DE69723485T2 - Verfahren zur Identifizierung von Wirkstoffen gegen HCV durch Verwendung von Strukturkoordinaten der Hepatitis-C-Virus-Protease - Google Patents
Verfahren zur Identifizierung von Wirkstoffen gegen HCV durch Verwendung von Strukturkoordinaten der Hepatitis-C-Virus-Protease Download PDFInfo
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- DE69723485T2 DE69723485T2 DE69723485T DE69723485T DE69723485T2 DE 69723485 T2 DE69723485 T2 DE 69723485T2 DE 69723485 T DE69723485 T DE 69723485T DE 69723485 T DE69723485 T DE 69723485T DE 69723485 T2 DE69723485 T2 DE 69723485T2
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- Communicable Diseases (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2527496P | 1996-09-12 | 1996-09-12 | |
| US25274 | 1996-09-12 | ||
| US731336 | 1996-10-18 | ||
| US08/731,336 US6153579A (en) | 1996-09-12 | 1996-10-18 | Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69723485D1 DE69723485D1 (de) | 2003-08-14 |
| DE69723485T2 true DE69723485T2 (de) | 2004-05-27 |
Family
ID=26699520
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69723485T Expired - Lifetime DE69723485T2 (de) | 1996-09-12 | 1997-09-12 | Verfahren zur Identifizierung von Wirkstoffen gegen HCV durch Verwendung von Strukturkoordinaten der Hepatitis-C-Virus-Protease |
| DE69712085T Expired - Lifetime DE69712085T2 (de) | 1996-09-12 | 1997-09-12 | Kristallisierbare zusammensetzungen, die einen komplex von protein-domäne ns3aus dem virus von hepatitis c und ns4a enthalten und damit bereitgestellte kristalle |
| DE69736995T Expired - Lifetime DE69736995T2 (de) | 1996-09-12 | 1997-09-12 | Kristallisierbare Zusammensetzungen, die einen Komplex von Protease-Domäne NS3 und NS4A aus dem Hepatitis C Virus enthalten, und damit bereitgestellte Kristalle |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69712085T Expired - Lifetime DE69712085T2 (de) | 1996-09-12 | 1997-09-12 | Kristallisierbare zusammensetzungen, die einen komplex von protein-domäne ns3aus dem virus von hepatitis c und ns4a enthalten und damit bereitgestellte kristalle |
| DE69736995T Expired - Lifetime DE69736995T2 (de) | 1996-09-12 | 1997-09-12 | Kristallisierbare Zusammensetzungen, die einen Komplex von Protease-Domäne NS3 und NS4A aus dem Hepatitis C Virus enthalten, und damit bereitgestellte Kristalle |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6153579A (enExample) |
| EP (1) | EP0935609B1 (enExample) |
| JP (1) | JP2001501602A (enExample) |
| AT (3) | ATE346088T1 (enExample) |
| AU (1) | AU736857B2 (enExample) |
| CA (1) | CA2264964A1 (enExample) |
| DE (3) | DE69723485T2 (enExample) |
| DK (1) | DK0935609T3 (enExample) |
| ES (2) | ES2202228T3 (enExample) |
| IL (1) | IL128826A0 (enExample) |
| PT (2) | PT935609E (enExample) |
| WO (1) | WO1998011134A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU227742B1 (en) | 1996-10-18 | 2012-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
| US6333186B1 (en) | 1999-01-08 | 2001-12-25 | Bristol-Myers Squibb Company | Modified forms of Hepatitis C NS3 protease for facilitating inhibitor screening and structural studies of protease: inhibitor complexes |
| US6524589B1 (en) * | 1999-04-08 | 2003-02-25 | Schering Corporation | Compositions of hepatitis C virus NS3/NS4A complex and methods for crystallizing same |
| JP2003511467A (ja) | 1999-10-14 | 2003-03-25 | ブリストル−マイヤーズ スクイブ カンパニー | アンドロゲンレセプターリガンド結合ドメインの結晶構造 |
| US7491808B2 (en) | 2000-06-15 | 2009-02-17 | Novartis Vaccines And Diagnostics, Inc. | HCV non-structural protein mutants and uses thereof |
| IL152719A0 (en) | 2000-06-28 | 2003-06-24 | Bristol Myers Squibb Co | Selective androgen receptor modulators and methods for their identification |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| AU2002217838A1 (en) | 2000-11-14 | 2002-05-27 | Bristol-Myers Squibb Company | A human serpin secreted from lymphoid cells LSI-01 |
| EP1567642A4 (en) | 2001-04-03 | 2006-02-08 | Bristol Myers Squibb Co | POLYNUCLEOTIDE ENCODING A NEW CYSTEINE PROTEASE OF THE CALPAIN SUPERFAMILY, CAN-12 AND THEIR VARIANTS |
| US20030027315A1 (en) * | 2001-09-24 | 2003-02-06 | Ada Yonath | Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, and methods of rationally designing or identifying antibiotics using structure coordinate data derived from such crystals |
| US20050009877A1 (en) * | 2003-05-15 | 2005-01-13 | Henry Lu | Methods of identifying HCV NS5B polymerase inhibitors and their uses |
| PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
| CN1894276B (zh) | 2003-10-27 | 2010-06-16 | 威特克斯医药股份有限公司 | Hcv ns3-ns4a蛋白酶抗药性突变体 |
| US8187874B2 (en) | 2003-10-27 | 2012-05-29 | Vertex Pharmaceuticals Incorporated | Drug discovery method |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| JP5409008B2 (ja) | 2005-11-11 | 2014-02-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｃ型肝炎ウイルス改変体 |
| US7705138B2 (en) | 2005-11-11 | 2010-04-27 | Vertex Pharmaceuticals Incorporated | Hepatitis C virus variants |
| EP1991229A2 (en) | 2006-02-27 | 2008-11-19 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| EP2194039A1 (en) * | 2006-03-16 | 2010-06-09 | Vertex Pharmceuticals Incorporated | Process for preparing optically enriched compounds |
| US8440443B1 (en) | 2006-05-16 | 2013-05-14 | Merck Sharp & Dohme Corp. | MEK1 polypeptides |
| BRPI0807907A2 (pt) | 2007-02-27 | 2017-05-16 | Vertex Pharma | co-cristais e composições farmacêuticas compreendendo os mesmos. |
| CN101903392A (zh) | 2007-02-27 | 2010-12-01 | 弗特克斯药品有限公司 | 丝氨酸蛋白酶的抑制剂 |
| TW200922933A (en) | 2007-08-30 | 2009-06-01 | Vertex Pharma | Co-crystals and pharmaceutical compositions comprising the same |
| US8988881B2 (en) * | 2007-12-18 | 2015-03-24 | Sandia Corporation | Heat exchanger device and method for heat removal or transfer |
| US9005417B1 (en) | 2008-10-01 | 2015-04-14 | Sandia Corporation | Devices, systems, and methods for microscale isoelectric fractionation |
| US9795961B1 (en) | 2010-07-08 | 2017-10-24 | National Technology & Engineering Solutions Of Sandia, Llc | Devices, systems, and methods for detecting nucleic acids using sedimentation |
| WO2012118982A2 (en) | 2011-03-02 | 2012-09-07 | Sandia Corporation | Axial flow heat exchanger devices and methods for heat transfer using axial flow devices |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4833233A (en) * | 1987-08-20 | 1989-05-23 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Human serum albumin crystals and method of preparation |
| US5353236A (en) * | 1992-04-23 | 1994-10-04 | The Board Of Trustees Of The Leland Stanford University | High-resolution crystallographic modelling of a macromolecule |
| US5453937A (en) * | 1993-04-28 | 1995-09-26 | Immunex Corporation | Method and system for protein modeling |
| IT1272179B (it) * | 1994-02-23 | 1997-06-16 | Angeletti P Ist Richerche Bio | Metodologia per riprodurre in vitro l'attivita' proteolitica della proteasi ns3 del virus hcv. |
-
1996
- 1996-10-18 US US08/731,336 patent/US6153579A/en not_active Expired - Lifetime
-
1997
- 1997-09-12 EP EP97942450A patent/EP0935609B1/en not_active Expired - Lifetime
- 1997-09-12 DE DE69723485T patent/DE69723485T2/de not_active Expired - Lifetime
- 1997-09-12 WO PCT/US1997/016182 patent/WO1998011134A1/en not_active Ceased
- 1997-09-12 AU AU44145/97A patent/AU736857B2/en not_active Ceased
- 1997-09-12 DK DK97942450T patent/DK0935609T3/da active
- 1997-09-12 AT AT03015398T patent/ATE346088T1/de not_active IP Right Cessation
- 1997-09-12 ES ES01101009T patent/ES2202228T3/es not_active Expired - Lifetime
- 1997-09-12 PT PT97942450T patent/PT935609E/pt unknown
- 1997-09-12 CA CA002264964A patent/CA2264964A1/en not_active Abandoned
- 1997-09-12 DE DE69712085T patent/DE69712085T2/de not_active Expired - Lifetime
- 1997-09-12 JP JP10513899A patent/JP2001501602A/ja not_active Ceased
- 1997-09-12 AT AT97942450T patent/ATE216400T1/de not_active IP Right Cessation
- 1997-09-12 PT PT01101009T patent/PT1118619E/pt unknown
- 1997-09-12 IL IL12882697A patent/IL128826A0/xx unknown
- 1997-09-12 ES ES97942450T patent/ES2175462T3/es not_active Expired - Lifetime
- 1997-09-12 AT AT01101009T patent/ATE244729T1/de not_active IP Right Cessation
- 1997-09-12 DE DE69736995T patent/DE69736995T2/de not_active Expired - Lifetime
-
1999
- 1999-02-25 US US09/257,667 patent/US6303287B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE216400T1 (de) | 2002-05-15 |
| US6153579A (en) | 2000-11-28 |
| ATE244729T1 (de) | 2003-07-15 |
| JP2001501602A (ja) | 2001-02-06 |
| IL128826A0 (en) | 2000-01-31 |
| ATE346088T1 (de) | 2006-12-15 |
| EP0935609B1 (en) | 2002-04-17 |
| EP0935609A1 (en) | 1999-08-18 |
| PT935609E (pt) | 2002-09-30 |
| DE69712085T2 (de) | 2002-11-28 |
| DK0935609T3 (da) | 2002-07-22 |
| HK1038573A1 (en) | 2002-03-22 |
| DE69736995D1 (de) | 2007-01-04 |
| PT1118619E (pt) | 2003-11-28 |
| DE69723485D1 (de) | 2003-08-14 |
| DE69712085D1 (de) | 2002-05-23 |
| AU736857B2 (en) | 2001-08-02 |
| US6303287B1 (en) | 2001-10-16 |
| AU4414597A (en) | 1998-04-02 |
| WO1998011134A1 (en) | 1998-03-19 |
| ES2202228T3 (es) | 2004-04-01 |
| ES2175462T3 (es) | 2002-11-16 |
| DE69736995T2 (de) | 2007-09-20 |
| HK1022700A1 (en) | 2000-08-18 |
| CA2264964A1 (en) | 1998-03-19 |
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