DE69732568D1 - Druckbeständige protein-mikrosphäre als ultraschallkontrastmittel - Google Patents

Druckbeständige protein-mikrosphäre als ultraschallkontrastmittel

Info

Publication number
DE69732568D1
DE69732568D1 DE69732568T DE69732568T DE69732568D1 DE 69732568 D1 DE69732568 D1 DE 69732568D1 DE 69732568 T DE69732568 T DE 69732568T DE 69732568 T DE69732568 T DE 69732568T DE 69732568 D1 DE69732568 D1 DE 69732568D1
Authority
DE
Germany
Prior art keywords
pressure
ultrasound contrast
resistant protein
microspheres
perfluoroalkane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69732568T
Other languages
English (en)
Other versions
DE69732568T2 (de
Inventor
G Jablonski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Biosystems Inc
Original Assignee
Molecular Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Biosystems Inc filed Critical Molecular Biosystems Inc
Application granted granted Critical
Publication of DE69732568D1 publication Critical patent/DE69732568D1/de
Publication of DE69732568T2 publication Critical patent/DE69732568T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE69732568T 1996-06-07 1997-06-05 Druckbeständige protein-mikrosphäre als ultraschallkontrastmittel Expired - Fee Related DE69732568T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US665028 1984-10-26
US08/665,028 US5976501A (en) 1996-06-07 1996-06-07 Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
PCT/US1997/009782 WO1997046264A2 (en) 1996-06-07 1997-06-05 Pressure resistant protein microspheres as ultrasonic imaging agents

Publications (2)

Publication Number Publication Date
DE69732568D1 true DE69732568D1 (de) 2005-03-31
DE69732568T2 DE69732568T2 (de) 2006-03-16

Family

ID=24668420

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69732568T Expired - Fee Related DE69732568T2 (de) 1996-06-07 1997-06-05 Druckbeständige protein-mikrosphäre als ultraschallkontrastmittel

Country Status (9)

Country Link
US (1) US5976501A (de)
EP (1) EP0907380B1 (de)
JP (1) JP2000512281A (de)
AT (1) ATE289520T1 (de)
AU (1) AU3478097A (de)
CA (1) CA2253734A1 (de)
DE (1) DE69732568T2 (de)
ES (1) ES2238724T3 (de)
WO (1) WO1997046264A2 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
CA2252617A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
GB9811116D0 (en) * 1998-05-23 1998-07-22 Andaris Ltd Method of altering heartbeat
US6186951B1 (en) * 1998-05-26 2001-02-13 Riverside Research Institute Ultrasonic systems and methods for fluid perfusion and flow rate measurement
US6319204B1 (en) * 2000-01-26 2001-11-20 George A Brock-Fisher Ultrasonic method for indicating a rate of perfusion
US7311893B2 (en) * 2000-07-25 2007-12-25 Neurochem (International) Limited Amyloid targeting imaging agents and uses thereof
GB0120645D0 (en) 2001-08-24 2001-10-17 Smiths Group Plc Medico-surgical devices
GB0307350D0 (en) 2003-03-29 2003-05-07 Smiths Group Plc Catheters
CA2569134C (en) * 2004-06-04 2010-11-23 Acusphere, Inc. Ultrasound contrast agent dosage formulation
DE602004026164D1 (de) * 2004-06-04 2010-05-06 Acusphere Inc Ultraschallkontrastmittel
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
BR112014032254B1 (pt) * 2012-06-26 2022-11-01 Ge Healthcare As Processo para a preparação de uma composição, aparelho, e, uso de um aparelho
US10842890B2 (en) * 2016-12-19 2020-11-24 The Johns Hopkins University Contrast agent and associated methods
WO2023156806A1 (en) * 2022-02-21 2023-08-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for manufacturing bubbles having a polymeric shell using sound waves for generating the bubbles

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
US5410516A (en) * 1988-09-01 1995-04-25 Schering Aktiengesellschaft Ultrasonic processes and circuits for performing them
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
DK0504340T3 (da) * 1990-10-05 1995-08-21 Bracco Int Bv Fremgangsmåde til fremstilling af stabile suspensioner af hule gasfyldte mikrokugler egnet til ultralyd-ekkografi
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
GB9221329D0 (en) * 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
PL176116B1 (pl) * 1993-01-25 1999-04-30 Sonus Pharma Inc Środek kontrastowy do ultrasonografii i sposób wytwarzania środka kontrastowego do ultrasonografii
IL110185A (en) * 1993-07-02 1999-05-09 Molecular Biosystems Inc Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
NO940711D0 (no) * 1994-03-01 1994-03-01 Nycomed Imaging As Preparation of gas-filled microcapsules and contrasts agents for diagnostic imaging
US5562893A (en) * 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules

Also Published As

Publication number Publication date
DE69732568T2 (de) 2006-03-16
ATE289520T1 (de) 2005-03-15
AU3478097A (en) 1998-01-05
EP0907380B1 (de) 2005-02-23
WO1997046264A3 (en) 1998-03-12
WO1997046264A2 (en) 1997-12-11
CA2253734A1 (en) 1997-12-11
ES2238724T3 (es) 2005-09-01
JP2000512281A (ja) 2000-09-19
US5976501A (en) 1999-11-02
EP0907380A2 (de) 1999-04-14

Similar Documents

Publication Publication Date Title
DE69732568D1 (de) Druckbeständige protein-mikrosphäre als ultraschallkontrastmittel
ES2183881T3 (es) Microesferas rellenas con gas con cubiertas que contienen fluor.
BR9509011A (pt) Recipiente e lipossoma contendo gás
DE69937294D1 (de) Von cyclophilin b abstammende tumorantigen-peptide
KR960703624A (ko) 단백질 캡슐화 불용성 가스 마이크로스피어 및 그것의 제조 및 초음파 영상화제로서의 이용(protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents)
NO934366L (no) Kovalent modifiserte mikropartikulaere kontrastmidler
CA2204535A1 (en) Molecules that home to a selected organ or tissue in vivo and methods of identifying same
WO2001049324A3 (en) Novel colloid synthetic vectors for gene therapy
WO1998029535A3 (en) Nanoscale particles synthesized within an assembled virion
RU93052889A (ru) Эхоконтрастное вещество и способ его получения
WO1996040280A3 (en) Liquid core microdroplets for ultrasound imaging
ATE239041T1 (de) Humane antikörper welche an humanen tnfalpha binden
WO2000061622A3 (en) Genes associated with diseases of the kidney
WO2004019861A3 (en) Stable ph optimized formulation of a modified antibody
NO944805D0 (no) Mikropartikkel, fremgangsmåte for fremstilling samt anvendelse derav i diagnostikken
JP2008543475A (ja) チャープ反転超音波コントラスト撮像
CA2268029A1 (en) Therapeutic and diagnostic applications of laminin and laminin-derived protein fragments
WO2001008711A3 (en) Stable microbubbles for the use as an ultrasound contrast agent
WO2000029448A3 (en) Human proteins having hydrophobic domains and dnas encoding these proteins
WO1997029199A3 (en) Prostate specific antigen peptides and uses thereof
WO2001057198A3 (en) Methods of generating protein expression arrays and the use thereof in rapid screening
WO2001012660A3 (en) HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS
WO2001002563A3 (en) HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS
EA200000198A1 (ru) 2-ациламинопропанамины в качестве антагонистов рецепторов тахикининов
CA2236837A1 (en) Detection of mammary tumor virus-like sequences in human breast cancer

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee