DE69818650D1 - Gerät und methoden zum einfnag und zur analyse von partikel-einheiten - Google Patents

Gerät und methoden zum einfnag und zur analyse von partikel-einheiten

Info

Publication number
DE69818650D1
DE69818650D1 DE69818650T DE69818650T DE69818650D1 DE 69818650 D1 DE69818650 D1 DE 69818650D1 DE 69818650 T DE69818650 T DE 69818650T DE 69818650 T DE69818650 T DE 69818650T DE 69818650 D1 DE69818650 D1 DE 69818650D1
Authority
DE
Germany
Prior art keywords
methods
analysis
snapping
particle units
particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69818650T
Other languages
English (en)
Other versions
DE69818650T2 (de
Inventor
W Terstappen
C Rao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immunivest Corp
Original Assignee
Immunivest Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunivest Corp filed Critical Immunivest Corp
Application granted granted Critical
Publication of DE69818650D1 publication Critical patent/DE69818650D1/de
Publication of DE69818650T2 publication Critical patent/DE69818650T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/025—High gradient magnetic separators
    • B03C1/031—Component parts; Auxiliary operations
    • B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
    • B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1028—Sorting particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/823—Immunogenic carrier or carrier per se
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/824—Immunological separation techniques
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/734—Fullerenes, i.e. graphene-based structures, such as nanohorns, nanococoons, nanoscrolls or fullerene-like structures, e.g. WS2 or MoS2 chalcogenide nanotubes, planar C3N4, etc.
    • Y10S977/753—Fullerenes, i.e. graphene-based structures, such as nanohorns, nanococoons, nanoscrolls or fullerene-like structures, e.g. WS2 or MoS2 chalcogenide nanotubes, planar C3N4, etc. with polymeric or organic binder
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/838—Magnetic property of nanomaterial
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/84—Manufacture, treatment, or detection of nanostructure
    • Y10S977/888—Shaping or removal of materials, e.g. etching
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69818650T 1997-03-25 1998-03-24 Gerät und methoden zum einfnag und zur analyse von partikel-einheiten Expired - Fee Related DE69818650T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4146097P 1997-03-25 1997-03-25
US41460P 1997-03-25
PCT/US1998/005911 WO1998043067A1 (en) 1997-03-25 1998-03-24 Apparatus and methods for capture and analysis of particulate entities

Publications (2)

Publication Number Publication Date
DE69818650D1 true DE69818650D1 (de) 2003-11-06
DE69818650T2 DE69818650T2 (de) 2004-08-12

Family

ID=21916637

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69818650T Expired - Fee Related DE69818650T2 (de) 1997-03-25 1998-03-24 Gerät und methoden zum einfnag und zur analyse von partikel-einheiten

Country Status (5)

Country Link
US (1) US6623983B1 (de)
EP (1) EP0970365B1 (de)
AT (1) ATE251306T1 (de)
DE (1) DE69818650T2 (de)
WO (1) WO1998043067A1 (de)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7282350B2 (en) 1998-02-12 2007-10-16 Immunivest Corporation Labeled cell sets for use as functional controls in rare cell detection assays
CA2397341A1 (en) * 2000-01-13 2001-07-19 Dhanesh Gohel Ferrofluid based arrays
AU2001261463A1 (en) * 2000-05-12 2001-11-26 University Of Cincinnati Magnetic bead-based arrays
US20020164659A1 (en) * 2000-11-30 2002-11-07 Rao Galla Chandra Analytical methods and compositions
ATE342552T1 (de) * 2001-01-05 2006-11-15 Immunivest Corp Einrichtungen und verfahren für bildobjekte
ES2329986T3 (es) 2001-09-06 2009-12-03 Rapid Micro Biosystems Inc Deteccion rapida de celulas en replicacion.
US6954128B2 (en) * 2001-11-30 2005-10-11 The Regents Of The University Of California High performance hybrid magnetic structure for biotechnology applications
US7148778B2 (en) * 2001-11-30 2006-12-12 The Regents Of The University Of California High performance hybrid magnetic structure for biotechnology applications
EP2359689B1 (de) 2002-09-27 2015-08-26 The General Hospital Corporation Mikrofluid-Vorrichtung zur Zelltrennung, sowie Verwendung derselben
US8580544B2 (en) * 2002-10-16 2013-11-12 Universal Bio Research Co. Ltd. Apparatus for introducing biological material, method of introducing biological material and magnetic support for introducing biological material
ES2784011T3 (es) 2002-10-16 2020-09-21 Streck Inc Procedimiento y dispositivo para recoger y preservar las células para su análisis
CN1280428C (zh) * 2003-05-19 2006-10-18 清华大学 一种基于微小颗粒的生物芯片系统及其应用
US7906345B2 (en) * 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
WO2005072855A1 (en) 2004-01-28 2005-08-11 Drexel University Magnetic fluid manipulators and methods for their use
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
EP1937829A4 (de) * 2005-09-26 2011-08-03 Rapid Micro Biosystems Inc Kassette mit wachstumsmedium
US20080070792A1 (en) 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8795609B2 (en) 2007-02-08 2014-08-05 Biokit, S.A. Magnetic particle washing station
JP2008209330A (ja) * 2007-02-28 2008-09-11 Hitachi High-Technologies Corp 磁気分離器およびそれを用いた分析装置
JP2010536565A (ja) * 2007-08-23 2010-12-02 シンベニオ・バイオシステムズ・インコーポレーテッド 目標種用のトラップ用磁気選別システム
WO2009039437A1 (en) 2007-09-20 2009-03-26 Magarray, Inc. Analyte detection with magnetic sensors
EP2584360A1 (de) * 2007-12-05 2013-04-24 Zyomyx Inc. Zelltestset und -verfahren
US20110127222A1 (en) * 2008-03-19 2011-06-02 Cynvenio Biosystems, Inc. Trapping magnetic cell sorting system
WO2009129415A1 (en) * 2008-04-16 2009-10-22 Cynvenio Biosystems, Llc Magnetic separation system with pre and post processing modules
ES2620012T3 (es) 2008-09-20 2017-06-27 The Board Of Trustees Of The Leland Stanford Junior University Diagnóstico no invasivo de la aneuploidia fetal por secuenciación
CN107121396B (zh) 2008-09-24 2020-06-30 曙光生命科学公司 用于检测分析物的方法
EP2359164A4 (de) 2008-12-10 2012-05-30 Abqmr Inc Kernmagnetresonanzgerät, verfahren und zugehörige technologie
US11634747B2 (en) * 2009-01-21 2023-04-25 Streck Llc Preservation of fetal nucleic acids in maternal plasma
ES2649572T3 (es) 2009-02-18 2018-01-12 Streck Inc. Conservación de ácidos nucleicos fuera de las células
US8790916B2 (en) 2009-05-14 2014-07-29 Genestream, Inc. Microfluidic method and system for isolating particles from biological fluid
WO2010144745A2 (en) * 2009-06-10 2010-12-16 Cynvenio Biosystems, Inc. Sheath flow devices and methods
US20110262989A1 (en) 2010-04-21 2011-10-27 Nanomr, Inc. Isolating a target analyte from a body fluid
US8841104B2 (en) 2010-04-21 2014-09-23 Nanomr, Inc. Methods for isolating a target analyte from a heterogeneous sample
US9428547B2 (en) 2010-04-21 2016-08-30 Dna Electronics, Inc. Compositions for isolating a target analyte from a heterogeneous sample
US9476812B2 (en) 2010-04-21 2016-10-25 Dna Electronics, Inc. Methods for isolating a target analyte from a heterogeneous sample
US9151763B2 (en) 2011-03-09 2015-10-06 Magarray, Inc. Systems and methods for high-throughput detection of an analyte in a sample
CN103562720B (zh) * 2011-03-28 2016-08-17 美迪恩斯生命科技株式会社 全血检样的免疫测定方法和测定试剂盒
WO2012151391A2 (en) 2011-05-04 2012-11-08 Streck, Inc. Inactivated virus compositions and methods of preparing such compositions
ES2797448T3 (es) 2011-08-01 2020-12-02 Bio Rad Laboratories Sistema de captura de células
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
US9174216B2 (en) 2013-03-13 2015-11-03 DeNovo Science, Inc. System for capturing and analyzing cells
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
HUE036509T2 (hu) 2011-11-07 2018-07-30 Rapid Micro Biosystems Inc Kazetta sterilitási vizsgálathoz
MX2014012439A (es) 2012-04-16 2015-01-16 Rapid Micro Biosystems Inc Dispositivo para cultivar celulas.
EP2664914A1 (de) * 2012-05-16 2013-11-20 Koninklijke Philips N.V. Magnetisch unterstützte Verarbeitung eines Mediums
DE102012210077A1 (de) * 2012-06-15 2013-12-19 Siemens Aktiengesellschaft Verfahren und Anordnung zur Markierung von Zellen in einer Zellsuspension
US9434940B2 (en) 2012-12-19 2016-09-06 Dna Electronics, Inc. Methods for universal target capture
US9551704B2 (en) 2012-12-19 2017-01-24 Dna Electronics, Inc. Target detection
US10000557B2 (en) 2012-12-19 2018-06-19 Dnae Group Holdings Limited Methods for raising antibodies
US9599610B2 (en) 2012-12-19 2017-03-21 Dnae Group Holdings Limited Target capture system
US9995742B2 (en) 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
US9804069B2 (en) 2012-12-19 2017-10-31 Dnae Group Holdings Limited Methods for degrading nucleic acid
US9606102B2 (en) 2013-01-26 2017-03-28 Denovo Sciences, Inc. System and method for capturing and analyzing cells
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
WO2014151820A1 (en) 2013-03-15 2014-09-25 Magarray, Inc. Magnetic tunnel junction sensors and methods for using the same
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
US20140374325A1 (en) * 2013-06-24 2014-12-25 Lothar Jung Magnetic Separator and Method
WO2015013244A1 (en) 2013-07-24 2015-01-29 Streck, Inc. Compositions and methods for stabilizing circulating tumor cells
US10349870B1 (en) 2014-09-22 2019-07-16 Verily Life Sciences Llc Magnetic switching
US11168351B2 (en) 2015-03-05 2021-11-09 Streck, Inc. Stabilization of nucleic acids in urine
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
US11506655B2 (en) 2016-07-29 2022-11-22 Streck, Inc. Suspension composition for hematology analysis control
WO2019046307A1 (en) 2017-08-29 2019-03-07 Celsee Diagnostics, Inc. SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS
GB201818412D0 (en) * 2018-11-12 2018-12-26 Lumiradx Tech Ltd A magnetic assembly for use in a device for conducting assays
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
SG11202112151UA (en) 2019-05-07 2021-12-30 Bio Rad Laboratories System and method for automated single cell processing
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
CN114302643B (zh) 2019-06-14 2024-02-27 伯乐实验室有限公司 用于自动化单细胞处理和分析的系统和方法
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
CN114002195A (zh) * 2021-10-22 2022-02-01 中国科学院广州生物医药与健康研究院 一种辅助悬浮细胞成像的系统及其使用方法和应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230685A (en) * 1979-02-28 1980-10-28 Northwestern University Method of magnetic separation of cells and the like, and microspheres for use therein
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US5670381A (en) 1988-01-29 1997-09-23 Abbott Laboratories Devices for performing ion-capture binding assays
US5158871A (en) * 1988-02-12 1992-10-27 University Of Connecticut Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates
US5108933A (en) * 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
US5081030A (en) * 1989-04-25 1992-01-14 The Johns Hopkins University Release of cells from affinity matrices
US5698271A (en) * 1989-08-22 1997-12-16 Immunivest Corporation Methods for the manufacture of magnetically responsive particles
FR2654836B1 (fr) * 1989-11-17 1994-01-28 Biotrol Sa Laboratoires Appareil d'execution automatique d'un immunodosage en plusieurs etapes successives d'au moins une substance biologique dans une pluralite d'echantillons biologiques, procede et reactif mettant en óoeuvre ledit appareil.
WO1994011078A1 (en) * 1992-11-16 1994-05-26 Immunivest Corporation Magnetic immobilization and manipulation of biological entities
US5541072A (en) * 1994-04-18 1996-07-30 Immunivest Corporation Method for magnetic separation featuring magnetic particles in a multi-phase system
US5200084A (en) * 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5622831A (en) * 1990-09-26 1997-04-22 Immunivest Corporation Methods and devices for manipulation of magnetically collected material
US6013532A (en) * 1990-09-26 2000-01-11 Immunivest Corporation Methods for magnetic immobilization and manipulation of cells
WO1992008133A1 (en) * 1990-10-29 1992-05-14 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
US5186827A (en) * 1991-03-25 1993-02-16 Immunicon Corporation Apparatus for magnetic separation featuring external magnetic means
US5646001A (en) * 1991-03-25 1997-07-08 Immunivest Corporation Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof
US5466574A (en) 1991-03-25 1995-11-14 Immunivest Corporation Apparatus and methods for magnetic separation featuring external magnetic means
US5795470A (en) * 1991-03-25 1998-08-18 Immunivest Corporation Magnetic separation apparatus
FR2679660B1 (fr) * 1991-07-22 1993-11-12 Pasteur Diagnostics Procede et dispositif magnetique d'analyse immunologique sur phase solide.
GB9304979D0 (en) * 1993-03-11 1993-04-28 Sinvent As Imobilisation and separation of cells and other particles
DE19501916A1 (de) 1994-01-24 1995-07-27 Hitachi Ltd Verfahren und Analysator zum Immuntest unter Verwendung magnetischer Teilchen
US5514340A (en) * 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
US5851770A (en) * 1994-04-25 1998-12-22 Variagenics, Inc. Detection of mismatches by resolvase cleavage using a magnetic bead support
GB9417912D0 (en) 1994-09-06 1994-10-26 Univ Leeds Diagnostic apparatus
US5705059A (en) * 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
FR2732116B1 (fr) * 1995-03-21 1997-05-09 Bio Merieux Procede et dispositif pour la determination qualitative et/ou quantitative d'un analyte, notamment d'une bacterie, dans un echantillon, par voie magnetique
GB2300258A (en) * 1995-04-28 1996-10-30 Philip John Jewess A separation device for magnetisable particles
US5741714A (en) * 1995-07-18 1998-04-21 Immunivest Corporation Detection of bound analyte by magnetic partitioning and masking
US5660990A (en) * 1995-08-18 1997-08-26 Immunivest Corporation Surface immobilization of magnetically collected materials
JP3996644B2 (ja) * 1996-06-07 2007-10-24 イムニベスト・コーポレイション 外部及び内部勾配を有する磁気分離

Also Published As

Publication number Publication date
DE69818650T2 (de) 2004-08-12
EP0970365A1 (de) 2000-01-12
EP0970365A4 (de) 2001-01-17
EP0970365B1 (de) 2003-10-01
ATE251306T1 (de) 2003-10-15
US6623983B1 (en) 2003-09-23
WO1998043067A1 (en) 1998-10-01

Similar Documents

Publication Publication Date Title
DE69818650D1 (de) Gerät und methoden zum einfnag und zur analyse von partikel-einheiten
ATE349694T1 (de) Vorrichtung zur automatischen elektrodenpositionierung
DE69630378D1 (de) Vorrichtung zum abtrennen und auffangen von polypen
DE69534301D1 (de) Kulturmedium und vorrichtung zum nachweis und zur quantifizierung von enterobakteriaceae
ATA900197A (de) Vorrichtung zum sammeln, testen und versenden von körperflüssigkeits-proben
DE69837703D1 (de) Methoden zum nachweis und zur analyse von virus
DE69929314D1 (de) Verfahren, vorrichtung und apparat um information bereit zustellen
DE69528807D1 (de) Verfahren und Vorrichtung zum Entdecken von Antwortgeräten
DE60134383D1 (de) Vorrichtung und Verfahren zum Sammeln von Datenverkehrsinformationen
DE69419461T2 (de) Vorrichtung zum Auffangen von zielmolekülen und diese Vorrichtung benutzendes Auffangverfahren
DE59700990D1 (de) Verfahren und Vorrichtung zum Ausrichten von flachen Gegenständen
DE69900810D1 (de) Verfahren und Vorrichtung zum Testen von ereignisgesteuerten Programmen
DE3484224D1 (de) Verfahren und einrichtung zur analyse, mit verwendung von mehrzahligen trennprozessen.
DE68915439D1 (de) Verfahren und vorrichtung zum sammeln und nachweisen von mikroorganismen.
DE69912715D1 (de) Verfahren und Vorrichtung zum Aufnehmen von Dokumenten
DE29621636U1 (de) Vorrichtung zum Absaugen und Auffangen von Knochenteilchen
DE69834493D1 (de) Verfahren und gerät zum nachweis und zur zählung von mikroorganismen
DE68909997T2 (de) Vorrichtung zur Kultur von tierischen Zellen, Kulturmethode und Mittel zum Nachweis der Kultur.
DE60124780D1 (de) Vorrichtung und verfahren zur serienvermehrung von säugerzellen zum animpfen
DE69902970D1 (de) Vorrichtung zum Sammeln von Bögen
DE69840034D1 (de) Verfahren und vorrichtung zum aufkonzentrieren und auffinden von mikrobiologischen arten
DE60132055D1 (de) Verfahren und Vorrichtung zum Reproduzieren von Dateien
DE9405141U1 (de) Vorrichtung zur Simulation von Straßenunebenheiten
DE69601062D1 (de) Vorrichtung zum Abscheiden von in Gasen dispergierten Teilchen
DE59704132D1 (de) Verfahren und vorrichtung zum gefrieren von zellsuspensionen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee