DE69735477T2 - Process zur verwendung des obese-gens und seines genprodukts zur stimulierung der entwicklung von haemotopoietischen zellen - Google Patents
Process zur verwendung des obese-gens und seines genprodukts zur stimulierung der entwicklung von haemotopoietischen zellen Download PDFInfo
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- DE69735477T2 DE69735477T2 DE69735477T DE69735477T DE69735477T2 DE 69735477 T2 DE69735477 T2 DE 69735477T2 DE 69735477 T DE69735477 T DE 69735477T DE 69735477 T DE69735477 T DE 69735477T DE 69735477 T2 DE69735477 T2 DE 69735477T2
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0641—Erythrocytes
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/0634—Cells from the blood or the immune system
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/14—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/355—Leptin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
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- Medicinal Chemistry (AREA)
- Immunology (AREA)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
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- Developmental Biology & Embryology (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58991596A | 1996-01-23 | 1996-01-23 | |
| US589915 | 1996-01-23 | ||
| US618957 | 1996-03-20 | ||
| US08/618,957 US6355237B1 (en) | 1994-09-14 | 1996-03-20 | Methods for using the obese gene and its gene product to stimulate hematopoietic development |
| US71329696A | 1996-09-13 | 1996-09-13 | |
| US713296 | 1996-09-13 | ||
| PCT/US1997/000767 WO1997027286A1 (en) | 1996-01-23 | 1997-01-21 | Methods for using the obese gene and its gene product to stimulate hematopoietic development |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69735477D1 DE69735477D1 (de) | 2006-05-11 |
| DE69735477T2 true DE69735477T2 (de) | 2006-11-30 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69735477T Expired - Fee Related DE69735477T2 (de) | 1996-01-23 | 1997-01-21 | Process zur verwendung des obese-gens und seines genprodukts zur stimulierung der entwicklung von haemotopoietischen zellen |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1731164A1 (enExample) |
| JP (2) | JP4018142B2 (enExample) |
| AT (1) | ATE320479T1 (enExample) |
| AU (1) | AU731685C (enExample) |
| CA (1) | CA2244693A1 (enExample) |
| DE (1) | DE69735477T2 (enExample) |
| DK (1) | DK0892849T3 (enExample) |
| ES (1) | ES2260784T3 (enExample) |
| PT (1) | PT892849E (enExample) |
| WO (1) | WO1997027286A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001968A (en) * | 1994-08-17 | 1999-12-14 | The Rockefeller University | OB polypeptides, modified forms and compositions |
| ATE303437T1 (de) * | 1996-01-04 | 2005-09-15 | Amgen Inc | Rezeptor des ob-proteins und verwandte zusammensetzungen und verfahren |
| US6541604B1 (en) | 1996-01-08 | 2003-04-01 | Genentech, Inc. | Leptin receptor having a WSX motif |
| US7074397B1 (en) | 1996-01-08 | 2006-07-11 | Genentech, Inc. | Method for enhancing proliferation or differentiation of a cell using ob protein |
| US20050019325A1 (en) | 1996-01-08 | 2005-01-27 | Carter Paul J. | WSX receptor agonist antibodies |
| IL120733A0 (en) * | 1997-04-29 | 1997-08-14 | Yeda Res & Dev | Leptin as an inhibitor of cell proliferation |
| FR2767136B1 (fr) * | 1997-08-06 | 2004-08-27 | Genset Sa | Recepteur complexe lsr, activite, clonage, et applications au diagnostic, a la prevention et/ou au traitement de l'obesite et des risques ou complications associes |
| FR2767135B1 (fr) | 1997-08-06 | 2002-07-12 | Genset Sa | Recepteur complexe lsr, activite, clonage, et application au diagnostic, a la prevention et/ou au traitement de d'obesite et des risques ou complications associes |
| AU4672199A (en) * | 1998-05-20 | 1999-12-06 | Yale University | Modulation of angiogenesis and wound healing |
| US7208572B2 (en) | 1998-08-21 | 2007-04-24 | Albany Medical College | Leptin-related peptides |
| US6777388B1 (en) | 1998-08-21 | 2004-08-17 | Clf Medical Technology Acceleration Program, Inc. | Leptin-related peptides |
| IL141683A0 (en) * | 1998-08-31 | 2002-03-10 | Univ New York | Stem cells bearing an fgf receptor on the cell surface |
| EP1127120B1 (en) | 1998-11-04 | 2008-05-28 | Serono Genetics Institute S.A. | Genomic and complete cdna sequences of human adipocyte-specific apm1 and biallelic markers thereof |
| CA2359757A1 (en) | 1999-02-10 | 2000-08-17 | Genset S.A. | Polymorphic markers of the lsr gene |
| US20050272652A1 (en) | 1999-03-29 | 2005-12-08 | Gault Victor A | Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity |
| IL132312A0 (en) * | 1999-09-05 | 2001-03-19 | Yeda Res & Dev | Use of leptin in inhibition of endothelial cell proliferation |
| US6566332B2 (en) | 2000-01-14 | 2003-05-20 | Genset S.A. | OBG3 globular head and uses thereof for decreasing body mass |
| US6989367B2 (en) | 2000-01-14 | 2006-01-24 | Genset S.A. | OBG3 globular head and uses thereof |
| US7338787B2 (en) | 2000-01-14 | 2008-03-04 | Serono Genetics Institute S.A. | Nucleic acids encoding OBG3 globular head and uses thereof |
| US20020058617A1 (en) | 2000-01-14 | 2002-05-16 | Joachim Fruebis | OBG3 globular head and uses thereof for decreasing body mass |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| EP1718665B1 (en) | 2004-02-11 | 2013-04-10 | Amylin Pharmaceuticals, LLC | Hybrid polypeptides with selectable properties |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| AU2006213607A1 (en) | 2005-02-11 | 2006-08-17 | Amylin Pharmaceuticals, Llc | GIP analog and hybrid polypeptides with selectable properties |
| EP1922336B1 (en) | 2005-08-11 | 2012-11-21 | Amylin Pharmaceuticals, LLC | Hybrid polypeptides with selectable properties |
| EP2330125A3 (en) | 2005-08-11 | 2012-12-12 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides with selectable properties |
| US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| TWI752920B (zh) | 2015-10-12 | 2022-01-21 | 美商再生元醫藥公司 | 活化瘦素受體的抗原結合蛋白 |
| FI3538554T3 (fi) | 2016-11-08 | 2025-09-24 | Regeneron Pharma | Antigeeniä sitovia proteiineja, jotka antagonisoivat leptiinireseptoria |
| AU2018390811A1 (en) | 2017-12-18 | 2020-07-02 | Regeneron Pharmaceuticals, Inc. | Bispecific antigen binding molecules that bind leptin receptor and/or GP130, and methods of use thereof |
| CA3094400A1 (en) | 2018-04-06 | 2019-10-10 | Regeneron Pharmaceuticals, Inc. | A leptin receptor agonist antibody for use in treating a metabolic dysfunction or hypoleptinemia |
| WO2020023621A1 (en) * | 2018-07-24 | 2020-01-30 | Puneeth Iyengar | Improved weight loss therapy |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5643748A (en) * | 1994-09-14 | 1997-07-01 | Progenitor, Inc. | HU-B1.219, a novel human hematopoietin receptor |
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- 1997-01-21 EP EP06004170A patent/EP1731164A1/en not_active Withdrawn
- 1997-01-21 PT PT97903840T patent/PT892849E/pt unknown
- 1997-01-21 DK DK97903840T patent/DK0892849T3/da active
- 1997-01-21 JP JP52692197A patent/JP4018142B2/ja not_active Expired - Fee Related
- 1997-01-21 ES ES97903840T patent/ES2260784T3/es not_active Expired - Lifetime
- 1997-01-21 EP EP97903840A patent/EP0892849B1/en not_active Expired - Lifetime
- 1997-01-21 AT AT97903840T patent/ATE320479T1/de not_active IP Right Cessation
- 1997-01-21 DE DE69735477T patent/DE69735477T2/de not_active Expired - Fee Related
- 1997-01-21 CA CA002244693A patent/CA2244693A1/en not_active Abandoned
- 1997-01-21 WO PCT/US1997/000767 patent/WO1997027286A1/en not_active Ceased
- 1997-01-21 AU AU18311/97A patent/AU731685C/en not_active Ceased
-
2006
- 2006-12-28 JP JP2006355150A patent/JP2007163502A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0892849A1 (en) | 1999-01-27 |
| ES2260784T3 (es) | 2006-11-01 |
| WO1997027286A1 (en) | 1997-07-31 |
| AU731685B2 (en) | 2001-04-05 |
| DK0892849T3 (da) | 2006-07-24 |
| CA2244693A1 (en) | 1997-07-31 |
| EP0892849B1 (en) | 2006-03-15 |
| EP0892849A4 (en) | 2004-08-25 |
| PT892849E (pt) | 2006-08-31 |
| JP4018142B2 (ja) | 2007-12-05 |
| EP1731164A1 (en) | 2006-12-13 |
| JP2007163502A (ja) | 2007-06-28 |
| AU731685C (en) | 2002-08-22 |
| DE69735477D1 (de) | 2006-05-11 |
| JP2001510982A (ja) | 2001-08-07 |
| ATE320479T1 (de) | 2006-04-15 |
| AU1831197A (en) | 1997-08-20 |
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|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |