DE69812400T2 - Messung der konzentration einer substanz - Google Patents
Messung der konzentration einer substanz Download PDFInfo
- Publication number
- DE69812400T2 DE69812400T2 DE69812400T DE69812400T DE69812400T2 DE 69812400 T2 DE69812400 T2 DE 69812400T2 DE 69812400 T DE69812400 T DE 69812400T DE 69812400 T DE69812400 T DE 69812400T DE 69812400 T2 DE69812400 T2 DE 69812400T2
- Authority
- DE
- Germany
- Prior art keywords
- fluorophore
- light
- signal
- concentration
- light source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title claims abstract description 34
- 239000013307 optical fiber Substances 0.000 claims abstract description 36
- 230000000694 effects Effects 0.000 claims abstract description 19
- 230000010354 integration Effects 0.000 claims description 35
- 229920000642 polymer Polymers 0.000 claims description 33
- 238000012360 testing method Methods 0.000 claims description 27
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 22
- 229910052760 oxygen Inorganic materials 0.000 claims description 22
- 239000001301 oxygen Substances 0.000 claims description 22
- 239000002245 particle Substances 0.000 claims description 19
- 230000005540 biological transmission Effects 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 230000008859 change Effects 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 238000004364 calculation method Methods 0.000 claims description 8
- 238000012545 processing Methods 0.000 claims description 6
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- 230000004044 response Effects 0.000 claims description 4
- 239000000741 silica gel Substances 0.000 claims description 4
- 229910002027 silica gel Inorganic materials 0.000 claims description 4
- BCNPOXJWLYPAGO-UHFFFAOYSA-K 4,7-diphenyl-1,10-phenanthroline;ruthenium(3+);trichloride Chemical group [Cl-].[Cl-].[Cl-].[Ru+3].C1=CC=CC=C1C1=CC=NC2=C1C=CC1=C(C=3C=CC=CC=3)C=CN=C21.C1=CC=CC=C1C1=CC=NC2=C1C=CC1=C(C=3C=CC=CC=3)C=CN=C21.C1=CC=CC=C1C1=CC=NC2=C1C=CC1=C(C=3C=CC=CC=3)C=CN=C21 BCNPOXJWLYPAGO-UHFFFAOYSA-K 0.000 claims description 2
- 239000012327 Ruthenium complex Substances 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims description 2
- 229920002379 silicone rubber Polymers 0.000 claims description 2
- 239000004945 silicone rubber Substances 0.000 claims description 2
- 239000000835 fiber Substances 0.000 abstract description 16
- 238000005259 measurement Methods 0.000 abstract description 10
- 230000004913 activation Effects 0.000 abstract description 7
- 238000003556 assay Methods 0.000 abstract 3
- 239000000975 dye Substances 0.000 description 10
- 239000010410 layer Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 239000011241 protective layer Substances 0.000 description 6
- 239000000872 buffer Substances 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 239000003990 capacitor Substances 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 239000007850 fluorescent dye Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- DHDHJYNTEFLIHY-UHFFFAOYSA-N 4,7-diphenyl-1,10-phenanthroline Chemical compound C1=CC=CC=C1C1=CC=NC2=C1C=CC1=C(C=3C=CC=CC=3)C=CN=C21 DHDHJYNTEFLIHY-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- 239000007983 Tris buffer Substances 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthene Chemical compound C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- MTYHUTYJKFVTJJ-UHFFFAOYSA-N 4-hydroxypyrene-1,2,3-trisulfonic acid Chemical compound OS(=O)(=O)C1=C(S(O)(=O)=O)C(S(O)(=O)=O)=C2C(O)=CC3=CC=CC4=CC=C1C2=C34 MTYHUTYJKFVTJJ-UHFFFAOYSA-N 0.000 description 1
- QXYRRCOJHNZVDJ-UHFFFAOYSA-N 4-pyren-1-ylbutanoic acid Chemical compound C1=C2C(CCCC(=O)O)=CC=C(C=C3)C2=C2C3=CC=CC2=C1 QXYRRCOJHNZVDJ-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 108020005199 Dehydrogenases Proteins 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 150000001335 aliphatic alkanes Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 150000004696 coordination complex Chemical class 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000000295 emission spectrum Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- LIIALPBMIOVAHH-UHFFFAOYSA-N herniarin Chemical compound C1=CC(=O)OC2=CC(OC)=CC=C21 LIIALPBMIOVAHH-UHFFFAOYSA-N 0.000 description 1
- JHGVLAHJJNKSAW-UHFFFAOYSA-N herniarin Natural products C1CC(=O)OC2=CC(OC)=CC=C21 JHGVLAHJJNKSAW-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 229910052747 lanthanoid Inorganic materials 0.000 description 1
- 150000002602 lanthanoids Chemical class 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- ZLQJVGSVJRBUNL-UHFFFAOYSA-N methylumbelliferone Natural products C1=C(O)C=C2OC(=O)C(C)=CC2=C1 ZLQJVGSVJRBUNL-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 150000002907 osmium Chemical class 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000001022 rhodamine dye Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000004071 soot Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- -1 sulfonic acid anilide Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6848—Needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N2021/7706—Reagent provision
- G01N2021/772—Tip coated light guide
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- External Artificial Organs (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9723229A GB2330903C (en) | 1997-11-03 | 1997-11-03 | Sensing the concentration of a substance |
| GB9723229 | 1997-11-03 | ||
| PCT/GB1998/001809 WO1999023476A1 (en) | 1997-11-03 | 1998-06-19 | Measuring the concentration of a substance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69812400D1 DE69812400D1 (de) | 2003-04-24 |
| DE69812400T2 true DE69812400T2 (de) | 2004-01-22 |
Family
ID=10821519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69812400T Expired - Lifetime DE69812400T2 (de) | 1997-11-03 | 1998-06-19 | Messung der konzentration einer substanz |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6531097B1 (enExample) |
| EP (1) | EP1029233B1 (enExample) |
| JP (1) | JP4221150B2 (enExample) |
| AT (1) | ATE235049T1 (enExample) |
| AU (1) | AU746460B2 (enExample) |
| CA (1) | CA2309089C (enExample) |
| DE (1) | DE69812400T2 (enExample) |
| DK (1) | DK1029233T3 (enExample) |
| ES (1) | ES2195356T3 (enExample) |
| GB (1) | GB2330903C (enExample) |
| PT (1) | PT1029233E (enExample) |
| WO (1) | WO1999023476A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008011578A1 (de) * | 2008-02-28 | 2009-09-03 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Photolumineszenz-Sensor |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6664111B2 (en) * | 2001-08-22 | 2003-12-16 | 3M Innovative Properties Company | Fluorescence based oxygen sensor systems |
| US7670844B2 (en) * | 2004-01-20 | 2010-03-02 | The Curators Of The University Of Missouri | Supported molecular biofluid viscosity sensors for in vitro and in vivo use |
| GB0505036D0 (en) * | 2005-03-11 | 2005-04-20 | Oxford Optronix Ltd | An optical measurement sensor |
| JP4358785B2 (ja) * | 2005-05-27 | 2009-11-04 | 麒麟麦酒株式会社 | 密封容器内の酸素量の測定方法及びこれに用いる密封容器のピアス装置 |
| GB2447966B8 (en) * | 2007-03-29 | 2012-02-08 | Fiberlogix Internat Ltd | Improved optical chemical sensor |
| US8081313B2 (en) * | 2007-05-24 | 2011-12-20 | Airbus Operations Limited | Method and apparatus for monitoring gas concentration in a fluid |
| JP4944006B2 (ja) * | 2007-12-17 | 2012-05-30 | 株式会社山武 | 温度センサ、及び温度測定方法 |
| JP5225773B2 (ja) * | 2008-07-09 | 2013-07-03 | アズビル株式会社 | 温度センサ、及び温度測定方法 |
| GB0813715D0 (en) * | 2008-07-28 | 2008-09-03 | Airbus Uk Ltd | A monitor and a method for measuring oxygen concentration |
| JP5365279B2 (ja) * | 2009-03-17 | 2013-12-11 | ソニー株式会社 | 発光材料、発光材料複合体及びその製造方法、蛍光標識試薬及びその製造方法、並びに、発光素子 |
| GB0918212D0 (en) | 2009-10-16 | 2009-12-02 | Univ Strathclyde | Intelligent pigments and plastics |
| US8694069B1 (en) | 2009-12-21 | 2014-04-08 | Kosense, LLC | Fiber-optic probe with embedded peripheral sensors for in-situ continuous monitoring |
| US20130005047A1 (en) * | 2010-03-25 | 2013-01-03 | Mocon, Inc. | Luminescence lifetime based analyte sensing instruments and calibration technique |
| GB201012078D0 (en) | 2010-07-19 | 2010-09-01 | Oxford Optronix Ltd | Concentration measurement using luminescene |
| GB2486677A (en) * | 2010-12-22 | 2012-06-27 | Agilent Technologies Inc | Ceramic injection needle for analysis system |
| WO2012155192A1 (en) * | 2011-05-13 | 2012-11-22 | Adelaide Research & Innovation Pty Ltd | A method of and a system for characterising a material |
| WO2012159013A1 (en) | 2011-05-18 | 2012-11-22 | Samuel Walker Inman | Irregular excitation of optical sensors |
| CN102495028B (zh) * | 2011-11-18 | 2013-10-23 | 江苏大学 | 一种混药浓度在线检测方法及其装置 |
| JP5839575B2 (ja) * | 2012-04-06 | 2016-01-06 | 本田技研工業株式会社 | 燃料電池内部用酸素濃度測定装置 |
| CN103630509A (zh) * | 2013-12-03 | 2014-03-12 | 江苏大学 | 一种在线检测农药浓度的装置及其检测方法 |
| US9097670B1 (en) * | 2014-03-06 | 2015-08-04 | Stardust Materials, LLC | System for measuring dye concentration in liquids |
| JP7665508B2 (ja) | 2018-08-31 | 2025-04-21 | ルシッド サイエンティフィック， インク． | 動的システムの測定 |
| EP3702759A1 (en) * | 2019-02-26 | 2020-09-02 | Nokia Technologies Oy | Method and apparatus for fluorescence lifetime measurement |
| US11193916B2 (en) * | 2019-05-02 | 2021-12-07 | SciLogica Corp. | Calibration of a gas sensor |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4557900A (en) * | 1982-09-28 | 1985-12-10 | Cardiovascular Devices, Inc. | Optical sensor with beads |
| US4895156A (en) * | 1986-07-02 | 1990-01-23 | Schulze John E | Sensor system using fluorometric decay measurements |
| US5043285A (en) * | 1987-07-09 | 1991-08-27 | Allied-Signal Inc. | Optical detection of oxygen |
| US5173432A (en) * | 1987-12-14 | 1992-12-22 | The Dow Chemical Company | Apparatus and method for measuring the concentration or partial pressure of oxygen |
| EP0329297A3 (en) * | 1988-02-16 | 1990-12-05 | Medex, Inc. | Method and apparatus for measuring partial pressure of oxygen in a fluid |
| US5102625A (en) * | 1990-02-16 | 1992-04-07 | Boc Health Care, Inc. | Apparatus for monitoring a chemical concentration |
| US5107445A (en) * | 1990-12-04 | 1992-04-21 | Luxtron Corporation | Modular luminescence-based measuring system using fast digital signal processing |
| GB2265709A (en) * | 1992-03-25 | 1993-10-06 | David Russell Blake | Reactive oxygen species measuring device |
| US5304809A (en) * | 1992-09-15 | 1994-04-19 | Luxtron Corporation | Luminescent decay time measurements by use of a CCD camera |
| WO1994010553A1 (en) * | 1992-10-23 | 1994-05-11 | Optex Biomedical, Inc. | Fibre-optic probe for the measurement of fluid parameters |
-
1997
- 1997-11-03 GB GB9723229A patent/GB2330903C/en not_active Expired - Fee Related
-
1998
- 1998-06-19 JP JP2000519291A patent/JP4221150B2/ja not_active Expired - Fee Related
- 1998-06-19 EP EP98930909A patent/EP1029233B1/en not_active Expired - Lifetime
- 1998-06-19 AT AT98930909T patent/ATE235049T1/de active
- 1998-06-19 DK DK98930909T patent/DK1029233T3/da active
- 1998-06-19 PT PT98930909T patent/PT1029233E/pt unknown
- 1998-06-19 AU AU81188/98A patent/AU746460B2/en not_active Ceased
- 1998-06-19 WO PCT/GB1998/001809 patent/WO1999023476A1/en not_active Ceased
- 1998-06-19 ES ES98930909T patent/ES2195356T3/es not_active Expired - Lifetime
- 1998-06-19 CA CA002309089A patent/CA2309089C/en not_active Expired - Fee Related
- 1998-06-19 DE DE69812400T patent/DE69812400T2/de not_active Expired - Lifetime
-
2000
- 2000-04-27 US US09/559,780 patent/US6531097B1/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008011578A1 (de) * | 2008-02-28 | 2009-09-03 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Photolumineszenz-Sensor |
Also Published As
| Publication number | Publication date |
|---|---|
| AU8118898A (en) | 1999-05-24 |
| GB2330903B (en) | 2002-05-15 |
| EP1029233A1 (en) | 2000-08-23 |
| EP1029233B1 (en) | 2003-03-19 |
| DE69812400D1 (de) | 2003-04-24 |
| CA2309089C (en) | 2009-02-10 |
| ATE235049T1 (de) | 2003-04-15 |
| DK1029233T3 (da) | 2003-06-16 |
| ES2195356T3 (es) | 2003-12-01 |
| GB2330903C (en) | 2002-05-15 |
| GB9723229D0 (en) | 1998-01-07 |
| CA2309089A1 (en) | 1999-05-14 |
| US6531097B1 (en) | 2003-03-11 |
| PT1029233E (pt) | 2003-07-31 |
| GB2330903A (en) | 1999-05-05 |
| JP2002529682A (ja) | 2002-09-10 |
| WO1999023476A1 (en) | 1999-05-14 |
| JP4221150B2 (ja) | 2009-02-12 |
| AU746460B2 (en) | 2002-05-02 |
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