin damage protective composition

Also Published As

Publication number Publication date
AU750916C (en) 2003-05-22
AU8898498A (en) 1999-03-01
EP1003760B1 (de) 2004-07-28
AU750916B2 (en) 2002-08-01
DE69835308T2 (de) 2007-08-09
EP1003760A4 (de) 2002-07-03
WO1999007719A1 (en) 1999-02-18
US6340746B1 (en) 2002-01-22
CA2299271C (en) 2009-02-03
DE69825288D1 (de) 2004-09-02
CA2299271A1 (en) 1999-02-18
EP1003760A1 (de) 2000-05-31

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