DE69835225T2 - Methode zur behandlung von durch glycocorticoidstörungen verursachten psychosen - Google Patents
Methode zur behandlung von durch glycocorticoidstörungen verursachten psychosen Download PDFInfo
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- DE69835225T2 DE69835225T2 DE69835225T DE69835225T DE69835225T2 DE 69835225 T2 DE69835225 T2 DE 69835225T2 DE 69835225 T DE69835225 T DE 69835225T DE 69835225 T DE69835225 T DE 69835225T DE 69835225 T2 DE69835225 T2 DE 69835225T2
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- glucocorticoid receptor
- psychosis
- receptor antagonist
- psychotic
- depression
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
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- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US6097397P | 1997-10-06 | 1997-10-06 | |
| US60973P | 1997-10-06 | ||
| PCT/US1998/020906 WO1999017779A1 (en) | 1997-10-06 | 1998-10-05 | Methods for treating psychosis associated with glucocorticoid related dysfunction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69835225D1 DE69835225D1 (de) | 2006-08-24 |
| DE69835225T2 true DE69835225T2 (de) | 2007-07-05 |
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| DE69835225T Expired - Lifetime DE69835225T2 (de) | 1997-10-06 | 1998-10-05 | Methode zur behandlung von durch glycocorticoidstörungen verursachten psychosen |
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| US (2) | US6150349A (enExample) |
| EP (1) | EP1023074B1 (enExample) |
| JP (3) | JP2001518509A (enExample) |
| KR (2) | KR100840957B1 (enExample) |
| CN (3) | CN1528315A (enExample) |
| AT (1) | ATE332696T1 (enExample) |
| AU (1) | AU747956B2 (enExample) |
| CA (1) | CA2302586C (enExample) |
| CY (1) | CY1106330T1 (enExample) |
| DE (1) | DE69835225T2 (enExample) |
| DK (1) | DK1023074T3 (enExample) |
| ES (1) | ES2268792T3 (enExample) |
| IL (2) | IL135469A0 (enExample) |
| NO (1) | NO327233B1 (enExample) |
| NZ (1) | NZ503250A (enExample) |
| PT (1) | PT1023074E (enExample) |
| WO (1) | WO1999017779A1 (enExample) |
Families Citing this family (35)
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| EP0903146A1 (en) * | 1997-09-23 | 1999-03-24 | Applied Research Systems ARS Holdings N.V. | 21-Hydroy-6,19-oxidoprogesterone (210h-60p) as antiglucocorticoid |
| GB9915625D0 (en) * | 1999-07-02 | 1999-09-01 | Cortendo Ab | Method |
| US6620802B1 (en) * | 1999-11-23 | 2003-09-16 | Corcept Therapeutics, Inc. | Methods of treating mild cognitive impairment using a glucocorticoid-specific receptor antagonist |
| SI1325022T1 (sl) * | 2000-09-18 | 2007-04-30 | Applied Research Systems | Metoda za pripravo 21-hidroksi-6,19-oksidoprogesterona (21oh-6op) |
| CN1820756A (zh) | 2001-03-23 | 2006-08-23 | 科塞普特治疗公司 | 使用糖皮质激素受体特效拮抗剂治疗压力症的方法 |
| EP1390037B1 (en) * | 2001-05-04 | 2010-12-22 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor-specific antagonists for the treatment of delirium |
| US7163934B2 (en) | 2001-05-04 | 2007-01-16 | Corcept Therapeutics, Inc. | Methods for treating delirium glucocorticoid receptor-specific antagonists |
| WO2003009853A1 (en) * | 2001-07-23 | 2003-02-06 | Corcept Therapeutics, Inc. | Methods for preventing antipsychotic-induced weight gain |
| NZ531477A (en) | 2001-08-31 | 2006-10-27 | Corcept Therapeutics Inc | Use of a glucocorticoid receptor antagonist comprising a steroidal skeleton with at least one phenyl-containing moiety in the 11-beta position of the steroidal skeleton to decrease cognitive deterioration in adults with Down's syndrome |
| DE60230936D1 (de) * | 2001-10-26 | 2009-03-05 | Organon Nv | Verwendung von (11beta, 17beta)-11-(1,3-Benzodioxol-5-yl)-17-Hydroxy-17-(1-Propinyl)-estra-4,9-dien-3-on zur Behandlung von schweren Depressionen |
| AU2002366217A1 (en) * | 2001-11-23 | 2003-06-10 | Akzo Nobel N.V. | Treatment of major depressive disorder using glucocorticoid receptor antagonists |
| US7326697B2 (en) * | 2002-04-29 | 2008-02-05 | Corcept Therapeutics, Inc. | Methods for increasing the therapeutic response to electroconvulsive therapy |
| WO2004004653A2 (en) * | 2002-07-02 | 2004-01-15 | Corcept Therapeutics, Inc. | Methods for treating psychosis associated with interferon-alpha therapy |
| AU2003299311A1 (en) * | 2002-12-18 | 2004-07-09 | University Of Zurich | Treatment of neuro-psychiatric disorders |
| US20040229855A1 (en) * | 2003-02-04 | 2004-11-18 | Corcept Therapeutics, Inc. | Antiglucocorticoids for the treatment of postpartum psychosis |
| US8097606B2 (en) * | 2003-07-23 | 2012-01-17 | Corcept Therapeutics, Inc. | Antiglucocorticoids for the treatment of catatonia |
| GB0400031D0 (en) | 2004-01-03 | 2004-02-04 | Univ Sheffield | Depression treatment |
| WO2006060736A2 (en) * | 2004-12-03 | 2006-06-08 | The Children's Hospital Of Philadelphia | A composition and use thereof in enhancing a therapeutic effect of an antiepileptic drug |
| CN100588393C (zh) * | 2004-12-15 | 2010-02-10 | 上海三合生物技术有限公司 | 赛米司酮类用于治疗抑郁症的用途 |
| US20060229505A1 (en) * | 2005-04-08 | 2006-10-12 | Mundt James C | Method and system for facilitating respondent identification with experiential scaling anchors to improve self-evaluation of clinical treatment efficacy |
| JP2009535430A (ja) * | 2006-05-02 | 2009-10-01 | コーセプト セラピューティクス， インコーポレイテッド | Ｉｌ−２を摂取している患者における抑うつを処置するためのグルココルチコイドレセプターｉｉアンタゴニストの使用 |
| EP1987814A1 (en) * | 2007-04-30 | 2008-11-05 | Exelgyn | Mifepristone pharmaceutical compositions and their methods of preparation |
| RU2327448C1 (ru) | 2007-05-23 | 2008-06-27 | Виктор Иванович Рощин | Средство для лечения зависимости от этилового спирта и/или от наркотиков, фармацевтическая композиция, активный ингредиент фармацевтической композиции, способ лечения зависимости от этилового спирта и/или от наркотиков для лечения психосоматических и неврологических осложнений у алкоголиков и/или наркоманов |
| WO2008157460A1 (en) * | 2007-06-15 | 2008-12-24 | Cook, Kevin, M. | Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties |
| US11103514B2 (en) * | 2010-05-26 | 2021-08-31 | Corcept Therapeutics, Inc. | Treatment of muscular dystrophy |
| JP5804395B2 (ja) * | 2011-02-03 | 2015-11-04 | ポップ テスト オンコロジー エルエルシー | 診断と治療のためのシステムおよび方法 |
| US10500216B2 (en) | 2011-11-18 | 2019-12-10 | Corcept Therapeutics, Inc. | Optimizing mifepristone absorption |
| US8986677B2 (en) * | 2012-07-30 | 2015-03-24 | Pop Test Cortisol Llc | Therapeutic compositions and methods |
| EP3265127B1 (en) * | 2015-03-02 | 2024-02-21 | Corcept Therapeutics, Inc. | Mifepristone and octreotide for use in the treatment of cushing's syndrome in a patient having an adrenocorticotropic hormone (acth)-secreting pancreatic neuroendocrine tumor |
| US9943526B2 (en) | 2015-04-21 | 2018-04-17 | Corcept Therapeutics, Inc. | Optimizing mifepristone levels for cushing's patients |
| EP3297728A4 (en) * | 2015-05-18 | 2019-07-03 | Corcept Therapeutics Incorporated | METHOD FOR DIAGNOSIS AND ASSESSMENT OF THE TREATMENT OF THE CUSHING SYNDROME |
| CN114680890A (zh) * | 2016-10-21 | 2022-07-01 | 西铁城时计株式会社 | 检测装置 |
| KR20210153056A (ko) | 2019-03-18 | 2021-12-16 | 리네트 케이. 니만 | 인슐린 감수성 개선 방법 |
| WO2021119432A1 (en) | 2019-12-11 | 2021-06-17 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| US11878025B2 (en) * | 2021-09-06 | 2024-01-23 | Slayback Pharma Llc | Pharmaceutical compositions of mifepristone |
Family Cites Families (7)
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|---|---|---|---|---|
| US4814333A (en) * | 1987-07-28 | 1989-03-21 | The Trustees Of Dartmouth College | Method for treatment of hypercortisolemic, depressed patients |
| US5348729A (en) * | 1988-11-30 | 1994-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | Evaluative means for detecting inflammatory reactivity |
| FR2696934B1 (fr) * | 1992-10-20 | 1995-06-02 | Conservatoire Nal Arts Metiers | Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir. |
| IL118974A (en) * | 1995-08-17 | 2001-09-13 | Akzo Nobel Nv | History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them |
| FR2739029B1 (fr) * | 1995-09-21 | 1997-11-21 | Roussel Uclaf | Nouvelle application therapeutique des composes antimineralo-corticoides |
| CA2250874A1 (en) * | 1996-04-09 | 1997-10-16 | Btg International Limited | Use of 7 alpha-substituted steroids to treat neuropsychiatric, immune or endocrine disorders |
| FR2757400B1 (fr) * | 1996-12-19 | 1999-12-17 | Hoechst Marion Roussel Inc | Application des composes antiglucocorticoides dans le traitement des psychoses ou des comportements addictifs |
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1998
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- 1998-10-05 KR KR1020077003769A patent/KR100840957B1/ko not_active Expired - Fee Related
- 1998-10-05 EP EP98950911A patent/EP1023074B1/en not_active Expired - Lifetime
- 1998-10-05 AU AU96832/98A patent/AU747956B2/en not_active Ceased
- 1998-10-05 CA CA002302586A patent/CA2302586C/en not_active Expired - Fee Related
- 1998-10-05 CN CNA200410039908XA patent/CN1528315A/zh active Pending
- 1998-10-05 KR KR1020007003683A patent/KR100804558B1/ko not_active Expired - Fee Related
- 1998-10-05 DE DE69835225T patent/DE69835225T2/de not_active Expired - Lifetime
- 1998-10-05 WO PCT/US1998/020906 patent/WO1999017779A1/en not_active Ceased
- 1998-10-05 ES ES98950911T patent/ES2268792T3/es not_active Expired - Lifetime
- 1998-10-05 AT AT98950911T patent/ATE332696T1/de active
- 1998-10-05 JP JP2000514650A patent/JP2001518509A/ja not_active Withdrawn
- 1998-10-05 IL IL13546998A patent/IL135469A0/xx active IP Right Grant
- 1998-10-05 NZ NZ503250A patent/NZ503250A/en not_active IP Right Cessation
- 1998-10-05 CN CNB988097923A patent/CN1187053C/zh not_active Expired - Fee Related
- 1998-10-05 PT PT98950911T patent/PT1023074E/pt unknown
- 1998-10-05 CN CNA2006101003657A patent/CN1919199A/zh active Pending
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1999
- 1999-02-04 US US09/244,457 patent/US6150349A/en not_active Expired - Lifetime
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- 2000-08-15 US US09/639,377 patent/US6362173B1/en not_active Expired - Lifetime
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2006
- 2006-10-05 CY CY20061101439T patent/CY1106330T1/el unknown
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2008
- 2008-10-21 JP JP2008271442A patent/JP2009051858A/ja not_active Withdrawn
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2009
- 2009-03-23 JP JP2009071039A patent/JP5180125B2/ja not_active Expired - Fee Related
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| EP1023074A1 (en) | 2000-08-02 |
| AU747956B2 (en) | 2002-05-30 |
| CN1187053C (zh) | 2005-02-02 |
| KR100804558B1 (ko) | 2008-02-20 |
| EP1023074B1 (en) | 2006-07-12 |
| CN1528315A (zh) | 2004-09-15 |
| CN1272788A (zh) | 2000-11-08 |
| KR100840957B1 (ko) | 2008-06-24 |
| AU9683298A (en) | 1999-04-27 |
| JP2009051858A (ja) | 2009-03-12 |
| KR20070032822A (ko) | 2007-03-22 |
| JP2001518509A (ja) | 2001-10-16 |
| ATE332696T1 (de) | 2006-08-15 |
| KR20010024431A (ko) | 2001-03-26 |
| JP2009132743A (ja) | 2009-06-18 |
| US6150349A (en) | 2000-11-21 |
| CY1106330T1 (el) | 2011-10-12 |
| DK1023074T3 (da) | 2006-11-06 |
| US6362173B1 (en) | 2002-03-26 |
| NO20001744L (no) | 2000-04-05 |
| CN1919199A (zh) | 2007-02-28 |
| NZ503250A (en) | 2001-09-28 |
| NO327233B1 (no) | 2009-05-18 |
| IL135469A0 (en) | 2001-05-20 |
| IL135469A (en) | 2007-03-08 |
| CA2302586C (en) | 2008-06-10 |
| ES2268792T3 (es) | 2007-03-16 |
| PT1023074E (pt) | 2006-12-29 |
| WO1999017779A1 (en) | 1999-04-15 |
| JP5180125B2 (ja) | 2013-04-10 |
| CA2302586A1 (en) | 1999-04-15 |
| NO20001744D0 (no) | 2000-04-05 |
| DE69835225D1 (de) | 2006-08-24 |
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