DE69822861D1 - Bentzothiophene - Google Patents
BentzothiopheneInfo
- Publication number
- DE69822861D1 DE69822861D1 DE69822861T DE69822861T DE69822861D1 DE 69822861 D1 DE69822861 D1 DE 69822861D1 DE 69822861 T DE69822861 T DE 69822861T DE 69822861 T DE69822861 T DE 69822861T DE 69822861 D1 DE69822861 D1 DE 69822861D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- compounds
- bentzothiophene
- cervix
- uterus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6094497P | 1997-10-03 | 1997-10-03 | |
US60944P | 1997-10-03 | ||
PCT/US1998/019559 WO1999018101A1 (en) | 1997-10-03 | 1998-09-18 | Benzothiophenes |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69822861D1 true DE69822861D1 (de) | 2004-05-06 |
DE69822861T2 DE69822861T2 (de) | 2005-01-27 |
Family
ID=22032709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69822861T Expired - Fee Related DE69822861T2 (de) | 1997-10-03 | 1998-09-18 | Bentzothiophene |
Country Status (9)
Country | Link |
---|---|
US (1) | US6403614B1 (de) |
EP (1) | EP1025098B1 (de) |
JP (1) | JP2001519349A (de) |
AT (1) | ATE263164T1 (de) |
AU (1) | AU9399898A (de) |
CA (1) | CA2306489A1 (de) |
DE (1) | DE69822861T2 (de) |
ES (1) | ES2217583T3 (de) |
WO (1) | WO1999018101A1 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3386500T3 (da) | 2015-12-09 | 2022-12-12 | Univ Illinois | Benzothiophen-baserede selektive østrogenreceptor ned-regulatorer |
WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
CN110177554B (zh) | 2017-01-06 | 2023-06-02 | G1治疗公司 | 用于治疗癌症的组合疗法 |
KR20190117582A (ko) | 2017-02-10 | 2019-10-16 | 쥐원 쎄라퓨틱스, 인크. | 벤조티오펜 에스트로겐 수용체 조정제 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1300575B (de) | 1965-05-21 | 1969-08-07 | Bristol Myers Co | Benzo[b]thiophene |
US3394125A (en) | 1965-10-23 | 1968-07-23 | Bristol Myers Co | 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group |
US4133814A (en) | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4230862A (en) | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
US4418068A (en) | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
US4380635A (en) | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
EP0062503A1 (de) * | 1981-04-03 | 1982-10-13 | Eli Lilly And Company | Benzothiophen-Verbindungen und Verfahren zu ihrer Herstellung |
US4358593A (en) | 1981-04-03 | 1982-11-09 | Eli Lilly And Company | Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes |
WO1989002893A1 (en) | 1987-09-30 | 1989-04-06 | The University Of Tennessee Research Corporation | Certain 3-substituted 2-alkyl benzothiophene derivatives |
US5395842A (en) | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
US5453752A (en) * | 1991-05-03 | 1995-09-26 | Georgia Tech Research Corporation | Compact broadband microstrip antenna |
DE4117512A1 (de) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
JP3157882B2 (ja) | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
US6756388B1 (en) | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
US7501441B1 (en) | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
WO1998049160A1 (en) * | 1997-04-30 | 1998-11-05 | Eli Lilly And Company | Antithrombotic agents |
-
1998
- 1998-09-18 AT AT98947152T patent/ATE263164T1/de not_active IP Right Cessation
- 1998-09-18 DE DE69822861T patent/DE69822861T2/de not_active Expired - Fee Related
- 1998-09-18 WO PCT/US1998/019559 patent/WO1999018101A1/en active IP Right Grant
- 1998-09-18 CA CA002306489A patent/CA2306489A1/en not_active Abandoned
- 1998-09-18 EP EP98947152A patent/EP1025098B1/de not_active Expired - Lifetime
- 1998-09-18 JP JP2000514912A patent/JP2001519349A/ja not_active Withdrawn
- 1998-09-18 AU AU93998/98A patent/AU9399898A/en not_active Abandoned
- 1998-09-18 ES ES98947152T patent/ES2217583T3/es not_active Expired - Lifetime
- 1998-09-30 US US09/164,024 patent/US6403614B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1999018101A1 (en) | 1999-04-15 |
EP1025098B1 (de) | 2004-03-31 |
AU9399898A (en) | 1999-04-27 |
EP1025098A1 (de) | 2000-08-09 |
ES2217583T3 (es) | 2004-11-01 |
US6403614B1 (en) | 2002-06-11 |
DE69822861T2 (de) | 2005-01-27 |
JP2001519349A (ja) | 2001-10-23 |
ATE263164T1 (de) | 2004-04-15 |
CA2306489A1 (en) | 1999-04-15 |
EP1025098A4 (de) | 2003-03-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |