DE69731960T2 - Verfahren und zusammensetzungen für die identifizierung von receptor effectoren - Google Patents
Verfahren und zusammensetzungen für die identifizierung von receptor effectoren Download PDFInfo
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- DE69731960T2 DE69731960T2 DE69731960T DE69731960T DE69731960T2 DE 69731960 T2 DE69731960 T2 DE 69731960T2 DE 69731960 T DE69731960 T DE 69731960T DE 69731960 T DE69731960 T DE 69731960T DE 69731960 T2 DE69731960 T2 DE 69731960T2
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- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US718910 | 1985-04-02 | ||
| US71891096A | 1996-09-24 | 1996-09-24 | |
| US85146997A | 1997-05-05 | 1997-05-05 | |
| US851469 | 1997-05-05 | ||
| PCT/US1997/017159 WO1998013513A2 (en) | 1996-09-24 | 1997-09-24 | Methods and compositions for identifying receptor effectors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69731960D1 DE69731960D1 (de) | 2005-01-20 |
| DE69731960T2 true DE69731960T2 (de) | 2005-12-15 |
Family
ID=27109999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69731960T Expired - Fee Related DE69731960T2 (de) | 1996-09-24 | 1997-09-24 | Verfahren und zusammensetzungen für die identifizierung von receptor effectoren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6159705A (enExample) |
| EP (1) | EP0929691B1 (enExample) |
| JP (1) | JP2001501097A (enExample) |
| AT (1) | ATE284972T1 (enExample) |
| AU (1) | AU733007B2 (enExample) |
| CA (1) | CA2266543C (enExample) |
| DE (1) | DE69731960T2 (enExample) |
| WO (1) | WO1998013513A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008064553B4 (de) * | 2008-12-22 | 2015-05-13 | Technische Universität Dresden | Verfahren zum Nachweis und/oder zur Identifizierung hormonell wirksamer Substanzen |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6255059B1 (en) | 1993-03-31 | 2001-07-03 | Cadus Pharmaceutical Corporation | Methods for identifying G protein coupled receptor effectors |
| US6100042A (en) | 1993-03-31 | 2000-08-08 | Cadus Pharmaceutical Corporation | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor |
| US7235648B1 (en) | 1993-03-31 | 2007-06-26 | Cadus Technologies, Inc. | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor |
| US20030054402A1 (en) | 1993-03-31 | 2003-03-20 | Cadus Pharmaceutical Corporation | Methods and compositions for identifying receptor effectors |
| US6864060B1 (en) | 1993-03-31 | 2005-03-08 | Cadus Technologies, Inc. | Yeast cells expressing modified G proteins and methods of use therefor |
| US7416881B1 (en) | 1993-03-31 | 2008-08-26 | Cadus Technologies, Inc. | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor |
| US6403305B1 (en) * | 1997-02-06 | 2002-06-11 | Cornell Research Foundation, Inc. | Methods of identifying peptide agonists or negative antagonists of a G protein coupled receptor |
| US6555339B1 (en) * | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| US7119190B2 (en) * | 1997-04-14 | 2006-10-10 | Arena Pharmaceuticals, Inc. | Endogenous and non-endogenous versions of human G protein-coupled receptors |
| AU743259B2 (en) * | 1997-04-14 | 2002-01-24 | Arena Pharmaceuticals, Inc. | A method of identifying modulators of cell surface membrane receptors useful in the treatment of disease |
| AU8142598A (en) | 1997-06-11 | 1998-12-30 | New York University | Prenylcysteine carboxyl methyltransferase, dna encoding same, and a method of screening for inhibitors thereof |
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| AU9791198A (en) * | 1997-10-07 | 1999-04-27 | Cadus Pharmaceutical Corporation | Yeast cells expressing modified g proteins and methods of use therefor |
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| US20020015967A1 (en) * | 1998-06-02 | 2002-02-07 | Lauren Silverman | Functional expression of adenosine receptors in yeast |
| FR2780512B1 (fr) * | 1998-06-25 | 2003-10-17 | Lipha | Utilisation de recepteurs de la famille rev-erb pour le criblage de substances utiles dans le traitement des dysfonctionnements du metabolisme lipidique |
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| US6251605B1 (en) | 1998-10-27 | 2001-06-26 | Cadus Pharmaceutical Corporation | Yeast cells having mutations in Cav1 and uses therefor |
| AU2030000A (en) * | 1998-11-25 | 2000-06-13 | Cadus Pharmaceutical Corporation | Methods and compositions for identifying receptor effectors |
| DE19860833C1 (de) * | 1998-12-30 | 2000-09-07 | Albrecht E Sippel | Methode zur zellulären High-Throughput(Hochdurchsatz)-Detektion von Rezeptor-Liganden-Interaktionen |
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| US6555325B1 (en) | 1999-06-14 | 2003-04-29 | Cadus Technologies, Inc. | System for detection of a functional interaction between a compound and a cellular signal transduction component |
| US7742877B1 (en) * | 1999-07-22 | 2010-06-22 | Becton, Dickinson & Company | Methods, apparatus and computer program products for formulating culture media |
| US7223533B2 (en) | 1999-09-10 | 2007-05-29 | Cadus Technologies, Inc. | Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways |
| US6406863B1 (en) * | 2000-06-23 | 2002-06-18 | Genetastix Corporation | High throughput generation and screening of fully human antibody repertoire in yeast |
| JP2004520824A (ja) * | 2000-12-01 | 2004-07-15 | ワイス | Ｒｇｓタンパク質のモジュレーターを検出するための方法および細胞 |
| GB0030038D0 (en) * | 2000-12-08 | 2001-01-24 | Univ Warwick | Yeast-based assay |
| JP2004530117A (ja) * | 2001-02-22 | 2004-09-30 | プラエシス ファーマシューティカルズ インコーポレーテッド | 生物プロセスを調節するペプチドを同定する方法 |
| CA2439383A1 (en) * | 2001-02-26 | 2002-09-06 | Arena Pharmaceuticals, Inc. | Endogenous and non-endogenous versions of human g protein-coupled receptors |
| EP1409656A4 (en) * | 2001-03-12 | 2005-01-12 | Darley Pharmaceuticals Ltd | SCREENING OF PHEROMONAL COMPOUNDS OF NON-STEROID AND NON-PEPTIDE INVERTEBRATE HAVING ACTIVITY MODULATING MITOGEN-ACTIVATED PROTEIN KINASE |
| US20070003980A1 (en) * | 2001-03-27 | 2007-01-04 | Woods Daniel F | Efficient methods to isolate effectors of proteins involved in olfactory or chemosensory pathways and efficient methods to use these effectors to alter organism olfaction, chemosensation, or behavior |
| US20100248268A1 (en) * | 2001-03-27 | 2010-09-30 | Woods Daniel F | Methods to utilize invertebrate chemosensory proteins for industrial and commercial uses |
| CA2442581A1 (en) * | 2001-03-27 | 2002-10-03 | Inscent, Inc. | Efficient methods for isolating functional g-protein coupled receptors and identifying active effectors and efficient methods to isolate proteins involved in olfaction and efficient methods to isolate and identifying active effectors |
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| EP1515985B1 (en) | 2002-01-23 | 2013-01-02 | Mohammed Raafat El-Gewely | Methods of screening molecular libraries for active molecules that restore the function of mutant p53 |
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| US7229762B2 (en) * | 2002-10-15 | 2007-06-12 | Duke University Medical Center | Proteomic screening for redox state dependent protein—protein interactions |
| EP1585807A4 (en) * | 2002-12-23 | 2006-05-24 | Glycofi Inc | STEROID RECEPTOR MODULATION OF GENE EXPRESSION |
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| US7718363B2 (en) * | 2003-04-25 | 2010-05-18 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds |
| US20050112551A1 (en) * | 2003-11-24 | 2005-05-26 | Agouron Pharmaceuticals, Inc. | Dual assay for evaluating activity and cytotoxicity of compounds in the same population of cells |
| EP1689348B1 (en) | 2003-12-05 | 2013-05-15 | Children's Hospital Medical Center | Oligosaccharide compositions and use thereof in the treatment of infection |
| JP5392992B2 (ja) * | 2007-03-30 | 2014-01-22 | アズワン株式会社 | 自己リン酸化受容体のアゴニスト、アンタゴニストのスクリーニング方法、遺伝子組換え酵母 |
| CA3187687A1 (en) | 2007-09-14 | 2009-03-19 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| US20090203149A1 (en) * | 2008-02-13 | 2009-08-13 | General Electric Company | Enhanced methods for gas and/or vapor phase analysis of biological assays |
| EP3336225B1 (en) | 2010-07-16 | 2020-02-19 | Adimab, LLC | Antibody libraries |
| JP7146637B2 (ja) * | 2015-12-22 | 2022-10-04 | アルブミディクス リミティド | 改善されたタンパク質発現株 |
| WO2017112847A1 (en) * | 2015-12-22 | 2017-06-29 | Albumedix A/S | Improved protein expression strains |
| JP2019510510A (ja) | 2016-02-24 | 2019-04-18 | アロマイクス・コーポレーション | 臭い（ｓｍｅｌｌ）、香り（ｓｃｅｎｔ）および食味（ｔａｓｔｅ）を検出するためのバイオセンサー |
| DK3642343T3 (en) | 2017-06-20 | 2022-03-14 | Albumedix Ltd | Improved protein expression strains |
| US10209239B1 (en) | 2017-08-16 | 2019-02-19 | Aromyx Corporation | Method of making an aromagraph comprising ectopic olfactory receptors |
| CN110904123B (zh) * | 2019-01-07 | 2021-11-05 | 广西科学院 | 一种用于促进高产甘蔗糖蜜酒精发酵的菌株及其应用 |
| WO2025008607A1 (en) * | 2023-07-06 | 2025-01-09 | Imperial College Innovations Limited | Determining the effects of modified peptides |
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| NZ207926A (en) * | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
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| EP0428000A1 (en) * | 1989-11-03 | 1991-05-22 | Abbott Laboratories | Fluorogenic substrates for the detection of proteolytic enzyme activity |
| US5283173A (en) * | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
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| CA2188950C (en) * | 1994-04-26 | 2001-07-03 | James R. Broach | Functional expression of mammalian adenylyl cyclase in yeast |
| WO1996023898A1 (en) * | 1995-01-31 | 1996-08-08 | Novo Nordisk A/S | A method of detecting biologically active substances |
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| US5569588A (en) * | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
-
1997
- 1997-09-24 WO PCT/US1997/017159 patent/WO1998013513A2/en not_active Ceased
- 1997-09-24 EP EP97944430A patent/EP0929691B1/en not_active Expired - Lifetime
- 1997-09-24 JP JP10515880A patent/JP2001501097A/ja not_active Ceased
- 1997-09-24 DE DE69731960T patent/DE69731960T2/de not_active Expired - Fee Related
- 1997-09-24 AT AT97944430T patent/ATE284972T1/de not_active IP Right Cessation
- 1997-09-24 AU AU45930/97A patent/AU733007B2/en not_active Ceased
- 1997-09-24 CA CA002266543A patent/CA2266543C/en not_active Expired - Fee Related
- 1997-09-24 US US08/936,632 patent/US6159705A/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008064553B4 (de) * | 2008-12-22 | 2015-05-13 | Technische Universität Dresden | Verfahren zum Nachweis und/oder zur Identifizierung hormonell wirksamer Substanzen |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998013513A2 (en) | 1998-04-02 |
| DE69731960D1 (de) | 2005-01-20 |
| ATE284972T1 (de) | 2005-01-15 |
| AU4593097A (en) | 1998-04-17 |
| EP0929691A2 (en) | 1999-07-21 |
| CA2266543A1 (en) | 1998-04-02 |
| WO1998013513A3 (en) | 1998-09-03 |
| CA2266543C (en) | 2003-12-09 |
| US6159705A (en) | 2000-12-12 |
| EP0929691B1 (en) | 2004-12-15 |
| AU733007B2 (en) | 2001-05-03 |
| JP2001501097A (ja) | 2001-01-30 |
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Legal Events
| Date | Code | Title | Description |
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| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |