DE69812708T2 - Neue arzneimittel enthaltend uridintriphosphat - Google Patents

Neue arzneimittel enthaltend uridintriphosphat Download PDF

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Publication number
DE69812708T2
DE69812708T2 DE69812708T DE69812708T DE69812708T2 DE 69812708 T2 DE69812708 T2 DE 69812708T2 DE 69812708 T DE69812708 T DE 69812708T DE 69812708 T DE69812708 T DE 69812708T DE 69812708 T2 DE69812708 T2 DE 69812708T2
Authority
DE
Germany
Prior art keywords
uridintriphosphate
medicament containing
new medicament
new
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69812708T
Other languages
English (en)
Other versions
DE69812708D1 (de
Inventor
Karol K Lacroix
Christy L Shaffer
Karla M Jacobus
Janet L Rideout
David J Drutz
Richard M Evans
William Pendergast
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inspire Pharmaceuticals Inc
Original Assignee
Inspire Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inspire Pharmaceuticals Inc filed Critical Inspire Pharmaceuticals Inc
Publication of DE69812708D1 publication Critical patent/DE69812708D1/de
Application granted granted Critical
Publication of DE69812708T2 publication Critical patent/DE69812708T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69812708T 1997-12-23 1998-12-23 Neue arzneimittel enthaltend uridintriphosphat Expired - Fee Related DE69812708T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/996,740 US5968913A (en) 1996-07-03 1997-12-23 Pharmaceutical compositions of uridine triphosphate
PCT/US1998/027409 WO1999032085A2 (en) 1997-12-23 1998-12-23 Novel pharmaceutical compositions of uridine triphosphate

Publications (2)

Publication Number Publication Date
DE69812708D1 DE69812708D1 (de) 2003-04-30
DE69812708T2 true DE69812708T2 (de) 2004-01-29

Family

ID=25543248

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69812708T Expired - Fee Related DE69812708T2 (de) 1997-12-23 1998-12-23 Neue arzneimittel enthaltend uridintriphosphat

Country Status (17)

Country Link
US (1) US5968913A (de)
EP (1) EP1041969B1 (de)
JP (1) JP2001526208A (de)
KR (1) KR20010033310A (de)
CN (1) CN1143672C (de)
AR (1) AR014176A1 (de)
AT (1) ATE235225T1 (de)
AU (1) AU747350B2 (de)
BR (1) BR9814426A (de)
CA (1) CA2316018A1 (de)
DE (1) DE69812708T2 (de)
ID (1) ID26137A (de)
IL (1) IL136895A0 (de)
NO (1) NO20003246L (de)
NZ (1) NZ505821A (de)
WO (1) WO1999032085A2 (de)
ZA (1) ZA9811833B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319908B1 (en) 1996-07-03 2001-11-20 Inspire Pharmaceuticals, Inc. Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof
US5763447C1 (en) 1996-07-23 2002-05-07 Inspire Pharmaceuticals Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds
TW593331B (en) * 1997-07-25 2004-06-21 Inspire Pharmaceuticals Inc Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof
US6872710B2 (en) * 1997-07-25 2005-03-29 Inspire Pharmaceuticals, Inc. Di(uridine 5′)-tetraphosphate and salts thereof
ATE261982T1 (de) 1997-07-25 2004-04-15 Inspire Pharmaceuticals Inc Salze von di(uridine 5'-tetraphosphate), verfahren zur herstellung und verwendungen davon
US7018985B1 (en) 2000-08-21 2006-03-28 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US7452870B2 (en) * 2000-08-21 2008-11-18 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with P2Y12 receptor antagonist compound
US7132408B2 (en) 2000-08-21 2006-11-07 Inspire Pharmaceuticals, Inc. Composition and method for inhibiting platelet aggregation
US6327215B1 (en) * 2000-09-28 2001-12-04 Vanguard International Semiconductor Corporation Local bit switch decode circuit and method
AR034635A1 (es) 2001-06-25 2004-03-03 Inspire Pharmaceuticals Inc Lubricacion de las articulaciones con agonistas del receptor purinergico p2y
MXPA04004215A (es) * 2001-11-06 2004-07-08 Inspire Pharmaceuticals Inc Metodo para el tratamiento o la prevencion de enfermedades inflamatorias.
CN1700894A (zh) * 2002-10-18 2005-11-23 莫利化学医药公司 使用羊毛硫抗生素治疗干眼病的方法
CA2565545A1 (en) * 2004-05-06 2005-12-08 Molichem Medicines, Inc. Treatment of ocular diseases and disorders using lantibiotic compositions
US7326683B2 (en) * 2004-05-06 2008-02-05 Molichem Medicines, Inc. Treatment of membrane-associated diseases and disorders using lantibiotic containing compositions
US7368439B2 (en) * 2005-06-15 2008-05-06 Bar - Ilan University Dinucleoside poly(borano)phosphate derivatives and uses thereof
US20120077778A1 (en) * 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
ES2640485T3 (es) 2011-08-12 2017-11-03 Universitätsklinikum Freiburg Uridina y análogos de uridina para el uso en el tratamiento de la enfermedad pulmonar obstructiva crónica
US9034442B2 (en) * 2012-11-30 2015-05-19 Corning Incorporated Strengthened borosilicate glass containers with improved damage tolerance
US10117806B2 (en) * 2012-11-30 2018-11-06 Corning Incorporated Strengthened glass containers resistant to delamination and damage

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB916309A (en) * 1959-12-14 1963-01-23 Ile Auguil Soc Civ Improvements in and relating to new therapeutic preparation for use as a muscular and nervous stimulant
JPS60126220A (ja) * 1983-12-09 1985-07-05 Otsuka Pharmaceut Factory Inc 核酸成分組成物
GB9027968D0 (en) * 1990-12-22 1991-02-13 Fisons Plc Method of treatment
US5164740A (en) * 1991-04-24 1992-11-17 Yehuda Ivri High frequency printing mechanism
FR2677250B1 (fr) * 1991-06-05 1995-01-20 Synthelabo Compositions pharmaceutiques contenant de l'adenosine-5-triphosphate disodique.
EP0517573A1 (de) * 1991-06-05 1992-12-09 Synthelabo Pharmazeutische Zusammensetzungen zur Behandlung von Atemwegserkrankungen
US5292498A (en) * 1991-06-19 1994-03-08 The University Of North Carolina At Chapel Hill Method of treating lung disease with uridine triphosphates
US5518179A (en) * 1991-12-04 1996-05-21 The Technology Partnership Limited Fluid droplets production apparatus and method
US5547131A (en) * 1992-12-04 1996-08-20 Bespak Plc Dispensing device with spray nozzle and driven piston
US5497763A (en) * 1993-05-21 1996-03-12 Aradigm Corporation Disposable package for intrapulmonary delivery of aerosolized formulations
US5593824A (en) * 1994-09-02 1997-01-14 Pharmacia Biotech, Inc. Biological reagent spheres
US5628984A (en) * 1995-07-31 1997-05-13 University Of North Carolina At Chapel Hill Method of detecting lung disease
US6423694B1 (en) * 1996-02-21 2002-07-23 Inspire Pharmaceuticals, Inc. Method of treating otitis media with uridine triphosphates and related compounds
DE69736468T2 (de) * 1996-03-27 2007-03-29 Inspire Pharmaceuticals, Inc. Verfahren zur behandlung der ziliardyskinesie mit uridintriphosphaten und verwandten verbindungen
US5789391A (en) * 1996-07-03 1998-08-04 Inspire Pharmaceuticals, Inc. Method of treating sinusitis with uridine triphosphates and related compounds
US5962432A (en) * 1996-07-03 1999-10-05 Inspire Pharmaceuticals, Inc. Sterilized, isotonic and pH-adjusted pharmaceutical formulation of uridine triphosphate
US5763447C1 (en) * 1996-07-23 2002-05-07 Inspire Pharmaceuticals Method of preventing or treating pneumonia in immobilized patients with uridine triphosphates and related compounds
US6159952A (en) * 1996-11-07 2000-12-12 Inspire Pharmaceuticals, Inc. Method of treating bronchitis with uridine triphosphate and related compounds

Also Published As

Publication number Publication date
IL136895A0 (en) 2001-06-14
NO20003246L (no) 2000-08-23
CN1284861A (zh) 2001-02-21
ATE235225T1 (de) 2003-04-15
CA2316018A1 (en) 1999-07-01
BR9814426A (pt) 2001-10-23
NO20003246D0 (no) 2000-06-21
WO1999032085A3 (en) 1999-09-02
ID26137A (id) 2000-11-23
CN1143672C (zh) 2004-03-31
ZA9811833B (en) 1999-07-20
KR20010033310A (ko) 2001-04-25
WO1999032085A2 (en) 1999-07-01
AR014176A1 (es) 2001-02-07
DE69812708D1 (de) 2003-04-30
US5968913A (en) 1999-10-19
AU747350B2 (en) 2002-05-16
NZ505821A (en) 2002-09-27
EP1041969A2 (de) 2000-10-11
AU2092299A (en) 1999-07-12
JP2001526208A (ja) 2001-12-18
EP1041969B1 (de) 2003-03-26

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee