DE69824971D1 - Von Tetrahydropyrrolo [1,2-a] Pyrazin-4-Spiro-3'-Pyrrolidine stabilisierte Zusammenstellung - Google Patents

Von Tetrahydropyrrolo [1,2-a] Pyrazin-4-Spiro-3'-Pyrrolidine stabilisierte Zusammenstellung

Info

Publication number
DE69824971D1
DE69824971D1 DE69824971T DE69824971T DE69824971D1 DE 69824971 D1 DE69824971 D1 DE 69824971D1 DE 69824971 T DE69824971 T DE 69824971T DE 69824971 T DE69824971 T DE 69824971T DE 69824971 D1 DE69824971 D1 DE 69824971D1
Authority
DE
Germany
Prior art keywords
acid
tetrahydropyrrolo
spiro
pyrrolidine
stabilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69824971T
Other languages
English (en)
Other versions
DE69824971T2 (de
Inventor
Mamoru Ohashi
Kazuyoshi Ogasawara
Yoshimi Shirai
Hiroshi Fujioka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of DE69824971D1 publication Critical patent/DE69824971D1/de
Application granted granted Critical
Publication of DE69824971T2 publication Critical patent/DE69824971T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69824971T 1997-10-20 1998-10-15 Stabilisierte Zusammensetzung aus Tetrahydropyrrolo [1,2-a] Pyrazin-4-Spiro-3'-Pyrrolidin Expired - Lifetime DE69824971T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP30663497 1997-10-20
JP30663497 1997-10-20
PCT/JP1998/004657 WO1999020276A1 (fr) 1997-10-20 1998-10-15 Composition medicamenteuse stable

Publications (2)

Publication Number Publication Date
DE69824971D1 true DE69824971D1 (de) 2004-08-12
DE69824971T2 DE69824971T2 (de) 2004-12-23

Family

ID=17959466

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824971T Expired - Lifetime DE69824971T2 (de) 1997-10-20 1998-10-15 Stabilisierte Zusammensetzung aus Tetrahydropyrrolo [1,2-a] Pyrazin-4-Spiro-3'-Pyrrolidin

Country Status (13)

Country Link
US (1) US6297244B1 (de)
EP (1) EP1038525B1 (de)
JP (1) JP3995414B2 (de)
KR (1) KR100571613B1 (de)
CN (1) CN1152686C (de)
AT (1) ATE270552T1 (de)
AU (1) AU9461898A (de)
DE (1) DE69824971T2 (de)
DK (1) DK1038525T3 (de)
ES (1) ES2224436T3 (de)
HK (1) HK1029921A1 (de)
PT (1) PT1038525E (de)
WO (1) WO1999020276A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1033132E (pt) * 1997-10-20 2005-09-30 Dainippon Pharmaceutical Co Composicao de farmaco rapidamente soluvel
JP4316203B2 (ja) 2001-08-08 2009-08-19 トビラ セラピューティクス インク 二環性化合物、その製造法および用途
ZA200409537B (en) * 2003-01-31 2006-10-25 Yamanouchi Pharma Co Ltd Stable solid medicinal composition for oral administration
AU2003236156A1 (en) * 2003-04-24 2005-01-04 Shin-Jen Shiao Pharmaceutical compositions used for immune disease treatment and improvement
JP2009504767A (ja) * 2005-08-17 2009-02-05 フレミング・アンド・カンパニー・ファーマシューティカルズ ビタミンｂ１２鼻用スプレーおよび使用方法
CN102186474A (zh) * 2008-08-14 2011-09-14 杏林制药株式会社 稳定的医药组合物
CN105263498B (zh) * 2013-05-15 2019-04-26 妥必徕疗治公司 赛尼克韦罗组合物及其制备和使用方法
EP3192510B1 (de) 2014-09-11 2022-01-05 Sumitomo Dainippon Pharma Co., Ltd. Ophthalmische suspensionsformulierung
WO2017155020A1 (ja) 2016-03-10 2017-09-14 大日本住友製薬株式会社 微細粒子含有組成物およびその製法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202450B (de) * 1991-06-26 1993-03-21 Dainippon Pharmaceutical Co
JP3158128B2 (ja) * 1992-12-25 2001-04-23 大日本製薬株式会社 コハク酸イミド誘導体
JPH08176105A (ja) * 1994-12-27 1996-07-09 Dainippon Pharmaceut Co Ltd ２−カルボキシコハク酸イミド誘導体

Also Published As

Publication number Publication date
ES2224436T3 (es) 2005-03-01
AU9461898A (en) 1999-05-10
EP1038525B1 (de) 2004-07-07
WO1999020276A1 (fr) 1999-04-29
US6297244B1 (en) 2001-10-02
EP1038525A1 (de) 2000-09-27
KR20010015780A (ko) 2001-02-26
HK1029921A1 (en) 2001-04-20
PT1038525E (pt) 2004-11-30
KR100571613B1 (ko) 2006-04-17
ATE270552T1 (de) 2004-07-15
DK1038525T3 (da) 2004-08-02
CN1282247A (zh) 2001-01-31
EP1038525A4 (de) 2003-03-26
CN1152686C (zh) 2004-06-09
DE69824971T2 (de) 2004-12-23
JP3995414B2 (ja) 2007-10-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DAINIPPON SUMITOMO PHARMA CO., LTD., OSAKA, JP