DE69736526D1 - Therapeutische verwendung von stickstoffmonoxydinhibitoren - Google Patents

Therapeutische verwendung von stickstoffmonoxydinhibitoren

Info

Publication number
DE69736526D1
DE69736526D1 DE69736526T DE69736526T DE69736526D1 DE 69736526 D1 DE69736526 D1 DE 69736526D1 DE 69736526 T DE69736526 T DE 69736526T DE 69736526 T DE69736526 T DE 69736526T DE 69736526 D1 DE69736526 D1 DE 69736526D1
Authority
DE
Germany
Prior art keywords
tissue
inhibitor
cells
population
bone marrow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69736526T
Other languages
English (en)
Other versions
DE69736526T2 (de
Inventor
Grigori N Enikolopov
Natalia I Peunova
Boris Kuzin
Hollis Cline
Tatiyana Michurina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cold Spring Harbor Laboratory
Original Assignee
Cold Spring Harbor Laboratory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cold Spring Harbor Laboratory filed Critical Cold Spring Harbor Laboratory
Publication of DE69736526D1 publication Critical patent/DE69736526D1/de
Application granted granted Critical
Publication of DE69736526T2 publication Critical patent/DE69736526T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69736526T 1996-11-13 1997-11-13 Therapeutische verwendung von stickstoffmonoxydinhibitoren Expired - Fee Related DE69736526T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3069096P 1996-11-13 1996-11-13
US30690P 1996-11-13
US4541197P 1997-05-02 1997-05-02
US45411P 1997-05-02
PCT/US1997/020575 WO1998020865A2 (en) 1996-11-13 1997-11-13 Therapeutic uses for nitric oxide inhibitors

Publications (2)

Publication Number Publication Date
DE69736526D1 true DE69736526D1 (de) 2006-09-28
DE69736526T2 DE69736526T2 (de) 2007-04-26

Family

ID=26706342

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69736526T Expired - Fee Related DE69736526T2 (de) 1996-11-13 1997-11-13 Therapeutische verwendung von stickstoffmonoxydinhibitoren

Country Status (7)

Country Link
US (2) US5977181A (de)
EP (1) EP0952828B1 (de)
AT (1) ATE336240T1 (de)
AU (1) AU5585598A (de)
CA (1) CA2271729A1 (de)
DE (1) DE69736526T2 (de)
WO (1) WO1998020865A2 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0952828B1 (de) 1996-11-13 2006-08-16 Cold Spring Harbor Laboratory Therapeutische verwendung von stickstoffmonoxydinhibitoren
WO2000071112A1 (en) * 1997-11-13 2000-11-30 Cold Spring Harbor Laboratory Therapeutic uses for nitric oxide inhibitors
US6372796B1 (en) * 1996-11-13 2002-04-16 Cold Spring Harbor Laboratory Therapeutic uses for nitric oxide inhibitors
US6593372B2 (en) 1996-11-13 2003-07-15 Cold Spring Harbor Laboratory Therapeutic uses for nitric oxide inhibitors
AU8647198A (en) * 1997-08-12 1999-03-01 Chugai Seiyaku Kabushiki Kaisha Remedies for diseases associated with bone resorption
US6589759B1 (en) 1999-03-30 2003-07-08 Trustees Of Boston University Compositions and methods for producing platelets and/or proplatelets from megakaryocytes
AU2003218099A1 (en) * 2002-03-12 2003-09-29 Lsu Medical Center Modulation of the immune response through the manipulation of arginine levels
WO2008034929A1 (es) * 2006-09-19 2008-03-27 Fundación Progreso Y Salud Método para el cultivo y mantenimiento de células troncales pluripotenciales y de células progenitoras de mamífero en estado no diferenciado
EP2318007B1 (de) 2008-08-15 2013-01-23 N30 Pharmaceuticals, Inc. Neuartige pyrrolhemmer der s-nitrosoglutathion-reduktase als therapeutische mittel
ES2572615T3 (es) 2008-08-15 2016-06-01 Nivalis Therapeutics, Inc. Nuevos inhibidores pirrólicos de S-nitrosoglutatión reductasa como agentes terapéuticos
US8642628B2 (en) * 2008-08-15 2014-02-04 N30 Pharmaceuticals, Inc. Pyrrole inhibitors of S-nitrosoglutathione reductase
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
AU2011230537C1 (en) 2010-03-26 2018-08-02 Trustees Of Dartmouth College Vista regulatory T cell mediator protein, vista binding agents and use thereof
EP2625577B1 (de) 2010-10-08 2019-06-26 Terumo BCT, Inc. Anpassbares verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem
US20140113945A1 (en) * 2011-07-05 2014-04-24 N30 Pharmaceuticals, Inc. Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents for Liver Toxicity
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
CN105246507B (zh) 2012-09-07 2019-01-25 达特茅斯大学理事会 用于诊断和治疗癌症的vista调节剂
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
DK3087098T3 (da) 2013-12-24 2020-06-08 Janssen Pharmaceutica Nv Anti-Vista-antistoffer og -fragmenter
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
JP6997619B2 (ja) 2014-06-11 2022-01-17 キャシー・エイ・グリーン 液性免疫の抑制または増進のための、ｖｉｓｔａアゴニスト及びｖｉｓｔａアンタゴニストの使用
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
JP2018505911A (ja) 2014-12-05 2018-03-01 イミュネクスト，インコーポレーテッド 推定上のｖｉｓｔａ受容体としてのｖｓｉｇ８の同定と、ｖｉｓｔａ／ｖｓｉｇ８調節剤を産生するためのその使用
CA2990360C (en) 2015-06-24 2024-02-13 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017137830A1 (en) 2016-02-12 2017-08-17 Janssen Pharmaceutica Nv Anti-vista (b7h5) antibodies
WO2017181139A2 (en) 2016-04-15 2017-10-19 Michael Molloy Anti-human vista antibodies and use thereof
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
EP3656841A1 (de) 2017-03-31 2020-05-27 Terumo BCT, Inc. Zellexpansion
US12043823B2 (en) 2021-03-23 2024-07-23 Terumo Bct, Inc. Cell capture and expansion

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08510745A (ja) * 1993-05-20 1996-11-12 リサーチ・コーポレイション・テクノロジーズ・インコーポレイテッド 骨髄前駆体細胞増殖および敗血症ショックの処置のためのペプチド
JPH07316023A (ja) * 1994-05-26 1995-12-05 Shiseido Co Ltd 育毛料
EP0952828B1 (de) 1996-11-13 2006-08-16 Cold Spring Harbor Laboratory Therapeutische verwendung von stickstoffmonoxydinhibitoren

Also Published As

Publication number Publication date
WO1998020865A2 (en) 1998-05-22
US20030119905A1 (en) 2003-06-26
CA2271729A1 (en) 1998-05-22
US5977181A (en) 1999-11-02
DE69736526T2 (de) 2007-04-26
AU5585598A (en) 1998-06-03
EP0952828B1 (de) 2006-08-16
WO1998020865A3 (en) 1998-07-23
ATE336240T1 (de) 2006-09-15
EP0952828A2 (de) 1999-11-03
US6809117B2 (en) 2004-10-26

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: ENIKOLOPOV, GRIGORI, COLD SPRING HARBOR, NY 11, US

Inventor name: PEUNOVA, NATALIA I., COLD SPRING HARBOR,YNY 11, US

Inventor name: KUZIN, BORIS, MOSCOW, 117607, RU

Inventor name: CLINE, HOLLIS, COLD SPRING HARBOUR, NY 11724, US

Inventor name: MICHURINA, TATIYANA, MOSCOW 117808, RU

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee