DE69737562T2 - Behandlung einer ischämischen störung und zur verbesserung des infarktergebnis - Google Patents
Behandlung einer ischämischen störung und zur verbesserung des infarktergebnis Download PDFInfo
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- DE69737562T2 DE69737562T2 DE69737562T DE69737562T DE69737562T2 DE 69737562 T2 DE69737562 T2 DE 69737562T2 DE 69737562 T DE69737562 T DE 69737562T DE 69737562 T DE69737562 T DE 69737562T DE 69737562 T2 DE69737562 T2 DE 69737562T2
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- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
- C07K16/2854—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72 against selectins, e.g. CD62
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72144796A | 1996-09-27 | 1996-09-27 | |
| US721447 | 1996-09-27 | ||
| PCT/US1997/017229 WO1998013058A1 (en) | 1996-09-27 | 1997-09-25 | Methods for treating an ischemic disorder and improving stroke outcome |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69737562D1 DE69737562D1 (de) | 2007-05-16 |
| DE69737562T2 true DE69737562T2 (de) | 2007-12-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69737562T Expired - Lifetime DE69737562T2 (de) | 1996-09-27 | 1997-09-25 | Behandlung einer ischämischen störung und zur verbesserung des infarktergebnis |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1829550A3 (enExample) |
| JP (1) | JP2001501612A (enExample) |
| AT (1) | ATE358492T1 (enExample) |
| AU (1) | AU4594297A (enExample) |
| CA (1) | CA2266640C (enExample) |
| DE (1) | DE69737562T2 (enExample) |
| DK (1) | DK0951292T3 (enExample) |
| ES (1) | ES2285740T3 (enExample) |
| PT (1) | PT951292E (enExample) |
| WO (1) | WO1998013058A1 (enExample) |
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| EP1712226A3 (en) * | 1996-04-05 | 2007-03-21 | The General Hospital Corporation | Treatment of a Hemoglobinopathy |
| US6315995B1 (en) * | 1996-09-27 | 2001-11-13 | The Trustees Of Columbia University In The City Of New York | Methods for treating an ischemic disorder and improving stroke outcome |
| US8128963B2 (en) | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
| WO1999049803A1 (en) * | 1998-04-01 | 1999-10-07 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting thrombosis in a patient whose blood is subjected to extracorporeal circulation |
| US7678390B2 (en) | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
| FR2816212A1 (fr) * | 2000-11-03 | 2002-05-10 | Air Liquide Sante Int | Utilisation de monoxyde de carbone (co) dans le traitement des inflammations du systeme cardiovasculaire |
| US20030198639A1 (en) * | 2002-04-16 | 2003-10-23 | Frenette Paul S. | Methods of treating sickle cell disease |
| GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
| EP1404811B1 (en) | 2001-06-21 | 2008-11-12 | Beth Israel Deaconess Medical Center, Inc. | Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis |
| US6472390B1 (en) * | 2001-11-13 | 2002-10-29 | Duke University | Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure |
| EP2042181A1 (en) | 2002-02-04 | 2009-04-01 | ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. | Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases |
| CA2475963A1 (en) * | 2002-02-13 | 2003-09-04 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating vascular disease |
| ES2546280T3 (es) | 2002-04-15 | 2015-09-22 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Monóxido de carbono para su uso en un método para tratar íleo |
| EP1499328B1 (en) * | 2002-04-15 | 2015-09-16 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Methods of treating necrotizing enterocolitis |
| JP2005522521A (ja) | 2002-04-15 | 2005-07-28 | ベス イスラエル デアコネス メディカル センター | ヘムオキシゲナーゼ−1およびヘム分解産物の使用法 |
| EP1505990B1 (en) | 2002-05-17 | 2011-08-24 | Yale University | Methods of treating hepatitis |
| DE10230165A1 (de) | 2002-07-04 | 2004-01-15 | Ino Therapeutics Gmbh | Verfahren und Vorrichtung zur Administration von Kohlenmonoxid |
| AU2003283982A1 (en) * | 2002-11-07 | 2004-06-03 | University Of Pittsburgh Of The Commonwealth System Of High Education | Treatment for hemorrhagic shock |
| EP1684580A2 (en) * | 2003-10-22 | 2006-08-02 | Fred Hutchinson Cancer Research Center | Methods, compositions and devices for inducing stasis in tissues and organs |
| EP1552840A1 (en) * | 2004-01-07 | 2005-07-13 | Aga Ab | Use of a xenon/carbon monoxide mixture for the protection of cells |
| SI1934236T1 (sl) | 2005-09-02 | 2013-02-28 | Glycomimetics, Inc. | Heterobifunkcionalni inhibitorji pan-selektina |
| US8895510B2 (en) | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| WO2010054393A1 (en) * | 2008-11-10 | 2010-05-14 | Mount Sinai School Of Medicine Of New York University | Methods of inhibiting inflammation-associated tissue damage by inhibiting neutrophil activity |
| CN101732348B (zh) * | 2008-11-11 | 2015-01-14 | 威世药业(如皋)有限公司 | 牛痘疫苗致炎兔皮提取物在制备急性脑血管疾病治疗药物中的用途 |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
| EP2734235B1 (en) | 2011-07-21 | 2017-03-22 | Alfama, Inc. | Ruthenium carbon monoxide releasing molecules and uses thereof |
| KR102055958B1 (ko) | 2011-12-22 | 2019-12-13 | 글리코미메틱스, 인크. | E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법 |
| EP2842966B1 (en) * | 2012-04-27 | 2018-08-15 | Nihon University | Therapeutic agent for epithelial and endothelial injury |
| CA2891514C (en) | 2012-12-07 | 2020-08-25 | Glycomimetics, Inc. | Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells |
| PT3227310T (pt) | 2014-12-03 | 2019-11-06 | Glycomimetics Inc | Inibidores heterobifuncionais de e-selectinas e recetores de quimiocina cxcr4 |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| US11433086B2 (en) | 2016-08-08 | 2022-09-06 | Glycomimetics, Inc. | Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4 |
| CN109890421B (zh) | 2016-10-07 | 2023-10-20 | 糖模拟物有限公司 | 高效的多聚体e-选择蛋白拮抗剂 |
| CA3054605A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| JP7275131B2 (ja) | 2017-11-30 | 2023-05-17 | グリコミメティクス, インコーポレイテッド | 骨髄浸潤リンパ球を動員する方法、およびその使用 |
| AU2018395417B2 (en) | 2017-12-29 | 2023-07-13 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| WO2019173229A1 (en) | 2018-03-05 | 2019-09-12 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| WO2022011247A1 (en) * | 2020-07-10 | 2022-01-13 | Children's Medical Center Corporation | Targeted drug delivery to sites of intravascular occlusion |
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| US5378464A (en) * | 1989-03-08 | 1995-01-03 | Board Of Regents Of The University Of Oklahoma | Modulation of inflammatory responses by administration of GMP-140 or antibody to GMP-140 |
| DE69333447T2 (de) * | 1992-05-22 | 2009-09-10 | Montana State University, Bozeman | Antikörper mit spezifikäten gegen mehrere adhäsionsmoleküle |
| US5591835A (en) * | 1992-06-29 | 1997-01-07 | Glycomed Incorporated | Substituted lactose derivatives |
| WO1994005314A1 (en) * | 1992-09-08 | 1994-03-17 | Centocor, Inc. | Peptide inhibitors of leukocyte adhesion |
| WO1994012215A1 (en) * | 1992-12-01 | 1994-06-09 | Protein Design Labs, Inc. | Humanized antibodies reactive with l-selectin |
| CA2182215A1 (en) * | 1994-01-28 | 1995-08-03 | Reiji Kannagi | Anti-inflammatory containing monoclonal antibodies having reactivity with sialyl-lewis x sugar chains originating in hemangioendothelial cell membrane |
| DE4403057C1 (de) * | 1994-02-02 | 1994-12-08 | Biotest Pharma Gmbh | Thrombozytenstabilisierende Faktor IX-Fragmente, deren Herstellung sowie sie enthaltende Arzneimittel |
| DE4421433C1 (de) * | 1994-06-18 | 1995-06-08 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit Wirkstoffen, die Kohlenmonoxid-Quellen darstellen, Verfahren zu seiner Herstellung und seine Verwendung |
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1997
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- 1997-09-25 ES ES97944453T patent/ES2285740T3/es not_active Expired - Lifetime
- 1997-09-25 AU AU45942/97A patent/AU4594297A/en not_active Abandoned
- 1997-09-25 DE DE69737562T patent/DE69737562T2/de not_active Expired - Lifetime
- 1997-09-25 WO PCT/US1997/017229 patent/WO1998013058A1/en not_active Ceased
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- 1997-09-25 EP EP07006886A patent/EP1829550A3/en not_active Withdrawn
- 1997-09-25 JP JP10515905A patent/JP2001501612A/ja active Pending
- 1997-09-25 PT PT97944453T patent/PT951292E/pt unknown
- 1997-09-25 CA CA2266640A patent/CA2266640C/en not_active Expired - Fee Related
- 1997-09-25 EP EP97944453A patent/EP0951292B1/en not_active Expired - Lifetime
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| EP0951292B1 (en) | 2007-04-04 |
| ES2285740T3 (es) | 2007-11-16 |
| DE69737562D1 (de) | 2007-05-16 |
| EP0951292A1 (en) | 1999-10-27 |
| PT951292E (pt) | 2007-06-18 |
| CA2266640A1 (en) | 1998-04-02 |
| WO1998013058A1 (en) | 1998-04-02 |
| CA2266640C (en) | 2011-05-24 |
| ATE358492T1 (de) | 2007-04-15 |
| EP1829550A3 (en) | 2008-04-30 |
| JP2001501612A (ja) | 2001-02-06 |
| EP0951292A4 (en) | 2004-08-04 |
| AU4594297A (en) | 1998-04-17 |
| EP1829550A2 (en) | 2007-09-05 |
| DK0951292T3 (da) | 2007-08-13 |
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