DE69827947T2 - Rapamycin-formulierungen zur oralen verabreichung - Google Patents

Rapamycin-formulierungen zur oralen verabreichung Download PDF

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Publication number
DE69827947T2
DE69827947T2 DE69827947T DE69827947T DE69827947T2 DE 69827947 T2 DE69827947 T2 DE 69827947T2 DE 69827947 T DE69827947 T DE 69827947T DE 69827947 T DE69827947 T DE 69827947T DE 69827947 T2 DE69827947 T2 DE 69827947T2
Authority
DE
Germany
Prior art keywords
oral administration
rapamycin formulations
rapamycin
formulations
oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69827947T
Other languages
English (en)
Other versions
DE69827947D1 (de
Inventor
Arwinder Singh Nagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE69827947D1 publication Critical patent/DE69827947D1/de
Publication of DE69827947T2 publication Critical patent/DE69827947T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
DE69827947T 1997-06-13 1998-06-11 Rapamycin-formulierungen zur oralen verabreichung Expired - Fee Related DE69827947T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87496597A 1997-06-13 1997-06-13
PCT/US1998/012142 WO1998056358A1 (en) 1997-06-13 1998-06-11 Rapamycin formulations for oral administration

Publications (2)

Publication Number Publication Date
DE69827947D1 DE69827947D1 (de) 2005-01-05
DE69827947T2 true DE69827947T2 (de) 2005-04-21

Family

ID=25364977

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69827947T Expired - Fee Related DE69827947T2 (de) 1997-06-13 1998-06-11 Rapamycin-formulierungen zur oralen verabreichung

Country Status (26)

Country Link
EP (1) EP0994697B1 (de)
JP (1) JP2002504124A (de)
KR (1) KR20010013650A (de)
CN (1) CN1133424C (de)
AR (1) AR012971A1 (de)
AT (1) ATE283687T1 (de)
AU (1) AU743584B2 (de)
BR (1) BR9810746A (de)
CA (1) CA2293793C (de)
CZ (1) CZ295276B6 (de)
DE (1) DE69827947T2 (de)
DK (1) DK0994697T3 (de)
ES (1) ES2232948T3 (de)
HU (1) HUP0003341A3 (de)
IL (1) IL132986A0 (de)
NO (1) NO996044D0 (de)
NZ (1) NZ501652A (de)
PL (1) PL337320A1 (de)
PT (1) PT994697E (de)
RU (1) RU2184541C2 (de)
SK (1) SK284472B6 (de)
TR (1) TR199903065T2 (de)
TW (1) TW574040B (de)
UA (1) UA65573C2 (de)
WO (1) WO1998056358A1 (de)
ZA (1) ZA985095B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
EP1709974A3 (de) * 2000-06-16 2006-12-06 Wyeth Verfahren zur behandlung von kardiovaskulären erkrankungen mit rapamycin
US6670355B2 (en) 2000-06-16 2003-12-30 Wyeth Method of treating cardiovascular disease
US20020013335A1 (en) * 2000-06-16 2002-01-31 American Home Products Corporation Method of treating cardiovascular disease
JP4969747B2 (ja) * 2001-01-19 2012-07-04 武田薬品工業株式会社 錠剤フィルムコーティング用組成物
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
IL162734A0 (en) 2002-02-01 2005-11-20 Ariad Gene Therapeutics Inc Phosphorus-containing compounds & uses thereof
GB0602632D0 (en) * 2006-02-08 2006-03-22 Pliva Istrazivacki Inst D O O Preparation Of A Solid Dosage From Comprising Tacrolimus And/Or Sirolimus
CN102138903B (zh) * 2011-03-17 2012-12-12 苏州特瑞药业有限公司 一种依维莫司固体口服药物组合物
CN110585159B (zh) * 2019-09-12 2021-11-02 杭州华东医药集团新药研究院有限公司 一种含有西罗莫司的片剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0525960B1 (de) * 1991-06-18 1996-03-20 American Home Products Corporation Verwendung von Rapamycin zur Behandlung von T-Zellen Lymphom/Leukämie bei Erwachsenen
US5352783A (en) * 1993-06-09 1994-10-04 Merck & Co., Inc. Microbial transformation product having immunosuppressive activity
IL111004A (en) * 1993-09-30 1998-06-15 American Home Prod Oral formulations of rapamycin
US5536729A (en) * 1993-09-30 1996-07-16 American Home Products Corporation Rapamycin formulations for oral administration
US5547948A (en) * 1995-01-17 1996-08-20 American Home Products Corporation Controlled release of steroids from sugar coatings
CA2230748C (en) * 1997-03-14 2010-08-03 American Home Products Corporation Rapamycin formulations for oral administration

Also Published As

Publication number Publication date
PT994697E (pt) 2005-02-28
AU743584B2 (en) 2002-01-31
AU7836898A (en) 1998-12-30
TW574040B (en) 2004-02-01
AR012971A1 (es) 2000-11-22
ES2232948T3 (es) 2005-06-01
RU2184541C2 (ru) 2002-07-10
PL337320A1 (en) 2000-08-14
EP0994697B1 (de) 2004-12-01
CZ295276B6 (cs) 2005-06-15
NO996044L (no) 1999-12-08
TR199903065T2 (xx) 2000-09-21
HUP0003341A2 (hu) 2001-02-28
NO996044D0 (no) 1999-12-08
NZ501652A (en) 2001-09-28
BR9810746A (pt) 2000-09-19
UA65573C2 (uk) 2004-04-15
HUP0003341A3 (en) 2001-03-28
CN1133424C (zh) 2004-01-07
JP2002504124A (ja) 2002-02-05
CA2293793C (en) 2006-07-11
EP0994697A1 (de) 2000-04-26
ATE283687T1 (de) 2004-12-15
WO1998056358A1 (en) 1998-12-17
DE69827947D1 (de) 2005-01-05
CZ450299A3 (cs) 2000-08-16
ZA985095B (en) 1999-12-13
SK284472B6 (sk) 2005-04-01
DK0994697T3 (da) 2005-02-14
IL132986A0 (en) 2001-03-19
CA2293793A1 (en) 1998-12-17
KR20010013650A (ko) 2001-02-26
CN1259864A (zh) 2000-07-12
SK171799A3 (en) 2000-07-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee