DE69727736D1 - Verfahren zur Aktivierung von Prothrombin zu Thrombin - Google Patents

Verfahren zur Aktivierung von Prothrombin zu Thrombin

Info

Publication number
DE69727736D1
DE69727736D1 DE69727736T DE69727736T DE69727736D1 DE 69727736 D1 DE69727736 D1 DE 69727736D1 DE 69727736 T DE69727736 T DE 69727736T DE 69727736 T DE69727736 T DE 69727736T DE 69727736 D1 DE69727736 D1 DE 69727736D1
Authority
DE
Germany
Prior art keywords
thrombin
prothrombin
absence
activating
activating prothrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69727736T
Other languages
English (en)
Other versions
DE69727736T2 (de
Inventor
Hiroshi Kaetsu
Jun Mizuguchi
Takayoshi Hamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemo Sero Therapeutic Research Institute Kaketsuken
Original Assignee
Chemo Sero Therapeutic Research Institute Kaketsuken
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeutic Research Institute Kaketsuken filed Critical Chemo Sero Therapeutic Research Institute Kaketsuken
Application granted granted Critical
Publication of DE69727736D1 publication Critical patent/DE69727736D1/de
Publication of DE69727736T2 publication Critical patent/DE69727736T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69727736T 1996-08-09 1997-08-06 Verfahren zur Aktivierung von Prothrombin zu Thrombin Expired - Lifetime DE69727736T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22769596 1996-08-09
JP22769596A JP3944267B2 (ja) 1996-08-09 1996-08-09 プロトロンビンの活性化方法および該方法に基づくトロンビンの製造方法

Publications (2)

Publication Number Publication Date
DE69727736D1 true DE69727736D1 (de) 2004-04-01
DE69727736T2 DE69727736T2 (de) 2004-11-25

Family

ID=16864906

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69727736T Expired - Lifetime DE69727736T2 (de) 1996-08-09 1997-08-06 Verfahren zur Aktivierung von Prothrombin zu Thrombin

Country Status (6)

Country Link
US (1) US5811279A (de)
EP (1) EP0823476B1 (de)
JP (1) JP3944267B2 (de)
AT (1) ATE260336T1 (de)
DE (1) DE69727736T2 (de)
DK (1) DK0823476T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274090B1 (en) * 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6472162B1 (en) * 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
WO2001005948A1 (en) * 1999-07-14 2001-01-25 The Research Foundation Of State University Of New York Assay of the activation state of platelets
EP1585386A4 (de) 2002-02-20 2009-09-02 American Integrated Biolog Inc Rekombinante produktion im speichel
US20070011752A1 (en) * 2005-05-06 2007-01-11 American Integrated Biologics, Inc. Production of human proteins in transgenic animal saliva
RU2457248C2 (ru) * 2010-06-09 2012-07-27 Общество с ограниченной ответственностью фирма "Технология-Стандарт" Способ промышленного получения тромбина
EA028016B1 (ru) * 2013-06-06 2017-09-29 Общество с ограниченной ответственностью "Гематологическая Корпорация" (ООО "ГемаКор") Набор для измерения параметров системы гемостаза в образце крови или ее компонентов
RU2698206C1 (ru) * 2018-07-02 2019-08-23 Общество с ограниченной ответственностью "Гематологическая Корпорация" (ООО "ГемаКор") Набор реагентов для диагностики степени нейровоспаления
GB2579630A (en) * 2018-12-07 2020-07-01 Biotherapy Services Ltd Methods and compositions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560475A (en) * 1969-06-19 1971-02-02 Baxter Laboratories Inc Prothrombin complex prepared by precipitation with polyethylene glycol
US3682881A (en) * 1970-10-02 1972-08-08 Baxter Laboratories Inc Fractionation of plasma using glycine and polyethylene glycol
US5138034A (en) * 1989-07-12 1992-08-11 The Green Cross Corporation Method of fractionating plasma proteins
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
JPH04365481A (ja) * 1991-06-11 1992-12-17 Green Cross Corp:The トロンビンの製造法
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
DE4137996A1 (de) * 1991-11-19 1993-05-27 Behringwerke Ag Verfahren zur herstellung eines virussicheren thrombinkonzentrates
JPH0733799A (ja) * 1993-07-20 1995-02-03 Green Cross Corp:The 高比活性トロンビンおよびその製造方法
JPH07308190A (ja) * 1994-05-18 1995-11-28 Green Cross Corp:The トロンビンの製造方法
US5677162A (en) * 1995-05-01 1997-10-14 New York Blood Center, Inc. Method for activating prothrombin to thrombin

Also Published As

Publication number Publication date
JP3944267B2 (ja) 2007-07-11
DE69727736T2 (de) 2004-11-25
DK0823476T3 (da) 2004-06-14
EP0823476B1 (de) 2004-02-25
ATE260336T1 (de) 2004-03-15
JPH1052267A (ja) 1998-02-24
EP0823476A2 (de) 1998-02-11
US5811279A (en) 1998-09-22
EP0823476A3 (de) 1999-09-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition