DE69809232T2 - Lösungspolymerisation von hochmolekularen polyphosphorestern in toluol - Google Patents
Lösungspolymerisation von hochmolekularen polyphosphorestern in toluolInfo
- Publication number
- DE69809232T2 DE69809232T2 DE69809232T DE69809232T DE69809232T2 DE 69809232 T2 DE69809232 T2 DE 69809232T2 DE 69809232 T DE69809232 T DE 69809232T DE 69809232 T DE69809232 T DE 69809232T DE 69809232 T2 DE69809232 T2 DE 69809232T2
- Authority
- DE
- Germany
- Prior art keywords
- temperature
- formula
- polymer
- reaction mixture
- high molecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
- C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
- C08G79/04—Phosphorus linked to oxygen or to oxygen and carbon
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/884,382 US6028163A (en) | 1997-06-27 | 1997-06-27 | Solution polymerization of high molecular weight poly(phosphoesters) in toluene |
PCT/US1998/012976 WO1999000446A1 (en) | 1997-06-27 | 1998-06-23 | Solution polymerization of high molecular weight poly(phosphoesters) in toluene |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69809232D1 DE69809232D1 (de) | 2002-12-12 |
DE69809232T2 true DE69809232T2 (de) | 2003-07-24 |
Family
ID=25384500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69809232T Expired - Fee Related DE69809232T2 (de) | 1997-06-27 | 1998-06-23 | Lösungspolymerisation von hochmolekularen polyphosphorestern in toluol |
Country Status (8)
Country | Link |
---|---|
US (2) | US6028163A (de) |
EP (1) | EP0990008B1 (de) |
JP (1) | JP2002508799A (de) |
AT (1) | ATE227317T1 (de) |
AU (1) | AU744323C (de) |
CA (1) | CA2295158A1 (de) |
DE (1) | DE69809232T2 (de) |
WO (1) | WO1999000446A1 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0001256A3 (en) | 1997-04-03 | 2002-12-28 | Univ Johns Hopkins Med | Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, method for making the same and using them |
UA54505C2 (uk) | 1997-04-03 | 2003-03-17 | Гілфорд Фармасьютікалз Інк. | Полімери, що біологічно розкладаються, зшиті фосфатами, композиції, вироби і способи для їх виготовлення і використання |
JP2002518349A (ja) | 1998-06-18 | 2002-06-25 | ジョンズ ホプキンス ユニバーシティ スクール オブ メディシン | 核酸デリバリー用ポリマー |
US6419709B1 (en) | 1998-10-02 | 2002-07-16 | Guilford Pharmaceuticals, Inc. | Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same |
US6153212A (en) * | 1998-10-02 | 2000-11-28 | Guilford Pharmaceuticals Inc. | Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same |
US6350464B1 (en) | 1999-01-11 | 2002-02-26 | Guilford Pharmaceuticals, Inc. | Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same |
US6537585B1 (en) * | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
WO2001091725A2 (en) * | 2000-05-31 | 2001-12-06 | Univ Johns Hopkins | Biologically useful polyphosphates |
WO2002004544A2 (en) | 2000-07-06 | 2002-01-17 | Guilford Pharmaceuticals | Polymers and polymerization processes |
GB0100624D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VII |
CA2438641A1 (en) * | 2001-02-15 | 2002-08-22 | King Pharmaceuticals, Inc. | Stabilized pharmaceutical and thyroid hormone compositions and method of preparation |
US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
WO2003000776A1 (en) * | 2001-05-14 | 2003-01-03 | Johns Hopkins Singapore Pte Ltd | Biodegradable polyphosphoramidates for controlled release of bioactive substances |
US7345138B2 (en) * | 2001-05-14 | 2008-03-18 | Johns Hopkins Singapore Pte Ltd. | Biodegradable polyphosphates for controlled release of bioactive substances |
US20030134892A1 (en) * | 2001-07-19 | 2003-07-17 | Wenbin Dang | Compositions for treatment of head and neck cancers, and methods of making and using the same |
AU2002354957A1 (en) * | 2001-07-19 | 2003-03-03 | Guilford Pharmaceuticals, Inc. | Biocompatible polymer containing composition for treatment of prostate cancers |
US20030180353A1 (en) * | 2001-08-10 | 2003-09-25 | Franz G. Andrew | Stabilized pharmaceutical compositions |
US20030198671A1 (en) * | 2001-08-10 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique plasma AUC properties |
US20030190349A1 (en) * | 2001-08-10 | 2003-10-09 | Franz G. Andrew | Methods of stabilizing pharmaceutical compositions |
US20030203967A1 (en) * | 2001-08-14 | 2003-10-30 | Franz G. Andrew | Levothyroxine compositions having unique Tmax properties |
US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
US20030198672A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique triidothyronine plasma AUC properties |
US20030165564A1 (en) * | 2001-10-29 | 2003-09-04 | Franz G. Andrew | Levothyroxine compositions having unique triiodothyronine Tmax properties |
US20090004741A1 (en) * | 2002-05-14 | 2009-01-01 | Jun Wang | Biodegradable polyphosphoramidates for controlled release of bioactive substances |
US7037618B2 (en) | 2002-06-05 | 2006-05-02 | Lynntech, Inc. | Apparatus and method for compressing a stack of electrochemical cells |
US7547388B2 (en) * | 2004-07-20 | 2009-06-16 | Think Village-Kerfoot, Llc | Superoxidant poiser for groundwater and soil treatment with in-situ oxidation-reduction and acidity-basicity adjustment |
US20040197301A1 (en) * | 2003-02-18 | 2004-10-07 | Zhong Zhao | Hybrid polymers and methods of making the same |
US7387793B2 (en) * | 2003-11-14 | 2008-06-17 | Eurand, Inc. | Modified release dosage forms of skeletal muscle relaxants |
GB0420987D0 (en) * | 2004-09-22 | 2004-10-20 | Rhodia Consumer Specialities L | Aminophosphinate polymers |
EP1808380A1 (de) * | 2006-01-13 | 2007-07-18 | Pepup S.A. | Flexibler Beutel für eine Flüssigkeit und Verfahren zu dessen Herstellung |
EP1826849A1 (de) | 2006-02-24 | 2007-08-29 | Auto-Juntas, S.A. Unipersonal | Membran-Elektroden-Einheit mit verstärkter Dichtungsstruktur |
JP2011518247A (ja) * | 2008-04-16 | 2011-06-23 | ボストン サイエンティフィック サイムド,インコーポレイテッド | フッ素化ポリマーをベースとする医療埋込み物被覆組成物 |
EP3485881B1 (de) | 2009-07-10 | 2024-03-13 | President and Fellows of Harvard College | Permanent geladene natrium- und calciumkanalblocker als entzündungshemmende mittel |
EP2621475A1 (de) | 2010-10-02 | 2013-08-07 | Link Research&Grants Corporation | Behandlung von tinnitus und zugehörigen dysfunktionen des gehörs |
MX2018001447A (es) | 2015-08-03 | 2019-02-21 | Harvard College | Bloqueadores de canal de ion cargado y metodos para su uso. |
WO2020185881A1 (en) | 2019-03-11 | 2020-09-17 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
US10786485B1 (en) | 2019-03-11 | 2020-09-29 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
JP2022527438A (ja) | 2019-03-11 | 2022-06-02 | ノシオン セラピューティクス,インコーポレイテッド | 荷電したイオンチャンネル遮断薬および使用方法 |
US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
US10927096B2 (en) | 2019-03-11 | 2021-02-23 | Nocion Therapeutics, Inc. | Ester substituted ion channel blockers and methods for use |
WO2021091586A1 (en) | 2019-11-06 | 2021-05-14 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
JP2023500891A (ja) | 2019-11-06 | 2023-01-11 | ノシオン セラピューティクス,インコーポレイテッド | 荷電したイオンチャンネル遮断薬および使用方法 |
US11332446B2 (en) | 2020-03-11 | 2022-05-17 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3664975A (en) * | 1970-04-13 | 1972-05-23 | Monsanto Co | Flame resistant polyurethane prepared by adding an ethane diphosphonate into the urethane-forming mixture |
JPS5232675B2 (de) * | 1972-12-27 | 1977-08-23 | ||
JPS5750812B2 (de) * | 1973-06-25 | 1982-10-29 | ||
US4072658A (en) * | 1974-05-18 | 1978-02-07 | Kanebo, Ltd. | Novel phosphorus- and bromine-containing polymers |
US4156663A (en) * | 1974-05-18 | 1979-05-29 | Kanebo, Ltd. | Flame resistant polymer composition containing phosphorus and bromine containing polymer |
DE3036119A1 (de) * | 1980-09-25 | 1982-04-08 | Chemische Werke Hüls AG, 4370 Marl | Verfahren zur herstellung von 2-isopropyl- und 2n-propyl-(delta)-oxazolin-copolymeren |
US4417044A (en) * | 1982-05-25 | 1983-11-22 | General Electric Company | Process for making polyetherimides |
US4650853A (en) * | 1985-11-15 | 1987-03-17 | The Dow Chemical Company | Process of polymerizing epoxides in solvent mixtures to form granular polymer products |
EP0328342A3 (de) * | 1988-02-08 | 1990-08-01 | MITSUI TOATSU CHEMICALS, Inc. | Verfahren zur Herstellung aromatischer Polyamide |
US5444113A (en) * | 1988-08-08 | 1995-08-22 | Ecopol, Llc | End use applications of biodegradable polymers |
US4954609A (en) * | 1989-02-28 | 1990-09-04 | Hoechst Celanese Corp. | Intermediate molecular weight fluorine containing polymide and method for preparation |
US5194581A (en) * | 1989-03-09 | 1993-03-16 | Leong Kam W | Biodegradable poly(phosphoesters) |
JP3034550B2 (ja) * | 1990-03-07 | 2000-04-17 | 東ソー株式会社 | 高分子量ポリアリーレンスルフィドの製造法 |
US5262516A (en) * | 1991-11-26 | 1993-11-16 | General Electric Company | Method for preparing polyetherimide-polyamide copolymers |
US5312894A (en) * | 1992-04-30 | 1994-05-17 | Kureha Kagaku Kogyo K.K. | Granular high-melt-stable poly(arylene thioether-ketone) and production process thereof |
US5525671A (en) * | 1993-12-28 | 1996-06-11 | Dainippon Ink And Chemicals, Inc. | Continuous production process for lactide copolymer |
-
1997
- 1997-06-27 US US08/884,382 patent/US6028163A/en not_active Expired - Fee Related
-
1998
- 1998-06-23 DE DE69809232T patent/DE69809232T2/de not_active Expired - Fee Related
- 1998-06-23 EP EP98932808A patent/EP0990008B1/de not_active Expired - Lifetime
- 1998-06-23 JP JP50564699A patent/JP2002508799A/ja active Pending
- 1998-06-23 CA CA002295158A patent/CA2295158A1/en not_active Withdrawn
- 1998-06-23 AT AT98932808T patent/ATE227317T1/de not_active IP Right Cessation
- 1998-06-23 US US09/102,813 patent/US5952451A/en not_active Expired - Fee Related
- 1998-06-23 AU AU82611/98A patent/AU744323C/en not_active Ceased
- 1998-06-23 WO PCT/US1998/012976 patent/WO1999000446A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0990008B1 (de) | 2002-11-06 |
DE69809232D1 (de) | 2002-12-12 |
AU744323C (en) | 2002-08-29 |
ATE227317T1 (de) | 2002-11-15 |
WO1999000446A8 (en) | 1999-04-01 |
WO1999000446A1 (en) | 1999-01-07 |
US6028163A (en) | 2000-02-22 |
US5952451A (en) | 1999-09-14 |
WO1999000446A9 (en) | 1999-05-06 |
EP0990008A1 (de) | 2000-04-05 |
CA2295158A1 (en) | 1999-01-07 |
AU8261198A (en) | 1999-01-19 |
AU744323B2 (en) | 2002-02-21 |
JP2002508799A (ja) | 2002-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |