DE69735436D1 - Methode zum nachweis von zell-apoptose - Google Patents

Methode zum nachweis von zell-apoptose

Info

Publication number
DE69735436D1
DE69735436D1 DE69735436T DE69735436T DE69735436D1 DE 69735436 D1 DE69735436 D1 DE 69735436D1 DE 69735436 T DE69735436 T DE 69735436T DE 69735436 T DE69735436 T DE 69735436T DE 69735436 D1 DE69735436 D1 DE 69735436D1
Authority
DE
Germany
Prior art keywords
detection
apoptosis
methods
cell apoptosis
kits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69735436T
Other languages
English (en)
Other versions
DE69735436T2 (de
Inventor
Robert Siman
Donna Bozyczko-Coyne
L Meyer
Venkatraman Bhat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon LLC
Original Assignee
Cephalon LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon LLC filed Critical Cephalon LLC
Application granted granted Critical
Publication of DE69735436D1 publication Critical patent/DE69735436D1/de
Publication of DE69735436T2 publication Critical patent/DE69735436T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69735436T 1996-11-15 1997-11-13 Methode zum nachweis von zell-apoptose Expired - Lifetime DE69735436T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3096196P 1996-11-15 1996-11-15
US30961P 1996-11-15
US967625 1997-11-12
US08/967,625 US6048703A (en) 1996-11-15 1997-11-12 Methods for detecting cell apoptosis
PCT/US1997/020214 WO1998021590A1 (en) 1996-11-15 1997-11-13 Methods for detecting cell apoptosis

Publications (2)

Publication Number Publication Date
DE69735436D1 true DE69735436D1 (de) 2006-05-04
DE69735436T2 DE69735436T2 (de) 2006-10-26

Family

ID=26706638

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69735436T Expired - Lifetime DE69735436T2 (de) 1996-11-15 1997-11-13 Methode zum nachweis von zell-apoptose

Country Status (9)

Country Link
US (2) US6048703A (de)
EP (1) EP0975971B1 (de)
AT (1) ATE320006T1 (de)
AU (1) AU5169998A (de)
CA (1) CA2270866A1 (de)
DE (1) DE69735436T2 (de)
DK (1) DK0975971T3 (de)
HK (1) HK1026739A1 (de)
WO (1) WO1998021590A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342611B1 (en) * 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
EP1116029B1 (de) * 1998-09-24 2007-12-26 Promega Corporation Antikörper für apoptosemarker und anwendungsverfahren
JP2002542261A (ja) * 1999-04-15 2002-12-10 メルク フロスト カナダ アンド カンパニー カスパーゼにより切断されたａｐｐを認識する抗体及びその使用法
WO2001016180A2 (en) * 1999-08-27 2001-03-08 Board Of Regents, The University Of Texas System Cd40 agonist compositions and methods of use
DE60115453T2 (de) * 2000-07-21 2006-08-24 Evotec Ag Verfahren zur detektion der apoptose durch ermittlung von cytochrom c als apoptosespezifischem marker, der durch zelluläre ausschüttungsvorgänge ins extrazelluläre medium abgegeben wird
AU2002361642A1 (en) * 2001-11-16 2003-06-10 The University Of Tennessee Research Corporation Recombinant antibody fusion proteins and methods for detection of apoptotic cells
US7357928B2 (en) 2002-04-08 2008-04-15 University Of Louisville Research Foundation, Inc. Method for the diagnosis and prognosis of malignant diseases
US7541150B2 (en) * 2002-04-08 2009-06-02 University Of Louisville Research Foundation, Inc Method for the diagnosis and prognosis of malignant diseases
DE60331310D1 (de) * 2002-06-26 2010-04-01 Univ Louisville Res Found Verfahren zum apoptosenachweis
US7396654B2 (en) 2004-04-15 2008-07-08 University Of Florida Research Foundation, Inc. Neural proteins as biomarkers for traumatic brain injury
ES2367311T3 (es) * 2004-04-15 2011-11-02 University Of Florida Research Foundation, Inc. Productos de degradación proteolítica de map-2 como biomarcadores de diagnóstico para las lesiones neurales.
US8492107B2 (en) * 2004-04-15 2013-07-23 University Of Florida Research Foundation, Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
WO2006081190A2 (en) 2005-01-25 2006-08-03 Five Prime Therapeutics, Inc. Compositions and methods for treating cardiac conditions
US8379197B2 (en) * 2006-01-05 2013-02-19 Chemimage Corporation Spectroscopic systems and methods for classifying and pharmaceutically treating cells
DK2044120T3 (da) * 2006-06-07 2019-04-15 Bioalliance Cv Antistoffer, der genkender en kulhydratholdig epitop på cd-43 og cea eksprimeret på cancerceller, og fremgangsmåder til anvendelse deraf
WO2008021211A2 (en) * 2006-08-10 2008-02-21 Fred Hutchinson Cancer Research Center Compositions and methods for modulating apoptosis in cells over-expressing bcl-2 family member proteins
NZ585959A (en) 2007-12-18 2012-09-28 Bioalliance Cv Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same
WO2009088837A2 (en) * 2007-12-31 2009-07-16 The University Of Louisville Research Foundation, Inc. Methods and products to target, capture and characterize stem cells
CA2733990C (en) * 2008-08-11 2018-12-11 Banyan Biomarkers, Inc. Biomarker detection process and assay of neurological condition
WO2011041737A2 (en) 2009-10-02 2011-04-07 Fred Hutchinson Cancer Research Center Gain-of-function bcl-2 inhibitors
WO2011041731A2 (en) 2009-10-02 2011-04-07 Fred Hutchinson Cancer Research Center Method of inhibiting bcl-2-related survival proteins
US9260517B2 (en) 2009-11-17 2016-02-16 Musc Foundation For Research Development Human monoclonal antibodies to human nucleolin
ES2690557T3 (es) 2011-06-02 2018-11-21 University Of Louisville Research Foundation, Inc. Nanopartículas conjugadas a un agente antinucleolina
WO2016179394A1 (en) 2015-05-05 2016-11-10 Malik Mohammad Tariq Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2165777A1 (en) * 1993-06-24 1995-01-05 Junying Yuan Programmed cell death genes and proteins
US5536639A (en) * 1994-03-25 1996-07-16 Cephalon, Inc. Methods for detecting calpain activation by detection of calpain activated spectrin breakdown products
US5605826A (en) * 1994-06-10 1997-02-25 Panorama Research, Inc. 24 kilodalton cytoplasmic protease activating DNA fragmentation in apoptosis
US6288037B1 (en) * 1996-01-29 2001-09-11 Basf Aktiengesellschaft Substrates and inhibitors for cysteine protease ICH-1

Also Published As

Publication number Publication date
EP0975971B1 (de) 2006-03-08
HK1026739A1 (en) 2000-12-22
CA2270866A1 (en) 1998-05-22
DE69735436T2 (de) 2006-10-26
DK0975971T3 (da) 2006-07-03
AU5169998A (en) 1998-06-03
US7256252B1 (en) 2007-08-14
EP0975971A1 (de) 2000-02-02
ATE320006T1 (de) 2006-03-15
EP0975971A4 (de) 2002-09-25
US6048703A (en) 2000-04-11
WO1998021590A1 (en) 1998-05-22

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