ES2183881T3 - Microesferas rellenas con gas con cubiertas que contienen fluor. - Google Patents
Microesferas rellenas con gas con cubiertas que contienen fluor.Info
- Publication number
- ES2183881T3 ES2183881T3 ES95927536T ES95927536T ES2183881T3 ES 2183881 T3 ES2183881 T3 ES 2183881T3 ES 95927536 T ES95927536 T ES 95927536T ES 95927536 T ES95927536 T ES 95927536T ES 2183881 T3 ES2183881 T3 ES 2183881T3
- Authority
- ES
- Spain
- Prior art keywords
- gas
- microspheras
- filled
- covers containing
- containing fluor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002872 contrast media Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000004005 microsphere Substances 0.000 abstract 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 238000002059 diagnostic imaging Methods 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acoustics & Sound (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Luminescent Compositions (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
SE FACILITAN AGENTES DE CONTRASTE PARA LA VISUALIZACION ULTRASONICA QUE ESTAN CONSTITUIDOS POR UNA SUSPENSION ACUOSA DE MICROESFERAS QUE INCLUYEN AL MENOS UN GAS, PREFERIBLEMENTE UN PERFLUOROCARBONO, ENCAPSULADO POR FUNDAS ELASTICAS DE UN MATERIAL BIOCOMPATIBLE AMFIFILICO QUE CONTIENE FLUORINA, PROCESOS PARA CONSTRUIR LAS MICROESFERAS, Y METODOS DE VISUALIZACION DIAGNOSTICA UTILIZANDO LOS AGENTES MEJORADOS DE CONTRASTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/284,782 US5562893A (en) | 1994-08-02 | 1994-08-02 | Gas-filled microspheres with fluorine-containing shells |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2183881T3 true ES2183881T3 (es) | 2003-04-01 |
Family
ID=23091515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95927536T Expired - Lifetime ES2183881T3 (es) | 1994-08-02 | 1995-07-31 | Microesferas rellenas con gas con cubiertas que contienen fluor. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5562893A (es) |
EP (1) | EP0769969B1 (es) |
JP (1) | JPH10505585A (es) |
KR (1) | KR970704475A (es) |
AT (1) | ATE224205T1 (es) |
AU (1) | AU703652B2 (es) |
CA (1) | CA2196599A1 (es) |
DE (1) | DE69528270T2 (es) |
ES (1) | ES2183881T3 (es) |
WO (1) | WO1996004018A1 (es) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5656211A (en) | 1989-12-22 | 1997-08-12 | Imarx Pharmaceutical Corp. | Apparatus and method for making gas-filled vesicles of optimal size |
US6001335A (en) | 1989-12-22 | 1999-12-14 | Imarx Pharmaceutical Corp. | Contrasting agents for ultrasonic imaging and methods for preparing the same |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US5776429A (en) | 1989-12-22 | 1998-07-07 | Imarx Pharmaceutical Corp. | Method of preparing gas-filled microspheres using a lyophilized lipids |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US6146657A (en) | 1989-12-22 | 2000-11-14 | Imarx Pharmaceutical Corp. | Gas-filled lipid spheres for use in diagnostic and therapeutic applications |
US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US5305757A (en) | 1989-12-22 | 1994-04-26 | Unger Evan C | Gas filled liposomes and their use as ultrasonic contrast agents |
US5469854A (en) | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5922304A (en) | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US5773024A (en) | 1989-12-22 | 1998-06-30 | Imarx Pharmaceutical Corp. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
US5705187A (en) | 1989-12-22 | 1998-01-06 | Imarx Pharmaceutical Corp. | Compositions of lipids and stabilizing materials |
US5874062A (en) | 1991-04-05 | 1999-02-23 | Imarx Pharmaceutical Corp. | Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
US6723303B1 (en) | 1991-09-17 | 2004-04-20 | Amersham Health, As | Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane |
US6875420B1 (en) | 1991-09-17 | 2005-04-05 | Amersham Health As | Method of ultrasound imaging |
MX9205298A (es) | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
IL108416A (en) * | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Colloids with phase difference as contrast ultrasound agents |
CA2154590C (en) * | 1993-01-25 | 2001-06-12 | Steven C. Quay | Phase shift colloids as ultrasound contrast agents |
CA2164813C (en) * | 1993-07-30 | 2009-11-24 | Ernest G. Schutt | Stabilized microbubble compositions for ultrasound |
AU7655194A (en) | 1993-09-09 | 1995-03-27 | Schering Aktiengesellschaft | Active principles and gas containing microparticles |
US7083572B2 (en) * | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
AU679295B2 (en) * | 1993-12-15 | 1997-06-26 | Bracco Suisse S.A. | Gas mixtures useful as ultrasound contrast media |
US5736121A (en) | 1994-05-23 | 1998-04-07 | Imarx Pharmaceutical Corp. | Stabilized homogenous suspensions as computed tomography contrast agents |
US5965109A (en) * | 1994-08-02 | 1999-10-12 | Molecular Biosystems, Inc. | Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier |
US5562893A (en) * | 1994-08-02 | 1996-10-08 | Molecular Biosystems, Inc. | Gas-filled microspheres with fluorine-containing shells |
US5730955A (en) * | 1994-08-02 | 1998-03-24 | Molecular Biosystems, Inc. | Process for making gas-filled microspheres containing a liquid hydrophobic barrier |
US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
US5830430A (en) | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
US5997898A (en) | 1995-06-06 | 1999-12-07 | Imarx Pharmaceutical Corp. | Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery |
US6033645A (en) | 1996-06-19 | 2000-03-07 | Unger; Evan C. | Methods for diagnostic imaging by regulating the administration rate of a contrast agent |
US6231834B1 (en) | 1995-06-07 | 2001-05-15 | Imarx Pharmaceutical Corp. | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same |
US5804162A (en) | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
US5820850A (en) * | 1995-06-07 | 1998-10-13 | Molecular Biosystems, Inc. | Gas-filled amino acid block co-polymer microspheres useful as ultrasound contrast agents |
US6139819A (en) | 1995-06-07 | 2000-10-31 | Imarx Pharmaceutical Corp. | Targeted contrast agents for diagnostic and therapeutic use |
US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
US5611344A (en) * | 1996-03-05 | 1997-03-18 | Acusphere, Inc. | Microencapsulated fluorinated gases for use as imaging agents |
DE69736981D1 (de) | 1996-05-01 | 2007-01-04 | Imarx Pharmaceutical Corp | In vitro verfahren zum einbringen von nukleinsäuren in eine zelle |
US5976501A (en) * | 1996-06-07 | 1999-11-02 | Molecular Biosystems, Inc. | Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion |
US5837221A (en) * | 1996-07-29 | 1998-11-17 | Acusphere, Inc. | Polymer-lipid microencapsulated gases for use as imaging agents |
US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
US5846517A (en) | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
ES2289188T3 (es) | 1996-09-11 | 2008-02-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Procedimiento para la obtencion de imagenes para el diagnostico usando un agente de contraste y un vasodilatador. |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
US6143276A (en) | 1997-03-21 | 2000-11-07 | Imarx Pharmaceutical Corp. | Methods for delivering bioactive agents to regions of elevated temperatures |
DE69838669T2 (de) * | 1997-04-30 | 2008-10-30 | Point Biomedical Corp., San Carlos | Mikropartikel, geeignet als kontrastmittel im ultraschall und zur wirkstoffgabe in den blutkreislauf |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
AU7702798A (en) * | 1997-05-30 | 1998-12-30 | Alliance Pharmaceutical Corporation | Methods and apparatus for monitoring and quantifying the movement of fluid |
US6045777A (en) * | 1997-06-30 | 2000-04-04 | Acusphere, Inc. | Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases |
US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
US6444192B1 (en) | 1999-02-05 | 2002-09-03 | The Regents Of The University Of California | Diagnostic imaging of lymph structures |
EP1202670A4 (en) * | 1999-08-13 | 2004-11-10 | Point Biomedical Corp | HOLLOW MICROSPHERES WITH CONTROLLED FRAGILITY FOR MEDICAL USE |
AU6635900A (en) * | 1999-08-13 | 2001-03-13 | Point Biomedical Corporation | Microparticles useful as ultrasonic contrast agents and for lymphatic system |
US6919068B2 (en) * | 2002-05-17 | 2005-07-19 | Point Biomedical Corporation | Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging |
US20030215394A1 (en) * | 2002-05-17 | 2003-11-20 | Short Robert E. | Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream |
US20040185108A1 (en) * | 2003-03-18 | 2004-09-23 | Short Robert E. | Method of preparing gas-filled polymer matrix microparticles useful for delivering drug |
US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
GB0811856D0 (en) * | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
US8846063B2 (en) | 2008-12-16 | 2014-09-30 | Kimberly-Clark Worldwide, Inc. | Personal care composition containing a volatile and a terpene alcohol |
US10279053B2 (en) | 2011-07-19 | 2019-05-07 | Nuvox Pharma Llc | Microbubble compositions, method of making same, and method using same |
CN113289034A (zh) | 2014-12-31 | 2021-08-24 | 蓝瑟斯医学影像公司 | 脂质封装的气体微球组合物及相关方法 |
NL2014178B1 (en) * | 2015-01-22 | 2017-01-05 | Tide Microfluidics B V | System and method for controlled manufacturing of mono-disperse microbubbles. |
IL262647B2 (en) | 2016-05-04 | 2023-03-01 | Lantheus Medical Imaging Inc | Methods and devices for preparing sharpness factors for ultrasound |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
CN109568289B (zh) * | 2017-09-28 | 2021-09-07 | 中国科学院深圳先进技术研究院 | 胎盘样硫酸软骨素a靶向传输系统及其制备方法和应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2602774B1 (fr) * | 1986-07-29 | 1990-10-19 | Atta | Nouvelles molecules amphiphiles polyhydroxylees et perfluoroalkylees ayant des proprietes tensioactives |
AU635200B2 (en) * | 1988-02-05 | 1993-03-18 | Schering Aktiengesellschaft Berlin Und Bergkamen | Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents |
US4957656A (en) * | 1988-09-14 | 1990-09-18 | Molecular Biosystems, Inc. | Continuous sonication method for preparing protein encapsulated microbubbles |
US5234680A (en) * | 1989-07-31 | 1993-08-10 | Johns Hopkins Univ. | Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI |
US5088499A (en) * | 1989-12-22 | 1992-02-18 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
GB9003821D0 (en) * | 1990-02-20 | 1990-04-18 | Danbiosyst Uk | Diagnostic aid |
US5137928A (en) * | 1990-04-26 | 1992-08-11 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
US5190982A (en) * | 1990-04-26 | 1993-03-02 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
US5149543A (en) * | 1990-10-05 | 1992-09-22 | Massachusetts Institute Of Technology | Ionically cross-linked polymeric microcapsules |
EP0504340B1 (en) * | 1990-10-05 | 1995-06-21 | BRACCO International B.V. | Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9106673D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
GB9116610D0 (en) * | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
FR2694559B1 (fr) * | 1992-08-06 | 1994-10-28 | Atta | Nouveaux dérivés amphiphiles d'aminoacides ou de peptides, leur procédé de préparation et leur utilisation dans des préparations à usage biomédical. |
US5562893A (en) * | 1994-08-02 | 1996-10-08 | Molecular Biosystems, Inc. | Gas-filled microspheres with fluorine-containing shells |
-
1994
- 1994-08-02 US US08/284,782 patent/US5562893A/en not_active Expired - Lifetime
-
1995
- 1995-07-31 AT AT95927536T patent/ATE224205T1/de not_active IP Right Cessation
- 1995-07-31 KR KR1019970700645A patent/KR970704475A/ko not_active Application Discontinuation
- 1995-07-31 CA CA002196599A patent/CA2196599A1/en not_active Abandoned
- 1995-07-31 WO PCT/US1995/009618 patent/WO1996004018A1/en active IP Right Grant
- 1995-07-31 EP EP95927536A patent/EP0769969B1/en not_active Expired - Lifetime
- 1995-07-31 JP JP8506664A patent/JPH10505585A/ja not_active Ceased
- 1995-07-31 DE DE69528270T patent/DE69528270T2/de not_active Expired - Fee Related
- 1995-07-31 ES ES95927536T patent/ES2183881T3/es not_active Expired - Lifetime
- 1995-07-31 AU AU31536/95A patent/AU703652B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
KR970704475A (ko) | 1997-09-06 |
EP0769969A1 (en) | 1997-05-02 |
EP0769969A4 (en) | 1999-12-29 |
DE69528270T2 (de) | 2003-05-08 |
DE69528270D1 (de) | 2002-10-24 |
CA2196599A1 (en) | 1996-02-15 |
EP0769969B1 (en) | 2002-09-18 |
US5562893A (en) | 1996-10-08 |
ATE224205T1 (de) | 2002-10-15 |
JPH10505585A (ja) | 1998-06-02 |
WO1996004018A1 (en) | 1996-02-15 |
AU3153695A (en) | 1996-03-04 |
AU703652B2 (en) | 1999-04-01 |
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