DE69810934T2 - Ribonukleosid-derivat und verfahren zu seiner herstellung - Google Patents

Ribonukleosid-derivat und verfahren zu seiner herstellung

Info

Publication number
DE69810934T2
DE69810934T2 DE69810934T DE69810934T DE69810934T2 DE 69810934 T2 DE69810934 T2 DE 69810934T2 DE 69810934 T DE69810934 T DE 69810934T DE 69810934 T DE69810934 T DE 69810934T DE 69810934 T2 DE69810934 T2 DE 69810934T2
Authority
DE
Germany
Prior art keywords
ribonucleoside
protection
derivative
group
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69810934T
Other languages
English (en)
Other versions
DE69810934D1 (de
Inventor
Stefan Pitsch
Patrick A Weiss
Luzi Jenny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qiagen AG
Original Assignee
Qiagen AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qiagen AG filed Critical Qiagen AG
Publication of DE69810934D1 publication Critical patent/DE69810934D1/de
Application granted granted Critical
Publication of DE69810934T2 publication Critical patent/DE69810934T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69810934T 1997-08-18 1998-08-17 Ribonukleosid-derivat und verfahren zu seiner herstellung Expired - Lifetime DE69810934T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH193197 1997-08-18
PCT/EP1998/005215 WO1999009044A1 (en) 1997-08-18 1998-08-17 Ribonucleoside-derivative and method for preparing the same

Publications (2)

Publication Number Publication Date
DE69810934D1 DE69810934D1 (de) 2003-02-27
DE69810934T2 true DE69810934T2 (de) 2003-11-27

Family

ID=4221948

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69810934T Expired - Lifetime DE69810934T2 (de) 1997-08-18 1998-08-17 Ribonukleosid-derivat und verfahren zu seiner herstellung

Country Status (8)

Country Link
US (1) US5986084A (de)
EP (1) EP1005478B1 (de)
JP (1) JP4473445B2 (de)
AT (1) ATE231518T1 (de)
AU (1) AU9532198A (de)
DE (1) DE69810934T2 (de)
ES (1) ES2191343T3 (de)
WO (1) WO1999009044A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001040515A1 (en) * 1999-11-12 2001-06-07 Isis Pharmaceuticals, Inc. Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
GB0227352D0 (en) * 2002-11-22 2002-12-31 Novartis Ag Organic compounds
US7560231B2 (en) 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
WO2005090562A1 (ja) * 2004-03-23 2005-09-29 Jun Fujita 軽度の低温により遺伝子の発現を促進させる配列
CA2513340A1 (en) 2004-08-25 2006-02-25 F. Hoffmann-La Roche Ag Reusable substrate for dna microarray production
ATE505540T1 (de) 2004-11-16 2011-04-15 Qiagen Gmbh Genabschaltung (gene silencing) durch hybride sens-dna und antisens-rna konstrukte, gekoppelt an ein peptid zur erleichterten aufnahme in zellen
US20060234973A1 (en) * 2005-04-14 2006-10-19 Kevin Fitzgerald Transcription factor RNA interference reagents and methods of use thereof
AU2006288394A1 (en) * 2005-09-05 2007-03-15 Jun Fujita Sequence capable of enhancing the expression of gene under moderately low temperature
US7759471B2 (en) 2005-10-31 2010-07-20 Agilent Technologies, Inc. Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection
US20090203897A1 (en) * 2008-02-08 2009-08-13 Operon Biotechnologies, Inc. Method of Using Polymer Embedded Solid Supports for Small Scale Oligonucleotide Synthesis
US9399655B2 (en) 2012-06-06 2016-07-26 University of Pittsburgh—of the Commonwealth System of Higher Education Catalytic glycosylation with designer thioglycoside and novel protecting groups for same and for synthesis of oligosaccharides
PL221806B1 (pl) 2013-03-21 2016-05-31 Inst Chemii Bioorg Polskiej Akademii Nauk Sposób wprowadzania acetalowych i acetaloestrowych grup ochronnych oraz związki do realizacji tego sposobu
CN104447848B (zh) * 2014-12-15 2017-01-18 扬州三友合成化工有限公司 一种（异丙氧基硅）氯甲烷的制备方法
WO2023097308A1 (en) 2021-11-29 2023-06-01 Hongene Biotech Corporation Synthesis of 2' acetyl-ester protected nucleosides

Also Published As

Publication number Publication date
JP2001515087A (ja) 2001-09-18
EP1005478B1 (de) 2003-01-22
ES2191343T3 (es) 2003-09-01
US5986084A (en) 1999-11-16
JP4473445B2 (ja) 2010-06-02
DE69810934D1 (de) 2003-02-27
EP1005478A1 (de) 2000-06-07
WO1999009044A1 (en) 1999-02-25
AU9532198A (en) 1999-03-08
ATE231518T1 (de) 2003-02-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition