DE69813498D1 - Verfahren zur freisetzung eines in einer multiplen emulsion enthaltenen aktivbestandteils - Google Patents

Verfahren zur freisetzung eines in einer multiplen emulsion enthaltenen aktivbestandteils

Info

Publication number
DE69813498D1
DE69813498D1 DE69813498T DE69813498T DE69813498D1 DE 69813498 D1 DE69813498 D1 DE 69813498D1 DE 69813498 T DE69813498 T DE 69813498T DE 69813498 T DE69813498 T DE 69813498T DE 69813498 D1 DE69813498 D1 DE 69813498D1
Authority
DE
Germany
Prior art keywords
emulsion
aqueous phase
releasing
active principle
active component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69813498T
Other languages
English (en)
Other versions
DE69813498T2 (de
Inventor
Jerome Bibette
Marie-Francoise F- Gra Ficheux
Calderon Fernando Leal
Lida Bonnakdar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Publication of DE69813498D1 publication Critical patent/DE69813498D1/de
Application granted granted Critical
Publication of DE69813498T2 publication Critical patent/DE69813498T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/02—Separation of non-miscible liquids
    • B01D17/04—Breaking emulsions
    • B01D17/047—Breaking emulsions with separation aids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4141—High internal phase ratio [HIPR] emulsions, e.g. having high percentage of internal phase, e.g. higher than 60-90 % of water in oil [W/O]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Colloid Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69813498T 1997-08-07 1998-08-05 Verfahren zur freisetzung eines in einer multiplen emulsion enthaltenen aktivbestandteils Expired - Lifetime DE69813498T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9710154A FR2767064B1 (fr) 1997-08-07 1997-08-07 Procede de liberation d'un principe actif contenu dans une emulsion multiple
PCT/FR1998/001748 WO1999007463A1 (fr) 1997-08-07 1998-08-05 Procede de liberation d'un principe actif contenu dans une emulsion multiple

Publications (2)

Publication Number Publication Date
DE69813498D1 true DE69813498D1 (de) 2003-05-22
DE69813498T2 DE69813498T2 (de) 2003-12-24

Family

ID=9510141

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69813498T Expired - Lifetime DE69813498T2 (de) 1997-08-07 1998-08-05 Verfahren zur freisetzung eines in einer multiplen emulsion enthaltenen aktivbestandteils

Country Status (11)

Country Link
US (1) US6627603B1 (de)
EP (1) EP0930933B1 (de)
JP (1) JP3725559B2 (de)
AT (1) ATE237395T1 (de)
AU (1) AU729461B2 (de)
CA (1) CA2267083C (de)
DE (1) DE69813498T2 (de)
ES (1) ES2200364T3 (de)
FR (1) FR2767064B1 (de)
PT (1) PT930933E (de)
WO (1) WO1999007463A1 (de)

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GB9828443D0 (en) * 1998-12-24 1999-02-17 Ici Plc Coating composition
FR2798601B1 (fr) * 1999-09-20 2001-12-21 Centre Nat Rech Scient Emulsion double polydisperse, emulsion double monodisperse correspondante et procede de preparation de l'emulsion monodisperse
FR2808703B1 (fr) * 2000-05-09 2002-08-02 Centre Nat Rech Scient Procede de preparation d'une emulsion double monodisperse
DE10211313A1 (de) * 2002-03-14 2003-10-02 Wacker Chemie Gmbh Mehrfachemulsionen
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
FR2860717B1 (fr) * 2003-10-13 2006-02-03 Ethypharm Sa Compositions de particules lipidiques solides monodisperses
FR2862235B1 (fr) * 2003-11-13 2007-12-28 Rhodia Chimie Sa Emulsion pour vehiculer une matiere active hydrophobe vers un substrat en milieu aqueux
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
JP2008546614A (ja) * 2005-06-17 2008-12-25 オーストラリアン ニュークリア サイエンス アンド テクノロジー オーガニゼーション 疎水性物質をその中へ含有する粒子
AU2006257727B2 (en) * 2005-06-17 2010-09-09 Encap Hive Pty Ltd Particles comprising a releasable dopant therein
CN101242814A (zh) 2005-06-17 2008-08-13 澳大利亚核科学技术组织 包含可释放掺杂剂的粒子
AU2006257726B2 (en) * 2005-06-17 2010-09-09 Australian Nuclear Science And Technology Organisation Particles having hydrophobic material therein
EP1984738A2 (de) 2006-01-11 2008-10-29 Raindance Technologies, Inc. Mikrofluidische vorrichtungen und verfahren zur verwendung bei der bildung und kontrolle von nanoreaktoren
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2481815B1 (de) 2006-05-11 2016-01-27 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
EP3536396B1 (de) 2006-08-07 2022-03-30 The President and Fellows of Harvard College Fluorkohlenstoffemulsionsstabilisierende tenside
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
US8528589B2 (en) 2009-03-23 2013-09-10 Raindance Technologies, Inc. Manipulation of microfluidic droplets
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
WO2011079176A2 (en) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
WO2011100604A2 (en) 2010-02-12 2011-08-18 Raindance Technologies, Inc. Digital analyte analysis
GB2482911A (en) 2010-08-20 2012-02-22 Sphere Fluidics Ltd Microdroplet emulsion system
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
EP2696847A1 (de) * 2011-04-14 2014-02-19 Novo Nordisk A/S Fettsäureacylierte aminosäuren zur oralen peptidfreisetzung
EP3709018A1 (de) 2011-06-02 2020-09-16 Bio-Rad Laboratories, Inc. Mikrofluidische vorrichtung zum nachweis von komponenten einer chemischen reaktion
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013165579A1 (en) * 2012-04-30 2013-11-07 Life Technologies Corporation Polymer-based emulsion breaking methods
CN104884078B (zh) * 2012-10-17 2017-06-20 诺和诺德股份有限公司 用于口服肽递送的脂肪酸酰化d‑氨基酸
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (de) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Verfahren zur detektion von latentem retrovirus
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
EP3662756A1 (de) * 2018-12-07 2020-06-10 General Mills, Inc. Multiple emulsionen, verfahren zur herstellung und anwendungen in nahrungsmitteln, kosmetik und pharmazeutika
CN110638666B (zh) * 2019-11-13 2022-06-24 瑞希(重庆)生物科技有限公司 一种w/o/w型多重乳液及其制备方法

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US5688761A (en) * 1991-04-19 1997-11-18 Lds Technologies, Inc. Convertible microemulsion formulations
DE69229779T2 (de) * 1991-04-19 1999-12-23 Lds Technologies, Inc. Konvertierbare mikroemulsionsverbindungen
US5589177A (en) * 1994-12-06 1996-12-31 Helene Curtis, Inc. Rinse-off water-in-oil-in-water compositions
DE19509301A1 (de) * 1995-03-15 1996-09-19 Henkel Kgaa Multiple W/O/W-Emulsionen

Also Published As

Publication number Publication date
WO1999007463A1 (fr) 1999-02-18
FR2767064A1 (fr) 1999-02-12
ES2200364T3 (es) 2004-03-01
FR2767064B1 (fr) 1999-11-12
CA2267083A1 (fr) 1999-02-18
CA2267083C (fr) 2004-01-27
AU729461B2 (en) 2001-02-01
PT930933E (pt) 2003-07-31
ATE237395T1 (de) 2003-05-15
EP0930933B1 (de) 2003-04-16
AU8988798A (en) 1999-03-01
EP0930933A1 (de) 1999-07-28
US6627603B1 (en) 2003-09-30
JP3725559B2 (ja) 2005-12-14
JP2000503685A (ja) 2000-03-28
DE69813498T2 (de) 2003-12-24

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