DE69830412D1 - Vorrichtung zur trennung und zum nachweis von polynucleotidfragmenten im hochdynamischen bereich - Google Patents

Vorrichtung zur trennung und zum nachweis von polynucleotidfragmenten im hochdynamischen bereich

Info

Publication number
DE69830412D1
DE69830412D1 DE69830412T DE69830412T DE69830412D1 DE 69830412 D1 DE69830412 D1 DE 69830412D1 DE 69830412 T DE69830412 T DE 69830412T DE 69830412 T DE69830412 T DE 69830412T DE 69830412 D1 DE69830412 D1 DE 69830412D1
Authority
DE
Germany
Prior art keywords
separating
dynamic range
high dynamic
polynucleotide fragments
detecting polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69830412T
Other languages
English (en)
Other versions
DE69830412T2 (de
Inventor
Paul Waterhouse
M Izmailov
Henryk Zaleski
A Renfrew
W Cassidy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Healthcare LLC
Original Assignee
Bayer Healthcare LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare LLC filed Critical Bayer Healthcare LLC
Publication of DE69830412D1 publication Critical patent/DE69830412D1/de
Application granted granted Critical
Publication of DE69830412T2 publication Critical patent/DE69830412T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8603—Signal analysis with integration or differentiation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Algebra (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Pure & Applied Mathematics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
DE69830412T 1997-03-18 1998-03-18 Vorrichtung zur trennung und zum nachweis von polynucleotidfragmenten im hochdynamischen bereich Expired - Fee Related DE69830412T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/819,910 US6014213A (en) 1994-12-12 1997-03-18 High dynamic range apparatus for separation and detection of polynucleotide fragments
US819910 1997-03-18
PCT/CA1998/000239 WO1998041854A1 (en) 1997-03-18 1998-03-18 High dynamic range apparatus for separation and detection of polynucleotide fragments

Publications (2)

Publication Number Publication Date
DE69830412D1 true DE69830412D1 (de) 2005-07-07
DE69830412T2 DE69830412T2 (de) 2006-01-26

Family

ID=25229414

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69830412T Expired - Fee Related DE69830412T2 (de) 1997-03-18 1998-03-18 Vorrichtung zur trennung und zum nachweis von polynucleotidfragmenten im hochdynamischen bereich

Country Status (6)

Country Link
US (1) US6014213A (de)
EP (1) EP1012593B1 (de)
AU (1) AU6491998A (de)
CA (1) CA2284888A1 (de)
DE (1) DE69830412T2 (de)
WO (1) WO1998041854A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6361672B1 (en) * 1996-06-10 2002-03-26 Transgenomic, Inc. Multiple laser diode electromagnetic radiation source in multiple electrophoresis channel systems
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
DE69940574D1 (de) 1998-05-16 2009-04-23 Applera Corp Optisches Gerät insbesondere zur Überwachung von DNS-Polymerasekettenreaktionen
CA2439307A1 (en) * 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
US6793790B1 (en) 2001-06-06 2004-09-21 The Regents Of The University Of California Sample collection system for gel electrophoresis
US6867005B2 (en) * 2001-10-24 2005-03-15 Beckman Coulter, Inc. Method and apparatus for increasing the dynamic range and accuracy of binding assays
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
US7091348B2 (en) * 2002-07-01 2006-08-15 Guava Technologies, Inc. Fluorescent dyes, energy transfer couples and methods
US6894264B2 (en) * 2002-10-15 2005-05-17 Applera Corporation System and methods for dynamic range extension using variable length integration time sampling
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US7654956B2 (en) 2004-07-13 2010-02-02 Dexcom, Inc. Transcutaneous analyte sensor
US8889348B2 (en) 2006-06-07 2014-11-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by nanopore using modified nucleotides
JP4991252B2 (ja) * 2006-11-10 2012-08-01 株式会社日立ハイテクノロジーズ 電気泳動装置、及び電気泳動分析方法
WO2009082488A2 (en) 2007-12-24 2009-07-02 Bergenbio As Methods for creating and identifying functional rna interference elements
US20110192723A1 (en) * 2010-02-08 2011-08-11 Genia Technologies, Inc. Systems and methods for manipulating a molecule in a nanopore
US9605307B2 (en) * 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
WO2012088339A2 (en) 2010-12-22 2012-06-28 Genia Technologies, Inc. Nanopore-based single dna molecule characterization using speed bumps
US8962242B2 (en) 2011-01-24 2015-02-24 Genia Technologies, Inc. System for detecting electrical properties of a molecular complex
US9110478B2 (en) 2011-01-27 2015-08-18 Genia Technologies, Inc. Temperature regulation of measurement arrays
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
JP2015525077A (ja) 2012-06-15 2015-09-03 ジェニア・テクノロジーズ・インコーポレイテッド チップの構成および高精度な核酸配列決定
US9605309B2 (en) 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
CN109797199A (zh) 2013-10-23 2019-05-24 吉尼亚科技公司 使用纳米孔的高速分子感测
US9567630B2 (en) 2013-10-23 2017-02-14 Genia Technologies, Inc. Methods for forming lipid bilayers on biochips
US11548011B2 (en) * 2018-07-23 2023-01-10 The Brigham And Women's Hospital, Inc. Magnetic levitation techniques to separate and analyze molecular entities

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3916197A (en) * 1973-11-28 1975-10-28 Particle Technology Inc Method and apparatus for classifying biological cells
JPS55156840A (en) * 1979-05-25 1980-12-06 Olympus Optical Co Ltd Specimen detector
JPS55164336A (en) * 1979-06-08 1980-12-22 Olympus Optical Co Ltd Inspecting material detecting method
US5171534A (en) * 1984-01-16 1992-12-15 California Institute Of Technology Automated DNA sequencing technique
US5207880A (en) * 1984-03-29 1993-05-04 The Board Of Regents Of The University Of Nebraska DNA sequencing
US5360523A (en) * 1984-03-29 1994-11-01 Li-Cor, Inc. DNA sequencing
US5230781A (en) * 1984-03-29 1993-07-27 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US4811218A (en) * 1986-06-02 1989-03-07 Applied Biosystems, Inc. Real time scanning electrophoresis apparatus for DNA sequencing
DE3618605A1 (de) * 1986-06-03 1987-12-10 Europ Lab Molekularbiolog Vorrichtung zur detektion von zur photonenemission anregbaren stoffen
US4823007A (en) * 1986-12-15 1989-04-18 Norand Corporation DNA sequencing gel reading system and method
JPH0799353B2 (ja) * 1987-03-31 1995-10-25 株式会社島津製作所 塩基配列決定装置
JP2550106B2 (ja) * 1987-10-30 1996-11-06 株式会社日立製作所 光分散検出型電気泳動装置
US5045172A (en) * 1987-11-25 1991-09-03 Princeton Biochemicals, Inc. Capillary electrophoresis apparatus
US5246866A (en) * 1987-12-23 1993-09-21 Hitachi Software Engineering Co., Ltd. Method for transcription of a DNA sequence
US4930893A (en) * 1988-03-25 1990-06-05 Molecular Dynamics Electrophoresis imaging system
US4927265A (en) * 1988-04-29 1990-05-22 501 Microphoretic Systems, Inc. Detector for fluorescence and absorption spectroscopy
US4962020A (en) * 1988-07-12 1990-10-09 President And Fellows Of Harvard College DNA sequencing
US5006210A (en) * 1989-02-06 1991-04-09 Iowa State University Research Foundation, Inc. Means and method for capillary zone electrophoresis with laser-induced indirect fluorescence detection
US4960999A (en) * 1989-02-13 1990-10-02 Kms Fusion, Inc. Scanning and storage of electrophoretic records
JP2853745B2 (ja) * 1989-04-12 1999-02-03 株式会社日立製作所 光検出電気泳動装置
US5062942A (en) * 1989-04-12 1991-11-05 Hitachi, Ltd. Fluorescence detection type electrophoresis apparatus
JPH083481B2 (ja) * 1989-06-07 1996-01-17 日立ソフトウェアエンジニアリング株式会社 蛍光式電気泳動パターン読み取り装置
US4981977A (en) * 1989-06-09 1991-01-01 Carnegie-Mellon University Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups
US5108179A (en) * 1989-08-09 1992-04-28 Myers Stephen A System and method for determining changes in fluorescence of stained nucleic acid in electrophoretically separated bands
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
US5092973A (en) * 1990-01-26 1992-03-03 The Board Of Trustees Of The Leland Stanford Junior University Rectangular capillaries for capillary electrophoresis
US5307148A (en) * 1990-04-05 1994-04-26 Hitachi, Ltd. Fluorescence detection type electrophoresis apparatus
US5104512A (en) * 1990-05-14 1992-04-14 Labintelligence, Inc. Gel electrophoresis system
JP2814408B2 (ja) * 1990-05-22 1998-10-22 日立ソフトウェアエンジニアリング 株式会社 蛍光パターン読み取り装置および蛍光パターン読み取り方法
JPH0743353B2 (ja) * 1990-05-31 1995-05-15 株式会社島津製作所 蛍光検出型ゲル電気泳動装置
US5119316A (en) * 1990-06-29 1992-06-02 E. I. Du Pont De Nemours And Company Method for determining dna sequences
JP2508404B2 (ja) * 1990-10-30 1996-06-19 株式会社島津製作所 塩基配列決定装置
JP2814409B2 (ja) * 1990-11-30 1998-10-22 日立ソフトウェアエンジニアリング 株式会社 多色泳動パターン読み取り装置
US5162654A (en) * 1991-02-01 1992-11-10 Wisconsin Alumni Research Foundation Detection apparatus for electrophoretic gels
JPH04271800A (ja) * 1991-02-28 1992-09-28 Hitachi Ltd 電気泳動装置
US5420691A (en) * 1991-03-15 1995-05-30 Matsushita Electric Industrial Co., Ltd. Electric component observation system
JP2873884B2 (ja) * 1991-03-22 1999-03-24 日立ソフトウェアエンジニアリング 株式会社 多色泳動パターン読み取り装置
US5419825A (en) * 1991-07-29 1995-05-30 Shimadzu Corporation Base sequencing apparatus
US5365455A (en) * 1991-09-20 1994-11-15 Vanderbilt University Method and apparatus for automatic nucleic acid sequence determination
US5208466A (en) * 1991-10-08 1993-05-04 Beckman Instruments, Inc. Apparatus and method for aligning capillary column and detection optics
JP2815506B2 (ja) * 1992-04-14 1998-10-27 株式会社日立製作所 光検出型電気泳動装置
CA2141802A1 (en) * 1992-08-10 1994-02-17 Bala S. Manian Differential separation assay methods and test kits
US5736410A (en) * 1992-09-14 1998-04-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
EP0592060B1 (de) * 1992-10-09 2001-07-18 The Board of Regents of the University of Nebraska Digitale DNS-Typisierung
US5324401A (en) * 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis
EP0626578B1 (de) * 1993-05-26 1998-07-29 Hitachi Electronics Engineering Co., Ltd. Gelelektrophoresegerät
US5439578A (en) * 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
US5786142A (en) * 1995-05-30 1998-07-28 Visible Genetics Inc. Electrophoresis and fluorescence detection method
US5710628A (en) * 1994-12-12 1998-01-20 Visible Genetics Inc. Automated electrophoresis and fluorescence detection apparatus and method

Also Published As

Publication number Publication date
EP1012593B1 (de) 2005-06-01
US6014213A (en) 2000-01-11
CA2284888A1 (en) 1998-09-24
WO1998041854A1 (en) 1998-09-24
AU6491998A (en) 1998-10-12
DE69830412T2 (de) 2006-01-26
EP1012593A1 (de) 2000-06-28

Similar Documents

Publication Publication Date Title
DE69830412D1 (de) Vorrichtung zur trennung und zum nachweis von polynucleotidfragmenten im hochdynamischen bereich
DE69728017D1 (de) Vorrichtungen und Verfahren zur Erkennung von mehreren Analyten in Proben
DE69737258D1 (de) Verfahren und Vorrichtung zur Detektion von akutem myokardischem Infarkt
DE69829089D1 (de) Vorrichtung und Apparat zur gleichzeitigen Detektion von mehreren Analyten
ATA900197A (de) Vorrichtung zum sammeln, testen und versenden von körperflüssigkeits-proben
DE69909281D1 (de) Vorrichtung zur präsentation und abgabe von mehreren produkten
DE69534301D1 (de) Kulturmedium und vorrichtung zum nachweis und zur quantifizierung von enterobakteriaceae
DE59404759D1 (de) Sortimentierverfahren und Vorrichtung dazu
DE69630378D1 (de) Vorrichtung zum abtrennen und auffangen von polypen
DE69735520D1 (de) Verfahren und Vorrichtung zum Verbinden von Bauteilen mit mehreren Zusatzwerkstoffen
DE69915926D1 (de) Verfahren und Echographiegerät zur Erfassung von Elastizitätsveränderungen
DE59703100D1 (de) Verfahren und Vorrichtung zum Entpalettieren von Artikeln
DE69723474T2 (de) Verfahren und vorrichtung zur erhöhung der zuverlässigkeit von visueller authentifikation
DE69521073T2 (de) Vorrichtung zum Feststellen von Aquaplaning
DE59000762D1 (de) Verfahren zur schnellen detektion von mikroorganismen in proben und vorrichtung zur durchfuehrung des verfahrens.
DE69703216D1 (de) Vorrichtung zum präsentieren von dokumenten
DE59904772D1 (de) Vorrichtung zur übernahme und beförderung von gegenständen
DE69007779D1 (de) Trocknungsverfahren und vorrichtung dazu.
DE69723604D1 (de) Vorrichtung zum Sortieren von Blättern oder dergleichen
DE69719477D1 (de) Vorrichtung und Verfahren zur Eingabe von Buchstaben
DE69834919D1 (de) Oberflächeninspektionsverfahren und vorrichtung
DE69725664D1 (de) Vorrichtung zur Erhöhung und Verringerung der Geschwindigkeit von Gegenständen
DE68921691D1 (de) Vorrichtung zum Nachweis und zur Erkennung von Farbe.
DE69014273D1 (de) Verfahren und Vorrichtung zur Feststellung von Unreinheiten in Halbleitern.
DE59709421D1 (de) Vorrichtung zur Ortung und Zertrümmerung von Konkrementen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee