CN1528315A - 治疗糖皮质素功能失调相关性精神病的方法 - Google Patents

治疗糖皮质素功能失调相关性精神病的方法 Download PDF

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Publication number
CN1528315A
CN1528315A CNA200410039908XA CN200410039908A CN1528315A CN 1528315 A CN1528315 A CN 1528315A CN A200410039908X A CNA200410039908X A CN A200410039908XA CN 200410039908 A CN200410039908 A CN 200410039908A CN 1528315 A CN1528315 A CN 1528315A
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China
Prior art keywords
psychosis
psychotic
antagonist
glucocorticoid
depression
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Pending
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CNA200410039908XA
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English (en)
Chinese (zh)
Inventor
A��F��ɳ�IJ���
A·F·沙茨伯格
��˹��ŵ��
J·K·贝拉诺夫
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Leland Stanford Junior University
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Leland Stanford Junior University
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Publication of CN1528315A publication Critical patent/CN1528315A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA200410039908XA 1997-10-06 1998-10-05 治疗糖皮质素功能失调相关性精神病的方法 Pending CN1528315A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6097397P 1997-10-06 1997-10-06
US60/060,973 1997-10-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB988097923A Division CN1187053C (zh) 1997-10-06 1998-10-05 糖皮质素受体拮抗剂用于制造治疗精神病药物的用途

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2006101003657A Division CN1919199A (zh) 1997-10-06 1998-10-05 治疗糖皮质素功能失调相关性精神病的方法

Publications (1)

Publication Number Publication Date
CN1528315A true CN1528315A (zh) 2004-09-15

Family

ID=22032889

Family Applications (3)

Application Number Title Priority Date Filing Date
CNA200410039908XA Pending CN1528315A (zh) 1997-10-06 1998-10-05 治疗糖皮质素功能失调相关性精神病的方法
CNB988097923A Expired - Fee Related CN1187053C (zh) 1997-10-06 1998-10-05 糖皮质素受体拮抗剂用于制造治疗精神病药物的用途
CNA2006101003657A Pending CN1919199A (zh) 1997-10-06 1998-10-05 治疗糖皮质素功能失调相关性精神病的方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CNB988097923A Expired - Fee Related CN1187053C (zh) 1997-10-06 1998-10-05 糖皮质素受体拮抗剂用于制造治疗精神病药物的用途
CNA2006101003657A Pending CN1919199A (zh) 1997-10-06 1998-10-05 治疗糖皮质素功能失调相关性精神病的方法

Country Status (17)

Country Link
US (2) US6150349A (enExample)
EP (1) EP1023074B1 (enExample)
JP (3) JP2001518509A (enExample)
KR (2) KR100840957B1 (enExample)
CN (3) CN1528315A (enExample)
AT (1) ATE332696T1 (enExample)
AU (1) AU747956B2 (enExample)
CA (1) CA2302586C (enExample)
CY (1) CY1106330T1 (enExample)
DE (1) DE69835225T2 (enExample)
DK (1) DK1023074T3 (enExample)
ES (1) ES2268792T3 (enExample)
IL (2) IL135469A0 (enExample)
NO (1) NO327233B1 (enExample)
NZ (1) NZ503250A (enExample)
PT (1) PT1023074E (enExample)
WO (1) WO1999017779A1 (enExample)

Cited By (1)

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WO2006063526A1 (fr) * 2004-12-15 2006-06-22 Shanghai Three-Alliance Biotechnologies Co., Ltd. Utilisation de la cymipristone pour le traitement de la depression

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EP0903146A1 (en) * 1997-09-23 1999-03-24 Applied Research Systems ARS Holdings N.V. 21-Hydroy-6,19-oxidoprogesterone (210h-60p) as antiglucocorticoid
GB9915625D0 (en) * 1999-07-02 1999-09-01 Cortendo Ab Method
US6620802B1 (en) * 1999-11-23 2003-09-16 Corcept Therapeutics, Inc. Methods of treating mild cognitive impairment using a glucocorticoid-specific receptor antagonist
SI1325022T1 (sl) * 2000-09-18 2007-04-30 Applied Research Systems Metoda za pripravo 21-hidroksi-6,19-oksidoprogesterona (21oh-6op)
CN1820756A (zh) 2001-03-23 2006-08-23 科塞普特治疗公司 使用糖皮质激素受体特效拮抗剂治疗压力症的方法
EP1390037B1 (en) * 2001-05-04 2010-12-22 Corcept Therapeutics, Inc. Use of glucocorticoid receptor-specific antagonists for the treatment of delirium
US7163934B2 (en) 2001-05-04 2007-01-16 Corcept Therapeutics, Inc. Methods for treating delirium glucocorticoid receptor-specific antagonists
WO2003009853A1 (en) * 2001-07-23 2003-02-06 Corcept Therapeutics, Inc. Methods for preventing antipsychotic-induced weight gain
NZ531477A (en) 2001-08-31 2006-10-27 Corcept Therapeutics Inc Use of a glucocorticoid receptor antagonist comprising a steroidal skeleton with at least one phenyl-containing moiety in the 11-beta position of the steroidal skeleton to decrease cognitive deterioration in adults with Down's syndrome
DE60230936D1 (de) * 2001-10-26 2009-03-05 Organon Nv Verwendung von (11beta, 17beta)-11-(1,3-Benzodioxol-5-yl)-17-Hydroxy-17-(1-Propinyl)-estra-4,9-dien-3-on zur Behandlung von schweren Depressionen
AU2002366217A1 (en) * 2001-11-23 2003-06-10 Akzo Nobel N.V. Treatment of major depressive disorder using glucocorticoid receptor antagonists
US7326697B2 (en) * 2002-04-29 2008-02-05 Corcept Therapeutics, Inc. Methods for increasing the therapeutic response to electroconvulsive therapy
WO2004004653A2 (en) * 2002-07-02 2004-01-15 Corcept Therapeutics, Inc. Methods for treating psychosis associated with interferon-alpha therapy
AU2003299311A1 (en) * 2002-12-18 2004-07-09 University Of Zurich Treatment of neuro-psychiatric disorders
US20040229855A1 (en) * 2003-02-04 2004-11-18 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of postpartum psychosis
US8097606B2 (en) * 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
GB0400031D0 (en) 2004-01-03 2004-02-04 Univ Sheffield Depression treatment
WO2006060736A2 (en) * 2004-12-03 2006-06-08 The Children's Hospital Of Philadelphia A composition and use thereof in enhancing a therapeutic effect of an antiepileptic drug
US20060229505A1 (en) * 2005-04-08 2006-10-12 Mundt James C Method and system for facilitating respondent identification with experiential scaling anchors to improve self-evaluation of clinical treatment efficacy
JP2009535430A (ja) * 2006-05-02 2009-10-01 コーセプト セラピューティクス， インコーポレイテッド Ｉｌ−２を摂取している患者における抑うつを処置するためのグルココルチコイドレセプターｉｉアンタゴニストの使用
EP1987814A1 (en) * 2007-04-30 2008-11-05 Exelgyn Mifepristone pharmaceutical compositions and their methods of preparation
RU2327448C1 (ru) 2007-05-23 2008-06-27 Виктор Иванович Рощин Средство для лечения зависимости от этилового спирта и/или от наркотиков, фармацевтическая композиция, активный ингредиент фармацевтической композиции, способ лечения зависимости от этилового спирта и/или от наркотиков для лечения психосоматических и неврологических осложнений у алкоголиков и/или наркоманов
WO2008157460A1 (en) * 2007-06-15 2008-12-24 Cook, Kevin, M. Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties
US11103514B2 (en) * 2010-05-26 2021-08-31 Corcept Therapeutics, Inc. Treatment of muscular dystrophy
JP5804395B2 (ja) * 2011-02-03 2015-11-04 ポップ テスト オンコロジー エルエルシー 診断と治療のためのシステムおよび方法
US10500216B2 (en) 2011-11-18 2019-12-10 Corcept Therapeutics, Inc. Optimizing mifepristone absorption
US8986677B2 (en) * 2012-07-30 2015-03-24 Pop Test Cortisol Llc Therapeutic compositions and methods
EP3265127B1 (en) * 2015-03-02 2024-02-21 Corcept Therapeutics, Inc. Mifepristone and octreotide for use in the treatment of cushing's syndrome in a patient having an adrenocorticotropic hormone (acth)-secreting pancreatic neuroendocrine tumor
US9943526B2 (en) 2015-04-21 2018-04-17 Corcept Therapeutics, Inc. Optimizing mifepristone levels for cushing's patients
EP3297728A4 (en) * 2015-05-18 2019-07-03 Corcept Therapeutics Incorporated METHOD FOR DIAGNOSIS AND ASSESSMENT OF THE TREATMENT OF THE CUSHING SYNDROME
CN114680890A (zh) * 2016-10-21 2022-07-01 西铁城时计株式会社 检测装置
KR20210153056A (ko) 2019-03-18 2021-12-16 리네트 케이. 니만 인슐린 감수성 개선 방법
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006063526A1 (fr) * 2004-12-15 2006-06-22 Shanghai Three-Alliance Biotechnologies Co., Ltd. Utilisation de la cymipristone pour le traitement de la depression

Also Published As

Publication number Publication date
EP1023074A1 (en) 2000-08-02
AU747956B2 (en) 2002-05-30
CN1187053C (zh) 2005-02-02
KR100804558B1 (ko) 2008-02-20
EP1023074B1 (en) 2006-07-12
CN1272788A (zh) 2000-11-08
KR100840957B1 (ko) 2008-06-24
AU9683298A (en) 1999-04-27
JP2009051858A (ja) 2009-03-12
KR20070032822A (ko) 2007-03-22
JP2001518509A (ja) 2001-10-16
ATE332696T1 (de) 2006-08-15
KR20010024431A (ko) 2001-03-26
DE69835225T2 (de) 2007-07-05
JP2009132743A (ja) 2009-06-18
US6150349A (en) 2000-11-21
CY1106330T1 (el) 2011-10-12
DK1023074T3 (da) 2006-11-06
US6362173B1 (en) 2002-03-26
NO20001744L (no) 2000-04-05
CN1919199A (zh) 2007-02-28
NZ503250A (en) 2001-09-28
NO327233B1 (no) 2009-05-18
IL135469A0 (en) 2001-05-20
IL135469A (en) 2007-03-08
CA2302586C (en) 2008-06-10
ES2268792T3 (es) 2007-03-16
PT1023074E (pt) 2006-12-29
WO1999017779A1 (en) 1999-04-15
JP5180125B2 (ja) 2013-04-10
CA2302586A1 (en) 1999-04-15
NO20001744D0 (no) 2000-04-05
DE69835225D1 (de) 2006-08-24

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