DE69722023D1 - Eine neue kristalline polymorphe form von fluticasonepropionat, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon - Google Patents

Eine neue kristalline polymorphe form von fluticasonepropionat, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon

Info

Publication number
DE69722023D1
DE69722023D1 DE69722023T DE69722023T DE69722023D1 DE 69722023 D1 DE69722023 D1 DE 69722023D1 DE 69722023 T DE69722023 T DE 69722023T DE 69722023 T DE69722023 T DE 69722023T DE 69722023 D1 DE69722023 D1 DE 69722023D1
Authority
DE
Germany
Prior art keywords
fluticasone propionate
production
pharmaceutical preparations
new crystalline
polymorphe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69722023T
Other languages
English (en)
Other versions
DE69722023T2 (de
Inventor
Simon Murray Cooper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE69722023D1 publication Critical patent/DE69722023D1/de
Application granted granted Critical
Publication of DE69722023T2 publication Critical patent/DE69722023T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Disintegrating Or Milling (AREA)
DE69722023T 1996-10-24 1997-10-23 Eine neue kristalline polymorphe form von fluticasonepropionat, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon Expired - Lifetime DE69722023T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9622173 1996-10-24
GBGB9622173.4A GB9622173D0 (en) 1996-10-24 1996-10-24 Particulate Products
PCT/GB1997/002929 WO1998017676A1 (en) 1996-10-24 1997-10-23 A novel polymorphic crystalline form of fluticasone propionate, a method for its production and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
DE69722023D1 true DE69722023D1 (de) 2003-06-18
DE69722023T2 DE69722023T2 (de) 2004-04-08

Family

ID=10801903

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69722023T Expired - Lifetime DE69722023T2 (de) 1996-10-24 1997-10-23 Eine neue kristalline polymorphe form von fluticasonepropionat, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon

Country Status (13)

Country Link
US (1) US6406718B1 (de)
EP (1) EP0937100B1 (de)
JP (1) JP2001502350A (de)
AT (1) ATE240345T1 (de)
AU (1) AU4717197A (de)
CA (1) CA2269134C (de)
DE (1) DE69722023T2 (de)
DK (1) DK0937100T3 (de)
ES (1) ES2198555T3 (de)
GB (1) GB9622173D0 (de)
PE (1) PE68099A1 (de)
PT (1) PT937100E (de)
WO (1) WO1998017676A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806462D0 (en) * 1998-03-26 1998-05-27 Glaxo Group Ltd Improved compositions for inhalation
GB9828204D0 (en) * 1998-12-21 1999-02-17 Smithkline Beecham Plc Process
EP1185248B1 (de) 1999-06-09 2012-05-02 Robert E. Sievers Überkritische fluidgestützte verneblung und blasen trochnen
US20020133032A1 (en) * 2000-02-25 2002-09-19 Jufang Barkalow Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
ES2292604T5 (es) 2000-08-05 2015-06-01 Glaxo Group Limited Éster S-fluorometílico del ácido 6 ,9 -difluoro-17 -[(2-furanilcarbonil)oxi]-11 -hidroxi-16 -metil-3-oxo-androsta-1,4-dien-17 -carbotioico como agente antiinflamatorio
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
GB0021927D0 (en) * 2000-09-07 2000-10-25 Glaxo Group Ltd Use of pharmaceutical combination
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
GB0208742D0 (en) * 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
JP2005511521A (ja) * 2001-10-10 2005-04-28 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 加圧ガス状流体による粉末処理
GB0125604D0 (en) * 2001-10-25 2001-12-19 Glaxo Group Ltd Novel process
ATE464880T1 (de) 2002-02-04 2010-05-15 Elan Pharma Int Ltd Arzneistoffnanopartikel mit lysozym- oberflächenstabilisator
GB0202564D0 (en) * 2002-02-04 2002-03-20 Glaxo Group Ltd Process
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US20040023935A1 (en) * 2002-08-02 2004-02-05 Dey, L.P. Inhalation compositions, methods of use thereof, and process for preparation of same
US20040109826A1 (en) * 2002-12-06 2004-06-10 Dey, L.P. Stabilized albuterol compositions and method of preparation thereof
US20040208833A1 (en) * 2003-02-04 2004-10-21 Elan Pharma International Ltd. Novel fluticasone formulations
CA2524773C (en) 2003-05-08 2014-04-08 Nektar Therapeutics Uk Ltd Particulate coformulations of active substances with excipients
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US20060009435A1 (en) * 2004-06-23 2006-01-12 Joseph Kaspi Synthesis and powder preparation of fluticasone propionate
WO2007009164A1 (en) 2005-07-15 2007-01-25 Eiffel Technologies Limited Method of particle formation
US10137083B2 (en) 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US11311477B2 (en) 2006-03-07 2022-04-26 Sgn Nanopharma Inc. Ophthalmic preparations
CA2645080A1 (en) * 2006-03-07 2007-09-13 Novavax,Inc. Nanoemulsions of poorly soluble pharmaceutical active ingredients and methods of making the same
EP2010153A2 (de) * 2006-04-03 2009-01-07 Teva Pharmaceutical Industries Limited Wirkstoffmikropartikel
WO2007134845A2 (en) * 2006-05-18 2007-11-29 Synthon B.V. Olanzapine pharmaceutical composition
CL2007002807A1 (es) * 2006-09-29 2008-04-11 Synthon Bv Composicion farmaceutica en estado solido que comprende olanzapina o una sal farmaceuticamente aceptable de la misma y lactosa anhidra; tableta farmaceutica oral; procedimiento de preparacion de dicha tableta, util en el tratamiento de la esquizofren
GB0702402D0 (en) 2007-02-08 2007-03-21 Thar Pharmaceuticals Inc Method of creating crystalline substances
WO2008097664A1 (en) 2007-02-11 2008-08-14 Map Pharmaceuticals, Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
US8088824B2 (en) * 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
JP2010111592A (ja) * 2008-11-04 2010-05-20 Aska Pharmaceutical Co Ltd プロピオン酸フルチカゾンを含む局所投与剤
HUE032426T2 (en) 2009-05-27 2017-09-28 Alkermes Pharma Ireland Ltd Inhibition of flake aggregation in nanoparticulate meloxicam formulations
US9012511B2 (en) 2010-05-19 2015-04-21 Alkermes Pharma Ireland Limited Nanoparticulate cinacalcet compositions
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition
JP2014520848A (ja) * 2011-07-08 2014-08-25 ファイザー・リミテッド １型プロピオン酸フルチカゾンの調製のための方法
FI3181128T3 (fi) * 2012-01-13 2023-06-02 Xspray Pharma Ab Publ Nilotinibin farmaseuttinen koostumus
DK3517541T3 (da) * 2012-05-08 2020-09-07 Nicox Ophthalmics Inc Polymorf form af fluticasonpropionat
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
US9446131B2 (en) 2013-01-31 2016-09-20 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9433680B2 (en) 2013-01-31 2016-09-06 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9452173B2 (en) 2013-01-31 2016-09-27 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
CN104004044A (zh) * 2013-02-25 2014-08-27 武汉诺安药业有限公司 高纯度丙酸氟替卡松制备方法
US10016415B2 (en) 2014-08-18 2018-07-10 Alkermes Pharma Ireland Limited Aripiprazole prodrug compositions
RS58746B2 (sr) 2014-08-18 2022-07-29 Alkermes Pharma Ireland Ltd Kompozicije proleka aripiprazola
CN108066329B (zh) * 2016-11-11 2021-11-16 江苏恒瑞医药股份有限公司 一种吸入用氟替卡松或其衍生物的微粒的制备方法
WO2021219230A1 (en) 2020-04-30 2021-11-04 Paolo Fiorina Antiviral treatment

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH24267A (en) * 1980-02-15 1990-05-29 Glaxo Group Ltd Androstane carbothioates and pharmaceutical compositions containing the same
GB2088877B (en) 1980-02-15 1984-07-04 Glaxo Group Ltd Androstane 17 carbothioates
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
IL104068A (en) * 1991-12-12 1998-10-30 Glaxo Group Ltd Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant
US5658549A (en) 1991-12-12 1997-08-19 Glaxo Group Limited Aerosol formulations containing propellant 134a and fluticasone propionate
GB9313650D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles

Also Published As

Publication number Publication date
JP2001502350A (ja) 2001-02-20
PE68099A1 (es) 1999-07-19
ES2198555T3 (es) 2004-02-01
EP0937100B1 (de) 2003-05-14
DK0937100T3 (da) 2003-09-01
DE69722023T2 (de) 2004-04-08
PT937100E (pt) 2003-09-30
US6406718B1 (en) 2002-06-18
AU4717197A (en) 1998-05-15
GB9622173D0 (en) 1996-12-18
WO1998017676A1 (en) 1998-04-30
EP0937100A1 (de) 1999-08-25
CA2269134A1 (en) 1998-04-30
ATE240345T1 (de) 2003-05-15
CA2269134C (en) 2007-01-09

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8330 Complete renunciation